CN103845562A - Pharmaceutical composition for treating traumatic injury - Google Patents

Abstract

The invention discloses a pharmaceutical composition for treating traumatic injury. The pharmaceutical composition is respectively prepared from the following raw materials in parts by weight: 12-28 parts of large brassaiopsis, 12-28 parts of small brassaiopsis, 6-14 parts of longgufeng, 6-14 parts of dragon blood, 6-14 parts of rhizoma drynariae, 6-14 parts of Philippine flemingia roots, 6-14 parts of elderberries, 6-14 parts of camphorwood and 3-7 parts of mint. The pharmaceutical composition is remarkable in clinical application effect.

Description

A kind of pharmaceutical composition for the treatment of traumatic injury

Technical field

The present invention relates to technical field of Chinese medicines, be specifically related to the pharmaceutical composition of the treatment traumatic injury being prepared from taking Chinese herbal medicine as preparation of raw material.

Background technology

Traumatic injury, general reference people is because the wound former thereby that be subject to such as falling, beat, knock, touch, traumatic injury comprises weapons, tumbling down, hits, sprain and contusion, stab, scratch, athletic injury etc., there are pain, swelling, hemorrhage or fracture, dislocation etc. in injury more, also comprise some visceral injuries, generally taking swelling, pain as main manifestations.

Some people occurs after traumatic injury, and the diagnosis and treatment of being eager are often used medicine fumigation and wash method, in fact sometimes does like this that very easily things turn out contrary to one's wishes.Not only be of no curative effect, and the state of an illness can be more and more serious.How fast traumatic injury detumescence? if only damaged soft tissue, suitable time, adopt Chinese herbal medicine fumigation and wash method, be of value to and alleviate disease.How traditional Chinese medical science fumigation and wash method medicine used is formed by Chinese herbal medicine compatibilities such as Radix Angelicae Sinensis, Radix Notoginseng, Flos Carthami, the Radix Paeoniae Alba, Radix Achyranthis Bidentatae, Myrrha, Olibanum, Oletum Trogopteroris, has effect of blood circulation promoting and blood stasis dispelling, alleviating pain and detumescence, but is sometimes also superficial charm.

The medicine brand of the treatment traumatic injury of at present domestic production closely reaches tens kinds, but use clinical in and effective and no side effects or toxic and side effects little in, Western medicine remains blank.As orthopedics department medicines such as the YUNNAN BAIYAO of current patient's use, pill for traumatic injuries, wound healing spirits, the analgesic effect of these medicines is also not obvious, in one week, do not subside a swelling, two weeks can not be crazy about by bone growth promoting, nonunion in one month, let alone activating blood circulation to dissipate blood stasis, the curative effect of reunion of fractured tendons and bones, affect orthopedics department patient's healing time for this reason, incured loss through delay the hope of recovering recovery from illness.

Summary of the invention

The technical problem to be solved in the present invention be in prior art to the effect of drugs for the treatment of traumatic injury the undesirable or deficiency such as slow that takes effect, provide a kind of effectively for the pharmaceutical composition of traumatic injury.

In pharmaceutical composition of the present invention, the consumption of each component is that inventor draws through a large amount of practice summaries, and this pharmaceutical composition is made up of the raw material of following weight parts:

DALUOSAN 12-28 part, Radix Ardisiae punctatae 12-28 part, Os Draconis wind 6-14 part, Sanguis Draxonis 6-14 part, Rhizoma Drynariae 6-14 part, Radix Flemingiae Philippinensis 6-14 part, Ramulus Sambuci Williamsii 6-14 part, Lignum cinnamomi camphorae 6-14 part, Herba Menthae 3-7 part.

Be preferably:

DALUOSAN 16-24 part, Radix Ardisiae punctatae 16-24 part, Os Draconis wind 8-12 part, Sanguis Draxonis 8-12 part, Rhizoma Drynariae 8-12 part, Radix Flemingiae Philippinensis 8-12 part, Ramulus Sambuci Williamsii 8-12 part, Lignum cinnamomi camphorae 8-12 part, Herba Menthae 4-6 part.

Optimum is:

20 parts of DALUOSAN, 20 parts of Radix Ardisiae punctatae, 10 parts of Os Draconis wind, 10 parts of Sanguis Draxonis, 10 parts of Rhizoma Drynariae, 10 parts of Radix Flemingiae Philippinensiss, 10 parts of Ramulus Sambuci Williamsii, 10 parts of Lignum cinnamomi camphoraes, 5 parts of Herba Menthaes.

The pharmaceutical composition of above-mentioned treatment traumatic injury can adopt existing conventional method to be prepared

The dosage form of medicine of the present invention can be the medically acceptable dosage forms such as medicated wine, spray, unguentum, and their preparation method, supplementary product consumption are undertaken by existing common process.

The present invention also comprises the application of aforementioned pharmaceutical compositions in the medicine of preparing treating traumatic injury.

In pharmaceutical composition prescription of the present invention:

DALUOSAN, Myrsinacea Ardisa shrub plant, nature and flavor: toil, cool.1. " detailed outline ": hardship, cool, nontoxic.2. " the SHENGCAO property of medicine is standby to be wanted ": sweet in the mouth, property is flat.3. " Luchuan book on Chinese herbal medicine ": arduous, cold in nature.Function cures mainly: heat-clearing and toxic substances removing, eliminating stasis to stop pain.Control sense, tonsillitis, acute angina, diphtheria, erysipelas, lymphadenitis, over-strained hemoptysis, heart peratodynia, rheumatic ostalgia, traumatic injury.1. " detailed outline ": control swelling throat numbness, mill water or vinegar are swallowed it.2. ((the SHENGCAO property of medicine is standby to be wanted)): control phlegm-fire, traumatic injury, eliminating blood stasis to promote regeneration of blood, wide muscle symplectic bone.3. " south of the Five Ridges gather medicinal herbs record ": control dry (infantile malnutrition) painful abdominal mass of children's.4. " Guangxi Chinese medicinal herbal ": dispelling the wind and dampness pathogens osteodynia, the arthroncus of knee.5. " Hunan medicine will ": control over-strained hemoptysis, metrorrhagia, heart peratodynia, abdominal distention stomachache.6. " Zhejiang conventional medical herbs among the people ": heat-clearing and toxic substances removing.

Radix Ardisiae punctatae, another name: blood party, a word used in place name of invigorating blood circulation, gland point Herba Ardisiae Japonicae, variegated leaf Radix Ardisiae Crenatae, little sunshade, Margarita lid sunshade, be root or the Herb of Myrsinacea plant Radix Ardisiae punctatae.Function cures mainly: promoting blood flow to regulate menstruation, timid wind dehumidifying.Control amenorrhea, dysmenorrhea, rheumatic arthralgia, traumatic injury.1. " the practical Chinese herbal medicine in Guangxi newly selects ": " stimulate the menstrual flow and enrich blood, wind-damp dispelling.Control menoxenia, amenorrhea, infertility, puerperal exposure to wind pain, paralysis, anemia." 2. Guangzhou air force " conventional Chinese herbal medicine handbook ": " dissipating blood stasis that dispels the wind, reducing swelling and alleviating pain.Treating rheumatic arthritis, traumatic injury, laryngopharynx swelling and pain, stomatitis.”

Os Draconis wind, another name: Caulis cyatheae spinulosae, large Rhizoma Osmundae are the stem of Cyatheaceae plant Caulis cyatheae spinulosae.Nature and flavor: micro-hardship; Flat, Gui Jing: kidney; Stomach; Lung meridian.Chemical analysis: containing Caulis cyatheae spinulosae flavone (hegoflavone) A, 2, 3-dihydro-3''-hydroxyl-6, the two apigenins (2 of 6''-, 3-dihydro-3''-hydroxy-6, 6''-biapigenin), Caulis cyatheae spinulosae flavone B is 2, 3-dihydro-6, the two luteolins (2 of 6''-, 3-dihydro-6, 6''-biluteolin), cyclolaudenol (cyclolaudenol), ring jackfruit sterol (cycloartenol), 5-cholestenol (cholest-5-enol), 24-methyl-5, 22-cholestadienol (24-methylcholesta-5, 22-dienol), 24-methyl-5-cholestenol (24-methylcholest-5-enol), 24-ethyl-5, 22-cholestadienol (24-ethylcholesta-5, 22-dienol), 24-ethyl-5-cholestenol (24-ethylcholest-5-enol) and 24-ethyl-5 α-cholesterol (24-ethyl-5 α-cholestanol).Function cures mainly: expelling wind and removing dampness; Promoting blood circulation to remove obstruction in the collateral; Relieving cough and asthma; Heat-clearing and toxic substances removing; Parasite killing.Cure mainly rheumatic arthralgia; Lumbago due to renal deficiency; Traumatic injury; Hernia; Acute toothache; Cough; Asthma; Scabies; Ascariasis; Enterobiasis and flu-prevention.

Sanguis Draxonis, another name: black horse Lin exhausts, sea wax, dragon's blood, wooden Sanguis Draxonis, is the resin in babassu Sanguis Draxonis fruit and trunk.Composition: be the mixture of a kind of resin ester and dracoresinotannol, approximately containing 57-82%; Another containing unbodied dracoalban approximately 2.5%, yellow dracoresene approximately 14%, insoluble resin 0.3%, vegetalitas dregs 18.4%, phlobaphene 0.03%, ash 8.3%.Function cures mainly: dissipating blood stasis analgesic therapy, hemostasia and promoting granulation.Control traumatic injury and lose, ecchymoma due to internal injury; Continuous bleeding due to traumatic injury, scrofula, ecthyma unhealed for long time.1. Tang Materia Medica: " main the five internal organs pathogen, leukorrhagia, pain relieving, removing mass blood, gold creation meat." 2. " Haiyao Bencao, Oversea Materia Medica ": " and leadingly traumatic fracture damage, all pain, tonify deficiency and vim and vigour are stirred thorn, and interior blood trouble is poly-, and should wine clothes." 3. " Japan hanako materia medica ": " control all malignant boil scabies and do not conform to person for a long time, apply.This property of medicine is anxious, also can not make more, but draws pus." 4. Wang Haogu: " reinforcing the heart envelope, deficiency of liver-blood." 5. " detailed outline ": " the loose all pains of stagnant blood, married woman's vim and vigour, children's Chi Zong.”

Rhizoma Drynariae, another name: monkey Rhizoma Zingiberis Recens, monkey Rhizoma Zingiberis Recens, Shi Maojiang, Shi An, Cortex Ampelopsis Aconitifoliae Radicis, stone Rhizoma Alpiniae Officinarum, delevay drynaria, Fortune's Drynaria Rhizome, broken benefit, tree Scolopendra, DIWUGONG, yellow parthenocissus, partridge chickens wing, Radix scopoliae sinensis, the broken benefit of meat, monkey palm Rhizoma Zingiberis Recens, Shi Lian, Rhizoma Zingiberis Recens, stone palm, Mao Jiang, drynaria baronii, rock Rhizoma Zingiberis Recens.Composition: Drynaria fortunei(Kunze) J.Smith rhizome is starch-containing 16.4%, glucose 5.37%, also containing naringin.Function cures mainly: the kidney invigorating, invigorate blood circulation, and hemostasis.Control suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatic arthralgia, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, clavus.1. " property of medicine opinion ": " poison in main bone, wind blood pain, five kinds of over strain six types of severe debility disease, mouthful (one makes " foot ") hands is not received, upper heat and lower cold." 2. " Japan hanako materia medica ": " control malignant boil, lose rotten meat, parasite killing." 3. " Kaibao Bencao ": " benefit is traumaticd fracture for main removing blood stasis, hemostasis." 4. " book on Chinese herbal medicine is just ": " treat the bone poison of being possessed, wind heat pain, or diseases caused by exogenous pathogenic factor rheumatism, so that the weak pain of two flaccidity of the lower limbs." 5. " book on Chinese herbal medicine is stated ": " control lumbago migratory arthralgia, apoplexy arthroncus of knee contraction gas card, has loose bowels, and drenches seminal emission, proctoptosis." 6. " Guangxi Chinese medicinal herbal ": " control infantile malnutrition." 7. " Traditional Chinese Medicine in Sichuan will ": " let out wetly, stimulate the menstrual flow.”

Radix Flemingiae Philippinensis, another name: golden pheasant lands, colour of loess chicken, rat tail, thoroughly Pheretima, Millettia Speciosa, winged steed, Niu Duntou, Glycine tomentella, colour of loess dusk, hang hitching post, very heavyly hang, energetically yellow, thousand tails swing, three strands of silks, Taurus tail, a thousand pieces of golds pendant, are the root of the climing property of leguminous plant Radix Flemingiae Philippinensis.Composition: containing multiple flavone compound, determined that structure has: climing property Radix Flemingiae Philippinensis element (flemiphilippinin) C, D in root.In addition containing 5,7,3 ＇, 4 ＇-tetrahydroxy-6, the two prenyl isoflavones (5 of 8-, 7,3 ', 4 ＇-tetrahydroxy-6,8-diprenylisoflavone), Radix Flemingiae Philippinensis element (flemichin) D, lupeol (lupeol), the positive alkanoic acid that cupreol (β-sitosterol) and carbon number are 22-30.Function cures mainly: expelling wind and removing dampness, repercussive removing toxic substances.Dispelling the wind and dampness pathogens arthralgia pain, chronic nephritis, traumatic injury, carbuncle, throat moth.1. " Zhiwu Mingshi Tukao ": " fill blood." 2. " south of the Five Ridges gather medicinal herbs record ": " dispel wind and remove dampness.Control brothers' arthralgia pain, lumbar rheumatism is had a pain, and reason traumatic injury wound, can relaxing muscles and tendons and activating QI and blood in the collateral." 3. " Nanning City's medicine will ": " strengthening bone and muscle, blood stasis removing is long-pending.Control traumatic injury, rheumatic ostalgia, extremity are aching and limp unable, jaundice.”

Ramulus Sambuci Williamsii, another name: Mu Herba sambuci chinensis, Rhizoma seu Herba Elatostematis stewardii, symplectic bone wood, pubescent angelica root, seven leaf five-leaved chaste trees, puts that rod is capable, Corallium Japonicum Kishinouye is joined, Schisandra propinqua (Wall.) Baill. Var. intermedia A. Smith, Cortex torricelliae tiliifoliae, seven leaf gold, Herba speranskiae tuberculatae, synthetism wind, is the stem branch of caprifoliaceae plant Ramulus Sambuci Williamsii.Function cures mainly: dispel the wind, dampness removing, invigorates blood circulation, pain relieving.Dispelling the wind and dampness pathogens bones and muscles pain, lumbago, edema, pruritus due to wind pathogen, urticaria, puerperal blood faints, treating swelling and pain by traumatic injury, fracture, wound hemorrhage.1. Tang Materia Medica: " main injured, reuniting the fractured tendons and bones, except pruritus due to wind pathogen, dental caries.Can be bath soup." 2. supplement to Thousand Golden Prescriptions: " injure trace blood and puerpera's stagnant blood, all blood are not all right or more than, and liquor clothes." 3. Wang Lian bodyguard " book of gathering medicinal herbs ": " promoting the circulation of blood relieves internal heat, and washes all skin ulcer scabies, terrible arrow wind." 4. " BAICAO mirror ": " control to fall and flutter carbuncle." 5. " modern Practical Chinese medicinal ": " be analgesic.Control brothers' hemiplegia and lumbago due to pathogenic wind-dampness, all pains between bone, the cold pain of extremity, swelling of the feet.Get injured by a fall again osteodynia, rubella, miliaria etc. for bathing soup stock.”

Lignum cinnamomi camphorae, another name: ZHANGCAI, lignum cinnamomi camphorae, Caulis Seu Radix Kadsurae Oblongifoliae, is the timber of canella Camphor tree, composition: Lignum cinnamomi camphorae is containing Camphora and armaticity volatile oil (name camphor oil).Camphor oil vacuum fractionation, can obtain white oil 20% (boiling point 160-165 DEG C), in containing 1, 8-Cineole 25-30%, australene, camphene, limonene etc.; Red oily 24% (boiling point 210-250 DEG C), in containing safrole, alpha-terpineol, carvacrol, eugenol etc.; Blue oil 1% (boiling point 250-300 DEG C), in containing Cadinene, bisabolence, α-camphorene, azulene.In the root of Lignum cinnamomi camphorae, still obtain laurolitsine and reticuline.Timber is still containing C16-25 normal alkane, C17-33 isoalkane, C16,20,22,24,26, OCS (wherein C26 alkanol accounts for 50%), cupreol, polyhydric alcohol, keto-alcohol etc.In bark, still detect propanoic acid, butanoic acid, valeric acid, caproic acid, sad, capric acid, lauric acid, myristic acid, stearic acid, oleic acid etc.Ye Zhongshang is containing the normal alkane of C16-33.The fatty oil of seed, wherein satisfied fatty acid accounts for 93%; The ratio of three saturated acids, two saturated acids, a saturated acid and triunsaturated glyceride is 80,17,1,2%.Marrow difference in season, contains Camphora 0.2-1.5% in leaf.In leaf, safrole content is 0.04-0.05%, irrelevant with season.The leaf of Lignum cinnamomi camphorae mutation contains heavy volatile oil 0.83%, light volatile oil 0.26%.In heavy oil, contain safrole 80%, Camphora 10%; In light oil, contain linalool 70%, Camphora 1%.In the leaf of Lignum cinnamomi camphorae sleeve of Yunnan, contain camphene, australene, P-cymene, linalool, alpha-terpineol, Camphora, citral, capraldehyde, methyl heptenone, 1, 8-Cineole and eugenol.The fuel-displaced 0.68-2% of fresh leaf of one of little kind of Mao Yezhang Herba Cymbopogonis Citrari Camphor tree, in leaf oil, Camphora is about 50%, and citral and methyl heptene are waken up and are about 42%, still contain in addition 1, 8-Cineole, australene, camphene and dl-limonene.The leaf oil of another essay kind hair leaf Lignum cinnamomi camphorae of Mao Yezhang is to contain terpenes and 1, 8-Cineole as main.Japan produces the leaf of Lignum cinnamomi camphorae and sprig produces volatile oil and Camphora approximately 1%, and volatile oil goes the excess oil after Camphora to account for 10%, in have the blue alkene approximately 3% of α-clothing, beta-elemene approximately 8%, β-caryophyllene approximately 35%, Humuleno approximately 18%, selinene 14%, nerolidol 1%.Separately have report, the main component in camphor oil high-boiling fration (boiling point >215 °) is the blue alkene of α-clothing, α-Lignum Santali Albi terpenes, β-Lignum Santali Albi terpenes and δ-Cadinene, and content is all more than 10%; Still containing γ-patchoulene, (-)-Cadina-1,3,5-triene, calacorene, eggplant limonene-9,11,1,6-dimethyl-4-isopropyl-7,8-dihydronaphthalene, beta-elemene, caryophyllene, Humuleno etc.Also get Sesquiterpene Polyesters campherenone, campherenol, kusunol from blue oil part.Japan produces the branch and leaf of Lignum cinnamomi camphorae and deposits steam distillation again after several days, can produce volatile oil 1～1.3%, and in oil, containing alcohols 90%, main is linalool, Camphora 2.1%.Function cures mainly: wind-damp dispelling, qi and blood circulation promotion, sharp joint.Control trusted subordinate's distending pain, beriberi, gout, scabies, traumatic injury.1. supplement to the Herbal: " main cardiac and abdominal pain, cholera, abdominal distention, dyspepsia does not disappear, the normal smelly water of acid regurgitation, wine boils and takes it.Also do to bathe soup and control beriberi, except scabies pruritus due to wind pathogen." 2. " book on Chinese herbal medicine is new again ": " traumatic injury folding bone is controlled in Nuan Xue road, sharp joint, and QI rising in reverse order stasis, holds concurrently to have an abortion.”

Herba Menthae, another name: luxuriant lotus dish, Ba Jian, Wu Ba Jian, southern Herba Menthae, cat thin severe, wild mint, the thin Ke, of yang invigorating dish Bo lotus, cease medicine, core Adiantum monochlamys Eaton., JIANZHONGXIAO, water Herba Leonuri, Rhizoma seu Herba Elatostematis stewardii, native Herba Menthae, Herba Menthae Rotundifoliae, Herba Moslae night, is herb or the leaf of labiate Herba Menthae or family Herba Menthae.Composition: fresh leaf is containing volatile oil 0.8-1%, and scapus leaf is containing 1.3-2%.In oil, main constituent is menthol, and secondly the about 77-78% of content is menthone, and content is 8-12%,, also containing menthyl acetate, camphene, limonene, isomenthone, pinene, piperitenone, resin and a small amount of tannin, rosmarinic acid.Function cures mainly: dispelling wind, heat radiation, ward off dirty, removing toxic substances.Control affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.1. " property of medicine opinion ": " remove anger gas, toxophoric antiperspirant, removing blood stasis dysentery relieving, easing joint movement." 2. " a thousand pieces of gold dietetic therapy ": " but kidney qi is made us implication perfume (or spice) clean.The main poison that exorcises evil spirits, except labor fraud." 3. Sun Si invite: " decoct soup and wash dermatitis rhus." 4. Tang Materia Medica: " main harmful wind, diaphoresis.(controlling) bad odor distention and fullness in the abdomen.Cholera.Dyspepsia does not disappear, the therapeutic method to keep the adverse QI flowing downwards." 5. " Treatise on Dietetic Therapy ": " pestle juice clothes, go heart wind heat." 6. " feeding habits book on Chinese herbal medicine ": " can draw all medicines joins the army and defends.Treat YIN YANG toxin syndrome, cold headache." 7. " Japan hanako materia medica ": " control apoplectic aphasia, spit.Except harmful wind.Treat abdominal distnetion.The therapeutic method to keep the adverse QI flowing downwards, dyspepsia and wind syndrome of head etc. disappear." 8. " Bencao Tujing ": " wind that cures the wound, wind syndrome of the head, the lattice of being open to the custom, children's's wind saliva." 9. amplification on Canon of Materia Medica: " and infantile convulsion, high fever, must this priming; Control hectic fever due to YIN-deficiency consumptive fever, with its juice and many medicines be cream." 10. Li Gao: " the main clear sharp head." (11) Wang Haogu: " can search irritability.More than main lung fills again, pain in the shoulder and back and wind and cold sweating." (12) " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control all typhoid fever headaches, cholera is vomited and diarrhoea, carbuncle, cellulitis, scabies, insane all skin ulcers." again: " all wind of refresh oneself on wild mint, only headache, dizzy, heating, remove wind-phlegm, controls the cough due to common cold, sinusitis with purulent discharge nose flows smelly tears, moves back chronic consumptive disease heating." (13) " detailed outline ": " throat, all diseases of ability to speak.Control scrofula, skin ulcer scabies, wind scabies urticaria." (14) " book on Chinese herbal medicine is stated ": " control apoplexy, epilepsy, hinders scorching strongly fragrant." (15) " medical center bun is wanted ": " more toothache, cough due to heat, resolving depression summer-heat, only excessive thirst, hemostasis dysentery, diuresis." (16) " book on Chinese herbal medicine is new again ": " corneal nebula disappears.”

From the angle of the traditional Chinese medical science, in pharmaceutical composition of the present invention, DALUOSAN blood circulation promoting and blood stasis dispelling, subduing swelling and detoxicating; Radix Ardisiae punctatae, Os Draconis wind promoting blood flow to regulate menstruation, expelling wind and removing dampness; The analgesic therapy of Sanguis Draxonis dissipating blood stasis; Rhizoma Drynariae the kidney invigorating bone strengthening, blood circulation promoting and blood stasis dispelling, the pain relieving of curing the wound; Radix Flemingiae Philippinensis, Ramulus Sambuci Williamsii expelling wind and removing dampness, repercussive removing toxic substances; Lignum cinnamomi camphorae wind-damp dispelling, the meridian dredging; Herba Menthae easing joint movement.All medicines share and can reach reducing swelling and alleviating pain, dredge the meridian passage, blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, bone and muscle strengthening, effect of expelling wind and removing dampness.

From the angle of doctor trained in Western medicine, in pharmaceutical composition of the present invention, the mechanism of action: there is high-effective penetrating power, can go deep into subcutaneous tissue and improve microcirculation, eliminate inner inflammation, promote the reparation of local damage tissue.

Compared to the prior art, the present invention has the following advantages:

1, pharmaceutical composition of the present invention all has good effect to various acute or chronic soft tissue injuries, fracture bone splits, cervical spondylosis scapulohumeral periarthritis etc.

2, the medicine of most treatment traumatic injury can produce skin allergy, but uses pharmaceutical composition of the present invention to be not only not easy allergy, otherwise also can treat the allergic symptoms such as the trace that uses other drug to produce is itched, redness.

3, pharmaceutical composition of the present invention, for old soft tissue injury, old rheumatism, is the product rarely having, can thoroughly cure.

Detailed description of the invention

With embodiment, the invention will be further described below, but the present invention is not limited to these embodiment.

Embodiment 1:

DALUOSAN 120g, Radix Ardisiae punctatae 280g, Os Draconis wind 60g, Sanguis Draxonis 140g, Rhizoma Drynariae 60g, Radix Flemingiae Philippinensis 140g, Ramulus Sambuci Williamsii 60g, Lignum cinnamomi camphorae 140g, Herba Menthae 30g.

Take above each raw material, clean and dry, co-grinding is crossed 80 mesh sieves, obtains powder after sterilizing.

Embodiment 2:

DALUOSAN 280g, Radix Ardisiae punctatae 120g, Os Draconis wind 140g, Sanguis Draxonis 60g, Rhizoma Drynariae 140g, Radix Flemingiae Philippinensis 60g, Ramulus Sambuci Williamsii 140g, Lignum cinnamomi camphorae 60g, Herba Menthae 70g.

Take above each raw material by proportional quantity, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filter, when filtrate is concentrated into relative density and is 1.30(70 DEG C, survey) extractum, add the deionized water of routine dose, dissolve, filter, fill, obtains spray.

Embodiment 3:

DALUOSAN 160g, Radix Ardisiae punctatae 240g, Os Draconis wind 80g, Sanguis Draxonis 120g, Rhizoma Drynariae 80g, Radix Flemingiae Philippinensis 120g, Ramulus Sambuci Williamsii 80g, Lignum cinnamomi camphorae 120g, Herba Menthae 40g.

Take above each raw material by proportional quantity, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filters, when filtrate is concentrated into relative density and is 1.30(70 DEG C, survey) extractum, add the propolis of routine dose, obtain unguentum.

Embodiment 4:

DALUOSAN 240g, Radix Ardisiae punctatae 160g, Os Draconis wind 120g, Sanguis Draxonis 80g, Rhizoma Drynariae 120g, Radix Flemingiae Philippinensis 80g, Ramulus Sambuci Williamsii 120g, Lignum cinnamomi camphorae 80g, Herba Menthae 60g.

Add adjuvant glycerol 240g to stir, pour into grinder-mixer repeatedly crushing, stirring after 2 days, become oily mixture, extract to obtain the about 2500g of fluid with high speed oil remover, filter, heating separated, obtains the about 800g of oily stock solution, add about 3200g vaseline to mix, after heating, stir, leave standstill to room temperature, obtain unguentum.

Embodiment 5:

DALUOSAN 200g, Radix Ardisiae punctatae 200g, Os Draconis wind 100g, Sanguis Draxonis 100g, Rhizoma Drynariae 100g, Radix Flemingiae Philippinensis 100g, Ramulus Sambuci Williamsii 100g, Lignum cinnamomi camphorae 100g, Herba Menthae 50g.

Take respectively above each raw material by proportional quantity, drying rear chopping, puts into container, with 60 left and right degree rice wines immersions, steeps powder, and sealing, after 60 days, filters out medicated wine, and fill, obtains medicated wine.

In order to verify its effect, the product that embodiment 5 is obtained has carried out clinical verification at local hospital to 288 routine patients, and result is as follows:

Clinical data

1 data and method

1.1 case selections: 2008-2014 March, fracture, comprises that various closed fracture, bone splits seam, stiff the stretching of causing of the fixing posterior joint of Gypsum Fibrosum are bent difficulty, operation posterior joint is stretched and bent difficulty etc.; The various ligaments of acute or chronic soft tissue injury, muscle, tendon, muscle are pulled, sprain, are dampened, and improper the caused chronic pain of above injury in treating; The postoperative dysfunction of tendon rupture; Muscular strain, cervical spondylosis, scapulohumeral periarthritis lumbar muscle strain, sciatica, (the not smooth type of muscular strain, vim and vigour) cervical spondylosis, scapulohumeral periarthritis, tenosynovitis, mouse hand etc.; Prolapse of lumbar intervertebral disc; The pain of neck shoulder, waist lower limb, each joint part, acid is swollen, heavy, numb; Rheumatism and rheumatoid arthrosis pain, postpartum rheumatic; There is above-mentioned symptom patient.

1.2 usings method: external, smear affected part, every day 2-3 time, continue a few days by 2 weeks according to severity of symptom, as recovery from illness can stop or continuing using a couple of days.

2, therapeutic outcome

Table 1 therapeutic effect

Conclusion: the medicated wine of the embodiment of the present invention 5, for fracture, comprises that various closed fracture, bone splits seam, stiff the stretching of causing of the fixing posterior joint of Gypsum Fibrosum are bent difficulty, operation posterior joint is stretched and bent difficulty etc.; The various ligaments of acute or chronic soft tissue injury, muscle, tendon, muscle are pulled, sprain, are dampened, and improper the caused chronic pain of above injury in treating; The postoperative dysfunction of tendon rupture; Muscular strain, cervical spondylosis, scapulohumeral periarthritis lumbar muscle strain, sciatica, (the not smooth type of muscular strain, vim and vigour) cervical spondylosis, scapulohumeral periarthritis, tenosynovitis, mouse hand etc.; Prolapse of lumbar intervertebral disc; The pain of neck shoulder, waist lower limb, each joint part, acid is swollen, heavy, numb; Rheumatism and rheumatoid arthrosis pain, postpartum rheumatic; Have above-mentioned symptom patient, symptom the lighter can fully recover on the 2nd, within general one week, can fully recover, and serious symptom person needs can be almost recovered for about 2 weeks.

Claims (4)

1. treat a pharmaceutical composition for traumatic injury, it is characterized in that it is made up of the raw material of following weight parts respectively:

DALUOSAN 12-28 part, Radix Ardisiae punctatae 12-28 part, Os Draconis wind 6-14 part, Sanguis Draxonis 6-14 part, Rhizoma Drynariae 6-14 part, Radix Flemingiae Philippinensis 6-14 part, Ramulus Sambuci Williamsii 6-14 part, Lignum cinnamomi camphorae 6-14 part, Herba Menthae 3-7 part.

2. a kind of pharmaceutical composition for the treatment of traumatic injury according to claim 1, is characterized in that: the weight portion of each raw material is:

DALUOSAN 16-24 part, Radix Ardisiae punctatae 16-24 part, Os Draconis wind 8-12 part, Sanguis Draxonis 8-12 part, Rhizoma Drynariae 8-12 part, Radix Flemingiae Philippinensis 8-12 part, Ramulus Sambuci Williamsii 8-12 part, Lignum cinnamomi camphorae 8-12 part, Herba Menthae 4-6 part.

3. a kind of pharmaceutical composition for the treatment of traumatic injury according to claim 2, is characterized in that: the weight portion of each raw material is:

20 parts of DALUOSAN, 20 parts of Radix Ardisiae punctatae, 10 parts of Os Draconis wind, 10 parts of Sanguis Draxonis, 10 parts of Rhizoma Drynariae, 10 parts of Radix Flemingiae Philippinensiss, 10 parts of Ramulus Sambuci Williamsii, 10 parts of Lignum cinnamomi camphoraes, 5 parts of Herba Menthaes.

4. the application of the pharmaceutical composition described in any one in the medicine of preparation treatment traumatic injury in claim 1-3.