CN108430473B - 抗增殖化合物以及其药物组合物和用途 - Google Patents
抗增殖化合物以及其药物组合物和用途 Download PDFInfo
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- CN108430473B CN108430473B CN201780005851.7A CN201780005851A CN108430473B CN 108430473 B CN108430473 B CN 108430473B CN 201780005851 A CN201780005851 A CN 201780005851A CN 108430473 B CN108430473 B CN 108430473B
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- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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| PCT/US2017/012457 WO2017120422A1 (en) | 2016-01-08 | 2017-01-06 | Antiproliferative compounds, and their pharmaceutical compositions and uses |
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| US9499514B2 (en) | 2014-07-11 | 2016-11-22 | Celgene Corporation | Antiproliferative compounds and methods of use thereof |
| WO2017120422A1 (en) * | 2016-01-08 | 2017-07-13 | Celgene Corporation | Antiproliferative compounds, and their pharmaceutical compositions and uses |
| EP3399979B9 (en) | 2016-01-08 | 2023-10-04 | Celgene Corporation | Formulations of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide |
| EP3399984B1 (en) | 2016-01-08 | 2023-09-06 | Arcus Biosciences, Inc. | Modulators of 5'-nucleotidase, ecto and the use thereof |
| MX2018015120A (es) | 2016-06-06 | 2019-04-15 | Celgene Corp | Tratamiento de una neoplasia maligna hematologica con 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin- 5-il)metil)-2,2-difluoroacetamida. |
| AR110498A1 (es) | 2016-12-08 | 2019-04-03 | Hoffmann La Roche | DERIVADOS DE ISOXAZOLIL ÉTER COMO MODULADORES ALOSTÉRICOS POSITIVOS (PAM) DE RECEPTORES DE GABAA a5 |
| WO2020242960A1 (en) | 2019-05-24 | 2020-12-03 | Biotheryx, Inc. | Compounds targeting proteins and pharmaceutical compositions thereof, and their therapeutic applications |
| US11633416B1 (en) | 2020-03-06 | 2023-04-25 | Arcus Biosciences, Inc. | Oral formulations of CD73 compounds |
| US20230270742A1 (en) * | 2020-07-07 | 2023-08-31 | Celgene Corporation | Pharmaceutical compositions comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile and methods of using the same |
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2019
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008027542A2 (en) * | 2006-08-30 | 2008-03-06 | Celgene Corporation | 5-substituted isoindoline compounds |
| WO2009145899A1 (en) * | 2008-05-30 | 2009-12-03 | Celgene Corporation | 5-substituted isoindoline compounds |
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