AU2012275562B2 - Compositions, uses, and preparation of platelet lysates - Google Patents

Compositions, uses, and preparation of platelet lysates Download PDF

Info

Publication number
AU2012275562B2
AU2012275562B2 AU2012275562A AU2012275562A AU2012275562B2 AU 2012275562 B2 AU2012275562 B2 AU 2012275562B2 AU 2012275562 A AU2012275562 A AU 2012275562A AU 2012275562 A AU2012275562 A AU 2012275562A AU 2012275562 B2 AU2012275562 B2 AU 2012275562B2
Authority
AU
Australia
Prior art keywords
composition
cells
stem cells
fibrinogen
platelet lysate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2012275562A
Other languages
English (en)
Other versions
AU2012275562A1 (en
Inventor
Ian B COPLAND
Jacques Galipeau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emory University
Childrens Healthcare of Atlanta Inc
Original Assignee
Emory University
Childrens Healthcare of Atlanta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47424507&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2012275562(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Emory University, Childrens Healthcare of Atlanta Inc filed Critical Emory University
Publication of AU2012275562A1 publication Critical patent/AU2012275562A1/en
Assigned to EMORY UNIVERSITY, CHILDREN'S HEALTHCARE OF ATLANTA, INC. reassignment EMORY UNIVERSITY Amend patent request/document other than specification (104) Assignors: CHILDREN'S HEATLHCARE OF ATLANTA, INC., EMORY UNIVERSITY
Application granted granted Critical
Publication of AU2012275562B2 publication Critical patent/AU2012275562B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0664—Dental pulp stem cells, Dental follicle stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0666—Mesenchymal stem cells from hair follicles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/115—Platelets, megakaryocytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2012275562A 2011-06-27 2012-06-26 Compositions, uses, and preparation of platelet lysates Active AU2012275562B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161501411P 2011-06-27 2011-06-27
US61/501,411 2011-06-27
US201161547897P 2011-10-17 2011-10-17
US61/547,897 2011-10-17
PCT/US2012/044211 WO2013003356A1 (en) 2011-06-27 2012-06-26 Compositions, uses, and preparation of platelet lysates

Publications (2)

Publication Number Publication Date
AU2012275562A1 AU2012275562A1 (en) 2014-01-23
AU2012275562B2 true AU2012275562B2 (en) 2016-10-20

Family

ID=47424507

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012275562A Active AU2012275562B2 (en) 2011-06-27 2012-06-26 Compositions, uses, and preparation of platelet lysates

Country Status (8)

Country Link
US (2) US9688959B2 (enExample)
EP (1) EP2723354B3 (enExample)
JP (1) JP6179955B2 (enExample)
CN (2) CN103702674B (enExample)
AU (1) AU2012275562B2 (enExample)
CA (1) CA2840568C (enExample)
ES (1) ES2811085T7 (enExample)
WO (1) WO2013003356A1 (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9682104B2 (en) 2012-01-26 2017-06-20 Jadi Cell Llc Lyophilized platelet lysates
WO2014117140A1 (en) * 2013-01-28 2014-07-31 Regenerative Sciences, Llc Device and methods for platelet lysis or activation
US10905721B2 (en) 2013-01-28 2021-02-02 Regenexx, Llc. Device and methods for platelet lysis or activation
AU2014312421A1 (en) * 2013-08-27 2016-04-14 Cook General Biotechnology Llc Bioactive compositions derivable from platelet concentrates, and methods for preparing and using same
HK1194912A2 (en) * 2013-09-17 2014-10-24 Bestop Group Holdings Ltd Growth factor concentrate and the use thereof
AU2015236088A1 (en) * 2014-03-25 2016-11-10 Cook Biotech Incorporated Extracellular matrix grafts loaded with exogenous factors
WO2016116560A1 (en) * 2015-01-21 2016-07-28 Turkof Edvin Platelet concentrate for increase of cell regeneration and cell growth
EP3258945B1 (en) 2015-02-16 2020-10-07 Nayacure Therapeutics Ltd. Modified blood clots
JP2018517771A (ja) * 2015-05-29 2018-07-05 ジャディ セル エルエルシー 粒状の凍結乾燥血小板溶解物組成物
CN107304412A (zh) * 2016-04-22 2017-10-31 南京医科大学第附属医院 视网膜色素上皮细胞的培养基及其应用
EP3254684B1 (en) 2016-06-08 2019-10-23 Lysatpharma GmbH Human platelet lysate or fraction enriched in human platelet-derived extracellular vesicles, for use in medicine
WO2018005751A1 (en) * 2016-06-29 2018-01-04 Arteriocyte, Inc. Dressings comprising platelet lysate
EP3558411B1 (en) * 2016-12-22 2024-04-17 Regenexx, LLC Device and methods for platelet lysis or activation
IT201700026465A1 (it) * 2017-03-09 2018-09-09 Biorigen S R L Supplementi per colture cellulari
ES2955282T3 (es) * 2017-06-16 2023-11-29 Centre Hospitalier Regional Et Univ De Lille Chru Proceso para preparar un lisado de plaquetas humanas combinadas y su uso para el tratamiento de trastornos neurológicos
CA3081647A1 (en) * 2017-12-22 2019-06-27 Chiesi Farmaceutici S.P.A. Mesenchymal stromal cells and methods for obtaining mesenchymal stromal cells from umbilical cord
FR3077823B1 (fr) 2018-02-15 2022-01-14 Maco Pharma Sa Procede de preparation d'un lysat plaquettaire irradie
FR3077824B1 (fr) 2018-02-15 2022-01-14 Maco Pharma Sa Procede de preparation d'un lysat plaquettaire irradie
CN108823156A (zh) * 2018-07-04 2018-11-16 陕西神州生物技术有限公司 用于修复的临床级人脐带间充质干细胞复合因子及冻干粉的制备方法
US12171784B2 (en) * 2018-08-07 2024-12-24 iFiX Medical Pty Ltd Platelet lysate compositions and uses thereof
JP7416786B2 (ja) * 2018-11-14 2024-01-17 オンデルゾークス・エン オントビッケリングスフォンズ オーデ クラウス・フランデレン 血小板放出物を調製するための方法
US11767511B2 (en) 2018-11-30 2023-09-26 Cellphire, Inc. Platelets as delivery agents
EP3887402A4 (en) 2018-11-30 2022-10-26 Cellphire, Inc. PLATELETS AS RELEASING AGENT
EP3920944A4 (en) * 2019-02-07 2023-03-29 Biobridge Global METHODS AND COMPOSITIONS RELATED TO PLATELET RELEASTAT AND PLATELET-RICH FIBRIN
US11529587B2 (en) 2019-05-03 2022-12-20 Cellphire, Inc. Materials and methods for producing blood products
BR112021023101A2 (pt) * 2019-05-22 2022-01-04 Thankstem S R L Método para expansão de células-tronco adultas do sangue total
US20210308066A1 (en) 2020-02-04 2021-10-07 Cellphire, Inc. Anti-fibrinolytic loaded platelets
CA3150936A1 (en) 2019-08-16 2021-02-25 Cellphire, Inc. Thrombosomes as an antiplatelet agent reversal agent
US20220280606A1 (en) * 2019-08-22 2022-09-08 Abdalla S AWIDI Method of preparing a de-fibrinated platelet lysate, and uses of said method
CN111303270B (zh) * 2020-02-18 2022-04-01 浙江中医药大学 一种利用套装制备血小板生长因子浓集物的方法
EP3881858A1 (en) 2020-03-20 2021-09-22 Rok Pangersic Heat-treated platelet-derived growth factor extract for use in a method of preventing or treating a tissue defect
CN111569139A (zh) * 2020-05-26 2020-08-25 上海市第六人民医院 一种负载血小板裂解液的自支撑自组装多层膜及其应用
WO2022025238A1 (ja) * 2020-07-31 2022-02-03 株式会社Rainbow 自家血小板由来の血小板溶解物
US20220273724A1 (en) 2021-02-17 2022-09-01 Cellphire Inc. Freeze-dried platelet derivative compositions for treating antiplatelet induced coagulopathy
CN113667636B (zh) * 2021-07-13 2024-09-24 安徽农业大学 猪血小板裂解液及其制备方法
CN114058576A (zh) * 2021-11-22 2022-02-18 新乡医学院 一种血小板裂解液及其制备方法和应用
CN114317430A (zh) * 2021-12-28 2022-04-12 河北银丰鼎诚生物技术有限公司 一种适用于脐血来源免疫细胞扩增的培养液
US20250115873A1 (en) * 2022-03-29 2025-04-10 Taro Matsumoto Method for producing human dedifferentiated fat cells and culture medium for producing human dedifferentiated fat cells from human mature adipocytes
EP4276173A1 (en) 2022-05-10 2023-11-15 Stemmatters, Biotecnologia e Medicina Regenerativa, S.A. Stable human platelet lysate composition, methods and uses thereof
WO2024120329A1 (zh) * 2022-12-06 2024-06-13 苏州血霁生物科技有限公司 一种分化血小板的方法、培养基及应用
JP7731557B2 (ja) 2022-12-30 2025-09-01 スピリット サイエンティフィック カンパニー リミテッド 血小板含有組成物及びその製造方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198357A (en) * 1988-04-26 1993-03-30 Ellco Food Ab Preparation of a blood platelet lysate for use in a cell culture medium for hybridoma cells
US20090023211A1 (en) * 2005-06-23 2009-01-22 Proliff Ab Blood platelet lysate and method of producing the same
US20090305401A1 (en) * 2006-09-18 2009-12-10 Dirk Strunk Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0107688B1 (en) * 1982-04-28 1986-10-01 The Trustees Of The Garfield Weston Trust For Research Into Heart Surgery Processes for the production of blood products
ATE342353T1 (de) 2001-05-21 2006-11-15 Omrix Biopharm Sa Abtrennung von plasmin(ogen) aus proteinlösungen
WO2006013778A1 (ja) * 2004-08-02 2006-02-09 Honda Motor Co., Ltd. 脚式移動ロボットの制御方法
US7629158B2 (en) * 2006-06-16 2009-12-08 The Procter & Gamble Company Cleaning and/or treatment compositions
EP1972685B1 (en) * 2007-03-20 2015-09-02 Université Paris Descartes Culture medium for gingival fibroblasts
CN101945994A (zh) 2007-12-19 2011-01-12 再生科学有限责任公司 促进干细胞移植和植入的组合物和方法
EP2077118A1 (en) 2008-01-07 2009-07-08 Gwo Rei Biomedical Technology Corp. Clottable concentrate of platelet growth factors and preparation method thereof
WO2009114785A2 (en) 2008-03-14 2009-09-17 Regenerative Sciences, Inc. Compositions and methods for cartilage repair
WO2009155069A1 (en) 2008-05-28 2009-12-23 Allan Mishra Compositions and methods for treating psychiatric and neurodegenerative disorders
US9144584B2 (en) * 2008-06-11 2015-09-29 Cell4Vet Corporation Adipose tissue-derived stem cells for veterinary use
EP3584310B1 (en) * 2008-09-16 2024-04-17 Mayo Foundation for Medical Education and Research Compositions containing platelet contents
US10039865B2 (en) 2008-09-22 2018-08-07 Omrix Biopharmaceuticals Ltd. Implantable device comprising a substrate pre-coated with stabilized fibrin
WO2010064267A1 (en) * 2008-12-05 2010-06-10 Universita' Degli Studi Di Pavia Platelets lysate and bioadesive compositions thereof for the treatment of mucositis
ITPI20090066A1 (it) 2009-05-26 2010-11-27 Consiglio Nazionale Ricerche Metodo per produrre un dispositivo applicabile a tessuti biologici, in particolare un patch per trattare tessuti danneggiati, e dispositivo ottenuto con tale metodo
ES2402144T3 (es) 2010-05-25 2013-04-29 Gwowei Technology Co., Ltd. Lisado plaquetario inactivado que contiene factores de crecimiento empobrecido en PDGF y VEGF y su procedimiento de preparación
CA2811493C (en) 2010-09-15 2020-06-16 Spinomix S.A. Method for separating target molecules or particles from fibrinogen-containing samples including blood components
IL210162A0 (en) 2010-12-21 2011-03-31 Omrix Biopharmaceuticals Viral inactivated platelet extract, use and preparation thereof
EP2540819A1 (en) 2011-06-27 2013-01-02 Rheinisch-Westfälische Technische Hochschule Aachen (RWTH) Method for cultivating cells in platelet-lysate-containing medium
EP2591812A1 (en) 2011-11-14 2013-05-15 University of Twente, Institute for Biomedical Technology and Technical Medicine (MIRA) A dextran-based tissuelette containing platelet-rich plasma lysate for cartilage repair
SG10201609718WA (en) 2011-11-23 2017-02-27 Cell Therapy Ltd Platelet lysate gel
US9682104B2 (en) 2012-01-26 2017-06-20 Jadi Cell Llc Lyophilized platelet lysates
WO2013116791A1 (en) 2012-02-02 2013-08-08 Mosaic Biosciences, Inc. Biomaterials for delivery of blood extracts and methods of using same
EP2733200A1 (en) 2012-11-15 2014-05-21 Biorigen International SA Cell culture supplements
EP3848058A1 (en) 2012-12-20 2021-07-14 Omrix Biopharmaceuticals Ltd. Viral inactivated biological mixture
AU2014312421A1 (en) * 2013-08-27 2016-04-14 Cook General Biotechnology Llc Bioactive compositions derivable from platelet concentrates, and methods for preparing and using same
TW201914595A (zh) * 2017-09-27 2019-04-16 法國里爾中央醫學中心 製備血小板裂解物組分的方法、血小板裂解物組分及其用於治療中樞神經系統疾病的用途
DE112018006568B4 (de) * 2017-12-20 2022-03-03 Sexton Biotechnologies, Inc. (Gesellschaft nach den Gesetzen des Staates Delaware) Verfahren zur Herstellung krankheitserregerreduzierter Thrombozytenzusammensetzungen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198357A (en) * 1988-04-26 1993-03-30 Ellco Food Ab Preparation of a blood platelet lysate for use in a cell culture medium for hybridoma cells
US20090023211A1 (en) * 2005-06-23 2009-01-22 Proliff Ab Blood platelet lysate and method of producing the same
US20090305401A1 (en) * 2006-09-18 2009-12-10 Dirk Strunk Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GEREMICCA, W. et al., Blood Transfus. 2010, Vol. 8, pages 107-112 *
RANZATO, E. et al., Journal of Cellular and Molecular Medicine. 2009, Vol. 13, No. 8B, pages 2030-2038 *

Also Published As

Publication number Publication date
EP2723354B3 (en) 2021-03-24
CN108671224B (zh) 2022-12-13
CA2840568C (en) 2021-05-04
CN103702674B (zh) 2018-05-29
CN108671224A (zh) 2018-10-19
EP2723354B1 (en) 2020-05-27
CA2840568A1 (en) 2013-01-03
EP2723354A1 (en) 2014-04-30
JP2014522833A (ja) 2014-09-08
ES2811085T7 (es) 2021-11-29
US20140127314A1 (en) 2014-05-08
WO2013003356A1 (en) 2013-01-03
EP2723354A4 (en) 2015-03-11
AU2012275562A1 (en) 2014-01-23
US20170304365A1 (en) 2017-10-26
US9688959B2 (en) 2017-06-27
JP6179955B2 (ja) 2017-08-16
CN103702674A (zh) 2014-04-02
ES2811085T3 (es) 2021-03-10

Similar Documents

Publication Publication Date Title
AU2012275562B2 (en) Compositions, uses, and preparation of platelet lysates
JP6246754B2 (ja) 組織修復のための混合細胞集団および細胞処理のための単離技術
Kasten et al. Instant stem cell therapy: characterization and concentration of human mesenchymal stem cells in vitro
US8501170B2 (en) Platelet fraction deriving from placental blood
JP2010508818A5 (enExample)
WO2014053418A9 (en) Method for obtaining mesenchymal stem cells and use thereof
JP7416786B2 (ja) 血小板放出物を調製するための方法
Sonker et al. Determining the effect of preparation and storage: an effort to streamline platelet components as a source of growth factors for clinical application
US10041039B2 (en) Method for producing pluripotent stem cells derived from dental pulp
AU2013206755B2 (en) Activating adipose-derived stem cells for transplantation
JP2014529406A (ja) 血管周囲薬用細胞の単離および治療的使用
AU2010320776A1 (en) Implant composition for the regeneration of neural tissue, process of preparation and uses thereof
US20250340833A1 (en) Method for isolating and culturing tissue-resident upar+/nestin+ stem cells, and use thereof
HK1195744B (en) Compositions, uses, and preparation of platelet lysates
HK1195744A (en) Compositions, uses, and preparation of platelet lysates
JP6674727B2 (ja) 細胞からエンドトキシンを除去する方法
US20190224239A1 (en) Heat-exposed platelet lysate compositions, and methods for preparing and using same
El-Gamal et al. The effect of activated pure platelete rich plasma (P-PRP) on the proliferation of adipose-derived mesenchymal stem cells (AD-MSCs) as a substitute for fetal bovine serum (FBS)
Mandour et al. Basic Sciences Behind BMAC and Expanded Stem Cells
Naskou Equine platelet lysate: unlocking the potentials of a novel biological product with multiple applications

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)