CN108633287A - 功效增强的car t细胞治疗 - Google Patents

功效增强的car t细胞治疗 Download PDF

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Publication number
CN108633287A
CN108633287A CN201680066975.1A CN201680066975A CN108633287A CN 108633287 A CN108633287 A CN 108633287A CN 201680066975 A CN201680066975 A CN 201680066975A CN 108633287 A CN108633287 A CN 108633287A
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Prior art keywords
tet2
cell
tet1
tet3
sequence
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Pending
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CN201680066975.1A
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Chinese (zh)
Inventor
G·莫茨
F·D·布什曼
J·A·弗拉伊塔
C·H·琼
J·J·梅勒霍斯特
C·L·诺布尔斯
R·M·扬
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Novartis AG
University of Pennsylvania Penn
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Novartis AG
University of Pennsylvania Penn
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CN201680066975.1A 2015-09-17 2016-09-16 功效增强的car t细胞治疗 Pending CN108633287A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562220196P 2015-09-17 2015-09-17
US62/220,196 2015-09-17
PCT/US2016/052260 WO2017049166A1 (en) 2015-09-17 2016-09-16 Car t cell therapies with enhanced efficacy

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CN108633287A true CN108633287A (zh) 2018-10-09

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US (2) US20180258149A1 (https=)
EP (1) EP3350320A1 (https=)
JP (3) JP7530702B2 (https=)
KR (1) KR20180051625A (https=)
CN (1) CN108633287A (https=)
AU (2) AU2016323985B2 (https=)
BR (1) BR112018005295A2 (https=)
CA (1) CA2999070A1 (https=)
HK (1) HK1250517A1 (https=)
IL (2) IL297003A (https=)
MX (2) MX2018003353A (https=)
MY (1) MY201101A (https=)
PH (1) PH12018500494A1 (https=)
SG (1) SG10202110257UA (https=)
WO (1) WO2017049166A1 (https=)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107557339A (zh) * 2017-09-19 2018-01-09 深圳市北科生物科技有限公司 特异性识别plac1的t细胞及其与细胞因子的联合的应用
CN107630005A (zh) * 2017-09-19 2018-01-26 深圳市北科生物科技有限公司 表达plac1特异性tcr的t细胞及其应用
CN112662704A (zh) * 2020-12-31 2021-04-16 江苏集萃医学免疫技术研究所有限公司 提高细胞产生单克隆的能力的方法
CN113795272A (zh) * 2019-02-08 2021-12-14 生物技术细胞和基因治疗公司 涉及car工程化的t细胞和细胞因子的治疗
WO2022120942A1 (zh) * 2020-12-11 2022-06-16 广州百暨基因科技有限公司 靶向cll1嵌合抗原受体及其应用
CN114729325A (zh) * 2019-09-06 2022-07-08 克里斯珀医疗股份公司 在培养物中具有改善的持久性的基因工程化t细胞
CN114728020A (zh) * 2019-07-24 2022-07-08 优瑞科生物技术公司 表达嵌合抗原受体和嵌合刺激受体的细胞及其用途
US12358990B2 (en) 2020-12-11 2025-07-15 Guangzhou Bio-Gene Technology Co., Ltd Anti-CLL1 antibody and use thereof

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US11161907B2 (en) 2015-02-02 2021-11-02 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
MX2017012939A (es) 2015-04-08 2018-05-22 Novartis Ag Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19.
SG11201708516YA (en) 2015-04-17 2017-11-29 David Maxwell Barrett Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
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US10434153B1 (en) 2015-05-20 2019-10-08 Kim Leslie O'Neill Use of car and bite technology coupled with an scFv from an antibody against human thymidine kinase 1 to specifically target tumors
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EP3331913A1 (en) 2015-08-07 2018-06-13 Novartis AG Treatment of cancer using chimeric cd3 receptor proteins
JP6905163B2 (ja) 2015-09-03 2021-07-21 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア サイトカイン放出症候群を予測するバイオマーカー
WO2017059245A2 (en) 2015-09-30 2017-04-06 Trustees Of Boston University Deadman and passcode microbial kill switches
GB201519340D0 (en) * 2015-11-02 2015-12-16 Cambridge Entpr Ltd Methods of T-lymphocyte expansion
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