KR102039706B1 - Cosmetic composition having increased skin absorption rate - Google Patents

Abstract

The present invention provides a cosmetic composition having an increased skin absorption rate, comprising: 80-95 parts by weight of fish collagen powder; 5-15 parts by weight of hyaluronic acid powder; 1-2 parts by weight of adenosine powder; 5-10 parts by weight of vitamin C powder; 5-10 parts by weight of niacinamide powder; 25 parts by weight of beta carotene powder; and 0.1-5 parts by weight of a dry powder prepared by mixing mastic gum, Boswellia sereta, Sophora tonkinensis and Lobelia chinensis in a weight ratio of 1-3 : 1-3 : 1-3: 1-3, followed by hot water extraction.

Description

Cosmetic composition having increased skin absorption rate

The present invention relates to a cosmetic composition with a high skin absorption rate.

Collagen is the most abundant protein in animal body, accounting for more than 30% of body protein, and has been found to be at least 19 types (Nakamura, YN et al., Relationship among collagen amount, distribution and architecture in the M. Longissimus thoracis and M. pectoralis profundus from pigs.Meat Science, 64, pp 43-50, 2003). In addition, collagen is a major protein of animal connective tissue, and supports tissues and organs and surrounds the body surface and plays a role in maintaining body shape. In particular, as a major component of connective tissue such as skin, cartilage and bone in the living body, 40% is widely distributed throughout the body, such as skin, 20% bone and cartilage, and other blood vessels and internal organs.

Unlike myofibrillar proteins, which have a double helix structure, collagen has a triple helix structure, about 14-15 nm in diameter, 280-300 nm in length, and an average molecular weight of about 300 KDa (Lehninger, AL Biochemistry, 2nd ed., Pp. 145, 1975), have a regular array of amino acids such as (Gly ~ XY) n and share within or between tropocollagen molecules, the basic molecules of fibrous proteins. Physically and biologically stable structures are formed by binding crosslinking (McClain, PE et al., Amino acid composition and cross-linking characteristics of collagen intramuscular connective tissue of striated muscle (Bostaurus). Biochemistry, 2 (7), pp 121-124, 1971).

Collagen has been applied as a raw material of leather or gelatin for a long time, and its field of application has become more diverse in recent years.

Collagen applied to medicines has been reported to have a healing effect on skin damaged by burns or wounds (Jeyanthi, R. et al., Solid tumour chemotherapy using implantable collagen ~ poly (HEMA) hydrogel containing 5 ~ fluorouracil. of Pharmacy & Pharmacology, 43, pp. 60-62, 1991).

In addition, collagen is not only used as a functional material of medicines, but also has a function of enhancing skin moisturizing, and thus is widely used in various fields such as cosmetic base materials.

In recent papers, peptides obtained from protein hydrolysates have been used as potential materials to improve wrinkles, improve moisturization, increase elasticity, and exhibit specific skin effects.

However, efficient methods for the application of collagen to the skin have not been fully developed. Therefore, active researches on how to apply collagen to the skin in a safe state without alteration and how to increase skin penetration are required.

Republic of Korea Patent Publication No. 2005 ~ 0026179

The present invention has been made to solve the above problems of the prior art,

By including fish collagen in a dry state, it can be applied to the skin in a safe way without alteration.The molecular weight of collagen can be effectively penetrated into the skin.The cosmetic composition containing fish collagen with excellent stability is included by including an excellent dispersant. It aims to provide.

In addition, the present invention has a synergistic action with the fish collagen, by containing a variety of functional ingredients to reduce the fishy, it is excellent in skin elasticity, antioxidant, wrinkle improvement, etc., fish collagen-containing cosmetic composition to prevent fishy occurrence It aims to provide.

The present invention,

80 to 95 parts by weight of fish collagen powder; 5-15 parts by weight of hyaluronic acid powder; 1-2 parts by weight of adenosine powder; 5 to 10 parts by weight of vitamin C powder; 5 to 10 parts by weight of niacinamide powder; 2 to 5 parts by weight of beta carotene powder; And 0.1 to 5 parts by weight of a dry powder prepared by mixing mastic gum, boswellia sereta, wild boil and whiskers in a weight ratio of 1 to 3: 1 to 3: 1 to 3: 1 to 3 and hot water extraction It provides a cosmetic composition containing a high skin absorption.

In one embodiment of the present invention, the cosmetic composition further comprises 2 to 5 parts by weight of the compound represented by the formula (1) and 2 to 5 parts by weight of polyglyceryl-3 methyl glucose distearate based on 100 parts by weight of the composition Can be.

[Formula 1]

Where

n is a natural number between 2 and 15,

x and y are mole fractions where a is 0.3 to 0.7, b is 0.3 to 0.7, and x + y is 1;

a and b are mole fractions, a is 0.3 to 0.7, b is 0.3 to 0.7, and a + b is 1.

In one embodiment of the present invention, the fish collagen powder may be fish scale collagen powder.

In one embodiment of the present invention, the cosmetic composition may be used by mixing with 30 to 500 parts by weight of water based on 100 parts by weight of the cosmetic composition.

In one embodiment of the present invention, the cosmetic composition may be used in admixture with at least one selected from the group consisting of a whitening cosmetic, an anti-wrinkle cosmetic, an antioxidant cosmetic, a skin elasticity cosmetic, a cosmetic pack material, and a cosmetic pack composition.

The cosmetic composition having a high skin absorption rate of the present invention can be applied to the skin in a safe manner without deterioration by including fish collagen in a dry state, and the molecular weight of collagen can be effectively penetrated into the skin, and by containing an excellent dispersant, Excellent stability when applied to

In addition, by synthesizing with fish collagen, by including a variety of functional ingredients to reduce fishy, provides excellent skin elasticity, antioxidant, wrinkle improvement and the like, it provides an effect that can be used without fishy.

Hereinafter, the present invention will be described in detail.

The present invention, fish collagen powder 80 to 95 parts by weight; 5-15 parts by weight of hyaluronic acid powder; 1-2 parts by weight of adenosine powder; 5 to 10 parts by weight of vitamin C powder; 5 to 10 parts by weight of niacinamide powder; 2 to 5 parts by weight of beta carotene powder; And 0.1 to 5 parts by weight of a dry powder prepared by mixing mastic gum, boswellia sereta, wild boil and whiskers in a weight ratio of 1 to 3: 1 to 3: 1 to 3: 1 to 3 and hot water extraction It relates to a fish collagen-containing cosmetic composition comprising.

In one embodiment of the present invention, the cosmetic composition further comprises 2 to 5 parts by weight of the compound represented by the formula (1) and 2 to 5 parts by weight of polyglyceryl-3 methyl glucose distearate based on 100 parts by weight of the composition Can be.

[Formula 1]

Where

n is a natural number between 2 and 15,

x and y are mole fractions where x is 0.3 to 0.7, y is 0.3 to 0.7, and x + y is 1;

a and b are mole fractions, a is 0.3 to 0.7, b is 0.3 to 0.7, and a + b is 1.

N is a natural number of 4-10, x and y are mole fractions a is 0.4-0.6, b is 0.4-0.6; It is preferable that a and b are mole fractions, a is 0.4-0.6, and b is 0.4-0.6.

The compound of Formula 1 is a styrene-acrylate copolymer substituted with a diisocyanate compound (Formula 3) and acrylic acid- (2-oxo-1,3-dioxolan-4-ylmethyl methacrylate) copolymer (following As a block copolymer of Formula 2), it is used as an emulsifier.

In the block copolymer, the styrene-acrylate copolymer portion is included as a hydrophobic portion, and the acrylic acid- (2-oxo-1,3-dioxolan-4-ylmethyl methacrylate) copolymer portion is a hydrophilic portion. Included.

The weight average molecular weight of the block copolymer which is the emulsion aid may be 10,000 to 100,000, more preferably 30,000 to 70,000. When the weight average molecular weight satisfies the above-mentioned range, it is advantageous for dispersing fine particles such as fish collagen.

It is preferable that the average particle diameter of the said copolymer is 10-100 nanometers. When the particle size is such, penetration into the skin and collection of the active ingredient are excellent. The copolymer thus obtained is remarkably stable in aqueous solution compared to low molecular weight micelles.

The block copolymer of Chemical Formula 1 is a styrene-acrylate copolymer substituted with an acrylic acid- (2-oxo-1,3-dioxolan-4-ylmethyl methacrylate) copolymer (Formula 2) and a diisocyanate compound It is formed by the reaction of Formula 3 below. Specifically, a block copolymer is formed by the reaction of the hydroxyl group of the carboxyl group of Formula 2 with the terminal isocyanate group of Formula 3.

[Formula 2]

[Formula 3]

In Equations 2 and 3,

n is a natural number between 2 and 15,

x and y are mole fractions where x is 0.3 to 0.7, y is 0.3 to 0.7, and x + y is 1;

a and b are mole fractions, a is 0.3 to 0.7, b is 0.3 to 0.7, and a + b is 1.

Fish collagen in the above means collagen obtained from fish. For example, collagen obtained from fish scales, fish skin, etc. can be mentioned.

In particular, the fish collagen powder in the present invention may be fish scale collagen powder. Fish scale collagen powder has a molecular weight of 300 Daltons to 1000 Daltons is very small and can be applied to the skin magnetically when applied to the skin, thereby providing an excellent absorption of the skin.

In one embodiment of the present invention, the cosmetic composition may be used by mixing with 30 to 500 parts by weight of water based on 100 parts by weight of the cosmetic composition.

In addition, in one embodiment of the present invention, the cosmetic composition may be used in admixture with one or more selected from the group consisting of a whitening cosmetic, an anti-wrinkle cosmetic, an antioxidant cosmetic, skin elasticity cosmetic, cosmetic pack material, and cosmetic pack composition. have.

In the cosmetic composition of the present invention, the dry powder of the mastic gum, boswellia serreta, wild boil and sputum hydrangea hot water extract, the components of the first 1-3: 1-3: 1-3: 1-3 Mix by weight ratio, add 50 to 500 parts by weight of water based on 100 parts by weight of the components, concentrate the hot water extract with hot water extraction for 0.5 to 5 hours, and evaporate and dry water from the concentrated mixture.

The ingredients provide the effects of skin elasticity, antioxidant, wrinkle improvement, and the like.

The mastic (Mastic, name: Pistacia lentiscus LINNE) is a food additive listed in the natural flavoring flavor No. 272 of the food additives, a viscous natural sap from the sumac and mastic trees native to Southeastern Hios Island, Greece It is gum. The components of the mastic are 60 to 70% of resin, 33% of alpha beta-Boswellic acid, 33% of olibanoresene, and contain arabic acid. Doing.

Mastic extracts are known to have anti-inflammatory, antioxidant and anti-cancer effects, and are widely used in Chinese medicine for the treatment or prevention of inflammatory diseases including arthritis, asthma and inflammatory bowel disease. The history of mastic is known to indicate that the ancient Greeks used mastic or sweeteners or beverages to alleviate any discomfort in the upper abdomen, stomach pain, indigestion, or stomach ulcers. Stick oil is used as a food, and mastic is also used as a drink or food ingredient in Iraq. Andukgyun's `` Clinical application of herbal medicine '' mentions that when ulcers are caused by skin infections caused by trauma, the powders are applied to the patient to promote the formation of granulation tissue, remove pain, and are mainly used for pain relief.

The Boswellia serreta are native to Africa, southern Arabia, or India, and light greenish oozes out of the stem. Boswellia sereta extract has been traditionally used for inflammation of skin rashes and ulcers, respiratory diseases such as asthma, bronchitis and laryngitis, and is known to have a medical effect on arthritis. The Boswellia serrata is representative of Boswellia sereta spp., And its extract contains a large amount of Boswellic acid, which shows very good elastase activity inhibition and glycosaminoglycan degradation inhibitory effect.

The ridges are vine-growing bush roots, also known as menispermum dahuricum DC. It resides in sunny foothills all over Korea and is known to contain alkaloids, taurisin, and terandrin in its roots and stems (Yakugawa Zasshi 1970). In addition, cynomenin and tauricin are known to be effective for hypertension and anti-inflammatory effects, and are currently being studied for the treatment of rheumatism by extracting and classifying total alkaloids (Acta Med Okayama 1976). .

The beard sputum flower is a medicinal plant that is used as a herbal medicine in oriental medicine contains various bioactive substances. Beard sputum flower powder is called semi-false, semi-perturbation, or quick sea color. It is distributed in sub-central and Jeju islands in Korea and inhabits wetlands of trenches, streams and ricefields. Beard sputum powder has traditionally been effective in diuretic, anti-inflammatory and detoxification, and has been used as a medicine to treat asthma, dyspnea, whooping cough, malignant boils, eczema and traumatic bleeding.

Fish collagen-containing cosmetic composition of the present invention may further comprise 5 ~ 10 parts by weight of paracres (paraclass, Acmella oleracea) extracted solids based on 100 parts by weight of the composition.

The paracrese is a plant of perennial or perennial herb of the Campanula asteraceae, and is native to tropical Brazil in East India and South America. When you eat the flowers and leaves, you can feel the unique flavor and it is mainly used as a spice.

Extracted solids obtained from paracres extract can be obtained by obtaining and extracting the hydrothermal extract of paracres by evaporating water. The paracrex extract solids contain Spilanthol. Therefore, it provides skin wrinkle reduction effect by inhibiting skin muscle contraction and helps the recovery of fibroblast cells, thereby increasing skin regeneration ability.

In addition, it provides moisture and nourishment to the skin to prevent damage to the skin, helps the skin texture to be smooth and shiny, and to soothe pores by removing sedative effects and skin and pore wastes from the skin stimulated by various stresses such as fine dust. Contracts and provides the effect of enhancing skin elasticity.

In addition, the fish collagen-containing cosmetic composition of the present invention can be applied to food in addition to the cosmetic, it can be usefully used as feed for livestock.

Hereinafter, the present invention will be described in more detail with reference to Examples. However, the following examples are intended to illustrate the present invention more specifically, but the scope of the present invention is not limited by the following examples. The following examples can be appropriately modified and changed by those skilled in the art within the scope of the present invention.

Preparation Example 1 Preparation of Block Copolymer Represented by Formula 1

(1) Preparation of styrene-acrylic acid copolymer substituted with diisocyanate compound

Nitrogen gas was refluxed, and 20 parts by weight of styrene and 20 parts by weight of acrylic acid were added to a 1 L reactor provided with a cooling device for easy temperature control. 60 parts by weight of ethyl acetate (EAc; ethyl aceate) was added as a solvent, and nitrogen gas was purged for 30 minutes. The temperature was maintained at 134 ° C, 0.1 parts by weight of AIBN (azobisisobutyronitrile) as a reaction initiator was added, and reacted for 1 hour to prepare a styrene-acrylic acid copolymer having a weight average molecular weight of 17,200.

100 parts by weight of ethyl acetate (EAc; ethyl aceate) as a solvent and 100 parts by weight of the styrene-acrylic acid copolymer solids prepared above were added to a 1L reactor equipped with a refrigeration device for nitrogen gas reflux and for easy temperature control. 10 parts by weight of hexamethylene diisocyanate, 54 mg of magnesium trifluorosulfonate, 0.5 part by weight of lonol and 0.15 part by weight of Tinuvin were added. The reaction was heated for 15 hours by raising the temperature to 110 ° C to prepare a styrene-acrylate copolymer in which the hydrogen portion of acrylic acid was substituted with hexamethylene diisocyanate.

(2) Preparation of Acrylic Acid- (2-oxo-1,3-dioxolan-4-ylmethyl methacrylate) Copolymer

20 parts by weight of acrylic acid, 20 parts by weight of 2-oxo-1,3-dioxolan-4-ylmethyl methacrylate, and 0.6 parts by weight of azo in a 1 L reactor equipped with a refrigeration device for nitrogen gas reflux and for easy temperature control. Isobutyronitrile was added.

60 parts by weight of methyl ethyl ketone was added as a solvent, and nitrogen gas was purged for 30 minutes. The temperature was maintained at 75 ° C., 0.1 parts by weight of AIBN (azobisisobutyronitrile), a reaction initiator, and reacted for 1 hour. Acrylic acid- (2-oxo-1,3-dioxolan-4-yl having a weight average molecular weight of 20,500 Methyl methacrylate) copolymers were prepared.

(3) Preparation of block copolymer represented by the formula (1)

100 ml of dimethylformamide and 290 mg of N, N-carbonyldiimidazole (CDI) were added to the reaction vessel and stirred. To this was added 20 g of acrylic acid- (2-oxo-1,3-dioxolan-4-ylmethyl methacrylate) copolymer prepared in (2) to acrylic acid- (2-oxo-1,3-diox Hydroxy end group of the solan-4-ylmethyl methacrylate) copolymer was activated. To the solution was added 25 mg of styrene-acrylate copolymer substituted with 0.5 mg of lonol, 0.15 mg of Tinuvin, and the hexamethylene diisocyanate prepared in (1) above, followed by heating to 110 ° C. After 15 hours of heating, the resultant was filtered through a nylon filter having a pore size of 0.45 micrometer, dispersed in tertiary distilled water, and then removed from the unreacted material and reagent through dialysis to obtain a weight average molecular weight of 42,150. A block copolymer was prepared.

Preparation Example 2 Preparation of Dry Powder of Hot Water Extract of Mixed Components

After mixing 1 part by weight of the mastic gum, 1 part by weight of Boswellia serreta powder, 1 part by weight of wild boiled powder and 1 part by weight of beard flower powder, further 10 parts by weight of water and concentrated for 1 hour while continuing to boil, A dry powder of the above ingredients was prepared through evaporation and drying of water.

Example 1: Fish Collagen-Containing Cosmetic Composition

87 parts by weight of fish scale collagen powder, 10 parts by weight of hyaluronic acid powder, 1.5 parts by weight of adenosine powder, 7 parts by weight of vitamin C powder, 8 parts by weight of niacinamide powder, 3 parts by weight of beta carotene powder, and prepared in Preparation Example 2 A fish collagen-containing cosmetic composition including 0.5 parts by weight of a dry powder was prepared.

Example 2: Fish Collagen-Containing Cosmetic Composition

Fish collagen is added by adding 3 parts by weight of the compound represented by Formula 1 and 3 parts by weight of polyglyceryl-3 methylglucose distearate based on 100 parts by weight of the cosmetic composition prepared in Example 1 A cosmetic composition was prepared.

Examples 3 and 4: Liquid fish collagen-containing cosmetic composition

100 parts by weight of distilled water was mixed with 100 parts by weight of the fish collagen-containing cosmetic composition prepared in Examples 1 and 2 to prepare a liquid fish collagen-containing cosmetic composition of Examples 3 and 4, respectively.

Test Example 1: Evaluation of Odor of Liquid Fish Collagen-Containing Cosmetic Composition

Since the fish collagen is contained in the cosmetic composition of the present invention, there is a fear of fishy occurrence. Therefore, the degree of fishy smell of the liquid fish collagen-containing cosmetic composition of Examples 3 and 4 of the present invention was confirmed by directly smelling, and the results are shown in Table 1 below.

○: no fishy smell, △: slightly present fishy, x: badly fishy

Example 4 Example 5 Fishy evaluation ○ ○

As shown in Table 1, the fish collagen-containing cosmetic composition of the present invention was confirmed that fishy smell does not occur, even though it contains fish scale collagen.

Test Example 2: Evaluation of Safety, Usability, Moisturizing, Skin Elasticity, Wrinkle Improvement Performance of Liquid Fish Collagen-Containing Cosmetic Composition

In order to evaluate the safety, usability, skin elasticity improvement, and wrinkle improvement performance of the liquid fish collagen containing cosmetic composition of Examples 3 and 4, blind tests were performed. As a comparative example, Retune Wrinkle Repair Cream (manufactured by LG H & H) was used.

In the experiment, 30 women in their 30s were selected as the experience group, and the collagen-containing cosmetic compositions of Examples 3, 4, and Comparative Example were divided into three groups of 10 people twice a day (morning and evening) for 1 month each. It was used.

<Safety Evaluation>

First, the occurrence of skin problems in relation to safety was confirmed, and the results are shown in Table 2 below.

○: not generated, △: slightly generated, ×: severely generated

Comparative Example 3 Example 3 Example 4 safety ○ ○ ○

As shown in Table 2, the fish collagen-containing cosmetic composition of the present invention did not cause skin troubles for all 30 subjects during the test for one month.

<Evaluation of feeling, skin elasticity and wrinkle improvement>

Blind test was conducted in a way that each experience group gave 1 to 10 points for feeling, skin elasticity improvement and wrinkle improvement, and averaged values given by each experience group to improve usability, skin elasticity and wrinkle improvement. Was evaluated and the results are shown in Table 3 below.

Comparative example Example 3 Example 4 Feeling 8.4 8.3 8.4 Skin elasticity improvement 4.2 6.1 6.5 wrinkle improvement 5.3 6.3 6.6 Sum 5.97 6.93 7.23

As confirmed from Table 4, the fish collagen-containing cosmetic composition of the present invention showed an excellent effect not only in the feeling of use but also in the skin elasticity improvement and wrinkle improvement than the commercially available collagen cream of the comparative example. In particular, the cosmetic composition of Example 4 was found to provide a better effect.

Test Example 3: Evaluation of stability of liquid fish collagen-containing cosmetic composition

The stability of the liquid fish collagen-containing cosmetic composition, the liquid collagen-containing cosmetic composition of the control group 1 and 2 obtained in Example 4 was observed by visual observation and evaluated as follows, the results are shown in Table 4 below.

As a control, a liquid fish collagen-containing cosmetic composition was prepared in the same manner as in Example 4, but 3 parts by weight of the compound represented by Formula 1 and 3 parts by weight of polyglyceryl-3 methylglucose distearate were not added. A liquid fish collagen-containing cosmetic composition was prepared in the same manner as in (Control 1) and Example 4, but 3 parts by weight of the compound represented by Formula 1 was not added (control 2).

The sample cosmetic compositions were visually observed for dispersion after 1 hour storage and 1 week storage at room temperature (about 25 ° C).

<Evaluation Criteria>

○: no sedimentation was observed

△: sedimentation is slightly confirmed

×: sedimentation occurs entirely

Sedimentation occurs 1 hour later In a week Example 4 ○ ○ Control 1 (without 3 parts by weight of the compound represented by Formula 1 and 3 parts by weight of polyglyceryl-3 methylglucose distearate) × × Control 2 (without 3 parts by weight of compound represented by Formula 1) △ ×

The composition of the form further comprises 3 parts by weight of the compound represented by the formula (1) and 3 parts by weight of polyglyceryl-3 methyl glucose distearate as shown in Example 4 from the test results of Table 4 is very dispersed state of the fish scale collagen particles It was confirmed that excellent. Therefore, it can be seen that the cosmetic composition of Example 4 can provide better skin coating and skin penetration performance. However, it can be seen that the cosmetic composition of the same type as the control is more suitable when sedimentation occurs so that uniform dispersion is not required largely.

Claims (1)

80 to 95 parts by weight of fish collagen powder; 5-15 parts by weight of hyaluronic acid powder; 1-2 parts by weight of adenosine powder; 5 to 10 parts by weight of vitamin C powder; 5 to 10 parts by weight of niacinamide powder; 2 to 5 parts by weight of beta carotene powder; And 0.1 to 5 parts by weight of a dry powder prepared by mixing mastic gum, boswellia sereta, wild boil and beard flower in a weight ratio of 1 to 3: 1 to 3: 1 to 3: 1 to 3 and hot water extraction As a cosmetic composition containing,
Further comprising 2 to 5 parts by weight of the compound represented by Formula 1 and 2 to 5 parts by weight of polyglyceryl-3 methylglucose distearate based on 100 parts by weight of the cosmetic composition,
The fish collagen powder is fish scale collagen powder,
The cosmetic composition is a cosmetic composition with a high skin absorption rate, characterized in that used in combination with 30 to 500 parts by weight of water based on 100 parts by weight of the composition:
[Formula 1]

Where
n is a natural number between 2 and 15,
x and y are mole fractions where x is 0.3 to 0.7, y is 0.3 to 0.7, and x + y is 1;
a and b are mole fractions, a is 0.3 to 0.7, b is 0.3 to 0.7, and a + b is 1.