CN108524663A - Composition for relieving pain and swelling and preparation method and preparation thereof - Google Patents
Composition for relieving pain and swelling and preparation method and preparation thereof Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 76
- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 208000002193 Pain Diseases 0.000 title claims abstract description 49
- 230000008961 swelling Effects 0.000 title abstract description 5
- 239000003814 drug Substances 0.000 claims abstract description 30
- 239000002674 ointment Substances 0.000 claims abstract description 25
- 239000002994 raw material Substances 0.000 claims abstract description 18
- 239000000463 material Substances 0.000 claims abstract description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 91
- 238000000605 extraction Methods 0.000 claims description 76
- 239000000284 extract Substances 0.000 claims description 72
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 62
- 239000007788 liquid Substances 0.000 claims description 52
- 235000019441 ethanol Nutrition 0.000 claims description 49
- 239000003921 oil Substances 0.000 claims description 41
- 235000019198 oils Nutrition 0.000 claims description 41
- 229940116257 pepper extract Drugs 0.000 claims description 37
- 239000000843 powder Substances 0.000 claims description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 32
- 229940105902 mint extract Drugs 0.000 claims description 31
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 28
- 201000010099 disease Diseases 0.000 claims description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
- 241000607479 Yersinia pestis Species 0.000 claims description 27
- 230000006378 damage Effects 0.000 claims description 27
- 240000004160 Capsicum annuum Species 0.000 claims description 21
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 20
- 239000000287 crude extract Substances 0.000 claims description 20
- 239000011159 matrix material Substances 0.000 claims description 16
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- 239000012153 distilled water Substances 0.000 claims description 15
- 229940039717 lanolin Drugs 0.000 claims description 15
- 235000019388 lanolin Nutrition 0.000 claims description 15
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 15
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- 239000008117 stearic acid Substances 0.000 claims description 15
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 15
- 235000011187 glycerol Nutrition 0.000 claims description 14
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- 235000016257 Mentha pulegium Nutrition 0.000 claims description 13
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 13
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 13
- 235000001050 hortel pimenta Nutrition 0.000 claims description 13
- 241000132171 Phryma leptostachya Species 0.000 claims description 11
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 10
- 235000019477 peppermint oil Nutrition 0.000 claims description 10
- 239000011780 sodium chloride Substances 0.000 claims description 10
- 238000004140 cleaning Methods 0.000 claims description 9
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- 238000001256 steam distillation Methods 0.000 claims description 4
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
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- 235000018978 Mentha arvensis Nutrition 0.000 description 1
- 235000001878 Mentha haplocalyx Nutrition 0.000 description 1
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- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
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- 206010030113 Oedema Diseases 0.000 description 1
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- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 208000016247 Soft tissue disease Diseases 0.000 description 1
- 208000010040 Sprains and Strains Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
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- 239000007791 liquid phase Substances 0.000 description 1
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- 210000003141 lower extremity Anatomy 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
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- XRRQZKOZJFDXON-UHFFFAOYSA-N nitric acid;silver Chemical compound [Ag].O[N+]([O-])=O XRRQZKOZJFDXON-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a composition for relieving pain and swelling, and a preparation method and a preparation thereof. The ointment is produced by adopting the modern advanced technology based on the Yi nationality medicine theory and Yi nationality medical experience of Yunnan, effectively retains active substances and active ingredients in medicinal materials, greatly improves the dissolution rate of crude drug ingredients, improves the bioavailability, effectively improves the treatment effect, overcomes the original defects, has no peculiar smell, has good stability, and is convenient to use, carry and store; the invention relates to a combination of national experience of Yi medicinal ointment and modern technology, which is the improvement of national medical experience. Meanwhile, the process is simple and feasible, and the raw materials and auxiliary materials are stable in source and easy to industrialize.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of composition for alleviating pain and detumescence and preparation method thereof with
Preparation.
Background technology
Nowadays, the patient of rheumatism is more and more, and has arthropathy and symptom mostly, and also some have pain, red,
It is swollen, many performances such as heat and function are impaired.According to statistics, cervical vertebra hyperplasia, scapulohumeral periarthritis and the scorching patient of rheumatism joint account for me
The 18% of state's population, incidence are up to 20%, patient group body Approximately people more than 200,000,000, wherein 80,000,000 severe cases.Especially in south China
Area, incidence are up to 40%.One investigation result in the 1197 a middle-aged person's health status in the ground pair such as Shanghai, Wuxi, Shenzhen is aobvious
Show, in the groups such as the industries such as science and technology, news, advertisement, office and teacher, performer, driver, shop-assistant, above-mentioned disease
Incidence be up to 50%.Can See, daily pain has become the major issue for influencing numerous population healths.Before China more than 2000 years
's《The Yellow Emperor's Canon of Internal Medicine》Just there is the record of external treatment with Chinese medicine therapy treatment pain.To in the treatment of rheumatic arthritis and Low Back Pain pain, accumulating
Many experiences are tired out, the application of percutaneous dosing is long-standing.Currently, the Chinese medicinal external-application ointment of China's clinical application has more than 500 to plant.
The drug for the treatment of rheumatism also compares more currently on the market, such as " traumatic injury and rheumatism cream ", " promoting blood circulation plaster for curing rheumatism ", " incense drug wind
Wet pain relieving ointment ", " Porous Capsium-Plaster " etc..But raw material is more required for most of drug, complex process and effect are general.
Therefore, it is necessary to invent composition for alleviating pain and detumescence and its preparation that a kind of raw material simply significantly alleviates symptom
Method and preparation.
Invention content
The first object of the present invention is to provide a kind of composition for alleviating pain and detumescence, and second is designed to provide one kind
The preparation of composition for alleviating pain and detumescence, third are designed to provide a kind of preparation side of the ointment for alleviating pain and detumescence
Method.
The first object of the present invention is achieved in that the raw material for including following parts by weight：It is 1-2 parts of pepper extract, thin
8-12 parts of lotus extract, 10-12 parts of Herba speranskiae tuberculatae extract.
The second object of the present invention is achieved in that the preparation is to be added pharmaceutically to connect in the composition
The auxiliary material received is prepared into ointment, powder, liquid preparation.
The third object of the present invention is achieved in that the preparation method of the ointment, comprises the steps of：
1）Each raw extract for taking formula rate, is dissolved with ethyl alcohol, is stirred evenly as medicine phases, is added in 75 ~ 85 DEG C of water-baths
3 ~ 7min of heat of solution；
2）It is used as oil phase after the stearic acid of formula rate, lanolin, atoleine, glycerine are weighed, adds in 75 ~ 85 DEG C of water-baths
3 ~ 7min of heat of solution；
3）It is used as water phase after distilled water, triethanolamine, octadecyl alcolol described in right 2 is weighed, is heated in 75 ~ 85 DEG C of water-baths
Dissolve 3 ~ 7min；
4）By step（3）Water phase be slowly added to step（ 2）Oil phase, stir while adding and be emulsified into matrix；
5 ）By step（1）In be uniformly mixed medicine phases, be slowly added to step（4）In matrix, uniform 3 ~ 7min is stirred by ultrasonic,
It is cooled to room temperature, you can.
Compared with prior art, beneficial effects of the present invention：
1, the reasonable science of composition compatibility of the invention, pure plant extract drug, and side effect is low, prepare simply, through clinic
It is apparent to test curative effect.
2, caused by the soft tissue disease of composition of the invention for joint, muscle, skeleton pain and periarticular
Moving obstacle and chronic rheumatism caused by Regional Pain, especially arthroncus have obvious curative effects.
3, composition of the invention is for office caused by lumbar vertebra strain, lumbar vertebrae cervical vertebra ache, hyperkinesia and labour excessively
Property pain in portion's has apparent curative effect.
4, the present invention is based on Yi nationality of Yunnan folk medicine experiences and Yi Nationality Medicine theory, in the bath of national folk medical applications
On agent, lotion and liniment experiential basis, using local autochthonal plant material, using modern plants extractive technique, invention combination
Science, preparation process is simple, has obtained the composition that pain symptom can be effectively relieved.The natural plant extracts raw material of the present invention
Pharmacological property be：Capsicum is civil for embrocating local congestion and swelling pain in the Yi nationality, distributed over Yunnan, Sichuan and Guizhou, and pepper extract of the invention stresses to treat the wound stasis of blood
It is swollen（Such as：It sprains, wound, the caused subcutaneous stasis of blood of damaging is swollen and painful swelling of joints）；Treat pain in waist and lower extremities, pernio, frostbite etc..Peppermint is in Yi nationality
Race is civil with for showering agent.The mint extract of the present invention stress to cure cold fever, laryngalgia, headache, conjunctival congestion with ophthalmalgia, myalgia,
Itchy skin with rubella, measles without adequate eruption etc..Lopseed is civil with for showering agent in the Yi nationality, distributed over Yunnan, Sichuan and Guizhou, and Herba speranskiae tuberculatae extract of the invention stresses to use
In rheumatic arthritis, oedema, traumatic injury, toothache, eczema.
5, capsicum（Capsicum annuum L.）Alias long red pepper, long capsicum, green pepper, bell pepper.Peppermint（Mentha haplocalyx Briq.）Alias wild mint, asia peppermint, apple mint herb, see swelling, fish mint, night breath is fragrant, lunar caustic is careless.It is deep
Grass, i.e. Caulis et folium gaultheriae yunnanensis（Gaultheria leucocarpa Bl. var. crenulata (Kurz) T. Z. Hsu.）Alias cylinder
Flowers and trees（Sichuan）, spice all over the mountain, Bai Zhumu, seedling mother-in-law be crazy, tiger urine（Hunan）, health and happiness tea, nine root of Aucklandia lappa Decne, the inferior tree of crow, Thickleaf Croton Root（Extensively
East）, step on energy（Guangxi Dong language）, yellow, tiger of going down the hill of going down the hill（Guangxi）, lopseed（《The southern regions of the Yunnan Province book on Chinese herbal medicine》（It is generally called in Yunnan））, dirty oil fruit（Cloud
South）, source is Ericaceae Gaultheria plant Caulis et folium gaultheriae yunnanensis, and dispelling wind and eliminating dampness is promoting blood circulation and removing obstruction in channels.
Specific implementation mode
With reference to embodiment, the present invention is further illustrated, but is not limited in any way to the present invention,
Based on present invention teach that made by it is any transform or replace, all belong to the scope of protection of the present invention.
Composition of the present invention for alleviating pain and detumescence includes the raw material of following parts by weight：Pepper extract 1-2
Part, 8-12 parts of mint extract, 10-12 parts of Herba speranskiae tuberculatae extract.
The preparation method of the pepper extract is to take the chilli without no disease and pests harm of going mouldy, and removes carpopodium and seed,
It crushes, crosses 80 mesh and sieve to obtain chilli powder, the 70% ethyl alcohol extraction of 10 ~ 15 times of amounts is then added, Extracting temperature is 50 ~ 60 DEG C, simultaneously
Ultrasonic wave assisted extraction, 25 ~ 35KHz of ultrasonic frequency, 100 ~ 150W of power repeat extraction 2 ~ 3 times, every time 15 ~ 25min, close
And extracting solution, it is concentrated under reduced pressure, spray drying, you can obtain pepper extract.
The preparation method of the mint extract is to take the peppermint stem and leaf of fresh no disease and pests harm, dry, beats powder and crosses 80 mesh
Sieve obtains Herba Menthae powder, then carries out supercritical CO21 ~ 2h, 8 ~ 10MPa of extracting pressure are extracted, extraction temperature is 45 ~ 55 DEG C, CO2Stream
Amount is 20 ~ 30L/h, collects peppermint oil, then concentrated, be dehydrated, filtered, you can obtain mint extract.
The preparation method of the Herba speranskiae tuberculatae extract is to take the lopseed blade of fresh no disease and pests harm, and cleaning is dried in the shade, cut
Grow up 2-3cm, and then the fragment of wide 1cm is extracted using Soxhlet extractor, extracting solution is 95% ethyl alcohol, and Extracting temperature is
88 ~ 92 DEG C, 4 ~ 5h is extracted, then collection extracting solution, which is evaporated under reduced pressure to ethyl alcohol, is evaporated to obtain crude extract, continues to carry out crude extract
Steam distillation to oil-free oozes now, by distillate stratification, obtains liquid level A and oil reservoir B；It is added in liquid level A
Then NaCl uses ether to carry out 2 ~ 3 extractions, obtains ether extraction liquid until it is saturated；Oil reservoir B and ether extraction liquid are closed
And distill, collect 220 ~ 224 DEG C of fraction, you can obtain Herba speranskiae tuberculatae extract.
The composition for alleviating pain and detumescence further includes the raw material of following parts by weight：It is 7-10 parts of atoleine, sweet
14-18 parts oily, 35-45 parts of stearic acid, 3-6 parts of octadecyl alcolol, 4-6 parts of lanolin, 4-6 parts of triethanolamine, distilled water 350-
370 parts.
The composition for alleviating pain and detumescence further includes the raw material of following parts by weight：0.5 ~ 1 part of Radix Arnebiae extract,
0.2 ~ 0.8 part of Tripterygium hypoglaucum extract.
The preparation method of the Radix Arnebiae extract is that alkanet is taken to clean up, and is dried, 80 mesh of pulverizing sieve, so
After carry out supercritical CO2Extract 2 ~ 3h, you can；The preparation method of the Tripterygium hypoglaucum extract is to take tripterygium hypoglaucum hutcs
Root cleans up, and dries, and the alcohol steep of 1 ~ 4 times of amount, while ultrasonic wave 15 ~ 25min of assisted extraction is then added, then subtracts
Pressure concentration, you can obtain pepper extract.
The preparation of composition of the present invention for alleviating pain and detumescence is to be added pharmaceutically to connect in the composition
The auxiliary material received is prepared into ointment, powder, liquid preparation.
The preparation method of the ointment, comprises the steps of：
1）Each raw extract for taking formula rate, is dissolved with ethyl alcohol, is stirred evenly as medicine phases, is added in 75 ~ 85 DEG C of water-baths
3 ~ 7min of heat of solution；
2）It is used as oil phase after the stearic acid of formula rate, lanolin, atoleine, glycerine are weighed, adds in 75 ~ 85 DEG C of water-baths
3 ~ 7min of heat of solution；
3）It is used as water phase after distilled water, triethanolamine, octadecyl alcolol described in right 2 is weighed, is heated in 75 ~ 85 DEG C of water-baths
Dissolve 3 ~ 7min；
4）By step（3）Water phase be slowly added to step（ 2）Oil phase, stir while adding and be emulsified into matrix；
5 ）By step（1）In be uniformly mixed medicine phases, be slowly added to step（4）In matrix, uniform 3 ~ 7min is stirred by ultrasonic,
It is cooled to room temperature, you can.
Embodiment 1
A kind of composition for alleviating pain and detumescence includes the raw material of following parts by weight：1 part of pepper extract, mint extract 8
Part, 10 parts of Herba speranskiae tuberculatae extract, 7 parts of atoleine, 14 parts of glycerine, 35 parts of stearic acid, 3 parts of octadecyl alcolol, 4 parts of lanolin,
4 parts of triethanolamine, 350 parts of distilled water.
The preparation method of the pepper extract is to take the chilli without no disease and pests harm of going mouldy, and removes carpopodium and seed,
It crushes, crosses 80 mesh and sieve to obtain chilli powder, the 70% ethyl alcohol extraction of 10 times of amounts is then added, Extracting temperature is 50 DEG C, while ultrasonic wave
Assisted extraction, ultrasonic frequency 25KHz, power 100W repeat extraction 2 times, each 15min, merge extracting solution, are concentrated under reduced pressure,
Spray drying, you can obtain pepper extract.
The preparation method of the mint extract is to take the peppermint stem and leaf of fresh no disease and pests harm, dry, beats powder and crosses 80 mesh
Sieve obtains Herba Menthae powder, then carries out supercritical CO21h, extracting pressure 8MPa are extracted, extraction temperature is 45 DEG C, CO2Flow is 20L/
H collects peppermint oil, then is concentrated, be dehydrated, filtered, you can obtains mint extract.
The preparation method of the Herba speranskiae tuberculatae extract is to take the lopseed blade of fresh no disease and pests harm, and cleaning is dried in the shade, cut
Grow up 2cm, then the fragment of wide 1cm is extracted using Soxhlet extractor, and extracting solution is 95% ethyl alcohol, Extracting temperature 88
DEG C, 4h is extracted, then collection extracting solution, which is evaporated under reduced pressure to ethyl alcohol, is evaporated to obtain crude extract, continues to carry out vapor steaming to crude extract
It evaporates to oil-free and oozes now, by distillate stratification, obtain liquid level A and oil reservoir B；NaCl is added in liquid level A, until it is full
With, then use ether carry out 2 times extraction, obtain ether extraction liquid；Oil reservoir B and ether extraction liquid are merged, distilled, is collected
220 DEG C of fraction, you can obtain Herba speranskiae tuberculatae extract.
The preparation of the composition for alleviating pain and detumescence described in the present embodiment is to be added pharmaceutically in the composition
The auxiliary material of receiving is prepared into ointment.
The preparation method of the ointment, comprises the steps of：
1）Each raw extract for taking formula rate, is dissolved with ethyl alcohol, is stirred evenly as medicine phases, is heated in 75 DEG C of water-baths molten
Solve 3min；
2）It is used as oil phase after the stearic acid of formula rate, lanolin, atoleine, glycerine are weighed, is heated in 75 DEG C of water-baths
Dissolve 3min；
3）It is used as water phase after distilled water, triethanolamine, octadecyl alcolol described in right 2 is weighed, is heated in 75 DEG C of water-baths molten
Solve 3min；
4）By step（3）Water phase be slowly added to step（ 2）Oil phase, stir while adding and be emulsified into matrix；
5 ）By step（1）In be uniformly mixed medicine phases, be slowly added to step（4）In matrix, uniform 3min is stirred by ultrasonic, it is cold
But to room temperature, you can.
Embodiment 2
A kind of composition for alleviating pain and detumescence includes the raw material of following parts by weight：2 parts of pepper extract, mint extract 12
Part, 12 parts of Herba speranskiae tuberculatae extract, 10 parts of atoleine, 18 parts of glycerine, 45 parts of stearic acid, 6 parts of octadecyl alcolol, lanolin 6
Part, 6 parts of triethanolamine, 370 parts of distilled water.
The preparation method of the pepper extract is to take the chilli without no disease and pests harm of going mouldy, and removes carpopodium and seed,
It crushes, crosses 80 mesh and sieve to obtain chilli powder, the 70% ethyl alcohol extraction of 15 times of amounts is then added, Extracting temperature is 60 DEG C, while ultrasonic wave
Assisted extraction, ultrasonic frequency 35KHz, power 150W repeat extraction 3 times, every time 15 ~ 25min, merge extracting solution, and decompression is dense
Contracting, spray drying, you can obtain pepper extract.
The preparation method of the mint extract is to take the peppermint stem and leaf of fresh no disease and pests harm, dry, beats powder and crosses 80 mesh
Sieve obtains Herba Menthae powder, then carries out supercritical CO22h, extracting pressure 10MPa are extracted, extraction temperature is 55 DEG C, CO2Flow is
30L/h collects peppermint oil, then is concentrated, be dehydrated, filtered, you can obtains mint extract.
The preparation method of the Herba speranskiae tuberculatae extract is to take the lopseed blade of fresh no disease and pests harm, and cleaning is dried in the shade, cut
Grow up 3cm, then the fragment of wide 1cm is extracted using Soxhlet extractor, and extracting solution is 95% ethyl alcohol, Extracting temperature 92
DEG C, 5h is extracted, then collection extracting solution, which is evaporated under reduced pressure to ethyl alcohol, is evaporated to obtain crude extract, continues to carry out vapor steaming to crude extract
It evaporates to oil-free and oozes now, by distillate stratification, obtain liquid level A and oil reservoir B；NaCl is added in liquid level A, until it is full
With, then use ether carry out 3 times extraction, obtain ether extraction liquid；Oil reservoir B and ether extraction liquid are merged, distilled, is collected
224 DEG C of fraction, you can obtain Herba speranskiae tuberculatae extract.
The preparation of the composition for alleviating pain and detumescence described in the present embodiment is to be added pharmaceutically in the composition
The auxiliary material of receiving is prepared into ointment.
The preparation method of the ointment, comprises the steps of：
1）Each raw extract for taking formula rate, is dissolved with ethyl alcohol, is stirred evenly as medicine phases, is heated in 85 DEG C of water-baths molten
Solve 7min；
2）It is used as oil phase after the stearic acid of formula rate, lanolin, atoleine, glycerine are weighed, is heated in 85 DEG C of water-baths
Dissolve 7min；
3）It is used as water phase after distilled water, triethanolamine, octadecyl alcolol described in right 2 is weighed, is heated in 85 DEG C of water-baths molten
Solve 7min；
4）By step（3）Water phase be slowly added to step（ 2）Oil phase, stir while adding and be emulsified into matrix；
5 ）By step（1）In be uniformly mixed medicine phases, be slowly added to step（4）In matrix, uniform 7min is stirred by ultrasonic, it is cold
But to room temperature, you can.
Embodiment 3
A kind of composition for alleviating pain and detumescence includes the raw material of following parts by weight：1.2 parts of pepper extract, mint extract
9 parts, 11 parts of Herba speranskiae tuberculatae extract.
The preparation method of the pepper extract is to take the chilli without no disease and pests harm of going mouldy, and removes carpopodium and seed,
It crushes, crosses 80 mesh and sieve to obtain chilli powder, the 70% ethyl alcohol extraction of 11 times of amounts is then added, Extracting temperature is 52 DEG C, while ultrasonic wave
Assisted extraction, ultrasonic frequency 27KHz, power 110W repeat extraction 2 times, each 16min, merge extracting solution, are concentrated under reduced pressure,
Spray drying, you can obtain pepper extract.
The preparation method of the mint extract is to take the peppermint stem and leaf of fresh no disease and pests harm, dry, beats powder and crosses 80 mesh
Sieve obtains Herba Menthae powder, then carries out supercritical CO21.2h, extracting pressure 9MPa are extracted, extraction temperature is 47 DEG C, CO2Flow is
22L/h collects peppermint oil, then is concentrated, be dehydrated, filtered, you can obtains mint extract.
The preparation method of the Herba speranskiae tuberculatae extract is to take the lopseed blade of fresh no disease and pests harm, and cleaning is dried in the shade, cut
Grow up 3cm, then the fragment of wide 1cm is extracted using Soxhlet extractor, and extracting solution is 95% ethyl alcohol, Extracting temperature 89
DEG C, 4.2h is extracted, then collection extracting solution, which is evaporated under reduced pressure to ethyl alcohol, is evaporated to obtain crude extract, continues to carry out vapor to crude extract
Distillation to oil-free oozes now, by distillate stratification, obtains liquid level A and oil reservoir B；NaCl is added in liquid level A, until its
Then saturation uses ether to carry out 3 extractions, obtains ether extraction liquid；Oil reservoir B and ether extraction liquid are merged, distilled, is collected
221 DEG C of fraction, you can obtain Herba speranskiae tuberculatae extract.
The preparation of the composition for alleviating pain and detumescence described in the present embodiment is to be added pharmaceutically in the composition
The auxiliary material of receiving is prepared into powder.
Embodiment 4
A kind of composition for alleviating pain and detumescence includes the raw material of following parts by weight：1.4 parts of pepper extract, mint extract
10 parts, 10.5 parts of Herba speranskiae tuberculatae extract.
The preparation method of the pepper extract is to take the chilli without no disease and pests harm of going mouldy, and removes carpopodium and seed,
It crushes, crosses 80 mesh and sieve to obtain chilli powder, the 70% ethyl alcohol extraction of 12 times of amounts is then added, Extracting temperature is 54 DEG C, while ultrasonic wave
Assisted extraction, ultrasonic frequency 29KHz, power 120W repeat extraction 3 times, each 17min, merge extracting solution, are concentrated under reduced pressure,
Spray drying, you can obtain pepper extract.
The preparation method of the mint extract is to take the peppermint stem and leaf of fresh no disease and pests harm, dry, beats powder and crosses 80 mesh
Sieve obtains Herba Menthae powder, then carries out supercritical CO21.4h, extracting pressure 9MPa are extracted, extraction temperature is 50 DEG C, CO2Flow is
24L/h collects peppermint oil, then is concentrated, be dehydrated, filtered, you can obtains mint extract.
The preparation method of the Herba speranskiae tuberculatae extract is to take the lopseed blade of fresh no disease and pests harm, and cleaning is dried in the shade, cut
Grow up 2cm, then the fragment of wide 1cm is extracted using Soxhlet extractor, and extracting solution is 95% ethyl alcohol, Extracting temperature 90
DEG C, 4.5h is extracted, then collection extracting solution, which is evaporated under reduced pressure to ethyl alcohol, is evaporated to obtain crude extract, continues to carry out vapor to crude extract
Distillation to oil-free oozes now, by distillate stratification, obtains liquid level A and oil reservoir B；NaCl is added in liquid level A, until its
Then saturation uses ether to carry out 3 extractions, obtains ether extraction liquid；Oil reservoir B and ether extraction liquid are merged, distilled, is collected
222 DEG C of fraction, you can obtain Herba speranskiae tuberculatae extract.
The preparation of the composition for alleviating pain and detumescence described in the present embodiment is to be added pharmaceutically in the composition
The auxiliary material of receiving is prepared into liquid preparation.
Embodiment 5
A kind of composition for alleviating pain and detumescence includes the raw material of following parts by weight：1.5 parts of pepper extract, mint extract
11 parts, 11.5 parts of Herba speranskiae tuberculatae extract, 8 parts of atoleine, 15 parts of glycerine, 40 parts of stearic acid, 4 parts of octadecyl alcolol, lanolin
5 parts, 5 parts of triethanolamine, 355 parts of distilled water, 0.5 part of Radix Arnebiae extract, 0.2 part of Tripterygium hypoglaucum extract.
The preparation method of the pepper extract is to take the chilli without no disease and pests harm of going mouldy, and removes carpopodium and seed,
It crushes, crosses 80 mesh and sieve to obtain chilli powder, the 70% ethyl alcohol extraction of 13 times of amounts is then added, Extracting temperature is 56 DEG C, while ultrasonic wave
Assisted extraction, ultrasonic frequency 32KHz, power 130W repeat extraction 2 times, each 21min, merge extracting solution, are concentrated under reduced pressure,
Spray drying, you can obtain pepper extract.
The preparation method of the mint extract is to take the peppermint stem and leaf of fresh no disease and pests harm, dry, beats powder and crosses 80 mesh
Sieve obtains Herba Menthae powder, then carries out supercritical CO21.8h, extracting pressure 9MPa are extracted, extraction temperature is 52 DEG C, CO2Flow is
26L/h collects peppermint oil, then is concentrated, be dehydrated, filtered, you can obtains mint extract.
The preparation method of the Herba speranskiae tuberculatae extract is to take the lopseed blade of fresh no disease and pests harm, and cleaning is dried in the shade, cut
Grow up 2cm, then the fragment of wide 1cm is extracted using Soxhlet extractor, and extracting solution is 95% ethyl alcohol, Extracting temperature 91
DEG C, 4.8h is extracted, then collection extracting solution, which is evaporated under reduced pressure to ethyl alcohol, is evaporated to obtain crude extract, continues to carry out vapor to crude extract
Distillation to oil-free oozes now, by distillate stratification, obtains liquid level A and oil reservoir B；NaCl is added in liquid level A, until its
Then saturation uses ether to carry out 2 extractions, obtains ether extraction liquid；Oil reservoir B and ether extraction liquid are merged, distilled, is collected
223 DEG C of fraction, you can obtain Herba speranskiae tuberculatae extract.
The preparation method of the Radix Arnebiae extract is that alkanet is taken to clean up, and is dried, 80 mesh of pulverizing sieve, so
After carry out supercritical CO2Extract 2h, you can；The preparation method of the Tripterygium hypoglaucum extract is to take the root of tripterygium hypoglaucum hutcs
Portion cleans up, and dries, and the alcohol steep of 1 times of amount, while ultrasonic wave assisted extraction 15min is then added, is then concentrated under reduced pressure,
It can be obtained pepper extract.
The preparation of the composition for alleviating pain and detumescence described in the present embodiment is to be added pharmaceutically in the composition
The auxiliary material of receiving is prepared into ointment.
The preparation method of the ointment, comprises the steps of：
1）Each raw extract for taking formula rate, is dissolved with ethyl alcohol, is stirred evenly as medicine phases, is heated in 80 DEG C of water-baths molten
Solve 5min；
2）It is used as oil phase after the stearic acid of formula rate, lanolin, atoleine, glycerine are weighed, is heated in 80 DEG C of water-baths
Dissolve 5min；
3）It is used as water phase after distilled water, triethanolamine, octadecyl alcolol described in right 2 is weighed, is heated in 80 DEG C of water-baths molten
Solve 5min；
4）By step（3）Water phase be slowly added to step（ 2）Oil phase, stir while adding and be emulsified into matrix；
5 ）By step（1）In be uniformly mixed medicine phases, be slowly added to step（4）In matrix, uniform 5min is stirred by ultrasonic, it is cold
But to room temperature, you can.
Embodiment 6
A kind of composition for alleviating pain and detumescence includes the raw material of following parts by weight：1 part of pepper extract, mint extract 8
Part, 10 parts of Herba speranskiae tuberculatae extract, 9 parts of atoleine, 16 parts of glycerine, 38 parts of stearic acid, 5 parts of octadecyl alcolol, 6 parts of lanolin,
6 parts of triethanolamine, 360 parts of distilled water, 1 part of Radix Arnebiae extract, 0.8 part of Tripterygium hypoglaucum extract.
The preparation method of the pepper extract is to take the chilli without no disease and pests harm of going mouldy, and removes carpopodium and seed,
It crushes, crosses 80 mesh and sieve to obtain chilli powder, the 70% ethyl alcohol extraction of 10 times of amounts is then added, Extracting temperature is 60 DEG C, while ultrasonic wave
Assisted extraction, ultrasonic frequency 35KHz, power 100W repeat extraction 2 times, each 25min, merge extracting solution, are concentrated under reduced pressure,
Spray drying, you can obtain pepper extract.
The preparation method of the mint extract is to take the peppermint stem and leaf of fresh no disease and pests harm, dry, beats powder and crosses 80 mesh
Sieve obtains Herba Menthae powder, then carries out supercritical CO21h, extracting pressure 10MPa are extracted, extraction temperature is 45 DEG C, CO2Flow be 20 ~
30L/h collects peppermint oil, then is concentrated, be dehydrated, filtered, you can obtains mint extract.
The preparation method of the Herba speranskiae tuberculatae extract is to take the lopseed blade of fresh no disease and pests harm, and cleaning is dried in the shade, cut
Grow up 2cm, then the fragment of wide 1cm is extracted using Soxhlet extractor, and extracting solution is 95% ethyl alcohol, Extracting temperature 92
DEG C, 4h is extracted, then collection extracting solution, which is evaporated under reduced pressure to ethyl alcohol, is evaporated to obtain crude extract, continues to carry out vapor steaming to crude extract
It evaporates to oil-free and oozes now, by distillate stratification, obtain liquid level A and oil reservoir B；NaCl is added in liquid level A, until it is full
With, then use ether carry out 2 times extraction, obtain ether extraction liquid；Oil reservoir B and ether extraction liquid are merged, distilled, is collected
224 DEG C of fraction, you can obtain Herba speranskiae tuberculatae extract.
The preparation method of the Radix Arnebiae extract is that alkanet is taken to clean up, and is dried, 80 mesh of pulverizing sieve, so
After carry out supercritical CO2Extract 3h, you can；The preparation method of the Tripterygium hypoglaucum extract is to take the root of tripterygium hypoglaucum hutcs
Portion cleans up, and dries, and the alcohol steep of 4 times of amounts, while ultrasonic wave assisted extraction 25min is then added, is then concentrated under reduced pressure,
It can be obtained pepper extract.
The preparation of the composition for alleviating pain and detumescence described in the present embodiment is to be added pharmaceutically in the composition
The auxiliary material of receiving is prepared into ointment.
The preparation method of the ointment, comprises the steps of：
1）Each raw extract for taking formula rate, is dissolved with ethyl alcohol, is stirred evenly as medicine phases, is heated in 82 DEG C of water-baths molten
Solve 6min；
2）It is used as oil phase after the stearic acid of formula rate, lanolin, atoleine, glycerine are weighed, is heated in 78 DEG C of water-baths
Dissolve 6min；
3）It is used as water phase after distilled water, triethanolamine, octadecyl alcolol described in right 2 is weighed, is heated in 82 DEG C of water-baths molten
Solve 6min；
4）By step（3）Water phase be slowly added to step（ 2）Oil phase, stir while adding and be emulsified into matrix；
5 ）By step（1）In be uniformly mixed medicine phases, be slowly added to step（4）In matrix, uniform 6min is stirred by ultrasonic, it is cold
But to room temperature, you can.
Embodiment 7
A kind of composition for alleviating pain and detumescence includes the raw material of following parts by weight：2 parts of pepper extract, mint extract 8
Part, 12 parts of Herba speranskiae tuberculatae extract, 0.7 part of Radix Arnebiae extract, 0.5 part of Tripterygium hypoglaucum extract.
The preparation method of the pepper extract is to take the chilli without no disease and pests harm of going mouldy, and removes carpopodium and seed,
It crushes, crosses 80 mesh and sieve to obtain chilli powder, the 70% ethyl alcohol extraction of 12 times of amounts is then added, Extracting temperature is 55 DEG C, while ultrasonic wave
Assisted extraction, ultrasonic frequency 30KHz, power 140W repeat extraction 3 times, each 23min, merge extracting solution, are concentrated under reduced pressure,
Spray drying, you can obtain pepper extract.
The preparation method of the mint extract is to take the peppermint stem and leaf of fresh no disease and pests harm, dry, beats powder and crosses 80 mesh
Sieve obtains Herba Menthae powder, then carries out supercritical CO22h, extracting pressure 10MPa are extracted, extraction temperature is 45 DEG C, CO2Flow is
25L/h collects peppermint oil, then is concentrated, be dehydrated, filtered, you can obtains mint extract.
The preparation method of the Herba speranskiae tuberculatae extract is to take the lopseed blade of fresh no disease and pests harm, and cleaning is dried in the shade, cut
Grow up 2cm, then the fragment of wide 1cm is extracted using Soxhlet extractor, and extracting solution is 95% ethyl alcohol, Extracting temperature 92
DEG C, 4 ~ 5h is extracted, then collection extracting solution, which is evaporated under reduced pressure to ethyl alcohol, is evaporated to obtain crude extract, continues to carry out vapor to crude extract
Distillation to oil-free oozes now, by distillate stratification, obtains liquid level A and oil reservoir B；NaCl is added in liquid level A, until its
Then saturation uses ether to carry out 2 extractions, obtains ether extraction liquid；Oil reservoir B and ether extraction liquid are merged, distilled, is collected
220 DEG C of fraction, you can obtain Herba speranskiae tuberculatae extract.
The preparation method of the Radix Arnebiae extract is that alkanet is taken to clean up, and is dried, 80 mesh of pulverizing sieve, so
After carry out supercritical CO2Extract 2.5h, you can；The preparation method of the Tripterygium hypoglaucum extract is to take tripterygium hypoglaucum hutcs
Root cleans up, and dries, and the alcohol steep of 2 times of amounts, while ultrasonic wave assisted extraction 20min is then added, then depressurizes dense
Contracting, you can obtain pepper extract.
The preparation of the composition for alleviating pain and detumescence described in the present embodiment is to be added pharmaceutically in the composition
The auxiliary material of receiving is prepared into powder.
Embodiment 8
A kind of composition for alleviating pain and detumescence, formulation weight are respectively：Pepper extract 1.7g, mint extract 10g,
Herba speranskiae tuberculatae extract 11.6g, atoleine 8g, glycerine 16g, stearic acid 40g, octadecyl alcolol 5g, lanolin 5g, three ethyl alcohol
Amine 5.5g, distilled water 365g
A kind of ointment of composition and preparation method thereof for alleviating pain and detumescence is：
1）By above-mentioned 3 Plant Extracts, is dissolved with a small amount of ethyl alcohol, stir evenly as medicine phases, heated in 80 DEG C of water-baths
Dissolve 5min；
2）After above-mentioned stearic acid, lanolin, atoleine, glycerine are weighed respectively, as oil phase, in 80 DEG C of water-baths
It dissolves by heating, 5min.
3）Mixed after above-mentioned distilled water, triethanolamine, octadecyl alcolol are weighed respectively, as water phase, heating water bath extremely
80 DEG C, 5min.
4）Above-mentioned water phase is slowly added to oil phase, is stirred while adding to emulsification, at matrix.
5）Above-mentioned three kinds of natural plant extracts are uniformly mixed, are slowly added in matrix, uniform 5min is stirred by ultrasonic, it is cold
But to room temperature, bottling.
The present embodiment is simple by ointment combination prepared by above-mentioned steps, compatibility is reasonable, preparation process is easy,.The ointment
Agent is easy to use, can directly smear grieved place, and curative effect is apparent, low for pure natural preparation, side effect.
Embodiment 9
A kind of composition for alleviating pain and detumescence, the composition include the raw material of following parts by weight：Pepper extract 1-2
Part, 8-12 parts of mint extract, 10-12 parts of Herba speranskiae tuberculatae extract.
Pepper extract：Take 80 mesh 1kg of raw material of hot pepper granularity, solid-liquid ratio 1：15,70% ethyl alcohol is Extraction solvent, extraction temperature
60 DEG C, ultrasonic frequency 28KHz, power 120W, extraction time 20min of degree extracts 3 times.
Mint extract：Supercritical CO2Method extracts peppermint powder 1kg, is packed into extraction kettle.Extracting pressure 9MPa, extraction temperature
Degree is 50 DEG C, CO2Flow extracts 1.5h under conditions of being 25L/h, collects peppermint oil, is dehydrated with anhydrous sodium sulfate, filter paper filtering
Up to extract 24.3g.
Herba speranskiae tuberculatae extract：The white strain leaf in the Yunnan 1kg is taken, mud is washed away, dries in the shade, scissors is cut into long 2-3cm, and wide 1cm or so is broken
Piece, packing is spare, weighs the white strain leaf 90g in Yunnan of drying in the shade, and is packed into filtration paper cylinder, suitable for reading to be covered with filter paper, is then withstood with glass bar
Filtration paper cylinder is slowly put into Soxhlet extractor, takes 95% ethyl alcohol 250ml, wherein 100ml that the round-bottomed flask of Soxhlet extractor is added,
150ml is incorporated in the extractor of filtration paper cylinder, is heated with electric jacket, and temperature is controlled at 90 DEG C, and the ethyl alcohol in round-bottomed flask is made to boil
It rises, alcohol vapour enters condenser pipe by tedge, and steam is condensed into liquid and enters extractor, is soaked to the white strain leaf in Yunnan
Bubble, liquid color slowly become green, siphonage occur when liquid level is more than siphon pipe highest point in extractor, solution flashes back
Bottle in extract enrichment flask, waits for that ethyl alcohol color graduates into green in flask, flows back after 5h, carries by repeatedly impregnating siphon
Solution colour in device is taken to become very light, it is almost white, when the rigid siphon of phegma is gone down in device to be extracted, stop heating immediately,
Liquid flows to original place flask by siphon pipe quickly in extractor, and the ethyl alcohol in flask is blackish green at this time.It is distilled to recover extraction
Ethyl alcohol in liquid, temperature control at 90 DEG C or so, distill about 2h after, thermometer mercury from 78.5 DEG C of rapid increases when, stop
Distillation, illustrates that ethyl alcohol is almost evaporated, and then uses steam distillation device instead, carries out steam distillation, has orange-yellow oil droplet through cold
It is solidifying to flow into conical flask, until oil-free oozes existing, stopping distillation.Distillate is set into pear shape separatory funnel, is gently shaken, after static, is had
Oil droplet slowly sinks to bottom, and bottom is all sunk to oil droplet, layering, and upper layer is yellow-green liquid, and lower layer is white oil reservoir, is opened
Separatory funnel makes oil reservoir be detached with liquid layer, and it is crude extract to obtain oil reservoir.After separation, NaCl is added in the liquid phase, makes its saturation, drops
Then the solubility of low extract in water uses 2 extractions of 100ml ether point, so that extract is substantially soluble in ether, be separated into second
Ether extract liquor and liquid layer.Merge crude extract and ether extraction liquid in 250ml distilling flasks, use condensation distilling apparatus instead, burning
Bottle is put into water-bath, and temperature is adjusted to 60 DEG C, steams ether（40 DEG C of boiling point）Recycling, claims its solution quality, then uses air instead
Flask is dried to be put into electric jacket and heats distillation, collected 220 ~ 224 DEG C of fraction, obtain extract 8g by condenser pipe.
Test example 1
Selection 100, Kunming finger-joint pain patients, wherein male 50, women 50, average age 45 years old, at random
It is divided into test group and control group, the ointment that experimental group is prepared using the embodiment of the present invention 1, application method is to squeeze out about
0.5ml amounts 3 times a day use one week（Medication cycle）；Control group is blank（Non- medication）, observe and record situation.
Therapeutic evaluation：It is effective that symptom, which completely eliminates,；It is to take effect that symptom controls substantially；Symptom is without substantially changeing
In vain.
As a result：Effective 46 in 50 cases of test group, 92% is accounted for；It takes effect 4, accounts for 8%；Invalid 0.
Effective 0 in 50 cases of control group；It takes effect 0；Invalid 50, account for 100%.
Test example 2
100, Kunming gonalgia patient, wherein male 50, women 50, average age 48 years old is selected to put down at random
It is divided into test group and control group, the ointment that experimental group is prepared using the embodiment of the present invention 5, application method is to squeeze out about
0.5ml amounts 3 times a day use one week（Medication cycle）；Control group is blank（Non- medication）, observe and record situation.
Therapeutic evaluation：It is effective that symptom, which completely eliminates,；It is to take effect that symptom controls substantially；Symptom is without substantially changeing
In vain.
As a result：Effective 48 in 50 cases of test group, 96% is accounted for；It takes effect 2, accounts for 4%；Invalid 0.
Effective 0 in 50 cases of control group；It takes effect 0；Invalid 50, account for 100%.
Test example 3
100, Kunming ankle-joint pain patients, wherein male 50, women 50, average age 45 years old are selected to put down at random
It is divided into test group and control group, the ointment that experimental group is prepared using the embodiment of the present invention 8, application method is to squeeze out about
0.5ml amounts 3 times a day use one week（Medication cycle）；Control group is blank（Non- medication）, observe and record situation.
Therapeutic evaluation：It is effective that symptom, which completely eliminates,；It is to take effect that symptom controls substantially；Symptom is without substantially changeing
In vain.
As a result：Effective 45 in 50 cases of test group, 90% is accounted for；It takes effect 5, accounts for 10%；Invalid 0.
Effective 0 in 50 cases of control group；It takes effect 0；Invalid 50, account for 100%.
Claims (9)
1. a kind of composition for alleviating pain and detumescence, it is characterised in that include the raw material of following parts by weight：Pepper extract 1-2
Part, 8-12 parts of mint extract, 10-12 parts of Herba speranskiae tuberculatae extract.
2. the composition according to claim 1 for alleviating pain and detumescence, it is characterised in that the system of the pepper extract
Preparation Method is to take the chilli without no disease and pests harm of going mouldy, and removes carpopodium and seed, is crushed, and crosses 80 mesh and sieves to obtain chilli powder, then
The 70% ethyl alcohol extraction of 10 ~ 15 times of amounts is added, Extracting temperature is 50 ~ 60 DEG C, while ultrasonic wave assisted extraction, ultrasonic frequency 25 ~
35KHz, 100 ~ 150W of power repeat extraction 2 ~ 3 times, every time 15 ~ 25min, merge extracting solution, are concentrated under reduced pressure, spray drying, i.e.,
Pepper extract can be obtained.
3. the composition according to claim 1 for alleviating pain and detumescence, it is characterised in that the system of the mint extract
Preparation Method is the peppermint stem and leaf for taking fresh no disease and pests harm, dry, beats powder and crosses 80 mesh and sieve to obtain Herba Menthae powder, then carries out overcritical
CO21 ~ 2h, 8 ~ 10MPa of extracting pressure are extracted, extraction temperature is 45 ~ 55 DEG C, CO2Flow is 20 ~ 30L/h, collects peppermint oil, then
It concentrated, be dehydrated, filtered, you can obtain mint extract.
4. the composition according to claim 1 for alleviating pain and detumescence, it is characterised in that the Herba speranskiae tuberculatae extract
Preparation method is to take the lopseed blade of fresh no disease and pests harm, and cleaning dries in the shade, is cut into long 2-3cm, the fragment of wide 1cm, then
It is extracted using Soxhlet extractor, extracting solution is 95% ethyl alcohol, and Extracting temperature is 88 ~ 92 DEG C, extracts 4 ~ 5h, then collects and carries
It takes liquid to be evaporated under reduced pressure to ethyl alcohol to be evaporated to obtain crude extract, continues to ooze now crude extract progress steam distillation to oil-free, will evaporate
Go out liquid stratification, obtains liquid level A and oil reservoir B；NaCl is added in liquid level A, until it is saturated, is then carried out using ether
2 ~ 3 extractions, obtain ether extraction liquid；Oil reservoir B and ether extraction liquid are merged, distillation collects 220 ~ 224 DEG C of fraction, i.e.,
Herba speranskiae tuberculatae extract can be obtained.
5. the composition according to claim 1 for alleviating pain and detumescence, it is characterised in that further include the original of following parts by weight
Material：7-10 parts of atoleine, 14-18 parts of glycerine, 35-45 parts of stearic acid, 3-6 parts of octadecyl alcolol, 4-6 parts of lanolin, three second
4-6 parts of hydramine, 350-370 parts of distilled water.
6. the composition according to claim 1 for alleviating pain and detumescence, it is characterised in that further include the original of following parts by weight
Material：0.5 ~ 1 part of Radix Arnebiae extract, 0.2 ~ 0.8 part of Tripterygium hypoglaucum extract.
7. the composition according to claim 6 for alleviating pain and detumescence, it is characterised in that the system of the Radix Arnebiae extract
Preparation Method is that alkanet is taken to clean up, and is dried, then 80 mesh of pulverizing sieve carries out supercritical CO22 ~ 3h is extracted, i.e.,
It can；The preparation method of the Tripterygium hypoglaucum extract is that the root of tripterygium hypoglaucum hutcs is taken to clean up, and dries, is then added
The alcohol steep of 1 ~ 4 times of amount, while ultrasonic wave 15 ~ 25min of assisted extraction, are then concentrated under reduced pressure, you can obtain pepper extract.
8. a kind of preparation according to any composition for alleviating pain and detumescence of claim 1 ~ 7, it is characterised in that described
Preparation be the auxiliary material pharmaceutically received is added in the composition to be prepared into ointment, powder, liquid preparation.
9. the preparation of the composition according to claim 8 for alleviating pain and detumescence, it is characterised in that the ointment
Preparation method comprises the steps of：
1）Each raw extract for taking formula rate, is dissolved with ethyl alcohol, is stirred evenly as medicine phases, is added in 75 ~ 85 DEG C of water-baths
3 ~ 7min of heat of solution；
2）It is used as oil phase after the stearic acid of formula rate, lanolin, atoleine, glycerine are weighed, adds in 75 ~ 85 DEG C of water-baths
3 ~ 7min of heat of solution；
3）It is used as water phase after distilled water, triethanolamine, octadecyl alcolol described in right 2 is weighed, is heated in 75 ~ 85 DEG C of water-baths
Dissolve 3 ~ 7min；
4）By step（3）Water phase be slowly added to step（ 2）Oil phase, stir while adding and be emulsified into matrix；
5 ）By step（1）In be uniformly mixed medicine phases, be slowly added to step（4）In matrix, uniform 3 ~ 7min is stirred by ultrasonic,
It is cooled to room temperature, you can.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113069388A (en) * | 2020-01-06 | 2021-07-06 | 广州樱奈儿化妆品有限公司 | Massage cream for relieving cervical vertebra pain and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1490018A (en) * | 2002-10-15 | 2004-04-21 | 李三猛 | Medicine for treating rheumatic disease |
| CN1569147A (en) * | 2004-04-27 | 2005-01-26 | 陈明元 | Tripterygium hypoglaucum contained transdermal plaster and its preparation |
| CN102293829A (en) * | 2011-08-31 | 2011-12-28 | 曾爱忠 | Externally applying medicine for relieving pain and preparation method thereof |
-
2018
- 2018-05-28 CN CN201810519393.5A patent/CN108524663A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1490018A (en) * | 2002-10-15 | 2004-04-21 | 李三猛 | Medicine for treating rheumatic disease |
| CN1569147A (en) * | 2004-04-27 | 2005-01-26 | 陈明元 | Tripterygium hypoglaucum contained transdermal plaster and its preparation |
| CN102293829A (en) * | 2011-08-31 | 2011-12-28 | 曾爱忠 | Externally applying medicine for relieving pain and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 欧广升: "《敷贴不求人》", 31 May 2010, 湖南科学技术出版社 * |
| 黄纯琪: "《中医常用方药的比较应用》", 30 November 2008, 广东科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113069388A (en) * | 2020-01-06 | 2021-07-06 | 广州樱奈儿化妆品有限公司 | Massage cream for relieving cervical vertebra pain and preparation method thereof |
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Application publication date: 20180914 |