CN108477460A - 一种有润肠通便功效的组合物及其制备方法 - Google Patents
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Abstract
本发明公开了一种有润肠通便功效的组合物及其制备方法,属于功能性食品领域。所述的有润肠通便功效的组合物,包括以下组分:玉竹,火麻仁,核桃仁,决明子,黑芝麻,菊花,橘皮,山楂;所述的有润肠通便功效的组合物是经过配料、煎煮或粉碎、制剂等步骤制得。本发明通过采用羊开口,嘟柿,白花灯笼叶为补强体系,提高有润肠通便功效的组合物的疗效显效率和胃口改善率。
Description
技术领域
本发明涉及功能性食品领域,特别是涉及一种具有润肠通便功效的植物组合物制成的用于治疗便秘的功能性食品。
背景技术
便秘是现代人们的一种常见病症,近年来发病率呈快速上升之势,主要是由于不健康的饮食习惯、偏食厌食、不均衡的饮食行为、体育运动量的减少、生活压力过大等因素所致,广泛分布于不同年龄段的人群,据不完全统计约5%的成年人和20%的儿童及中老年人患有本病症,严重影响人们的健康和生活。便秘通常分为机能性便秘和器质性便秘两大类。儿童便秘更是受到社会和家庭的高度重视和关注,儿童便秘主要是由挑食厌食、饮食不规律、脾胃虚弱、自身脏器机能及发育不全等原因所致,通常会使儿童胃肠道菌群失衡,导致精力不集中、思维迟钝、营养不良、心情急躁、消瘦、免疫力下降、易感冒、生长迟缓、食欲下降,甚至因便秘产生的毒素侵入人体内而引起头晕、恶心、心烦易怒、口舌生疮、腹胀等一系列身体中毒症状,重者更是可引起结肠粘膜炎、心衰、哮喘等多种疾病。在儿童便秘中约80%-90%的为机能性便秘,通过合理的调理或治疗可以得到根治,不会带来大的危害。如不能得到及时的调理和治疗,可能造成不可逆转的器质性便秘,严重危害儿童的生长发育和身体健康。
目前我国治疗便秘的药物主要以泻药为主,按其作用原理可分为:容积性泻药、刺激性泻药、润滑性泻药、润湿性泻药等,但传统的泻药大多具有剌激性和毒副作用大的缺点,据有关医学专家指出,长期使用或滥用刺激性泻药将可能引起体内严重的潜在性内环境紊乱,如低血钾、慢性低血钠以及进展性肾功能不全等,还可能造成肠壁细胞功能和形态的变化,从而引起大肠上皮的损伤,还有可能引起对这类泻药依赖的恶性循环,使肠道的蠕动力减弱,从而加重便秘,损伤脾胃,对健康造成极为不利的影响。此外,一些泻药还存在疗效不明显,毒副作用大,治疗范围十分有限的缺点。目前市场上不管是内服或外用的泻药,主要是用于成人,在用于儿童便秘使用时,存在明显的不安全因素且难以发挥根治的效果。因此,为儿童便秘患者开发出一种安全有效、具有润肠通便改善便秘功效的功能性食品或药品就成为了当务之急。
发明内容
本发明的目的就是针对现有技术的上述不足及改进需求,提供了一种有润肠通便功效用于便秘的主要由天然植物组合物制成的功能性食品,本功能性食品由玉竹、火麻仁、核桃仁、决明子、黑芝麻、菊花、橘皮、山楂、羊开口、嘟柿、白花灯笼叶、益生菌粉为主要原料经过科学配比并加入适量的赋形剂或食品添加剂精制而成,通过微发酵后产品具有滋阴生津、润肠通便、清火散热、行气化积、调理肠道、利于吸收的功效,从而通过协同作用能起到改善便秘和养护肠道的功效,对于儿童便秘能起到较好的调养和治疗效果。
为了解决以上技术问题,本发明采用以下技术方案:
一种有润肠通便功效的组合物,按质量分计,包括以下原料:玉竹13-17份,火麻仁13-17份,核桃仁7-13份,决明子7-13份,黑芝麻7-13份,菊花7-13份,橘皮7-13份,山楂6-10份。
进一步地,有润肠通便功效的组合物,包括以下组分:微发酵植物组分,益生菌粉,赋形剂,食品助剂;所述植物组分包括玉竹,火麻仁,核桃仁,决明子,黑芝麻,菊花,橘皮,山楂,羊开口,嘟柿,白花灯笼叶;所述微发酵所用原料为α淀粉酶、生香酵母、醋酸菌;所述羊开口,嘟柿,白花灯笼叶的重量比为(4-8):(8-12):(2-4);
所述的α淀粉酶、生香酵母、醋酸菌的重量比为(4-6):(2-4):(0.5-1.5)。
进一步地,所述α淀粉酶、生香酵母、醋酸菌的重量比为5:3:1。
进一步地,所述有润肠通便功效的组合物以重量份为单位,包括以下原料:玉竹13-17份,火麻仁13-17份,核桃仁7-13份,决明子7-13份,黑芝麻7-13份,菊花7-13份,橘皮7-13份,山楂6-10份,羊开口4-8份,嘟柿8-12份,白花灯笼叶2-4份,益生菌粉0.5-1.0份,赋形剂10-100份,食品助剂0.5-1.0份。
进一步地,所述玉竹15份,火麻仁15份,核桃仁10份,决明子10份,黑芝麻10份,菊花10份,橘皮10份,山楂8份,羊开口6份,嘟柿10份,白花灯笼叶3份,益生菌粉0.75份,赋形剂90份,香精0.75份。
进一步地,所述组合物为固体饮料、颗粒剂、冲调粉剂或咀嚼片的至少一种。
进一步地,所述赋形剂,包括食用或药用级的白砂糖、红糖、葡萄糖、糊精、乳糖、淀粉、硬脂酸镁、糖精钠、聚维酮、低取代羟丙基纤维素、碳酸镁、水果粉、蔬菜粉中的至少一种。
进一步地,所述赋形剂为白砂糖粉。
进一步地,所述食品助剂为香精。
一种上述有润肠通便功效的组合物的制备方法,所述组合物为固体饮料或颗粒剂、冲调粉剂或咀嚼片,其制备方法分别如下:
(1)微发酵:将玉竹,火麻仁,核桃仁,决明子,黑芝麻,菊花,橘皮,山楂中的一种或几种按需粉碎后按比例混合后制成浆料,加入α淀粉酶、生香酵母、醋酸菌,在25℃下发酵2-3天,过滤干燥即可;
(2)冲调粉剂:将玉竹,火麻仁,核桃仁,决明子,黑芝麻,菊花,橘皮,山楂微发酵后,于75-85℃烘烤至香,粉碎成过120目筛的细粉,混匀,再加入益生菌粉、赋形剂、食品助剂混匀,制成;
固体饮料或颗粒剂:将火麻仁,核桃仁、决明子、黑芝麻、羊开口、嘟柿、白花灯笼叶混合微发酵后,加60-80%乙醇回流提取二次,第一次加5-7倍量回流提取1.5-2小时,第二次加3-5倍量回流提取1-1.5小时,合并醇提取液回收乙醇至无醇味,药渣备用,另取玉竹,菊花、橘皮、山楂混合微发酵后,与上述醇提后的药渣合并加水煎煮二次,第一次加6-8倍量的水煎煮1.5-2小时;第二次加4-6倍量的水煎煮1-1.5小时,过滤,滤液与上述醇提浓缩液合并减压浓缩至相对密度为1.2-1.3的稠膏,加入赋形剂,混匀、制粒、干燥、整粒,再加入益生菌粉、食品助剂,混匀,制成;
咀嚼片:取火麻仁,核桃仁、决明子、黑芝麻、羊开口、嘟柿、白花灯笼叶混合微发酵后,加60-80%乙醇回流提取二次,第一次加5-7倍量回流提取1.5-2小时,第二次加3-5倍量回流提取1-1.5小时,合并醇提取液回收乙醇至无醇味,药渣备用,另取玉竹,菊花、橘皮、山楂混合微发酵后,与上述醇提后的药渣合并加水煎煮二次,第一次加6-8倍量的水煎煮1.5-2小时;第二次加4-6倍量的水煎煮1-1.5小时,过滤,滤液与上述醇提浓缩液合并减压浓缩至相对密度为1.3-1.4的稠膏,真空干燥得干膏,粉碎成细粉,加入赋形剂,制粒,过14目筛,60-80℃干燥,过16目筛整粒,加入赋形剂、益生菌粉、食用香精,混匀,压片,制成咀嚼片。
本发明的制备方法精选以上原材料,经配料、粉碎(或水煮或醇提、过滤、浓缩)、加入适量赋形剂或食品添加剂混合(或制粒)、干燥、再加入益生菌粉混匀、包装工艺加工而制得。
赋形剂优选固体赋形剂,包括例如食用或药用级的白砂糖、红糖、葡萄糖、糊精、乳糖、淀粉、硬脂酸镁、糖精钠、聚维酮、低取代羟丙基纤维素、碳酸镁、水果粉、蔬菜粉等,更优选白砂糖粉。
本发明提供的组合物对于阴虚肠燥型功能性便秘显示出良好的调养和治疗效果,尤其适用于肠燥便秘、食积不化、热结便秘、排便不畅的儿童使用。该组合物配方精练、功效确切、针对性强、配伍严谨。所用成分寒凉不伤胃,阴柔不呆滞,津血可互生,从而达到标本兼治的效果。
本发明的组合物可以制成固体饮料、口服液、粉剂、片剂、胶囊剂、颗粒剂、丸剂,其中优选为固体饮料、冲调粉剂、口服液或咀嚼片。
本发明具有以下有益效果:
(1)由实施例1-3和对比例5的数据可见,实施例1-3制得的有润肠通便功效的组合物的疗效显效率和胃口改善率显著高于对比例5制得的有润肠通便功效的组合物的疗效显效率和胃口改善率;同时由实施例1-3的数据可见,实施例1为最优实施例。
(2)由实施例1和对比例1-4的数据可见,羊开口,嘟柿,白花灯笼叶在制备有润肠通便功效的组合物中起到了协同作用,协同提高了有润肠通便功效的组合物的疗效显效率和胃口改善率;这是:
本发明提供的组合物对于阴虚肠燥型功能性便秘显示出良好的调养和治疗效果,尤其适用于肠燥便秘、食积不化、热结便秘、排便不畅的儿童使用。该组合物配方精练、功效确切、针对性强、配伍严谨。所用成分寒凉不伤胃,阴柔不呆滞,津血可互生,从而达到标本兼治的效果。本组合物的组方既针对机能性便秘阴虚津亏、肠道失润、菌群失衡这一主要病机,确立相应的治则治法,又依据中医药传统的药食同源养生理论,顺应了五脏六腑“以通为用、以降为顺”的养生治疗特点,没有了传统泻药的剌激性和毒副作用,食用更安全,形成了独特的中医药养生组方特点。从而达到滋阴生津、润肠通便、清火散热、行气化积、调理肠道的功效,用于阴虚肠燥型功能性便秘人群使用功效确切,尤其是更适用于肠燥便秘、食积不化、热结便秘、排便不畅的儿童使用。本发明中通过利用α淀粉酶、生香酵母、醋酸菌形成微发酵体系对中药组合物,进行预处理,能够提高肠胃吸收效率,改善肠道微生物环境,增强药效的功效。;
羊开口味甘、平,归肺、胃、肠、膀胱经,理气舒肝、利水通淋,含多种可溶性果糖,钙、锌、硒等人体所需的多种矿物质及微量元素,对肠胃中微生物菌落群有高效的调节作用,并且富含花青素,蛋氨酸、异亮氨酸、苯氨酸、赖氨酸等,能有效促进肠道蠕动,通气排便;嘟柿花色苷色素,能消除体内炎症,其性寒,与羊开口实现互补,可以有效中和寒性,适合儿童使用,并且嘟柿富含水果酸,可以提高羊开口黄酮类物质的稳定性和在肠胃中的吸收效果,改善肠胃的吸收功能;白花灯笼叶主治骨蒸潮热,咽喉肿痛,具有降火功效,能改善虚火过旺引起的便秘,但其味苦,且不容易被肠胃吸收,加入嘟柿利用其水果酸促进白花灯笼叶纤维破壁,更容易被儿童吸收,并且与嘟柿、羊开口共同使用,使风味得到了极大的提高,从而改善儿童胃口;
(3)由对比例6-8的数据可见,羊开口,嘟柿,白花灯笼叶的重量比不在(4-8):(8-12):(2-4)范围内时,制得的有润肠通便功效的组合物的疗效显效率和胃口改善率与实施例1-3的数值相差甚大,远小于实施例1-3的数值。本发明羊开口,嘟柿,白花灯笼叶作为补强体系,实施例1-3控制制备有润肠通便功效的组合物时通过添加羊开口,嘟柿,白花灯笼叶的重量比为(4-8):(8-12):(2-4)进行微发酵,实现在补强体系中利用羊开口,调节肠胃微生物群落平衡;嘟柿,与羊开口一起使用,有效中和寒性;白花灯笼叶具有降火功效,并与嘟柿、羊开口共同使用,使风味得到了极大的提高,从而改善儿童胃口;通过羊开口,嘟柿,白花灯笼叶构成的补强体系在本发明的有润肠通便功效的组合物中,提高有润肠通便功效的组合物的疗效显效率和胃口改善率。
具体实施方式
为便于更好地理解本发明,通过以下实例加以说明,这些实例属于本发明的保护范围,但不限制本发明的保护范围。
在实施例中,有润肠通便功效的组合物以重量份为单位,包括以下原料:玉竹13-17份,火麻仁13-17份,核桃仁7-13份,决明子7-13份,黑芝麻7-13份,菊花7-13份,橘皮7-13份,山楂6-10份,羊开口4-8份,嘟柿8-12份,白花灯笼叶2-4份,益生菌粉0.5-1.0份,赋形剂10-100份,食品助剂0.5-1.0份。所述组合物为固体饮料或颗粒剂、冲调粉剂或咀嚼片的至少一种。所述赋形剂为食用或药用级的白砂糖。所述食品助剂为食用香精。
所述的有润肠通便功效的组合物的制备方法,所述组合物为固体饮料、冲调粉剂或咀嚼片,其制备方法分别如下:
(1)微发酵:将玉竹,火麻仁,核桃仁,决明子,黑芝麻,菊花,橘皮,山楂,羊开口,嘟柿,白花灯笼叶中的一种或几种按需粉碎后按比例混合后制成浆料,加入α淀粉酶、生香酵母、醋酸菌,在25℃下发酵2-3天,过滤干燥即可;
(2)冲调粉剂:将玉竹,火麻仁,核桃仁,决明子,黑芝麻,菊花,橘皮,山楂,羊开口,嘟柿,白花灯笼叶微发酵后,于75-85℃烘烤至香,粉碎成过120目筛的细粉,混匀,再加入益生菌粉、赋形剂、食品助剂混匀,制成;
固体饮料:将火麻仁,核桃仁、决明子、黑芝麻、羊开口、嘟柿、白花灯笼叶混合微发酵后,加60-80%乙醇回流提取二次,第一次加5-7倍量回流提取1.5-2小时,第二次加3-5倍量回流提取1-1.5小时,合并醇提取液回收乙醇至无醇味,药渣备用,另取玉竹,菊花、橘皮、山楂混合微发酵后,与上述醇提后的药渣合并加水煎煮二次,第一次加6-8倍量的水煎煮1.5-2小时;第二次加4-6倍量的水煎煮1-1.5小时,过滤,滤液与上述醇提浓缩液合并减压浓缩至相对密度为1.2-1.3的稠膏,加入赋形剂,混匀、制粒、干燥、整粒,再加入益生菌粉、食品助剂,混匀,制成固体饮料;
咀嚼片:取火麻仁,核桃仁、决明子、黑芝麻、羊开口、嘟柿、白花灯笼叶混合微发酵后,加60-80%乙醇回流提取二次,第一次加5-7倍量回流提取1.5-2小时,第二次加3-5倍量回流提取1-1.5小时,合并醇提取液回收乙醇至无醇味,药渣备用,另取玉竹,菊花、橘皮、山楂混合微发酵后,与上述醇提后的药渣合并加水煎煮二次,第一次加6-8倍量的水煎煮1.5-2小时;第二次加4-6倍量的水煎煮1-1.5小时,过滤,滤液与上述醇提浓缩液合并减压浓缩至相对密度为1.3-1.4的稠膏,真空干燥得干膏,粉碎成细粉,加入赋形剂,制粒,过14目筛,60-80℃干燥,过16目筛整粒,加入赋形剂、益生菌粉、食用香精,混匀,压片,制成咀嚼片。
实施例1
取玉竹15重量份,火麻仁15重量份,核桃仁、决明子各10重量份,黑芝麻、菊花、橘皮各10重量份,山楂8质量份,羊开口6份,嘟柿10份,白花灯笼叶3份,混合后制成浆料,加入重量比为5:3:1的α淀粉酶、生香酵母、醋酸菌,在25℃下发酵2天,过滤干燥后,于85℃烘烤至香,粉碎成过120目筛的细粉,混匀,再加入益生菌粉0.75重量份、糖粉90重量份、食用香精0.75重量份,混匀,制成可直接冲调服用的粉剂(玉竹火麻仁冲调粉)。
实施例2
取火麻仁13重量份,核桃仁、决明子各13重量份,黑芝麻7重量份,羊开口4份,嘟柿12份,白花灯笼叶2份,混合后制成浆料,加入重量比为4:4:0.5的α淀粉酶、生香酵母、醋酸菌,在25℃下发酵2天,过滤干燥后,加80%乙醇回流提取二次,第一次加5倍量回流提取2小时,第二次加3倍量回流提取1.5小时,合并醇提取液回收乙醇至无醇味,药渣备用;另取玉竹15重量份,菊花、橘皮各13重量份,山楂6质量份,混合后制成浆料,加入重量比为4:4:0.5的α淀粉酶、生香酵母、醋酸菌,在25℃下发酵3天,过滤干燥后,与上述醇提后的药渣合并加水煎煮二次,第一次加6倍量的水煎煮2小时;第二次加4倍量的水煎煮1.5小时,过滤,滤液与上述醇提浓缩液合并减压浓缩至相对密度为1.3(60℃热测)的稠膏,加入白糖粉90重量份,混匀、制粒、干燥、整粒,再加入益生菌粉0.5重量份、食用香精1.0重量份,混匀,制成固体饮料(玉竹火麻仁固体饮料)。
实施例3
取火麻仁17重量份,核桃仁、决明子各7重量份,黑芝麻13重量份,混合后制成浆料,羊开口8份,嘟柿8份,白花灯笼叶4份,加入重量比为6:2:1.5的α淀粉酶、生香酵母、醋酸菌,在25℃下发酵3天,过滤干燥后,加60%乙醇回流提取二次,第一次加7倍量回流提取1.5小时,第二次加5倍量回流提取1小时,合并醇提取液回收乙醇至无醇味,药渣备用;另取玉竹15重量份,菊花、橘皮各7重量份,山楂10质量份,混合后制成浆料,加入重量比为6:2:1.5的α淀粉酶、生香酵母、醋酸菌,在25℃下发酵2天,过滤干燥后,与上述醇提后的药渣合并加水煎煮二次,第一次加8倍量的水煎煮1.5小时;第二次加6倍量的水煎煮1小时,滤过,滤液与上述醇提浓缩液合并减压浓缩至相对密度为1.4(60℃热测)的稠膏,真空干燥(干燥温度为60-80℃,真空度为-0.06-0.08mpa),得干膏,粉碎成细粉,加入白糖粉10.0重量份,混匀,用10%聚维酮的乙醇溶液制粒,过14目筛,60-80℃干燥,过16目筛整粒,加入低取代羟丙基纤维素0.75重量份、硬脂酸镁0.05重量份、益生菌粉1.0重量份、食用香精0.5重量份,混匀,压片,制成咀嚼片(玉竹火麻仁咀嚼片)。
对比例1
与实施例1的制备工艺基本相同,唯有不同的是制备有润肠通便功效的组合物的原料中缺少羊开口,嘟柿,白花灯笼叶。
对比例2
与实施例1的制备工艺基本相同,唯有不同的是制备有润肠通便功效的组合物的原料中缺少羊开口。
对比例3
与实施例1的制备工艺基本相同,唯有不同的是制备有润肠通便功效的组合物的原料中缺少嘟柿。
对比例4
与实施例1的制备工艺基本相同,唯有不同的是制备有润肠通便功效的组合物的原料中缺少白花灯笼叶。
对比例5
采用中国专利文献“一种润肠通便的中药及其制品(公开号:CN102600358B)”中具体实施例1所述的方法制备润肠通便的中药。
对比例6
与实施例1的制备工艺基本相同,唯有不同的是制备有润肠通便功效的组合物的原料中羊开口2份,嘟柿14份,白花灯笼叶1份。
对比例7
与实施例1的制备工艺基本相同,唯有不同的是制备有润肠通便功效的组合物的原料中羊开口10份,嘟柿6份,白花灯笼叶5份。
对比例8
与实施例1的制备工艺基本相同,唯有不同的是制备有润肠通便功效的组合物的原料中羊开口2份,嘟柿6份,白花灯笼叶5份。
收治门诊患者110例,年龄8-14岁,男女各一半;将以上患者随机分为11组,分别服用实施例和对比例的产品,一日1次,2周为一疗程。疗效判定标准:显效:用药一个疗程以内症状、体症明显改善。统计每组病人中显效率。在用本发明药物治疗的过程中,未发现病人出现任何腹泻、腹痛、腹胀等不良反应,临床用药安全,无毒副作用,尤其适合于儿童长期服用。
统计每组父母对儿童疗程结束后胃口评价,统计胃口得到显著改善的概率。
对实施例1-3和对比例1-8制得的产品进行疗效显效率、胃口改善率,结果如下表所示。
实验项目 | 疗效显效率 | 胃口改善率 |
实施例1 | 0.9 | 0.8 |
实施例2 | 0.9 | 0.8 |
实施例3 | 0.9 | 0.8 |
对比例1 | 0.5 | 0.3 |
对比例2 | 0.8 | 0.7 |
对比例3 | 0.8 | 0.6 |
对比例4 | 0.8 | 0.7 |
对比例5 | 0.5 | 0.3 |
对比例6 | 0.7 | 0.4 |
对比例7 | 0.7 | 0.5 |
对比例8 | 0.7 | 0.5 |
由上表可知:(1)由实施例1-3和对比例5的数据可见,实施例1-3制得的有润肠通便功效的组合物的疗效显效率和胃口改善率显著高于对比例5制得的有润肠通便功效的组合物的疗效显效率和胃口改善率;同时由实施例1-3的数据可见,实施例1为最优实施例。
(2)由实施例1和对比例1-4的数据可见,羊开口,嘟柿,白花灯笼叶在制备有润肠通便功效的组合物中起到了协同作用,协同提高了有润肠通便功效的组合物的疗效显效率和胃口改善率;这是:
本发明提供的组合物对于阴虚肠燥型功能性便秘显示出良好的调养和治疗效果,尤其适用于肠燥便秘、食积不化、热结便秘、排便不畅的儿童使用。该组合物配方精练、功效确切、针对性强、配伍严谨。所用成分寒凉不伤胃,阴柔不呆滞,津血可互生,从而达到标本兼治的效果。本组合物的组方既针对机能性便秘阴虚津亏、肠道失润、菌群失衡这一主要病机,确立相应的治则治法,又依据中医药传统的药食同源养生理论,顺应了五脏六腑“以通为用、以降为顺”的养生治疗特点,没有了传统泻药的剌激性和毒副作用,食用更安全,形成了独特的中医药养生组方特点。从而达到滋阴生津、润肠通便、清火散热、行气化积、调理肠道的功效,用于阴虚肠燥型功能性便秘人群使用功效确切,尤其是更适用于肠燥便秘、食积不化、热结便秘、排便不畅的儿童使用。本发明中通过利用α淀粉酶、生香酵母、醋酸菌形成微发酵体系对中药组合物,进行预处理,能够提高肠胃吸收效率,改善肠道微生物环境,增强药效的功效。;
羊开口味甘、平,归肺、胃、肠、膀胱经,理气舒肝、利水通淋,含多种可溶性果糖,钙、锌、硒等人体所需的多种矿物质及微量元素,对肠胃中微生物菌落群有高效的调节作用,并且富含花青素,蛋氨酸、异亮氨酸、苯氨酸、赖氨酸等,能有效促进肠道蠕动,通气排便;嘟柿花色苷色素,能消除体内炎症,其性寒,与羊开口实现互补,可以有效中和寒性,适合儿童使用,并且嘟柿富含水果酸,可以提高羊开口黄酮类物质的稳定性和在肠胃中的吸收效果,改善肠胃的吸收功能;白花灯笼叶主治骨蒸潮热,咽喉肿痛,具有降火功效,能改善虚火过旺引起的便秘,但其味苦,且不容易被肠胃吸收,加入嘟柿利用其水果酸促进白花灯笼叶纤维破壁,更容易被儿童吸收,并且与嘟柿、羊开口共同使用,使风味得到了极大的提高,从而改善儿童胃口;
(3)由对比例6-8的数据可见,羊开口,嘟柿,白花灯笼叶的重量比不在(4-8):(8-12):(2-4)范围内时,制得的有润肠通便功效的组合物的疗效显效率和胃口改善率与实施例1-3的数值相差甚大,远小于实施例1-3的数值。本发明羊开口,嘟柿,白花灯笼叶作为补强体系,实施例1-3控制制备有润肠通便功效的组合物时通过添加羊开口,嘟柿,白花灯笼叶的重量比为(4-8):(8-12):(2-4)进行微发酵,实现在补强体系中利用羊开口,调节肠胃微生物群落平衡;嘟柿,与羊开口一起使用,有效中和寒性;白花灯笼叶具有降火功效,并与嘟柿、羊开口共同使用,使风味得到了极大的提高,从而改善儿童胃口;通过羊开口,嘟柿,白花灯笼叶构成的补强体系在本发明的有润肠通便功效的组合物中,提高有润肠通便功效的组合物的疗效显效率和胃口改善率。
以上内容不能认定本发明具体实施只局限于这些说明,对于本发明所属技术领域的普通技术人员来说,在不脱离本发明构思前提下,还可以做出若干简单推演或替换,都应当视为属于本发明由所提交的权利要求书确定的专利保护范围。
Claims (10)
1.一种有润肠通便功效的组合物,其特征在于,按质量分计,包括以下原料:玉竹13-17份,火麻仁13-17份,核桃仁7-13份,决明子7-13份,黑芝麻7-13份,菊花7-13份,橘皮7-13份,山楂6-10份。
2.根据权利要求1所述的有润肠通便功效的组合物,其特征在于,包括以下组分:微发酵植物组分,益生菌粉,赋形剂,食品助剂;所述植物组分包括玉竹,火麻仁,核桃仁,决明子,黑芝麻,菊花,橘皮,山楂,羊开口,嘟柿,白花灯笼叶;所述微发酵所用原料为α淀粉酶、生香酵母、醋酸菌;所述羊开口,嘟柿,白花灯笼叶的重量比为(4-8):(8-12):(2-4);所述的α淀粉酶、生香酵母、醋酸菌的重量比为(4-6):(2-4):(0.5-1.5)。
3.根据权利要求2所述的有润肠通便功效的组合物,其特征在于,所述α淀粉酶、生香酵母、醋酸菌的重量比为5:3:1。
4.根据权利要求2所述的有润肠通便功效的组合物,其特征在于,所述有润肠通便功效的组合物以重量份为单位,包括以下原料:玉竹13-17份,火麻仁13-17份,核桃仁7-13份,决明子7-13份,黑芝麻7-13份,菊花7-13份,橘皮7-13份,山楂6-10份,羊开口4-8份,嘟柿8-12份,白花灯笼叶2-4份,益生菌粉0.5-1.0份,赋形剂10-100份,食品助剂0.5-1.0份。
5.根据权利要求2所述的有润肠通便功效的组合物,其特征在于,所述有润肠通便功效的组合物以重量份为单位,包括以下原料:玉竹15份,火麻仁15份,核桃仁10份,决明子10份,黑芝麻10份,菊花10份,橘皮10份,山楂8份,羊开口6份,嘟柿10份,白花灯笼叶3份,益生菌粉0.75份,赋形剂90份,香精0.75份。
6.根据权利要求1或2所述的有润肠通便功效的组合物,其特征在于,所述组合物为固体饮料、颗粒剂、冲调粉剂或咀嚼片的至少一种。
7.根据权利要求1或2所述的有润肠通便功效的组合物,其特征在于,所述赋形剂,包括食用或药用级的白砂糖、红糖、葡萄糖、糊精、乳糖、淀粉、硬脂酸镁、糖精钠、聚维酮、低取代羟丙基纤维素、碳酸镁、水果粉、蔬菜粉中的至少一种。
8.根据权利要求2所述的有润肠通便功效的组合物,其特征在于,所述赋形剂为白砂糖粉。
9.根据权利要求2所述的有润肠通便功效的组合物,其特征在于,所述食品助剂为香精。
10.一种根据权利要求1-9任一项所述的有润肠通便功效的组合物的制备方法,其特征在于,所述组合物为固体饮料、颗粒剂、冲调粉剂或咀嚼片,其制备方法分别如下:
(1)微发酵:将玉竹,火麻仁,核桃仁,决明子,黑芝麻,菊花,橘皮,山楂,羊开口,嘟柿,白花灯笼叶中的一种或几种按需粉碎后按比例混合后制成浆料,加入α淀粉酶、生香酵母、醋酸菌,在25℃下发酵2-3天,过滤干燥即可;
(2)冲调粉剂:将玉竹,火麻仁,核桃仁,决明子,黑芝麻,菊花,橘皮,山楂,羊开口,嘟柿,白花灯笼叶微发酵后,于75-85℃烘烤至香,粉碎成过120目筛的细粉,混匀,再加入益生菌粉、赋形剂、食品助剂混匀,制成;
固体饮料或颗粒剂:将火麻仁,核桃仁、决明子、黑芝麻、羊开口、嘟柿、白花灯笼叶混合微发酵后,加60-80%乙醇回流提取二次,第一次加5-7倍量回流提取1.5-2小时,第二次加3-5倍量回流提取1-1.5小时,合并醇提取液回收乙醇至无醇味,药渣备用,另取玉竹,菊花、橘皮、山楂混合微发酵后,与上述醇提后的药渣合并加水煎煮二次,第一次加6-8倍量的水煎煮1.5-2小时;第二次加4-6倍量的水煎煮1-1.5小时,过滤,滤液与上述醇提浓缩液合并减压浓缩至相对密度为1.2-1.3的稠膏,加入赋形剂,混匀、制粒、干燥、整粒,再加入益生菌粉、食品助剂,混匀,制成;
咀嚼片:取火麻仁,核桃仁、决明子、黑芝麻、羊开口、嘟柿、白花灯笼叶混合微发酵后,加60-80%乙醇回流提取二次,第一次加5-7倍量回流提取1.5-2小时,第二次加3-5倍量回流提取1-1.5小时,合并醇提取液回收乙醇至无醇味,药渣备用,另取玉竹,菊花、橘皮、山楂混合微发酵后,与上述醇提后的药渣合并加水煎煮二次,第一次加6-8倍量的水煎煮1.5-2小时;第二次加4-6倍量的水煎煮1-1.5小时,过滤,滤液与上述醇提浓缩液合并减压浓缩至相对密度为1.3-1.4的稠膏,真空干燥得干膏,粉碎成细粉,加入赋形剂,制粒,过14目筛,60-80℃干燥,过16目筛整粒,加入赋形剂、益生菌粉、食用香精,混匀,压片,制成咀嚼片。
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