CN1084623C - 特定的α－半乳糖基神经酰胺、药物组合物及其用途 - Google Patents

特定的α－半乳糖基神经酰胺、药物组合物及其用途 Download PDF

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Publication number
CN1084623C
CN1084623C CN93116586A CN93116586A CN1084623C CN 1084623 C CN1084623 C CN 1084623C CN 93116586 A CN93116586 A CN 93116586A CN 93116586 A CN93116586 A CN 93116586A CN 1084623 C CN1084623 C CN 1084623C
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CN
China
Prior art keywords
integer
galactosylceramide
compound
formula
galactopyranosyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CN93116586A
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English (en)
Chinese (zh)
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CN1088093A (zh
Inventor
肥塚靖彦
蒲谷浩司
元木一宏
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Kirin Pharma KK
Kirin Holdings Co Ltd
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Kirin Brewery Co Ltd
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Publication of CN1088093A publication Critical patent/CN1088093A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN93116586A 1992-07-16 1993-07-16 特定的α－半乳糖基神经酰胺、药物组合物及其用途 Expired - Lifetime CN1084623C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP212015/92 1992-07-16
JP21201592 1992-07-16
JP8521993 1993-03-19
JP85219/93 1993-03-19

Publications (2)

Publication Number Publication Date
CN1088093A CN1088093A (zh) 1994-06-22
CN1084623C true CN1084623C (zh) 2002-05-15

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ID=26426239

Family Applications (1)

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CN93116586A Expired - Lifetime CN1084623C (zh) 1992-07-16 1993-07-16 特定的α－半乳糖基神经酰胺、药物组合物及其用途

Country Status (12)

Country Link
US (3) US5767092A (https=)
EP (1) EP0650732B1 (https=)
JP (1) JP3088461B2 (https=)
KR (1) KR100277621B1 (https=)
CN (1) CN1084623C (https=)
AT (1) ATE200224T1 (https=)
AU (1) AU684466B2 (https=)
CA (1) CA2140013C (https=)
DE (1) DE69330096T2 (https=)
FI (1) FI950166A7 (https=)
TW (1) TW261533B (https=)
WO (1) WO1994002168A1 (https=)

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US6417167B1 (en) 1997-02-05 2002-07-09 Kirin Beer Kabushiki Kaisha Lyophilized compositions containing shingoglycolipid and process for preparing them
ATE286735T1 (de) * 1997-04-10 2005-01-15 Kirin Brewery Verwendung von a-glycosylceramiden zur herstellung eines therapeutischen mittelszur behandlung von autoimmunkrankheiten
TW575420B (en) * 1997-09-22 2004-02-11 Kirin Brewery Composition for enhancing cellular immunogenicity comprising alpha-glycosylceramides
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DE60215530T2 (de) * 2001-08-16 2007-05-31 Daiichi Asubio Pharma Co., Ltd. Neues glykolipid, und heilmittel für autoimmunerkrankungen, das dieses als wirkstoff enthält
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CA2593715C (en) 2005-01-28 2015-05-05 Brigham Young University Bacterial glycolipid activation of cd1d-restricted nkt cells
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US20070231344A1 (en) * 2005-10-28 2007-10-04 The Brigham And Women's Hospital, Inc. Conjugate vaccines for non-proteinaceous antigens
PL2056842T3 (pl) * 2006-04-07 2013-03-29 Scripps Research Inst Modyfikowany galaktozyloceramid do leczenia chorób nowotworowych
AU2007269299B2 (en) * 2006-06-30 2013-01-17 Brigham Young University Adjuvants and methods of use
US8263576B2 (en) * 2006-08-15 2012-09-11 Mayo Foundation For Medical Education And Research Non-natural sphingolipid analogs and uses thereof
US8916164B2 (en) * 2007-08-29 2014-12-23 Abivax Methods of enhancing adjuvaticity of vaccine compositions
CN102066394B (zh) * 2007-10-12 2015-04-01 路易吉·潘扎 用作免疫佐剂的糖脂的类似物
EP2058011A1 (en) * 2007-11-07 2009-05-13 Wittycell Nkt cell activating gycolipids covalently bound antigens and/or drug
US8207135B2 (en) * 2007-12-05 2012-06-26 Wittycell Compositions for and methods of enhancing the immune response to antigens
JP5809560B2 (ja) * 2008-10-08 2015-11-11 アビヴァックス インフルエンザに対して使用するためのワクチン組成物
LT2939683T (lt) 2009-02-16 2017-03-27 Cerenis Therapeutics Holding Sa Apolipoproteino a-i mimetikai
CN107011359A (zh) 2010-10-18 2017-08-04 塞伦尼斯医疗控股有限公司 可用于胆固醇动员的化合物、组合物和方法
WO2012074116A1 (ja) 2010-12-02 2012-06-07 独立行政法人理化学研究所 アロNKT細胞を用いた免疫療法およびそのためのT細胞抗原受容体（TCR）遺伝子のα鎖領域が均一なVα-Jαに再構成されている細胞および該細胞由来NKT細胞のバンキング
EP2811831B1 (en) 2012-02-07 2018-04-11 The Regents Of The University Of California Glycosphingolipids for use in modulating immune responses
JP6283809B2 (ja) 2012-08-22 2018-02-28 株式会社レグイミューン Ｉ型糖尿病の予防又は治療のための製剤
CA2925878A1 (en) 2012-10-12 2014-04-17 The Brigham And Women's Hospital, Inc. Glycosphingolipids and methods of use thereof
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JP2015205835A (ja) * 2014-04-21 2015-11-19 国立大学法人福井大学 中性子線障害防護剤
KR20230117371A (ko) 2020-12-04 2023-08-08 가부시키가이샤 레그이뮨 체내 동태가 개선된 CD1d 리간드 화합물 함유 리포솜 제제

Citations (1)

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Also Published As

Publication number Publication date
US6071884A (en) 2000-06-06
DE69330096T2 (de) 2001-10-18
AU684466B2 (en) 1997-12-18
EP0650732B1 (en) 2001-04-04
DE69330096D1 (de) 2001-05-10
CA2140013A1 (en) 1994-02-03
KR100277621B1 (ko) 2001-02-01
FI950166A7 (fi) 1995-01-31
US5767092A (en) 1998-06-16
AU4583593A (en) 1994-02-14
CN1088093A (zh) 1994-06-22
ATE200224T1 (de) 2001-04-15
EP0650732A1 (en) 1995-05-03
CA2140013C (en) 2002-08-27
WO1994002168A1 (fr) 1994-02-03
JP3088461B2 (ja) 2000-09-18
EP0650732A4 (en) 1998-04-01
TW261533B (https=) 1995-11-01
KR950702431A (ko) 1995-07-29
US6017892A (en) 2000-01-25
FI950166A0 (fi) 1995-01-13
HK1009937A1 (en) 1999-09-17

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