CN108697759B - 补体活性的调节剂 - Google Patents

补体活性的调节剂 Download PDF

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Publication number
CN108697759B
CN108697759B CN201680081854.4A CN201680081854A CN108697759B CN 108697759 B CN108697759 B CN 108697759B CN 201680081854 A CN201680081854 A CN 201680081854A CN 108697759 B CN108697759 B CN 108697759B
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administration
complement
pharmaceutical composition
hemolysis
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Chinese (zh)
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CN108697759A (zh
Inventor
S·J·德马科
M·D·霍尔蒂
G·V·帕克
A·里卡多
S·托比
D·A·特雷科
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University Corporation of Beijing
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Ra Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Amplifiers (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
CN201680081854.4A 2015-12-16 2016-12-07 补体活性的调节剂 Active CN108697759B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210878127.8A CN115920000B (zh) 2015-12-16 2016-12-07 补体活性的调节剂

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562268360P 2015-12-16 2015-12-16
US62/268,360 2015-12-16
US201662331320P 2016-05-03 2016-05-03
US62/331,320 2016-05-03
US201662347486P 2016-06-08 2016-06-08
US62/347,486 2016-06-08
PCT/US2016/065228 WO2017105939A1 (en) 2015-12-16 2016-12-07 Modulators of complement activity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202210878127.8A Division CN115920000B (zh) 2015-12-16 2016-12-07 补体活性的调节剂

Publications (2)

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CN108697759A CN108697759A (zh) 2018-10-23
CN108697759B true CN108697759B (zh) 2022-08-02

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CN202210878127.8A Active CN115920000B (zh) 2015-12-16 2016-12-07 补体活性的调节剂

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US (3) US10835574B2 (https=)
EP (4) EP4218790B1 (https=)
JP (3) JP7126940B2 (https=)
KR (1) KR20180094913A (https=)
CN (2) CN108697759B (https=)
AU (1) AU2016370210A1 (https=)
CA (1) CA3007772A1 (https=)
CY (2) CY1123031T1 (https=)
DK (2) DK3389692T3 (https=)
ES (2) ES2941640T3 (https=)
FI (1) FI3685847T3 (https=)
HR (2) HRP20230182T1 (https=)
HU (1) HUE061759T2 (https=)
IL (1) IL259762B (https=)
LT (2) LT3389692T (https=)
MX (2) MX2018007352A (https=)
PL (2) PL3685847T3 (https=)
PT (2) PT3685847T (https=)
RS (2) RS60134B1 (https=)
RU (2) RU2733720C2 (https=)
SG (1) SG11201804721SA (https=)
SI (2) SI3389692T1 (https=)
SM (1) SMT202000213T1 (https=)
TW (2) TWI779805B (https=)
WO (1) WO2017105939A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015274482B2 (en) 2014-06-12 2018-11-08 Ucb Holdings, Inc. Modulation of complement activity
EP3250230B9 (en) 2015-01-28 2022-02-23 RA Pharmaceuticals, Inc. Modulators of complement activity
ES2941640T3 (es) * 2015-12-16 2023-05-24 Ra Pharmaceuticals Inc Moduladores de la actividad del complemento
MX2019006527A (es) 2016-12-07 2019-08-01 Ra Pharmaceuticals Inc Moduladores de la actividad del complemento.
BR112020010916A2 (pt) 2017-12-04 2020-11-17 Ra Pharmaceuticals, Inc moduladores da atividade do complemento
CN112996561A (zh) * 2018-10-30 2021-06-18 亚力兄制药公司 用于治疗阵发性睡眠性血红蛋白尿症(pnh)的抗c5抗体的皮下剂量和施用
EP3934675A2 (en) 2019-03-08 2022-01-12 RA Pharmaceuticals, Inc. Zilucoplan as deep tissue penetrating c5 inhibitor
BR112021017820A2 (pt) * 2019-04-24 2022-02-08 Ra Pharmaceuticals Inc Composições e métodos para modulação da atividade de complemento
CN113966224A (zh) 2019-06-04 2022-01-21 Ra制药公司 采用补体抑制剂的炎性疾病治疗
EP4028126B1 (en) 2019-09-12 2025-02-26 RA Pharmaceuticals, Inc. Treatment of a neurological disease with complement inhibitors
MX2022013606A (es) 2020-04-30 2023-01-16 Alnylam Pharmaceuticals Inc Composiciones de ácido ribonucleico interferente (arni) del factor b de complemento (cfb) y métodos de uso de las mismas.
TW202333749A (zh) 2021-10-29 2023-09-01 美商艾拉倫製藥股份有限公司 補體因子ｂ（ｃｆｂ）ｉｒｎａ組成物及其使用方法

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CN103347895A (zh) * 2010-10-01 2013-10-09 阿雷克森制药公司 与人补体成分c5结合的多肽
CN103561765A (zh) * 2011-05-05 2014-02-05 沃尔斯塔特免疫疗法公司 补体因子b类似物及其用途
CN104231085A (zh) * 2013-09-05 2014-12-24 复旦大学附属肿瘤医院 靶向特异性补体系统抑制剂、其制备方法及应用

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