CN108463461B - 头孢烯化合物、其制备和用途 - Google Patents

头孢烯化合物、其制备和用途 Download PDF

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Publication number
CN108463461B
CN108463461B CN201680072172.7A CN201680072172A CN108463461B CN 108463461 B CN108463461 B CN 108463461B CN 201680072172 A CN201680072172 A CN 201680072172A CN 108463461 B CN108463461 B CN 108463461B
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CN
China
Prior art keywords
amino
methyl
pyridin
pyrrolo
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201680072172.7A
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English (en)
Chinese (zh)
Other versions
CN108463461A (zh
Inventor
S·N·迈蒂
D·Q·阮
A·V·N·雷迪
J·伊普
C·M·哈
R·林格
R·单
M·R·玛达拉
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Naeja-Rgm Pharmaceuticals Inc
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Naeja-Rgm Pharmaceuticals Inc
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Publication of CN108463461A publication Critical patent/CN108463461A/zh
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Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
CN201680072172.7A 2015-12-10 2016-12-05 头孢烯化合物、其制备和用途 Expired - Fee Related CN108463461B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562265625P 2015-12-10 2015-12-10
US62/265625 2015-12-10
PCT/CA2016/051428 WO2017096472A1 (en) 2015-12-10 2016-12-05 Cephem compounds, their production and use

Publications (2)

Publication Number Publication Date
CN108463461A CN108463461A (zh) 2018-08-28
CN108463461B true CN108463461B (zh) 2021-11-19

Family

ID=59012429

Family Applications (1)

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CN201680072172.7A Expired - Fee Related CN108463461B (zh) 2015-12-10 2016-12-05 头孢烯化合物、其制备和用途

Country Status (13)

Country Link
US (2) US9751894B2 (https=)
EP (1) EP3386977A4 (https=)
JP (1) JP6967000B2 (https=)
KR (2) KR102135230B1 (https=)
CN (1) CN108463461B (https=)
AU (1) AU2016367284C1 (https=)
BR (1) BR112018009725A8 (https=)
CA (1) CA3005779C (https=)
EA (1) EA039648B1 (https=)
HK (1) HK1254209A1 (https=)
IL (1) IL259234B (https=)
WO (1) WO2017096472A1 (https=)
ZA (1) ZA201802654B (https=)

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* Cited by examiner, † Cited by third party
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WO2017096472A1 (en) 2015-12-10 2017-06-15 Naeja-Rgm Pharmaceuticals Inc. Cephem compounds, their production and use
KR20200091395A (ko) * 2017-09-27 2020-07-30 페도라 파마슈티칼스 인코포레이티드 디아자비시클로옥탄 유도체의 결정형 및 그의 제조 방법
TWI795549B (zh) * 2018-04-06 2023-03-11 日商富士軟片股份有限公司 新穎青黴烷衍生物或其鹽、醫藥組成物及其應用
KR102484880B1 (ko) 2018-06-08 2023-01-05 엘지디스플레이 주식회사 신축 가능한 표시장치, 패널 구동회로 및 구동방법
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
EP3833665B1 (en) 2018-08-09 2023-07-19 Antabio SAS Diazabicyclooctanones as inhibitors of serine beta-lactamases
US12257307B2 (en) 2019-06-24 2025-03-25 Diverse Biotech, Inc. β-lactam-cannabinoid conjugate molecules

Citations (5)

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CN1333776A (zh) * 1998-11-27 2002-01-30 盐野义制药株式会社 具有广谱抗菌作用的含有咪唑并[4,5－b]吡啶鎓甲基的头孢烯化合物
EP1489084A1 (en) * 2002-03-18 2004-12-22 Shionogi & Co., Ltd. Broad-spectrum cephem compounds
CN101343281A (zh) * 2007-04-20 2009-01-14 山东轩竹医药科技有限公司 新型脒基吡啶基头孢菌素类化合物
CN102203100A (zh) * 2008-10-31 2011-09-28 盐野义制药株式会社 具有邻苯二酚基团的头孢菌素
US8809314B1 (en) * 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound

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US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
IL77458A (en) * 1985-01-14 1990-07-26 Eisai Co Ltd Cephem derivatives,their production and antibacterial compositions containing them and certain novel intermediates therefor
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JP2003026679A (ja) * 2001-07-10 2003-01-29 Banyu Pharmaceut Co Ltd 新規カルバペネム誘導体
CA2504730C (en) 2002-10-30 2011-04-12 Astellas Pharma Inc. Cephem compounds
JP2009530228A (ja) 2006-03-16 2009-08-27 アステラス製薬株式会社 セフェム化合物および抗菌薬としての利用
KR20130018845A (ko) * 2010-04-05 2013-02-25 시오노기세야쿠 가부시키가이샤 카테콜기를 갖는 세펨 화합물
CN102918047A (zh) 2010-04-05 2013-02-06 盐野义制药株式会社 具有假儿茶酚基团的头孢烯类化合物
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CN1333776A (zh) * 1998-11-27 2002-01-30 盐野义制药株式会社 具有广谱抗菌作用的含有咪唑并[4,5－b]吡啶鎓甲基的头孢烯化合物
EP1489084A1 (en) * 2002-03-18 2004-12-22 Shionogi & Co., Ltd. Broad-spectrum cephem compounds
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CN101343281A (zh) * 2007-04-20 2009-01-14 山东轩竹医药科技有限公司 新型脒基吡啶基头孢菌素类化合物
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Also Published As

Publication number Publication date
JP6967000B2 (ja) 2021-11-17
USRE48097E1 (en) 2020-07-14
JP2018536678A (ja) 2018-12-13
US9751894B2 (en) 2017-09-05
US20170166587A1 (en) 2017-06-15
AU2016367284A1 (en) 2018-05-10
KR20190042752A (ko) 2019-04-24
HK1254209A1 (zh) 2019-07-12
EA039648B1 (ru) 2022-02-21
AU2016367284B2 (en) 2018-05-17
BR112018009725A2 (en) 2018-11-06
CN108463461A (zh) 2018-08-28
EA201891381A1 (ru) 2019-01-31
IL259234B (en) 2018-12-31
WO2017096472A1 (en) 2017-06-15
KR102135230B1 (ko) 2020-07-17
AU2016367284C1 (en) 2018-09-20
EP3386977A4 (en) 2019-05-22
KR20180066264A (ko) 2018-06-18
ZA201802654B (en) 2019-07-31
CA3005779A1 (en) 2017-06-15
EP3386977A1 (en) 2018-10-17
CA3005779C (en) 2020-04-07
BR112018009725A8 (pt) 2019-02-26

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