JP6179955B2 - 血小板溶解物の組成物、用途および調製 - Google Patents

血小板溶解物の組成物、用途および調製 Download PDF

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JP6179955B2
JP6179955B2 JP2014518918A JP2014518918A JP6179955B2 JP 6179955 B2 JP6179955 B2 JP 6179955B2 JP 2014518918 A JP2014518918 A JP 2014518918A JP 2014518918 A JP2014518918 A JP 2014518918A JP 6179955 B2 JP6179955 B2 JP 6179955B2
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fibrinogen
cell
cells
platelet
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JP2014522833A (ja
JP2014522833A5 (enExample
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ビー コプランド，イアン
ビー コプランド，イアン
ガリポー，ジャック
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Children's Healthcare of Atlanta
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
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    • C12N2502/00—Coculture with; Conditioned medium produced by
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  • Animal Behavior & Ethology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
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  • Materials Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2014518918A 2011-06-27 2012-06-26 血小板溶解物の組成物、用途および調製 Active JP6179955B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161501411P 2011-06-27 2011-06-27
US61/501,411 2011-06-27
US201161547897P 2011-10-17 2011-10-17
US61/547,897 2011-10-17
PCT/US2012/044211 WO2013003356A1 (en) 2011-06-27 2012-06-26 Compositions, uses, and preparation of platelet lysates

Publications (3)

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JP2014522833A JP2014522833A (ja) 2014-09-08
JP2014522833A5 JP2014522833A5 (enExample) 2015-08-06
JP6179955B2 true JP6179955B2 (ja) 2017-08-16

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JP2014518918A Active JP6179955B2 (ja) 2011-06-27 2012-06-26 血小板溶解物の組成物、用途および調製

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US (2) US9688959B2 (enExample)
EP (1) EP2723354B3 (enExample)
JP (1) JP6179955B2 (enExample)
CN (2) CN108671224B (enExample)
AU (1) AU2012275562B2 (enExample)
CA (1) CA2840568C (enExample)
ES (1) ES2811085T7 (enExample)
WO (1) WO2013003356A1 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9682104B2 (en) 2012-01-26 2017-06-20 Jadi Cell Llc Lyophilized platelet lysates
US10905721B2 (en) 2013-01-28 2021-02-02 Regenexx, Llc. Device and methods for platelet lysis or activation
EP2948210A4 (en) * 2013-01-28 2016-10-19 Regenerative Sciences Llc DEVICE AND METHODS FOR LYING OR ACTIVATION OF BLOOD PLAQUETTES
ES2837854T3 (es) * 2013-08-27 2021-07-01 Cook General Biotechnology Llc Composiciones bioactivas derivables de concentrados plaquetarios y procedimientos para prepararlas y utilizarlas
HK1194912A2 (en) * 2013-09-17 2014-10-24 Bestop Group Holdings Ltd Growth factor concentrate and the use thereof
CA2943787A1 (en) * 2014-03-25 2015-10-01 Cook Biotech Incorporated Extracellular matrix grafts loaded with exogenous factors
EP3247367B1 (en) * 2015-01-21 2023-07-12 Turkof, Edvin Platelet concentrate for increase of cell regeneration and cell growth
CN107427535A (zh) * 2015-02-16 2017-12-01 纳雅康医疗有限公司 经修饰的血凝块
AU2016270679B2 (en) * 2015-05-29 2021-08-19 Jadi Cell Llc Particulate lyophilized platelet lysate compositions
CN107304412B (zh) * 2016-04-22 2026-06-16 南京医科大学第一附属医院 视网膜色素上皮细胞的培养基及其应用
EP3254684B1 (en) 2016-06-08 2019-10-23 Lysatpharma GmbH Human platelet lysate or fraction enriched in human platelet-derived extracellular vesicles, for use in medicine
CN109862899A (zh) 2016-06-16 2019-06-07 护眼国际有限责任公司 治疗干眼综合征及其他创伤性非角质化上皮表面的组合物和方法
WO2018005751A1 (en) * 2016-06-29 2018-01-04 Arteriocyte, Inc. Dressings comprising platelet lysate
CN110325226B (zh) * 2016-12-22 2022-03-15 瑞金尼克斯有限责任公司 用于血小板裂解或激活的设备和方法
IT201700026465A1 (it) * 2017-03-09 2018-09-09 Biorigen S R L Supplementi per colture cellulari
CN110891582A (zh) * 2017-06-16 2020-03-17 里尔大学中心医院 制备混合人血小板裂解液的方法、混合人血小板裂解液及其用于治疗神经系统疾病的用途
MX2020006321A (es) * 2017-12-22 2020-09-18 Chiesi Farm Spa Celulas estromales mesenquimales y metodos para obtener celulas estromales mesenquimales del cordon umbilical.
FR3077824B1 (fr) 2018-02-15 2022-01-14 Maco Pharma Sa Procede de preparation d'un lysat plaquettaire irradie
FR3077823B1 (fr) 2018-02-15 2022-01-14 Maco Pharma Sa Procede de preparation d'un lysat plaquettaire irradie
CN108823156A (zh) * 2018-07-04 2018-11-16 陕西神州生物技术有限公司 用于修复的临床级人脐带间充质干细胞复合因子及冻干粉的制备方法
WO2020028944A1 (en) * 2018-08-07 2020-02-13 The University Of Sydney Platelet lysate compositions and uses thereof
JP7416786B2 (ja) 2018-11-14 2024-01-17 オンデルゾークス・エン オントビッケリングスフォンズ オーデ クラウス・フランデレン 血小板放出物を調製するための方法
US11767511B2 (en) 2018-11-30 2023-09-26 Cellphire, Inc. Platelets as delivery agents
EP3887404A4 (en) 2018-11-30 2022-11-02 Cellphire, Inc. SLIDES LOADED WITH ANTI-CANCER AGENTS
JP2022519781A (ja) * 2019-02-07 2022-03-24 バイオブリッジ グローバル 血小板放出物および多血小板フィブリンに関する方法および組成物
CA3138529C (en) 2019-05-03 2025-10-07 Cellphire, Inc. MATERIALS AND PROCESSES FOR THE PRODUCTION OF BLOOD PRODUCTS
CN113924361A (zh) * 2019-05-22 2022-01-11 善克思腾(股份)责任有限公司 从全血中扩增成体干细胞的方法
WO2021034719A1 (en) 2019-08-16 2021-02-25 Cellphire, Inc. Thrombosomes as an antiplatelet agent reversal agent
CA3152224A1 (en) * 2019-08-22 2021-02-25 Abdalla S. AWIDI Method of preparing a de-fibrinated platelet lysate, and uses of said method
CA3170196A1 (en) 2020-02-04 2021-08-12 Cellphire, Inc. Anti-fibrinolytic loaded platelets
CN111303270B (zh) * 2020-02-18 2022-04-01 浙江中医药大学 一种利用套装制备血小板生长因子浓集物的方法
EP3881858A1 (en) 2020-03-20 2021-09-22 Rok Pangersic Heat-treated platelet-derived growth factor extract for use in a method of preventing or treating a tissue defect
CN111569139A (zh) * 2020-05-26 2020-08-25 上海市第六人民医院 一种负载血小板裂解液的自支撑自组装多层膜及其应用
US20230270791A1 (en) * 2020-07-31 2023-08-31 Rainbow (Rainbow Inc.) Platelet lysate derived from autologous platelets
TW202245814A (zh) 2021-02-17 2022-12-01 美商賽菲爾公司 用於治療抗血小板誘導的凝血病之凍乾血小板衍生物組成物
CN113667636B (zh) * 2021-07-13 2024-09-24 安徽农业大学 猪血小板裂解液及其制备方法
US12702682B2 (en) 2021-11-04 2026-08-11 Cellphire, Inc. Platelet derivative compositions, and methods of making and using such compositions
CN114058576A (zh) * 2021-11-22 2022-02-18 新乡医学院 一种血小板裂解液及其制备方法和应用
CN114317430A (zh) * 2021-12-28 2022-04-12 河北银丰鼎诚生物技术有限公司 一种适用于脐血来源免疫细胞扩增的培养液
WO2023190736A1 (ja) * 2022-03-29 2023-10-05 学校法人日本大学 ヒト脱分化脂肪細胞の製造方法及びヒト成熟脂肪細胞からヒト脱分化脂肪細胞を製造するための培地
EP4276173A1 (en) 2022-05-10 2023-11-15 Stemmatters, Biotecnologia e Medicina Regenerativa, S.A. Stable human platelet lysate composition, methods and uses thereof
WO2024120329A1 (zh) * 2022-12-06 2024-06-13 苏州血霁生物科技有限公司 一种分化血小板的方法、培养基及应用
TWI909123B (zh) 2022-12-30 2025-12-21 思必瑞特生技股份有限公司 含血小板之組合物及其製備方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4680177A (en) * 1982-04-28 1987-07-14 Trustees of the Garfield Weston Trust for Research into Heart Surgery Processes for the production of blood products
SE8801537D0 (sv) * 1988-04-26 1988-04-26 Ellco Food Ab Cellodlingsmedium samt forfarande for dess framstellning
IL158754A0 (en) 2001-05-21 2004-05-12 Omrix Biopharm Sa Removal of plasmin(ogen) from protein solutions
EP1798005B1 (en) * 2004-08-02 2009-09-09 HONDA MOTOR CO., Ltd. Control method of leg type moving robot
SE528214C2 (sv) * 2005-06-23 2006-09-26 Proliff Ab Förfarande för framställning av blodplättslysat
US7629158B2 (en) * 2006-06-16 2009-12-08 The Procter & Gamble Company Cleaning and/or treatment compositions
US20090305401A1 (en) * 2006-09-18 2009-12-10 Dirk Strunk Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics
EP1972685B1 (en) * 2007-03-20 2015-09-02 Université Paris Descartes Culture medium for gingival fibroblasts
WO2009085969A2 (en) 2007-12-19 2009-07-09 Regenerative Sciences, Llc Compositions and methods to promote implantation and engrafment of stem cells
EP2077118A1 (en) 2008-01-07 2009-07-08 Gwo Rei Biomedical Technology Corp. Clottable concentrate of platelet growth factors and preparation method thereof
CN102026546A (zh) 2008-03-14 2011-04-20 再生科学有限责任公司 软骨修复的合成物和方法
WO2009155069A1 (en) 2008-05-28 2009-12-23 Allan Mishra Compositions and methods for treating psychiatric and neurodegenerative disorders
US9144584B2 (en) * 2008-06-11 2015-09-29 Cell4Vet Corporation Adipose tissue-derived stem cells for veterinary use
EP2334785B2 (en) * 2008-09-16 2019-08-14 Mayo Foundation For Medical Education And Research Compositions containing platelet contents
US10039865B2 (en) 2008-09-22 2018-08-07 Omrix Biopharmaceuticals Ltd. Implantable device comprising a substrate pre-coated with stabilized fibrin
DK2373321T3 (en) 2008-12-05 2016-06-13 Biomed Device S R L Biovedhæftende platelet lysate and compositions thereof for the treatment of mucostitis
ITPI20090066A1 (it) 2009-05-26 2010-11-27 Consiglio Nazionale Ricerche Metodo per produrre un dispositivo applicabile a tessuti biologici, in particolare un patch per trattare tessuti danneggiati, e dispositivo ottenuto con tale metodo
EP2389942B1 (en) 2010-05-25 2013-01-23 GwoWei Technology Co., Ltd. Virally-inactivated growth factors-containing platelet lysate depleted of PDGF and VEGF and preparation method thereof
CA2811493C (en) 2010-09-15 2020-06-16 Debiopharm International Sa Method for separating target molecules or particles from fibrinogen-containing samples including blood components
IL210162A0 (en) 2010-12-21 2011-03-31 Omrix Biopharmaceuticals Viral inactivated platelet extract, use and preparation thereof
EP2540819A1 (en) 2011-06-27 2013-01-02 Rheinisch-Westfälische Technische Hochschule Aachen (RWTH) Method for cultivating cells in platelet-lysate-containing medium
EP2591812A1 (en) 2011-11-14 2013-05-15 University of Twente, Institute for Biomedical Technology and Technical Medicine (MIRA) A dextran-based tissuelette containing platelet-rich plasma lysate for cartilage repair
EA029443B1 (ru) 2011-11-23 2018-03-30 Селл Терапи Лимитед Фармацевтическая композиция на основе лизата тромбоцитов
US9682104B2 (en) 2012-01-26 2017-06-20 Jadi Cell Llc Lyophilized platelet lysates
EP2822533B1 (en) 2012-02-02 2021-01-20 Mosaic Biosciences, Inc. Biomaterials for delivery of blood extracts and methods of using same
EP2733200A1 (en) 2012-11-15 2014-05-21 Biorigen International SA Cell culture supplements
EP2934603A1 (en) 2012-12-20 2015-10-28 Omrix Biopharmaceuticals Ltd. Viral inactivated biological mixture
ES2837854T3 (es) * 2013-08-27 2021-07-01 Cook General Biotechnology Llc Composiciones bioactivas derivables de concentrados plaquetarios y procedimientos para prepararlas y utilizarlas
TW201914595A (zh) * 2017-09-27 2019-04-16 法國里爾中央醫學中心 製備血小板裂解物組分的方法、血小板裂解物組分及其用於治療中樞神經系統疾病的用途
CN111770777A (zh) * 2017-12-20 2020-10-13 塞克斯顿生物技术公司 减少病原体的血小板组合物及相关方法

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