KR100983076B1 - Skin cream cosmetic composition - Google Patents

Abstract

The present invention is a cream composition comprising a natural herbal extract in 50 to 80% by weight, 2 to 10% by weight of red ginseng, 2 to 10% by weight, 2 to 10% by weight of Echo vinegar and 2 to 10% by weight of gold silver coins The present invention relates to a skin cream composition for acne, characterized in that it contains 1 to 5% by weight of the extracted extract in a homogeneous mixture, and contains four kinds of natural herbal extracts other than gold and silver, and has excellent sterilizing power and moisture supply power, and has no fragrance and no alcohol. It is a new concept cosmetic that can be used safely for sensitive skin, which is very useful for the makeup industry.

Acne Only, Skin Cream, Composition

Description

Composition of skin cream for acnes

The present invention relates to a cream composition that alleviates and cleans skin troubles. In particular, it contains four kinds of natural herbal extracts other than gold and silver, so it has excellent sterilizing power and water supply, and can be used safely on sensitive skin as a new concept cosmetic of fragrance and non-alcoholic. It relates to a cream composition dedicated to acne skin.

Commonly used cream compositions are made by blending oils and waxes, moisturizers, hydrophilic emulsifiers, lipophilic emulsifiers, purified water, appropriate amounts of fragrances, pigments, lighting agents and other additives. The basic cream composition blended as described above is developed and marketed for acne skin cream containing a small amount of herbal extracts such as green tea extract and gold. On the other hand, the human body needs a small amount of vitamins and minerals in addition to the three major nutrients of carbohydrates, proteins and fats, and these vitamins and minerals are absolutely necessary for promoting human metabolism and activating metabolism. Recently, research on cosmetics for acne skin using natural herbal extracts containing a large amount of minerals beneficial to the human body using such natural herbal extracts has been conducted. In particular, herbal medicines such as rhubarb, red ginseng, vigor, eoseongcho, and gold and silver are found to be effective for acne skin.

The present invention is a cream composition that stabilizes and cleans acne skin by killing acne bacillus (P.acnes) which is the main cause of acne production. An object of the present invention is to provide a skin cream composition for relieving and cleaning skin troubles by combining a plurality of inorganic compositions including herbal extracts such as rhubarb, red ginseng, vigor, eoseongcho, gold and silver.

In order to achieve the above object, the present invention provides a cream composition comprising an oily base such as oil and wax, emulsifier, purified water, and lighting agent, oil and wax 20% to 60%, moisturizer 2% to 10%, hydrophilic emulsifier 2% Homogeneous 1-5% extracts, such as rhubarb, red ginseng, vigor, fishery vinegar, gold and silver, in a cream composition consisting of 5% to 5%, 1% to 4% lipophilic emulsifier, 20% to 40% purified water, and other suitable amounts It provides a cream composition for acne skin, characterized in that the mixture.

The cream composition exclusively for acne skin of the present invention relates to a cream composition that alleviates and cleans skin troubles, and contains four kinds of natural herbal extracts other than gold, silver and silver, and has excellent sterilizing power and moisture supply power, and is a new concept cosmetic of fragrance-free and non-alcoholic. It can be used with confidence and is very useful for the makeup industry.

The present invention is a cream composition comprising a natural herbal extract in 50 to 80% by weight, 2 to 10% by weight of red ginseng, 2 to 10% by weight, 2 to 10% by weight of Echo vinegar and 2 to 10% by weight of gold silver coins It relates to a skin cream composition for acne, characterized in that the homogeneous mixture by containing 1 to 5% by weight of the extracted extract in the cream composition.

Acne skin cream composition according to the present invention is 20% to 60% oil and wax, 2% to 10% moisturizer, 2% to 5% hydrophilic emulsifier, 1% to 4% lipophilic emulsifier, 20% to 40% purified water, And 3% mixed herbal extracts are mixed homogeneously in a cream composition consisting of an appropriate amount of fragrances and other additives.

As described in detail the process of producing four natural herbal extracts other than gold and silver coins. Firstly, the sorting process is performed. In other words, the yellow rye, red ginseng, vigor, eoseongcho, gold and silver coins are screened and unnecessary foreign substances, for example, blemishes, soil, humus, etc. are removed by a mechanical method. Secondly, the filtration process is performed after the first extraction to extract the active ingredient from the selected composition. That is, the composition and the ethanol (100%) 5-6 times the screening process was added to the extractor and extracted by heating at 90 ℃ to 100 ℃, 5 hours to 6 hours and filtered through a filter equipped with a 300 mesh filter. Third, a second extraction and filtration process is performed by extracting the active ingredient from the residues of sulfuric acid, red ginseng, ginseng, eoseongcho, and gold and silver, which have undergone primary filtration after extraction with ethanol (100%). In other words, by using the extraction solvent ethanol (100%) to extract the residue of the ethanol, gosam, ginseng, eoseongcho, gold and silver coins after the first extraction using ethanol (100%), ethanol (100%) about 90 to 100 After heating for 5 hours at ℃, and filtered with a filter equipped with a 300 mesh filter. Fourth, a third extraction and filtering process is performed using ethanol (100%) of the extraction solvent to extract the active ingredient from the residues of sulfuric acid, red ginseng, ginseng, eoseongcho, and gold and silver, which have undergone filtration. That is, after extracting the extractant with ethanol (100%) in the extractor and adding the purified water of about 5-6 times to the residues of sulfuric acid, red ginseng, ginseng, eoseongcho, and gold and silver, which were subjected to filtration, 90 ° C to 100 ° C for 5 hours. The mixture is extracted by heating and filtered through a filter equipped with a 300 mesh filter. Fifthly, after the third extraction using purified water, the fourth extraction and filtration process are performed to extract the active ingredient from the residues of the rhubarb, red ginseng, vigor, eoseongcho, and gold and silver. That is, after extracting the purified water using the extractor in the third step and adding about 5 to 6 times the purified water to the residues of the rhubarb, red ginseng, vigor, eoseongcho, and gold and silver, which were subjected to the filtration process, the mixture was heated and extracted at 90 ° C. to 100 ° C. for 5 hours, and then 300 mesh filter. Filter with a strainer equipped. Sixth, all the extracts after the extraction and filtering through a total of four times are mixed. That is, after the first, second, third, and fourth extraction, the extract after the filtration process is mixed homogeneously in a mixer. Seventhly, the mixed extract is concentrated under reduced pressure. That is, the pressure is reduced to 700 mmHg or less at 50 ° C. and concentrated as much as the raw material input amount. Eighth, the concentrate is left for 24 hours and then the precipitate (starch) is filtered. That is, in order to increase the content of the active ingredient, the concentrate is left for 24 hours under conditions of 5 ° C. and then filtered to remove the precipitate (starch). When the filtration process to remove the precipitate (starch) is complete, it is combined with the cream composition.

Here, the cream composition will be described in detail. Glyceryl stearate SE, lipophilic glyceryl stearate, polysorbate 60, stearic acid, cetanol, cetearyl octanoate, squalane, jojoba oil, tocopherol acetate, silicone oil 200/100, propyl paraoxybenzoate, di Take an amount corresponding to 20 to 30% of an oily raw material such as butyl hydroxytoluene and mix under the conditions of 80 ℃, separately, purified water, 1,3-butylene glycol, glycerin, carboxyvinyl polymer, paraoxyacetic acid methyl , Water-soluble raw materials such as imidazolidinyl urea, allantoin, editiei, hyaluronic acid extract, rhubarb, red ginseng, ginseng, vigor, fish vinegar, gold and silver coin, etc. Mix. Subsequently, triethanolamine diluted in an oily raw material mixture, an aqueous raw material mixture, and purified water is mixed, homogenized, and emulsified by a homomixer at 80 ° C. to prepare an acne skin cream.

[Example]

A manufacturing process diagram for preparing the cream composition of the present invention is shown in FIG.

Test Example 1 Inhibitory Effect of the Composition (Example) of the Present Invention on Skin Microorganisms

Inhibitory effect of the skin microorganism was tested using the cream composition of the present invention prepared by the method of the above embodiment. The inhibition test for the microorganisms of the cream composition was used as follows. Ten subjects were selected and the cream composition of the present invention was applied only to one side of the face and after 2 hours, the distribution of microorganisms on both sides of the face was examined. Wipe both sides of the face using a sterile cotton pad and place it in sterile distilled water and stir vigorously for about 3 minutes. 100 μl of the stirred solution was collected and plated on Tryptic soy agar medium, and then cultured at 37 ° C. for 24 hours, and the number of colonies formed was measured.

The inhibitory effect on the skin microorganisms for the ten experimenters by the above method is shown in Table 1 below. Table 1 is a graph showing the arithmetic mean of the total number of colonies of the skin-derived microorganisms in the face portion of the cream composition of the present invention and the control cream-coated side to 10 test subjects.

Table 1. Inhibitory effect of creams on skin supernatants

 (Unit: colony)

Cream The side without cream Reduction Experimenter 1 111 1,233 0.91 Experimenter 2 103 245 0.58 Experimenter 3 164 1,261 0.87 Experimenter 4 482 3,213 0.85 Experimenter 5 155 3,875 0.96 Experimenter 6 148 2,960 0.95 Experimenter7 299 3,737 0.92 Experimenter8 159 252 0.37 Experimenter9 196 3,920 0.95 Experimenter10 273 368 0.26

Test Example 2 Antimicrobial Effects of the Compositions of the Present Invention on Acne Bacteria

Among the causes of acne are Propionibacterium acnes that live on sebum in anaerobic conditions where sebum does not drain out of the pores. The bacterium breaks down triglyceride, the main component of sebum, and turns it into free fatty acid. These free fatty acids are very irritating to the skin, causing inflammation of the hair follicle wall and the cells around the pores. As a result, keratin thickening and swelling around the pores, clogged pores sebum is not able to escape smoothly, acne.

Therefore, in this experiment, Propionibacterium, a bacterium that blocks pores and causes acne . In order to suppress the growth of acnes , we tried to make acne cream using natural herbal extracts that are harmless to the skin.

① Use strain: Propionibacterium acnes KCTC 3314

   ② Culture conditions: Anaerobic culture at 37 ℃

   ③ Experiment Method: Paper disc method (paper size: 8mm)

   ④ Herbal Medicine Sample: 11 kinds of herbal extracts

   ⑤ Experimental Content

Acne P. acnes KCTC 3314 is inoculated with platinum to GAM broth and anaerobicly cultured at 37 ° C for 24 hours.

       Ii) GAM semisolid medium is prepared and sterilized. (About 0.8% of agar content)

       Ⅲ) Add 1ml of acne bacteria culture medium to GAM medium, which is cooled down properly (about 50 ℃), mix well and pour into Petri dish.

       V) Firm the medium and place the paper disc moistened with the sample.

       Iii) Anaerobic culture for 3 days at 37 ℃.

       I) Check the clear zone around the paper disc and measure the activity of each herb against acne.

   ⑥ Results

        항균) Antimicrobial activity of each herbal extract

Herbal medicine
Test bacteria Distilled water Eoseongcho goldthread cloves Neck Book Chrysanthemum Gold coins Gosam Windproof Vigor Jinho In P. acnes - * *** - * * * * ** * ** *

 ※ Sample volume: 30µl

      ***: strong activity (> 20mm), **: medium (15 ~ 20mm), *: weak activity (9 ~ 15mm),

        -: No activity (<9mm)

 ※ Active size

    Huangyan> Kangheol, Gosam> Geumeunhwa, Eoseongcho, Chrysanthemum, Injinho, Gobon, Mokeunpi

The antimicrobial activity of 12 medicinal herb extracts against acne was the highest in the order of Rhubarb extract.

        Ii) Comparison of the activity of creams containing herbal extracts

Herbal cream
activation  cream Barberry Cream Gold and silver cream Ginseng cream Revitalizing Cream Eochocho Cream Activity level - *** * * * * Size of Growth Low Ring
(clear zone size: mm) 8 24 9 9 9 9

  ※ amount of cream: 0.1g (content of herbal extract: 10%)

  ※ Active size

     Yellow Lotus Cream> Gold Silver Cocoa, Ginseng, Root, Eochocho Cream

Compared with other companies' products, the products of other companies showed little activity, but its acne skin cream showed excellent activity.

       Iii) Comparison of the activity of creams with different compositions of herbal extracts

Herbal cream
activation  A  B  C  D  E Activity level *** *** *** ** ** Size of Growth Low Ring
(clear zone size: mm) 25 26 20 18 18

 ※ Cream: 0.05g

       ***: strong activity (> 20mm), **: medium (15 ~ 20mm), *: weak activity (9 ~ 15mm),

         -: No activity (<9mm)

 ※ Active size

            B> A> C> D, E

   A: 8% of yellow lotus, 0.5% of gold and silver coins, 0.5% of red ginseng, 1.0% of strong ginseng, 0.5% of eosungcho

   B: 7% of yellow lotus, 1.0% of gold and silver coins, 0.5% of red ginseng, 1.5% of active ginseng, 0.5% of eosungcho

   C: 10% sulfur

   D: 4% of yellow lotus, 0.25% of gold and silver coins, 0.25% of red ginseng, 0.5% of active ginseng, 0.25% of effervescent

   E: Rhubarb 3.5%, Gold and Silver 0.5%, Red Ginseng 0.25%, Strong 0.75%, Eoseongcho 0.25%

Compared with the activity of the herbal extract and its active ingredient berberine, the herbal extract was slightly more active than berberine, which seems to be due to the synergistic action of the other ingredients in the extract.

        활성) Comparison with commercial acne cream

sample
activation Third Party Cream 1 Third party cream
2 Third party cream
3 Third party cream
4 Third party cream
5 Third Party Cream6 Produced with the composition of the present invention
cream Activity level * - - * - - *** Size of Growth Low Ring
(clear zone size: mm) 13 - - 9 - - 20

 ※ 0.05g sample amount

     ***: strong activity (> 20mm), **: medium (15 ~ 20mm), *: weak activity (9 ~ 15mm),

      -: No activity (<9mm)

 ※ The active size is in the order of Dongbu FTEL> Aekyung Industrial Co., Ltd.> Bio Lee Co., Ltd.

The dosage of the herbal composition of the present invention to the human body may vary depending on the age, weight, sex, dosage form, health condition and degree of disease of the patient, and once a day at a predetermined time interval according to the judgment of a doctor or a pharmacist. It may be divided into several doses. For example, when administered orally, formulated into tablets, capsules, soft capsules, and the like, based on an adult patient having an average weight of 70 kg, the dosage is generally administered at a unit dosage of 50 to 2400 mg / day, and when administered as an injection. Generally, a unit dose of 50 to 400 mg / day and an ointment are generally administered in a unit dose of 300 to 2400 mg / day, and typically 150 to 1200 mg / day when administered as a transdermal drug. Administered in unit dosages of. The dosage is an example of an average case and may be high or low depending on individual differences. In addition, if the daily dose of these herbal compositions is less than the dosage, a significant effect is not obtained, and if it exceeds the above, it is not only uneconomical but also out of the range of normal doses, which may cause undesirable side effects. do.

In particular, when the herbal composition of the present invention is administered to the human body, in view of the general characteristics of natural extracts, it is considered that there is no concern of side effects compared with other synthetic pharmaceuticals, and in fact, the toxicity test results of standardized herbal extracts have no effect on the living body. Proved to be absent.

Reference Example 1: Toxicity Test

Experimental Example A dry powder extract obtained at a weight ratio of 2 g / kg was orally administered to SD (Spraque-Dawley) rats and observed for 2 weeks. No abnormalities were found compared to the control.

1 is a manufacturing process for producing a cream composition of the present invention.

Figure 2 is a contrast sample showing the contrast of the cream containing the extract of the present invention (A, B, C, D and E) with other companies.

Claims (1)

In the skin cream cosmetic composition comprising a natural herbal extract of fragrance-free and non-alcoholic, the composition is 50 to 80% by weight, 2 to 10% by weight of red ginseng, 2 to 10% by weight of active ginseng, 2 to 10% by weight of Echo and silver coins A skin cream cosmetic composition, comprising 1 to 5% by weight of the extract extracted in a composition ratio of 2 to 10% by weight in a homogeneous mixture.

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