CN108570083A - 大环内脂的结晶形式及其用途 - Google Patents

大环内脂的结晶形式及其用途 Download PDF

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Publication number
CN108570083A
CN108570083A CN201810569806.0A CN201810569806A CN108570083A CN 108570083 A CN108570083 A CN 108570083A CN 201810569806 A CN201810569806 A CN 201810569806A CN 108570083 A CN108570083 A CN 108570083A
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China
Prior art keywords
cem
another embodiment
peaks
water
crystalline
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Pending
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CN201810569806.0A
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English (en)
Chinese (zh)
Inventor
D·E·佩雷拉
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Cempra Pharmaceuticals Inc
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Cempra Pharmaceuticals Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44673574&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN108570083(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cempra Pharmaceuticals Inc filed Critical Cempra Pharmaceuticals Inc
Publication of CN108570083A publication Critical patent/CN108570083A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201810569806.0A 2010-03-22 2011-03-22 大环内脂的结晶形式及其用途 Pending CN108570083A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31606310P 2010-03-22 2010-03-22
US61/316,063 2010-03-22
CN2011800174629A CN103080122A (zh) 2010-03-22 2011-03-22 大环内脂的结晶形式及其用途

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2011800174629A Division CN103080122A (zh) 2010-03-22 2011-03-22 大环内脂的结晶形式及其用途

Publications (1)

Publication Number Publication Date
CN108570083A true CN108570083A (zh) 2018-09-25

Family

ID=44673574

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201810569806.0A Pending CN108570083A (zh) 2010-03-22 2011-03-22 大环内脂的结晶形式及其用途
CN2011800174629A Pending CN103080122A (zh) 2010-03-22 2011-03-22 大环内脂的结晶形式及其用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2011800174629A Pending CN103080122A (zh) 2010-03-22 2011-03-22 大环内脂的结晶形式及其用途

Country Status (19)

Country Link
US (4) US8975386B2 (https=)
EP (2) EP3009442B1 (https=)
JP (4) JP5711352B2 (https=)
KR (2) KR20180101643A (https=)
CN (2) CN108570083A (https=)
AU (2) AU2011232627B2 (https=)
BR (1) BR112012023950A2 (https=)
CA (1) CA2793884C (https=)
DK (1) DK2550286T3 (https=)
ES (1) ES2564097T3 (https=)
HR (1) HRP20160168T1 (https=)
IL (1) IL222018B (https=)
MX (1) MX361413B (https=)
MY (1) MY162411A (https=)
NZ (1) NZ602544A (https=)
PL (1) PL2550286T3 (https=)
RU (1) RU2650883C2 (https=)
SI (1) SI2550286T1 (https=)
WO (1) WO2011119604A1 (https=)

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CN105732745A (zh) 2007-10-25 2016-07-06 森普拉制药公司 大环内酯类抗菌剂的制备方法
AU2009308182B2 (en) 2008-10-24 2016-05-19 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
DK2550286T3 (en) * 2010-03-22 2016-02-29 Cempra Pharmaceuticals Inc CRYSTALLINE FORMS OF A MACROLID AND APPLICATIONS THEREOF
CN105198944B (zh) 2010-05-20 2018-06-01 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES
MX2014011537A (es) 2012-03-27 2015-02-10 Cempra Pharmaceuticals Inc Formulaciones parenterales para la administracion de antibioticos macrolidos.
HK1217665A1 (zh) 2013-03-14 2017-01-20 森普拉制药公司 用於治療呼吸道疾病的方法及其製劑
RU2015138797A (ru) 2013-03-15 2017-04-24 Семпра Фармасьютикалс, Инк. Конвергентные способы получения макролидных антибактериальных агентов
US9982005B2 (en) 2013-04-04 2018-05-29 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
KR20170039689A (ko) * 2014-08-05 2017-04-11 셈프라 파마슈티컬스, 인크. 항균제의 분말 경구 현탁제 제형
CN104151382B (zh) * 2014-08-08 2016-09-14 广东东阳光药业有限公司 一种固态大环内酯的晶型
CN104311611B (zh) * 2014-08-13 2017-01-18 广东东阳光药业有限公司 一种制备固态大环内酯的方法
US10633407B2 (en) 2014-10-08 2020-04-28 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
JP2018509452A (ja) 2015-03-25 2018-04-05 プレジデント アンド フェローズ オブ ハーバード カレッジ 修飾デソサミン糖をもつマクロライドおよびその使用
JP6112696B1 (ja) * 2015-10-05 2017-04-12 富山化学工業株式会社 ソリスロマイシンを含む錠剤
EP3190122A1 (en) * 2016-01-08 2017-07-12 LEK Pharmaceuticals d.d. A novel synthetic pathway towards solithromycin and purification thereof
WO2018045294A1 (en) * 2016-09-02 2018-03-08 Cempra Pharmaceuticals, Inc. Processes for preparing fluoroketolides
CN115003309B (zh) 2019-12-02 2024-05-24 阿里量子解决方法公司 一种具有结构式i的化合物的晶型

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Patent Citations (5)

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Also Published As

Publication number Publication date
RU2650883C2 (ru) 2018-04-18
US8759500B2 (en) 2014-06-24
CA2793884A1 (en) 2011-09-29
CA2793884C (en) 2019-09-10
AU2016203986A1 (en) 2016-06-30
PL2550286T3 (pl) 2016-07-29
AU2011232627A1 (en) 2012-10-18
JP2017081953A (ja) 2017-05-18
JP6121387B2 (ja) 2017-04-26
KR20180101643A (ko) 2018-09-12
JP2015063536A (ja) 2015-04-09
EP3009442A1 (en) 2016-04-20
EP2550286A4 (en) 2013-10-02
KR20130056226A (ko) 2013-05-29
EP3009442B1 (en) 2019-06-19
MX2012010895A (es) 2013-02-15
AU2016203986B2 (en) 2016-10-06
MX361413B (es) 2018-12-05
US8975386B2 (en) 2015-03-10
BR112012023950A2 (pt) 2016-07-05
JP5711352B2 (ja) 2015-04-30
JP2013522367A (ja) 2013-06-13
HK1177937A1 (en) 2013-08-30
HRP20160168T1 (hr) 2016-03-25
IL222018B (en) 2019-05-30
EP2550286B1 (en) 2015-12-09
SI2550286T1 (sl) 2016-04-29
NZ602544A (en) 2014-11-28
AU2011232627B2 (en) 2016-03-17
JP2020002168A (ja) 2020-01-09
US20190040096A1 (en) 2019-02-07
US20130252915A1 (en) 2013-09-26
KR102006200B1 (ko) 2019-08-01
WO2011119604A1 (en) 2011-09-29
MY162411A (en) 2017-06-15
DK2550286T3 (en) 2016-02-29
US20130018008A1 (en) 2013-01-17
RU2012144614A (ru) 2014-04-27
US20160244472A1 (en) 2016-08-25
CN103080122A (zh) 2013-05-01
EP2550286A1 (en) 2013-01-30
ES2564097T3 (es) 2016-03-17

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