CN108636153B - 射流装置 - Google Patents

射流装置 Download PDF

Info

Publication number
CN108636153B
CN108636153B CN201810305985.7A CN201810305985A CN108636153B CN 108636153 B CN108636153 B CN 108636153B CN 201810305985 A CN201810305985 A CN 201810305985A CN 108636153 B CN108636153 B CN 108636153B
Authority
CN
China
Prior art keywords
channel
diffusion
components
component
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201810305985.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN108636153A (zh
Inventor
塞缪尔·科亨
图奥马斯·诺尔斯
克里斯托夫·多布森
卢克·拉加
敦坎·怀特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cambridge Enterprise Ltd
Original Assignee
Cambridge Enterprise Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Enterprise Ltd filed Critical Cambridge Enterprise Ltd
Publication of CN108636153A publication Critical patent/CN108636153A/zh
Application granted granted Critical
Publication of CN108636153B publication Critical patent/CN108636153B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30Injector mixers
    • B01F25/31Injector mixers in conduits or tubes through which the main component flows
    • B01F25/313Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/42Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4331Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30Micromixers
    • B01F33/3039Micromixers with mixing achieved by diffusion between layers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G01N2013/003Diffusion; diffusivity between liquids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Fluid-Driven Valves (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CN201810305985.7A 2012-10-23 2013-10-22 射流装置 Expired - Fee Related CN108636153B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201219014A GB201219014D0 (en) 2012-10-23 2012-10-23 Fluidic device
GB1219014.6 2012-10-23
CN201380067708.2A CN104995509B (zh) 2012-10-23 2013-10-22 射流装置

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201380067708.2A Division CN104995509B (zh) 2012-10-23 2013-10-22 射流装置

Publications (2)

Publication Number Publication Date
CN108636153A CN108636153A (zh) 2018-10-12
CN108636153B true CN108636153B (zh) 2021-02-02

Family

ID=47359320

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201810305985.7A Expired - Fee Related CN108636153B (zh) 2012-10-23 2013-10-22 射流装置
CN201380067708.2A Expired - Fee Related CN104995509B (zh) 2012-10-23 2013-10-22 射流装置

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201380067708.2A Expired - Fee Related CN104995509B (zh) 2012-10-23 2013-10-22 射流装置

Country Status (13)

Country Link
US (2) US9958369B2 (cg-RX-API-DMAC7.html)
EP (2) EP2912455B1 (cg-RX-API-DMAC7.html)
JP (1) JP6509118B2 (cg-RX-API-DMAC7.html)
CN (2) CN108636153B (cg-RX-API-DMAC7.html)
AU (1) AU2013336424B2 (cg-RX-API-DMAC7.html)
CA (1) CA2888858C (cg-RX-API-DMAC7.html)
DK (1) DK2912455T3 (cg-RX-API-DMAC7.html)
ES (1) ES2950284T3 (cg-RX-API-DMAC7.html)
FI (1) FI2912455T3 (cg-RX-API-DMAC7.html)
GB (1) GB201219014D0 (cg-RX-API-DMAC7.html)
PL (1) PL2912455T3 (cg-RX-API-DMAC7.html)
PT (1) PT2912455T (cg-RX-API-DMAC7.html)
WO (1) WO2014064438A1 (cg-RX-API-DMAC7.html)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201219014D0 (en) 2012-10-23 2012-12-05 Cambridge Entpr Ltd Fluidic device
GB201320146D0 (en) 2013-11-14 2014-01-01 Cambridge Entpr Ltd Fluidic separation and detection
GB2528632A (en) * 2014-04-30 2016-02-03 Cambridge Entpr Ltd Fluidic analysis and separation
GB201511651D0 (en) 2015-07-02 2015-08-19 Cambridge Entpr Ltd Viscosity measurements
EP3115768B1 (en) * 2015-07-07 2017-12-27 Malvern Instruments Limited Method and apparatus for determining diffusion properties of a sample
GB201602946D0 (en) 2016-02-19 2016-04-06 Fluidic Analytics Ltd And Cambridge Entpr Ltd Improvements in or relating to microfluidic free-flow electrophoresis
EP3439783A1 (en) 2016-04-06 2019-02-13 Fluidic Analytics Limited Improvements in or relating to flow balancing
CN115184315A (zh) * 2016-04-15 2022-10-14 伯克利之光生命科技公司 用于坞内测定的方法、系统和试剂盒
GB2553519B (en) 2016-09-02 2019-12-18 Fluidic Analytics Ltd Improvements in or relating to a fluid flow controller for microfluidic devices
GB201615452D0 (en) 2016-09-12 2016-10-26 Fluidic Analytics Ltd Improvements in or relating to valves for microfluidics devices
GB201615472D0 (en) 2016-09-12 2016-10-26 Fluidic Analytics Ltd Improvements in or relating to a reagent cartridge
GB2553780A (en) 2016-09-12 2018-03-21 Fluidic Analytics Ltd Improvements in or relating to a device and a method for labelling a component
EP3721209B1 (en) 2017-10-15 2024-02-07 Berkeley Lights, Inc. Methods for in-pen assays
GB201720627D0 (en) * 2017-12-11 2018-01-24 Cambridge Entpr Ltd Fluidic apparatus and methods
GB201820870D0 (en) 2018-12-20 2019-02-06 Cambridge Entpr Ltd Detection of components
GB201904376D0 (en) * 2019-03-29 2019-05-15 Fluidic Analytics Ltd Improvements in or relating to a method of separating and amalysing a component
US20220219168A1 (en) * 2019-06-10 2022-07-14 University Of Massachusetts Microgradient-based microfluidic devices and high-throughput analytical methods
US11525658B2 (en) * 2020-08-28 2022-12-13 Valeriy Kulaha Combined depth gauge

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101172575A (zh) * 2007-10-30 2008-05-07 华东师范大学 氨分解制氢的整体式微型反应器
CN102401760A (zh) * 2011-11-04 2012-04-04 华中科技大学 十字型三维水力聚焦微混合装置
CN104995509B (zh) * 2012-10-23 2018-04-27 剑桥企业有限公司 射流装置

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US705565A (en) * 1901-07-13 1902-07-29 John W Wharton Oil-fuel generator.
US4360497A (en) * 1981-04-24 1982-11-23 Phillips Petroleum Company Feedstock nozzle and use in carbon black reactor
JPS63208739A (ja) * 1987-02-25 1988-08-30 Takashi Inaga 毛細管式分子拡散係数測定方法
US5529681A (en) * 1993-03-30 1996-06-25 Microparts Gesellschaft Fur Mikrostrukturtechnik Mbh Stepped mould inserts, high-precision stepped microstructure bodies, and methods of producing the same
US5716852A (en) 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5948684A (en) 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
US5974867A (en) 1997-06-13 1999-11-02 University Of Washington Method for determining concentration of a laminar sample stream
US6368871B1 (en) * 1997-08-13 2002-04-09 Cepheid Non-planar microstructures for manipulation of fluid samples
US5842787A (en) * 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
DE19928123A1 (de) * 1999-06-19 2000-12-28 Karlsruhe Forschzent Statischer Mikrovermischer
AU2001290879A1 (en) * 2000-09-15 2002-03-26 California Institute Of Technology Microfabricated crossflow devices and methods
US20040008572A1 (en) * 2002-07-09 2004-01-15 Stuart Joseph Y. Coaxial jet mixer nozzle with protruding centerbody and method for mixing two or more fluid components
CN1242262C (zh) 2002-08-21 2006-02-15 中国科学院大连化学物理研究所 二维或多维毛细管电泳分离生物大分子的方法
EP2127736A1 (en) * 2003-04-10 2009-12-02 The President and Fellows of Harvard College Formation and control of fluidic species
JP4431857B2 (ja) * 2003-05-30 2010-03-17 富士フイルム株式会社 マイクロデバイス
US7347617B2 (en) * 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
WO2005033672A1 (en) 2003-10-01 2005-04-14 Caliper Life Sciences, Inc. Method for measuring diffusivities of compounds using microfluidic devices
US7099778B2 (en) * 2003-12-30 2006-08-29 Caliper Life Sciences, Inc. Method for determining diffusivity and molecular weight in a microfluidic device
JP2007039643A (ja) * 2005-07-06 2007-02-15 Fujifilm Corp 有機顔料分散液の製造方法、およびそれにより得られる有機顔料微粒子
JP4273425B2 (ja) * 2005-09-28 2009-06-03 独立行政法人産業技術総合研究所 マイクロ流路利用分子分析方法
JP2008292371A (ja) * 2007-05-25 2008-12-04 Institute Of Physical & Chemical Research 蛍光相関分光による複数成分相互作用の分析方法及び相互作用制御化合物のスクリーニング方法
US7837379B2 (en) * 2007-08-13 2010-11-23 The Charles Stark Draper Laboratory, Inc. Devices for producing a continuously flowing concentration gradient in laminar flow
JP4932655B2 (ja) * 2007-09-28 2012-05-16 富士フイルム株式会社 マイクロデバイスおよび流体混合方法
JP5419251B2 (ja) * 2008-02-20 2014-02-19 富士フイルム株式会社 微粒子製造方法及び微粒子製造装置
EP2148198A1 (en) 2008-07-21 2010-01-27 Centre National de la Recherche Scientifique (CNRS) Determination of the hydrodynamic radii and/or content of constituents of a mixture by analysis of the Taylor dispersion of the mixture in a capillary tube
US8142741B2 (en) * 2009-01-13 2012-03-27 Kobe Steel, Ltd. Reactor and method for manufacturing reactor
MX336714B (es) * 2009-11-24 2016-01-28 Opko Diagnostics Llc Mezclado y entrega de fluidos en sistemas microfluidicos.
US20120218857A1 (en) * 2011-02-28 2012-08-30 Uchicago Argonne, Llc Microfluidic mixer, method for mixing fluids
CN102279118A (zh) * 2011-05-05 2011-12-14 山东省科学院生物研究所 一种生物反应器在线检测系统的浓度梯度扩散取样装置
GB201320146D0 (en) 2013-11-14 2014-01-01 Cambridge Entpr Ltd Fluidic separation and detection
GB2528632A (en) 2014-04-30 2016-02-03 Cambridge Entpr Ltd Fluidic analysis and separation
GB201511651D0 (en) 2015-07-02 2015-08-19 Cambridge Entpr Ltd Viscosity measurements
GB201602946D0 (en) 2016-02-19 2016-04-06 Fluidic Analytics Ltd And Cambridge Entpr Ltd Improvements in or relating to microfluidic free-flow electrophoresis
EP3439783A1 (en) 2016-04-06 2019-02-13 Fluidic Analytics Limited Improvements in or relating to flow balancing
JP2019520981A (ja) 2016-06-27 2019-07-25 フルイディック・アナリティクス・リミテッド マイクロ流体デバイスの改良またはマイクロ流体デバイスへの試料充填に関する改良
GB2553519B (en) 2016-09-02 2019-12-18 Fluidic Analytics Ltd Improvements in or relating to a fluid flow controller for microfluidic devices
GB2553780A (en) 2016-09-12 2018-03-21 Fluidic Analytics Ltd Improvements in or relating to a device and a method for labelling a component
GB201615472D0 (en) 2016-09-12 2016-10-26 Fluidic Analytics Ltd Improvements in or relating to a reagent cartridge
GB201615452D0 (en) 2016-09-12 2016-10-26 Fluidic Analytics Ltd Improvements in or relating to valves for microfluidics devices

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101172575A (zh) * 2007-10-30 2008-05-07 华东师范大学 氨分解制氢的整体式微型反应器
CN102401760A (zh) * 2011-11-04 2012-04-04 华中科技大学 十字型三维水力聚焦微混合装置
CN104995509B (zh) * 2012-10-23 2018-04-27 剑桥企业有限公司 射流装置

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Convective mixing and chemical reactions in microchannels with high flow rates;Norbert Kockmann et al.;《Sensors and Actuators B》;20060209;第117卷;第495–508页 *
Investigations into mixing of fluids in microchannels with lateral obstructions;Pankaj Kumar Sahu et al.;《Microsyst Technol》;20120706;第19卷;第493–501页 *
Optical Measurement of Transverse Molecular Diffusion in a Microchannel;Andrew Evan Kamholz et al.;《Biophysical Journal》;20010430;第80卷;第1967–1972页 *
Two-Dimensional Microfluidics Using Circuits of Wettability Contrast;Patricia Burriel et al.;《Langmuir Letter》;20100310;第26卷;第4613–4615页 *

Also Published As

Publication number Publication date
PL2912455T3 (pl) 2023-08-21
US9958369B2 (en) 2018-05-01
CN104995509A (zh) 2015-10-21
AU2013336424B2 (en) 2018-09-27
PT2912455T (pt) 2023-07-25
AU2013336424A1 (en) 2015-05-14
EP4218993A3 (en) 2023-08-30
US10670504B2 (en) 2020-06-02
CA2888858A1 (en) 2014-05-01
CN108636153A (zh) 2018-10-12
DK2912455T3 (da) 2023-07-31
CN104995509B (zh) 2018-04-27
EP2912455B1 (en) 2023-04-19
US20180328831A1 (en) 2018-11-15
GB201219014D0 (en) 2012-12-05
CA2888858C (en) 2021-05-11
US20150285724A1 (en) 2015-10-08
WO2014064438A1 (en) 2014-05-01
FI2912455T3 (fi) 2023-07-20
EP2912455A1 (en) 2015-09-02
ES2950284T3 (es) 2023-10-06
JP2015532443A (ja) 2015-11-09
EP4218993A2 (en) 2023-08-02
JP6509118B2 (ja) 2019-05-08

Similar Documents

Publication Publication Date Title
CN108636153B (zh) 射流装置
Liu et al. Liposomes: preparation, characteristics, and application strategies in analytical chemistry
Pahlow et al. Bioanalytical application of surface‐and tip‐enhanced R aman spectroscopy
Hu et al. Intrinsic and membrane-facilitated α-synuclein oligomerization revealed by label-free detection through solid-state nanopores
Tiefenauer et al. Challenges in the development of functional assays of membrane proteins
Ruggeri et al. Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity
CN106457243B (zh) 流体的分析和分离
Zand et al. Nanofluidic platform for single mitochondria analysis using fluorescence microscopy
Baker et al. Photolithographic fabrication of microapertures with well-defined, three-dimensional geometries for suspended lipid membrane studies
Yong et al. Regulating the translocation of DNA through poly (N-isopropylacrylamide)-decorated switchable nanopores by cononsolvency effect
Oshima et al. Evaluation of lateral diffusion of lipids in continuous membranes between freestanding and supported areas by fluorescence recovery after photobleaching
JP5142763B2 (ja) 分子分析方法および分子分析素子
Zhang et al. Ion transport in pH-regulated double-barreled nanopores
Ando et al. Nanometric Gap Structure with a Fluid Lipid Bilayer for the Selective Transport and Detection of Biological Molecules
Xie et al. Diffusional microfluidics for protein analysis
Ajiri et al. Silica Nanopillar arrays for monitoring diffraction-based label-free biomolecule separation
Chen et al. Characterizing the Lateral Friction of Nanoparticles on On‐Chip Integrated Black Lipid Membranes
Liu et al. Vesicle adhesion visualized with total internal reflection imaging ellipsometry biosensor
Shivanka et al. Insights on using plastic-based dual in-plane nanopore sensors for differentiation and shape determinations of single protein molecules
Shiekh et al. Proteoliposomes on 2D-MoS₂ plasmonic nanocavities for enhanced Raman spectroscopy with machine learning-based identification and classification
JP2018072134A (ja) 検出方法及びデバイス
Barik Dielectrophoresis on nanostructured substrates for enhanced plasmonic biosensing
Runas et al. Measuring Lipid Bilayer Permeability with Biomimetic Membranes
Yusko Nanopores with Fluid Walls for Characterizing Proteins and Peptides

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20210202