CN108601751A - 雷公藤红素的类似物 - Google Patents
雷公藤红素的类似物 Download PDFInfo
- Publication number
- CN108601751A CN108601751A CN201680076127.9A CN201680076127A CN108601751A CN 108601751 A CN108601751 A CN 108601751A CN 201680076127 A CN201680076127 A CN 201680076127A CN 108601751 A CN108601751 A CN 108601751A
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- obesity
- compound
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- 0 C[C@@](CC[C@](CC*)C1)(CC2)[C@]1(C)[C@](C)(CC[C@]13C)[C@@]2(C)C1=CC=C(C(C)=C1O)C3=CC1=O Chemical compound C[C@@](CC[C@](CC*)C1)(CC2)[C@]1(C)[C@](C)(CC[C@]13C)[C@@]2(C)C1=CC=C(C(C)=C1O)C3=CC1=O 0.000 description 16
- OENVHBDUFPTPFN-UHFFFAOYSA-N CC(C)=CCC(F)(F)F Chemical compound CC(C)=CCC(F)(F)F OENVHBDUFPTPFN-UHFFFAOYSA-N 0.000 description 1
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- HPIFWVFTPJZGSI-UHFFFAOYSA-N CC(C)SC(c1ccccc1)=O Chemical compound CC(C)SC(c1ccccc1)=O HPIFWVFTPJZGSI-UHFFFAOYSA-N 0.000 description 1
- HPZIGUXQWMHSPN-IJUIMPLNSA-N CC(C=C1[C@@]2(C)CC[C@@]3(C)[C@H](C[C@@](C)(CC4)C(OC)=O)[C@@]4(C)CC[C@@H]1C3)c(c(C)c1O)c2cc1O Chemical compound CC(C=C1[C@@]2(C)CC[C@@]3(C)[C@H](C[C@@](C)(CC4)C(OC)=O)[C@@]4(C)CC[C@@H]1C3)c(c(C)c1O)c2cc1O HPZIGUXQWMHSPN-IJUIMPLNSA-N 0.000 description 1
- RSVDGUAMRWSJDI-KYYWSHRGSA-N CC(CC[C@](C)(C1)C(N)=O)(CC2)[C@]1(C)[C@](C)(CC[C@]13C)[C@@]2(C)C1=CC=C(C(C)=C1OC)C3=CC1=O Chemical compound CC(CC[C@](C)(C1)C(N)=O)(CC2)[C@]1(C)[C@](C)(CC[C@]13C)[C@@]2(C)C1=CC=C(C(C)=C1OC)C3=CC1=O RSVDGUAMRWSJDI-KYYWSHRGSA-N 0.000 description 1
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- RLFGTOOUIPVTOS-UHFFFAOYSA-N CC(N1CCC(C)CC1)O Chemical compound CC(N1CCC(C)CC1)O RLFGTOOUIPVTOS-UHFFFAOYSA-N 0.000 description 1
- JXSUJBXSKZGCNH-UHFFFAOYSA-N CC(O)ON(CCC1)C1=O Chemical compound CC(O)ON(CCC1)C1=O JXSUJBXSKZGCNH-UHFFFAOYSA-N 0.000 description 1
- CDDHRXNRAWZSAZ-MBWFPREASA-N CCC(N[C@](C)(CC[C@]1(C)CC2)CC1[C@](C)(CC[C@]13C)[C@@]2(C)C1=CC=C(C(C)=C1O)C3=CC1=O)=O Chemical compound CCC(N[C@](C)(CC[C@]1(C)CC2)CC1[C@](C)(CC[C@]13C)[C@@]2(C)C1=CC=C(C(C)=C1O)C3=CC1=O)=O CDDHRXNRAWZSAZ-MBWFPREASA-N 0.000 description 1
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- SZZMMKGXYKHGKN-UHFFFAOYSA-N CCCN1CCOCCC1 Chemical compound CCCN1CCOCCC1 SZZMMKGXYKHGKN-UHFFFAOYSA-N 0.000 description 1
- DRBNQAWOXBAPOC-UHFFFAOYSA-N CCN1CCN(CC)CCC1 Chemical compound CCN1CCN(CC)CCC1 DRBNQAWOXBAPOC-UHFFFAOYSA-N 0.000 description 1
- ROPPLSSCVJALEF-BMMNFCMRSA-N C[C@@](CCC(C)(C1)N(C)C)(CC2)[C@@H]1[C@](C)(CC[C@]13C)[C@@]2(C)C1=CC=C(C(C)=C1O)C3=CC1=O Chemical compound C[C@@](CCC(C)(C1)N(C)C)(CC2)[C@@H]1[C@](C)(CC[C@]13C)[C@@]2(C)C1=CC=C(C(C)=C1O)C3=CC1=O ROPPLSSCVJALEF-BMMNFCMRSA-N 0.000 description 1
- SNVBOOLBULGABE-PUTYEYRUSA-N C[C@@](CC[C@](C)(C1)C(O)=O)(CC2)C1[C@](C)(CC[C@@]1(C)c(c3c4C)cc(OC(C)=O)c4OC(C)=O)[C@@]2(C)C1=CC3SCCOC(C)=O Chemical compound C[C@@](CC[C@](C)(C1)C(O)=O)(CC2)C1[C@](C)(CC[C@@]1(C)c(c3c4C)cc(OC(C)=O)c4OC(C)=O)[C@@]2(C)C1=CC3SCCOC(C)=O SNVBOOLBULGABE-PUTYEYRUSA-N 0.000 description 1
- WCDFYUNYTICGNU-MPXNBLPNSA-N C[C@@](CC[C@](C)(C1)N(C)C(C)=O)(CC2)C1[C@](C)(CC1)[C@@]2(C)C2[C@]1(C)C1=CC3OC3C(O)=C(C)C1=CC2 Chemical compound C[C@@](CC[C@](C)(C1)N(C)C(C)=O)(CC2)C1[C@](C)(CC1)[C@@]2(C)C2[C@]1(C)C1=CC3OC3C(O)=C(C)C1=CC2 WCDFYUNYTICGNU-MPXNBLPNSA-N 0.000 description 1
- DMDJJWIPFKMRRO-SVAVSJLESA-N C[C@@](CC[C@]1(C)CC([C@@]2(C)CCC3(C)C)=CCC(C(C)=C4C)C2=CC4=C)(C[C@]13[I]=C)C(N)=O Chemical compound C[C@@](CC[C@]1(C)CC([C@@]2(C)CCC3(C)C)=CCC(C(C)=C4C)C2=CC4=C)(C[C@]13[I]=C)C(N)=O DMDJJWIPFKMRRO-SVAVSJLESA-N 0.000 description 1
- USZWMUIRGFCAQK-MWVPMHEFSA-N C[C@H](C1)C(CS(N)(=O)=O)C[C@](C)(CC2)[C@@H]1[C@](C)(CC[C@]13C)C[C@@H]2C1=CC=C(C(C)=C1O)C3=CC1=O Chemical compound C[C@H](C1)C(CS(N)(=O)=O)C[C@](C)(CC2)[C@@H]1[C@](C)(CC[C@]13C)C[C@@H]2C1=CC=C(C(C)=C1O)C3=CC1=O USZWMUIRGFCAQK-MWVPMHEFSA-N 0.000 description 1
- BEBIZIZPAIDLKO-QSCLWWSOSA-N C[C@](CC1)(CC[C@](C)(CC2)C(N)=O)[C@H]2[C@](C)(CC[C@]23C)[C@@]1(C)C2=CC=C(C(C)=C1O)C3=CC1=O Chemical compound C[C@](CC1)(CC[C@](C)(CC2)C(N)=O)[C@H]2[C@](C)(CC[C@]23C)[C@@]1(C)C2=CC=C(C(C)=C1O)C3=CC1=O BEBIZIZPAIDLKO-QSCLWWSOSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Liquid Crystal (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Optical Filters (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202411356905.2A CN119241632A (zh) | 2015-10-23 | 2016-10-21 | 雷公藤红素的类似物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562245356P | 2015-10-23 | 2015-10-23 | |
| US62/245,356 | 2015-10-23 | ||
| PCT/US2016/058313 WO2017070615A1 (en) | 2015-10-23 | 2016-10-21 | Analogs of celastrol |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202411356905.2A Division CN119241632A (zh) | 2015-10-23 | 2016-10-21 | 雷公藤红素的类似物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108601751A true CN108601751A (zh) | 2018-09-28 |
Family
ID=58558149
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680076127.9A Pending CN108601751A (zh) | 2015-10-23 | 2016-10-21 | 雷公藤红素的类似物 |
| CN202411356905.2A Pending CN119241632A (zh) | 2015-10-23 | 2016-10-21 | 雷公藤红素的类似物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202411356905.2A Pending CN119241632A (zh) | 2015-10-23 | 2016-10-21 | 雷公藤红素的类似物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10662218B2 (OSRAM) |
| EP (1) | EP3364956A4 (OSRAM) |
| JP (3) | JP7034078B2 (OSRAM) |
| CN (2) | CN108601751A (OSRAM) |
| AU (3) | AU2016342375B2 (OSRAM) |
| BR (1) | BR112018008103A2 (OSRAM) |
| MA (1) | MA45430A (OSRAM) |
| WO (1) | WO2017070615A1 (OSRAM) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109705187A (zh) * | 2019-01-29 | 2019-05-03 | 石家庄学院 | 一种雷公藤红素衍生物及其制备方法与应用 |
| CN111202737A (zh) * | 2020-03-20 | 2020-05-29 | 中国药科大学 | 雷公藤红素酰胺衍生物在制备治疗自身性免疫疾病药物的应用 |
| CN112094313A (zh) * | 2019-06-17 | 2020-12-18 | 中国科学院上海药物研究所 | 一类氨基取代的雷公藤红素衍生物以及其制备方法和用途 |
| CN112110977A (zh) * | 2019-06-21 | 2020-12-22 | 中国科学院上海药物研究所 | 一类雷公藤红素衍生物、其制备方法及用途 |
| CN115677812A (zh) * | 2022-01-18 | 2023-02-03 | 聊城大学 | 一类雷公藤红素衍生物及其制备方法与应用 |
| CN119431489A (zh) * | 2024-11-13 | 2025-02-14 | 肇源县总医院 | 一种雷公藤红素衍生物及其制备方法 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108601751A (zh) | 2015-10-23 | 2018-09-28 | Erx制药股份有限公司 | 雷公藤红素的类似物 |
| EP4183853B1 (en) | 2016-04-15 | 2024-10-02 | Beckman Coulter, Inc. | Photoactive macromolecules and uses thereof |
| ES2992544T3 (es) | 2016-06-15 | 2024-12-13 | Targa Biomedical Inc | Reactivos, composiciones y métodos para mejorar la viabilidad y función de células, tejidos y órganos |
| CN108026141B (zh) * | 2016-07-04 | 2022-03-29 | 艾凯奇（厦门）生物科技有限公司 | 孤儿核受体Nur77的配体及其用途 |
| CN115038697A (zh) | 2020-01-15 | 2022-09-09 | 佛罗里达大学研究基金公司 | 治疗剂和治疗方法 |
| WO2022072094A2 (en) * | 2020-08-28 | 2022-04-07 | University Of Florida Research Foundation, Incorporated | Modulators of nuclear receptor subfamily 4 group a member 1 (nr4a1) and uses thereof |
| WO2023249354A1 (ko) * | 2022-06-21 | 2023-12-28 | 서울대학교산학협력단 | 디메틸제일아스테럴을 포함하는 근육 감소로 인한 질환 예방 또는 치료용 약학 조성물 |
| CA3261461A1 (en) * | 2022-07-15 | 2024-01-18 | Celloram Inc. | CELASTROL DERIVATIVES |
| WO2024108035A1 (en) * | 2022-11-17 | 2024-05-23 | Erx Pharmaceuticals, Inc | Compositions and methods for treatment of prader-willi syndrome |
| EP4618998A1 (en) * | 2022-11-17 | 2025-09-24 | ERX Pharmaceuticals Inc. | Celastrol salts, crystalline forms, and uses thereof |
| WO2025106760A1 (en) * | 2023-11-16 | 2025-05-22 | Erx Pharmaceuticals Corporation | Intranasal formulations of celastrol |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007117466A2 (en) * | 2006-03-31 | 2007-10-18 | Massachusetts Institute Of Technology | Celastrol, gedunin, and derivatives thereof as hsp90 inhibitors |
| US20100240581A1 (en) * | 2006-11-13 | 2010-09-23 | The Trustees Of Columbia University In The City Of New York | Selective proteasome inhibitors for treating diabetes |
| US20110166216A1 (en) * | 2007-08-17 | 2011-07-07 | Burnham Institute For Medical Research | Compositions and Methods for Inhibiting Growth and Metastasis of Melanoma |
| CN102574890A (zh) * | 2010-08-23 | 2012-07-11 | 苏州润新生物科技有限公司 | 某些化学个体、组合物及方法 |
| WO2013177353A2 (en) * | 2012-05-25 | 2013-11-28 | S.P.M. Flow Control, Inc. | Apparatus and methods for evaluating systems associated with wellheads |
| CN104822374A (zh) * | 2012-09-27 | 2015-08-05 | 儿童医学中心公司 | 用于治疗肥胖症的化合物和其使用方法 |
| WO2015148802A1 (en) * | 2014-03-26 | 2015-10-01 | The Children's Medical Center Corporation | Celastrol and derivatives for the treatment of obesity |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| JP2594486B2 (ja) | 1991-01-15 | 1997-03-26 | アルコン ラボラトリーズ インコーポレイテッド | 局所的眼薬組成物 |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US20030027786A1 (en) | 2001-06-06 | 2003-02-06 | Karsten Maeder | Lipase inhibiting composition |
| FR2875913A1 (fr) | 2004-09-29 | 2006-03-31 | Sea On Line Sa | Systeme d'alerte anti-collision installe a bord d'un vehicule marin et procede d'analyse anti-collision |
| ES2277568B1 (es) | 2005-12-30 | 2008-04-01 | Consejo Superior De Investigaciones Cientificas | Derivados de triterpenoquinona y triterpenofenoles y su aplicacion para el tratamiento de tumores y enfermedades parasitarias. |
| CN104812898B (zh) | 2012-05-25 | 2018-01-30 | 博格有限责任公司 | 通过调节热休克蛋白质(HSP)90‑β治疗代谢综合征的方法 |
| CN108601751A (zh) | 2015-10-23 | 2018-09-28 | Erx制药股份有限公司 | 雷公藤红素的类似物 |
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2016
- 2016-10-21 CN CN201680076127.9A patent/CN108601751A/zh active Pending
- 2016-10-21 EP EP16858395.3A patent/EP3364956A4/en active Pending
- 2016-10-21 CN CN202411356905.2A patent/CN119241632A/zh active Pending
- 2016-10-21 US US15/771,077 patent/US10662218B2/en active Active
- 2016-10-21 AU AU2016342375A patent/AU2016342375B2/en active Active
- 2016-10-21 WO PCT/US2016/058313 patent/WO2017070615A1/en not_active Ceased
- 2016-10-21 JP JP2018541085A patent/JP7034078B2/ja active Active
- 2016-10-21 MA MA045430A patent/MA45430A/fr unknown
- 2016-10-21 BR BR112018008103-5A patent/BR112018008103A2/pt not_active Application Discontinuation
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2020
- 2020-04-15 US US16/849,554 patent/US11753436B2/en active Active
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2021
- 2021-11-04 JP JP2021179997A patent/JP7339992B2/ja active Active
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2022
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2023
- 2023-07-17 US US18/353,272 patent/US20240190911A1/en active Pending
- 2023-08-25 JP JP2023136867A patent/JP2023164877A/ja not_active Withdrawn
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2024
- 2024-03-07 AU AU2024201504A patent/AU2024201504A1/en not_active Abandoned
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109705187A (zh) * | 2019-01-29 | 2019-05-03 | 石家庄学院 | 一种雷公藤红素衍生物及其制备方法与应用 |
| CN112094313A (zh) * | 2019-06-17 | 2020-12-18 | 中国科学院上海药物研究所 | 一类氨基取代的雷公藤红素衍生物以及其制备方法和用途 |
| CN112094313B (zh) * | 2019-06-17 | 2023-07-04 | 中国科学院上海药物研究所 | 一类氨基取代的雷公藤红素衍生物以及其制备方法和用途 |
| CN112110977A (zh) * | 2019-06-21 | 2020-12-22 | 中国科学院上海药物研究所 | 一类雷公藤红素衍生物、其制备方法及用途 |
| WO2020253814A1 (zh) * | 2019-06-21 | 2020-12-24 | 中国科学院上海药物研究所 | 一类雷公藤红素衍生物、其制备方法及用途 |
| CN112110977B (zh) * | 2019-06-21 | 2022-02-25 | 中国科学院上海药物研究所 | 一类雷公藤红素衍生物、其制备方法及用途 |
| CN111202737A (zh) * | 2020-03-20 | 2020-05-29 | 中国药科大学 | 雷公藤红素酰胺衍生物在制备治疗自身性免疫疾病药物的应用 |
| CN111202737B (zh) * | 2020-03-20 | 2022-08-05 | 中国药科大学 | 雷公藤红素酰胺衍生物在制备治疗自身性免疫疾病药物的应用 |
| CN115677812A (zh) * | 2022-01-18 | 2023-02-03 | 聊城大学 | 一类雷公藤红素衍生物及其制备方法与应用 |
| CN115677812B (zh) * | 2022-01-18 | 2023-12-15 | 聊城大学 | 一类雷公藤红素衍生物及其制备方法与应用 |
| CN119431489A (zh) * | 2024-11-13 | 2025-02-14 | 肇源县总医院 | 一种雷公藤红素衍生物及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US11753436B2 (en) | 2023-09-12 |
| MA45430A (fr) | 2019-05-01 |
| EP3364956A4 (en) | 2019-05-01 |
| RU2018118633A3 (OSRAM) | 2020-02-17 |
| EP3364956A1 (en) | 2018-08-29 |
| JP7034078B2 (ja) | 2022-03-11 |
| AU2024201504A1 (en) | 2024-03-28 |
| US20240190911A1 (en) | 2024-06-13 |
| US10662218B2 (en) | 2020-05-26 |
| AU2022204238A1 (en) | 2022-07-07 |
| AU2016342375B2 (en) | 2022-03-17 |
| JP2018531289A (ja) | 2018-10-25 |
| CN119241632A (zh) | 2025-01-03 |
| US20180362575A1 (en) | 2018-12-20 |
| JP7339992B2 (ja) | 2023-09-06 |
| AU2022204238B2 (en) | 2023-12-14 |
| CA3002924A1 (en) | 2017-04-27 |
| AU2016342375A1 (en) | 2018-05-17 |
| BR112018008103A2 (pt) | 2018-11-06 |
| WO2017070615A1 (en) | 2017-04-27 |
| US20210061851A1 (en) | 2021-03-04 |
| RU2018118633A (ru) | 2019-11-25 |
| JP2023164877A (ja) | 2023-11-14 |
| JP2022017473A (ja) | 2022-01-25 |
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