CN108671224B - 血小板裂解物的组合物、用途和制备 - Google Patents

血小板裂解物的组合物、用途和制备 Download PDF

Info

Publication number
CN108671224B
CN108671224B CN201810498785.8A CN201810498785A CN108671224B CN 108671224 B CN108671224 B CN 108671224B CN 201810498785 A CN201810498785 A CN 201810498785A CN 108671224 B CN108671224 B CN 108671224B
Authority
CN
China
Prior art keywords
composition
fibrinogen
platelet
cells
phpl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201810498785.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN108671224A (zh
Inventor
伊恩·B·科普兰
雅克·加利波
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emory University
Childrens Healthcare of Atlanta Inc
Original Assignee
Emory University
Childrens Healthcare of Atlanta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47424507&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN108671224(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Emory University, Childrens Healthcare of Atlanta Inc filed Critical Emory University
Publication of CN108671224A publication Critical patent/CN108671224A/zh
Application granted granted Critical
Publication of CN108671224B publication Critical patent/CN108671224B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0664—Dental pulp stem cells, Dental follicle stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0666—Mesenchymal stem cells from hair follicles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/115—Platelets, megakaryocytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201810498785.8A 2011-06-27 2012-06-26 血小板裂解物的组合物、用途和制备 Active CN108671224B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161501411P 2011-06-27 2011-06-27
US61/501,411 2011-06-27
US201161547897P 2011-10-17 2011-10-17
US61/547,897 2011-10-17
PCT/US2012/044211 WO2013003356A1 (en) 2011-06-27 2012-06-26 Compositions, uses, and preparation of platelet lysates
CN201280036793.1A CN103702674B (zh) 2011-06-27 2012-06-26 血小板裂解物的组合物、用途和制备

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201280036793.1A Division CN103702674B (zh) 2011-06-27 2012-06-26 血小板裂解物的组合物、用途和制备

Publications (2)

Publication Number Publication Date
CN108671224A CN108671224A (zh) 2018-10-19
CN108671224B true CN108671224B (zh) 2022-12-13

Family

ID=47424507

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201810498785.8A Active CN108671224B (zh) 2011-06-27 2012-06-26 血小板裂解物的组合物、用途和制备
CN201280036793.1A Active CN103702674B (zh) 2011-06-27 2012-06-26 血小板裂解物的组合物、用途和制备

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201280036793.1A Active CN103702674B (zh) 2011-06-27 2012-06-26 血小板裂解物的组合物、用途和制备

Country Status (8)

Country Link
US (2) US9688959B2 (enExample)
EP (1) EP2723354B3 (enExample)
JP (1) JP6179955B2 (enExample)
CN (2) CN108671224B (enExample)
AU (1) AU2012275562B2 (enExample)
CA (1) CA2840568C (enExample)
ES (1) ES2811085T7 (enExample)
WO (1) WO2013003356A1 (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9682104B2 (en) 2012-01-26 2017-06-20 Jadi Cell Llc Lyophilized platelet lysates
US20160002598A1 (en) * 2013-01-28 2016-01-07 Regenerative Science, LLC Device and methods for platelet lysis or activation
US10905721B2 (en) 2013-01-28 2021-02-02 Regenexx, Llc. Device and methods for platelet lysis or activation
AU2014312421A1 (en) * 2013-08-27 2016-04-14 Cook General Biotechnology Llc Bioactive compositions derivable from platelet concentrates, and methods for preparing and using same
HK1194912A2 (en) * 2013-09-17 2014-10-24 Bestop Group Holdings Ltd Growth factor concentrate and the use thereof
WO2015148723A1 (en) * 2014-03-25 2015-10-01 Cook Biotech Incorporated Extracellular matrix grafts loaded with exogenous factors
CA2974225C (en) * 2015-01-21 2023-08-08 Edvin TURKOF Platelet concentrate for increase of cell regeneration and cell growth
US10905716B2 (en) 2015-02-16 2021-02-02 Nayacure Therapeutics Ltd. Modified blood clots
WO2016196515A1 (en) * 2015-05-29 2016-12-08 Amit Patel Particulate lyophilized platelet lysate compositions
CN107304412A (zh) * 2016-04-22 2017-10-31 南京医科大学第附属医院 视网膜色素上皮细胞的培养基及其应用
EP3254684B1 (en) 2016-06-08 2019-10-23 Lysatpharma GmbH Human platelet lysate or fraction enriched in human platelet-derived extracellular vesicles, for use in medicine
WO2018005751A1 (en) * 2016-06-29 2018-01-04 Arteriocyte, Inc. Dressings comprising platelet lysate
EP3558411B1 (en) * 2016-12-22 2024-04-17 Regenexx, LLC Device and methods for platelet lysis or activation
IT201700026465A1 (it) * 2017-03-09 2018-09-09 Biorigen S R L Supplementi per colture cellulari
CA3067294A1 (en) 2017-06-16 2018-12-20 Centre Hospitalier Regional Et Universitaire De Lille (Chru) Process for preparing a pooled human platelet lysate, pooled human platelet lysate and its use for treating neurological disorders
JP7286651B2 (ja) * 2017-12-22 2023-06-05 キエージ・フアルマチエウテイチ・エツセ・ピ・ア 間葉系間質細胞及び臍帯から間葉系間質細胞を得るための方法
FR3077824B1 (fr) 2018-02-15 2022-01-14 Maco Pharma Sa Procede de preparation d'un lysat plaquettaire irradie
FR3077823B1 (fr) 2018-02-15 2022-01-14 Maco Pharma Sa Procede de preparation d'un lysat plaquettaire irradie
CN108823156A (zh) * 2018-07-04 2018-11-16 陕西神州生物技术有限公司 用于修复的临床级人脐带间充质干细胞复合因子及冻干粉的制备方法
JP2021534231A (ja) * 2018-08-07 2021-12-09 アイフィックス メディカル プロプライアタリー リミティド 血小板溶解物組成物およびその使用
PL3880217T3 (pl) * 2018-11-14 2024-05-20 Onderzoeks en Ontwikkelingsfonds Rode Kruis-Vlaanderen Sposoby otrzymywania materiału uwalnianego z płytek krwi
US11767511B2 (en) 2018-11-30 2023-09-26 Cellphire, Inc. Platelets as delivery agents
CA3121484A1 (en) 2018-11-30 2020-06-04 Cellphire, Inc. Platelets loaded with anti-cancer agents
EP3920944A4 (en) * 2019-02-07 2023-03-29 Biobridge Global METHODS AND COMPOSITIONS RELATED TO PLATELET RELEASTAT AND PLATELET-RICH FIBRIN
CN114072159A (zh) 2019-05-03 2022-02-18 塞尔菲乐有限公司 用于生产血液产品的材料和方法
EP3973051A1 (en) * 2019-05-22 2022-03-30 Thankstem S.R.L. Method for expanding adult stem cells from whole blood
EP4013496A4 (en) 2019-08-16 2023-10-18 Cellphire Inc. THROMBOSOMES AS AN AGENT FOR REMOVING THE THROMBOCYTE AGGREGATION-INHIBITING EFFECT
CA3152224A1 (en) * 2019-08-22 2021-02-25 Abdalla S. AWIDI Method of preparing a de-fibrinated platelet lysate, and uses of said method
WO2021158645A1 (en) 2020-02-04 2021-08-12 Cellphire, Inc. Methods of treating congenital hemophilia with anti-fibrinolytic loaded platelets
CN111303270B (zh) * 2020-02-18 2022-04-01 浙江中医药大学 一种利用套装制备血小板生长因子浓集物的方法
EP3881858A1 (en) 2020-03-20 2021-09-22 Rok Pangersic Heat-treated platelet-derived growth factor extract for use in a method of preventing or treating a tissue defect
CN111569139A (zh) * 2020-05-26 2020-08-25 上海市第六人民医院 一种负载血小板裂解液的自支撑自组装多层膜及其应用
JP7137883B2 (ja) * 2020-07-31 2022-09-15 株式会社Rainbow 自家血小板由来の血小板溶解物
US20220273724A1 (en) 2021-02-17 2022-09-01 Cellphire Inc. Freeze-dried platelet derivative compositions for treating antiplatelet induced coagulopathy
CN113667636B (zh) * 2021-07-13 2024-09-24 安徽农业大学 猪血小板裂解液及其制备方法
CN114058576A (zh) * 2021-11-22 2022-02-18 新乡医学院 一种血小板裂解液及其制备方法和应用
CN114317430A (zh) * 2021-12-28 2022-04-12 河北银丰鼎诚生物技术有限公司 一种适用于脐血来源免疫细胞扩增的培养液
WO2023190736A1 (ja) * 2022-03-29 2023-10-05 学校法人日本大学 ヒト脱分化脂肪細胞の製造方法及びヒト成熟脂肪細胞からヒト脱分化脂肪細胞を製造するための培地
EP4276173A1 (en) * 2022-05-10 2023-11-15 Stemmatters, Biotecnologia e Medicina Regenerativa, S.A. Stable human platelet lysate composition, methods and uses thereof
CN120225662A (zh) * 2022-12-06 2025-06-27 苏州血霁生物科技有限公司 一种分化血小板的方法、培养基及应用
JP7731557B2 (ja) 2022-12-30 2025-09-01 スピリット サイエンティフィック カンパニー リミテッド 血小板含有組成物及びその製造方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009152084A2 (en) * 2008-06-11 2009-12-17 Cell4Vet Llc Adipose tissue-derived stem cells for veterinary use
WO2010064267A1 (en) * 2008-12-05 2010-06-10 Universita' Degli Studi Di Pavia Platelets lysate and bioadesive compositions thereof for the treatment of mucositis
JP2011508771A (ja) * 2008-01-07 2011-03-17 クオ レイ バイオメディカル テクノロジー コーポレイション 凝固可能な血小板成長因子濃縮物及びその調製法
CN105636599A (zh) * 2013-08-27 2016-06-01 库克通用生物技术有限责任公司 可来源于血小板浓缩液的生物活性组合物及其制备和使用方法
WO2019126494A1 (en) * 2017-12-20 2019-06-27 Cook Regentec Llc Pathogen reduced platelet compositions and related methods
CN111107857A (zh) * 2017-09-27 2020-05-05 里尔大学中心医院 制备血小板裂解物级分的方法、血小板裂解物级分及其用于治疗中枢神经系统疾病的用途

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0107688B1 (en) * 1982-04-28 1986-10-01 The Trustees Of The Garfield Weston Trust For Research Into Heart Surgery Processes for the production of blood products
SE8801537D0 (sv) * 1988-04-26 1988-04-26 Ellco Food Ab Cellodlingsmedium samt forfarande for dess framstellning
CZ20033097A3 (cs) 2001-05-21 2004-06-16 Omrix Biopharmaceuticals S.A. Způsob odstranění plasmin(ogenu) z proteinových roztoků
DE602005016580D1 (de) * 2004-08-02 2009-10-22 Honda Motor Co Ltd Steuerverfahren für schreitroboter
SE528214C2 (sv) 2005-06-23 2006-09-26 Proliff Ab Förfarande för framställning av blodplättslysat
US7629158B2 (en) * 2006-06-16 2009-12-08 The Procter & Gamble Company Cleaning and/or treatment compositions
WO2008034803A1 (en) * 2006-09-18 2008-03-27 Medizinische Universität Graz Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics
EP1972685B1 (en) * 2007-03-20 2015-09-02 Université Paris Descartes Culture medium for gingival fibroblasts
CN101945994A (zh) 2007-12-19 2011-01-12 再生科学有限责任公司 促进干细胞移植和植入的组合物和方法
CN102026546A (zh) 2008-03-14 2011-04-20 再生科学有限责任公司 软骨修复的合成物和方法
US20090297485A1 (en) 2008-05-28 2009-12-03 Allan Mishra Compositions and methods for treating psychiatric and neurodegenerative disorders
DK3095856T3 (da) * 2008-09-16 2019-10-21 Mayo Found Medical Education & Res Sammensætninger med trombocytindhold
US10039865B2 (en) 2008-09-22 2018-08-07 Omrix Biopharmaceuticals Ltd. Implantable device comprising a substrate pre-coated with stabilized fibrin
ITPI20090066A1 (it) 2009-05-26 2010-11-27 Consiglio Nazionale Ricerche Metodo per produrre un dispositivo applicabile a tessuti biologici, in particolare un patch per trattare tessuti danneggiati, e dispositivo ottenuto con tale metodo
EP2389942B1 (en) 2010-05-25 2013-01-23 GwoWei Technology Co., Ltd. Virally-inactivated growth factors-containing platelet lysate depleted of PDGF and VEGF and preparation method thereof
WO2012035508A2 (en) 2010-09-15 2012-03-22 Spinomix S.A. Method for separating target molecules or particles from fibrinogen-containing samples including blood components
IL210162A0 (en) 2010-12-21 2011-03-31 Omrix Biopharmaceuticals Viral inactivated platelet extract, use and preparation thereof
EP2540819A1 (en) 2011-06-27 2013-01-02 Rheinisch-Westfälische Technische Hochschule Aachen (RWTH) Method for cultivating cells in platelet-lysate-containing medium
EP2591812A1 (en) 2011-11-14 2013-05-15 University of Twente, Institute for Biomedical Technology and Technical Medicine (MIRA) A dextran-based tissuelette containing platelet-rich plasma lysate for cartilage repair
LT2782555T (lt) 2011-11-23 2019-06-25 Cell Therapy Limited Trombocitų lizato gelis
US9682104B2 (en) 2012-01-26 2017-06-20 Jadi Cell Llc Lyophilized platelet lysates
WO2013116791A1 (en) 2012-02-02 2013-08-08 Mosaic Biosciences, Inc. Biomaterials for delivery of blood extracts and methods of using same
EP2733200A1 (en) 2012-11-15 2014-05-21 Biorigen International SA Cell culture supplements
JP6254187B2 (ja) 2012-12-20 2017-12-27 オムリックス・バイオファーマシューティカルズ・リミテッドＯｍｒｉｘ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ． ウイルス不活性化生物学的混合物

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011508771A (ja) * 2008-01-07 2011-03-17 クオ レイ バイオメディカル テクノロジー コーポレイション 凝固可能な血小板成長因子濃縮物及びその調製法
WO2009152084A2 (en) * 2008-06-11 2009-12-17 Cell4Vet Llc Adipose tissue-derived stem cells for veterinary use
WO2010064267A1 (en) * 2008-12-05 2010-06-10 Universita' Degli Studi Di Pavia Platelets lysate and bioadesive compositions thereof for the treatment of mucositis
CN105636599A (zh) * 2013-08-27 2016-06-01 库克通用生物技术有限责任公司 可来源于血小板浓缩液的生物活性组合物及其制备和使用方法
CN111107857A (zh) * 2017-09-27 2020-05-05 里尔大学中心医院 制备血小板裂解物级分的方法、血小板裂解物级分及其用于治疗中枢神经系统疾病的用途
WO2019126494A1 (en) * 2017-12-20 2019-06-27 Cook Regentec Llc Pathogen reduced platelet compositions and related methods

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Blood components for topical use in tissue regeneration: evaluation of corneal lesions treated with platelet lysate and considerations on repair mechanisms;Geremicca 等;《Blood Transufs》;20100401;第8卷(第2期);第107-112页 *
Platelet lysate promotes in vitro wound scratch closure of;Ranzato 等;《JOURNAL OF CELLULAR AND MOLECULAR MEDICINE》;20080809;第13卷(第8b期);第2030-2038页 *
富血小板血浆(PRP)裂解液在苯扎溴胺诱导的小鼠干眼治疗中的作用;胡晓琴 等;《眼科新进展》;20191105;第39卷(第11期);第1019-1023页 *

Also Published As

Publication number Publication date
AU2012275562A1 (en) 2014-01-23
EP2723354B1 (en) 2020-05-27
CN103702674A (zh) 2014-04-02
ES2811085T7 (es) 2021-11-29
ES2811085T3 (es) 2021-03-10
JP6179955B2 (ja) 2017-08-16
US9688959B2 (en) 2017-06-27
CN103702674B (zh) 2018-05-29
EP2723354A4 (en) 2015-03-11
AU2012275562B2 (en) 2016-10-20
EP2723354A1 (en) 2014-04-30
US20170304365A1 (en) 2017-10-26
CN108671224A (zh) 2018-10-19
CA2840568C (en) 2021-05-04
CA2840568A1 (en) 2013-01-03
US20140127314A1 (en) 2014-05-08
JP2014522833A (ja) 2014-09-08
WO2013003356A1 (en) 2013-01-03
EP2723354B3 (en) 2021-03-24

Similar Documents

Publication Publication Date Title
CN108671224B (zh) 血小板裂解物的组合物、用途和制备
JP5767672B2 (ja) 組織修復のための混合細胞集団および細胞処理のための単離技術
JP6947430B2 (ja) 細胞培養方法
JP2010508818A5 (enExample)
WO2014053418A9 (en) Method for obtaining mesenchymal stem cells and use thereof
JP2010529987A5 (enExample)
US10041039B2 (en) Method for producing pluripotent stem cells derived from dental pulp
WO2018183825A1 (en) Generation of therapeutic cells using extracellular components of target organs
AU2013206755B2 (en) Activating adipose-derived stem cells for transplantation
US20250340833A1 (en) Method for isolating and culturing tissue-resident upar+/nestin+ stem cells, and use thereof
HK1195744B (en) Compositions, uses, and preparation of platelet lysates
HK1195744A (en) Compositions, uses, and preparation of platelet lysates
Leung et al. Osteochondral tissue engineering for osteoarthritis using infrapatellar fat-pad derived mesenchymal stem cells
US20190224239A1 (en) Heat-exposed platelet lysate compositions, and methods for preparing and using same

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant