CN108350462B - 嵌合抗原受体及其用途 - Google Patents
嵌合抗原受体及其用途 Download PDFInfo
- Publication number
- CN108350462B CN108350462B CN201680064592.0A CN201680064592A CN108350462B CN 108350462 B CN108350462 B CN 108350462B CN 201680064592 A CN201680064592 A CN 201680064592A CN 108350462 B CN108350462 B CN 108350462B
- Authority
- CN
- China
- Prior art keywords
- leu
- receptor
- cancer
- ser
- gly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Developmental Biology & Embryology (AREA)
- Plant Pathology (AREA)
- Neurosurgery (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210429775.5A CN114891116A (zh) | 2015-09-11 | 2016-09-10 | 嵌合抗原受体及其用途 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2015903719 | 2015-09-11 | ||
| AU2015903719A AU2015903719A0 (en) | 2015-09-11 | Chimeric antigen receptor and uses thereof | |
| PCT/AU2016/050851 WO2017041143A1 (en) | 2015-09-11 | 2016-09-10 | Chimeric antigen receptors and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210429775.5A Division CN114891116A (zh) | 2015-09-11 | 2016-09-10 | 嵌合抗原受体及其用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108350462A CN108350462A (zh) | 2018-07-31 |
| CN108350462B true CN108350462B (zh) | 2022-05-27 |
Family
ID=58240468
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210429775.5A Pending CN114891116A (zh) | 2015-09-11 | 2016-09-10 | 嵌合抗原受体及其用途 |
| CN201680064592.0A Active CN108350462B (zh) | 2015-09-11 | 2016-09-10 | 嵌合抗原受体及其用途 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210429775.5A Pending CN114891116A (zh) | 2015-09-11 | 2016-09-10 | 嵌合抗原受体及其用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US12121539B2 (enExample) |
| EP (2) | EP3347474B1 (enExample) |
| JP (4) | JP6957471B2 (enExample) |
| KR (2) | KR20180043841A (enExample) |
| CN (2) | CN114891116A (enExample) |
| AU (4) | AU2016318230B2 (enExample) |
| ES (1) | ES2848478T3 (enExample) |
| WO (1) | WO2017041143A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3226897T3 (da) | 2014-12-05 | 2021-04-19 | Memorial Sloan Kettering Cancer Center | Antistoffer der rammer b-cellemodningsantigen og fremgangsmåder til anvendelse |
| KR20180043841A (ko) * | 2015-09-11 | 2018-04-30 | 카리나 바이오테크 피티와이 엘티디 | 키메라 항원 수용체 및 이의 용도 |
| PL233352B1 (pl) * | 2016-09-15 | 2019-10-31 | Adamed Spolka Z Ograniczona Odpowiedzialnoscia | Przeciwnowotworowe białko fuzyjne |
| BR112020008638A2 (pt) | 2017-11-01 | 2020-10-20 | Juno Therapeutics Inc | receptores de antígenos quiméricos específicos para antígenos de maturação de células b (bcma) |
| AU2018359907A1 (en) | 2017-11-06 | 2020-05-07 | Fred Hutchinson Cancer Center | Combination of a cell therapy and a gamma secretase inhibitor |
| US12491153B2 (en) | 2018-01-03 | 2025-12-09 | Qu Biologics Inc. | Innate targeting of adoptive cellular therapies |
| WO2019166453A1 (en) * | 2018-03-01 | 2019-09-06 | F. Hoffmann-La Roche Ag | Specificity assay for novel target antigen binding moieties |
| KR20250151559A (ko) * | 2018-03-15 | 2025-10-21 | 펀다멘탈 솔류션스 코포레이션 | 프로그램 가능한 면역세포 수용체 복합체 시스템 |
| JP2021524248A (ja) * | 2018-05-21 | 2021-09-13 | バイオセプター・(ユーケー)・リミテッド | 修飾されたリンカードメインを有するキメラ抗原受容体およびその使用 |
| CN110856724B (zh) * | 2018-08-24 | 2022-05-27 | 杭州康万达医药科技有限公司 | 包含核酸及car修饰的免疫细胞的治疗剂及其应用 |
| AU2019372331A1 (en) | 2018-11-01 | 2021-05-27 | Juno Therapeutics, Inc. | Methods for treatment using chimeric antigen receptors specific for B-cell maturation antigen |
| WO2021019222A1 (en) * | 2019-07-26 | 2021-02-04 | Biosceptre (Uk) Limited | P2x7 receptor targeted therapy |
| US20250281611A1 (en) * | 2021-03-11 | 2025-09-11 | Biosceptre ( Aust ) Pty Ltd | Novel cell therapy system |
| CN117881421A (zh) * | 2021-09-01 | 2024-04-12 | 生物权威(澳大利亚)有限责任公司 | 用于刺激免疫活性的方法和组合物 |
| CN120187747A (zh) * | 2022-09-14 | 2025-06-20 | 生物权威(澳大利亚)有限责任公司 | 工程化免疫细胞的富集 |
| JP2025531030A (ja) * | 2022-09-14 | 2025-09-19 | バイオセプター (オースト) プロプライエタリー・リミテッド | 免疫細胞のインビボ検出 |
| JP2025531021A (ja) * | 2022-09-14 | 2025-09-19 | バイオセプター (オースト) プロプライエタリー・リミテッド | 免疫細胞を検出する方法 |
| WO2025054416A1 (en) * | 2023-09-06 | 2025-03-13 | The Regents Of The University Of California | Methods for treating cancer |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011020155A1 (en) * | 2009-08-20 | 2011-02-24 | Biosceptre International Limited | Anti p2x7 receptor antibodies and fragments thereof |
| WO2011075789A1 (en) * | 2009-12-24 | 2011-06-30 | Biosceptre International Limited | Antibodies to non-functional oligomeric p2x7 receptors |
| WO2012079000A1 (en) * | 2010-12-09 | 2012-06-14 | The Trustees Of The University Of Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2014055657A1 (en) * | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4579821A (en) | 1981-11-23 | 1986-04-01 | University Patents, Inc. | Control of DNA sequence transcription |
| US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
| US4940661A (en) | 1984-05-17 | 1990-07-10 | Genentech, Inc. | Metallothionein transcription control sequences and use thereof |
| US5512483A (en) | 1993-05-21 | 1996-04-30 | Mcgill University | Expression vectors responsive to steroid hormones |
| US5464758A (en) | 1993-06-14 | 1995-11-07 | Gossen; Manfred | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
| EP0828829A1 (en) | 1995-05-26 | 1998-03-18 | Zeneca Limited | A gene switch comprising an ecdysone receptor |
| US5851796A (en) | 1995-06-07 | 1998-12-22 | Yale University | Autoregulatory tetracycline-regulated system for inducible gene expression in eucaryotes |
| AUPP991199A0 (en) | 1999-04-21 | 1999-05-13 | University Of Sydney, The | Methods for diagnosing pre-cancerous and cancerous conditions |
| WO2001020155A1 (fr) | 1999-09-16 | 2001-03-22 | Liangqi Zhang | Membrane de reduction de pression pour carburateur |
| AUPQ968700A0 (en) | 2000-08-28 | 2000-09-21 | Intreat Pty Limited | Treatment of urinary incontinence |
| AUPR201500A0 (en) | 2000-12-11 | 2001-01-11 | Biosceptre Pty Ltd | Methods for identifying pre-neoplastic and neoplastic states in mammals |
| DK1360203T3 (da) | 2001-01-17 | 2009-04-20 | Intreat Pty Ltd | Antistoffer mod ikke-funktionel P2X7-receptordiagnose og behandling af cancerlidelser og andre tilstande |
| US20030203411A1 (en) * | 2001-06-05 | 2003-10-30 | Sabbadini Roger A. | Methods of minicell-based delivery |
| AU2002322192B2 (en) | 2001-09-03 | 2008-05-01 | Biosceptre International Limited | Antibodies to non-functional P2X7receptor, diagnosis and treatment of cancers and other conditions |
| CA2402930A1 (en) * | 2002-09-19 | 2004-03-19 | William Herman | Targeted ligands |
| CA2567655C (en) | 2004-06-02 | 2015-06-30 | Diatech Pty Ltd | Binding moieties based on shark ignar domains |
| WO2008043146A1 (en) | 2006-10-10 | 2008-04-17 | Biosceptre International Limited | Antibodies against non functional p2x7 receptor |
| JP2010505426A (ja) | 2006-10-10 | 2010-02-25 | バイオスセプター インターナショナル リミテッド | 非機能性p2x7受容体に対する抗体を産生するハイブリドーマ |
| BRPI0815416A2 (pt) * | 2007-08-15 | 2014-10-21 | Amunix Inc | Composições e métodos para modificar propriedades de polipeptídeos biologicamente ativos |
| JP5670192B2 (ja) * | 2007-09-14 | 2015-02-18 | バイオセプター・インターナショナル・リミテッド | 新規p2x7エピトープ |
| ATE542139T1 (de) | 2007-09-14 | 2012-02-15 | Biosceptre Int Ltd | Purinerge (p2x)-rezeptoren in extrazellulärer körperflüssigkeit |
| US8840186B2 (en) | 2007-11-07 | 2014-09-23 | L&P Swiss Holding Ag | Support assembly and corresponding seat structure |
| KR101701300B1 (ko) | 2008-07-04 | 2017-02-01 | 바이오셉터 (어스트) 피티와이 엘티디 | 항p2x7 펩티드 및 에피토프 |
| JP5164806B2 (ja) | 2008-11-12 | 2013-03-21 | サンデン株式会社 | 車両用通信制御装置 |
| CN102858985A (zh) * | 2009-07-24 | 2013-01-02 | 西格马-奥尔德里奇有限责任公司 | 基因组编辑方法 |
| CN106310245A (zh) | 2010-09-10 | 2017-01-11 | 生物权威(澳大利亚)有限责任公司 | 陪伴动物治疗 |
| EP2646461A2 (en) | 2010-12-03 | 2013-10-09 | Cyclogenix Ltd | VARIANTS OF igNAR |
| EP2651442B1 (en) | 2010-12-14 | 2020-04-22 | University of Maryland, Baltimore | Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer |
| US9566318B2 (en) | 2011-07-01 | 2017-02-14 | Biosceptre (Aust) Pty Ltd | Combination therapy |
| JP6673838B2 (ja) * | 2014-02-14 | 2020-04-01 | セレクティスCellectis | 免疫細胞と病的細胞の両方に存在する抗原を標的とするように操作された、免疫療法のための細胞 |
| KR102558502B1 (ko) | 2014-12-05 | 2023-07-20 | 시티 오브 호프 | Cs1 표적화된 키메라 항원 수용체-변형된 t 세포 |
| JP6912386B2 (ja) | 2015-01-26 | 2021-08-04 | ザ ユニバーシティー オブ シカゴ | 癌特異的なIL13Rα2を認識するCAR T細胞 |
| JP6790062B2 (ja) | 2015-04-02 | 2020-11-25 | バイオセプター・(ユーケー)・リミテッド | 疼痛治療 |
| KR20180043841A (ko) * | 2015-09-11 | 2018-04-30 | 카리나 바이오테크 피티와이 엘티디 | 키메라 항원 수용체 및 이의 용도 |
| EP3442576A4 (en) | 2016-04-15 | 2020-05-13 | Trustees of Dartmouth College | HIGH AFFINITY B7-H6 ANTIBODIES AND ANTIBODY FRAGMENTS |
| US20190284298A1 (en) | 2016-07-19 | 2019-09-19 | Unum Therapeutics Inc. | Use of antibody-coupled t cell receptor (actr) with multiple anti-cancer antibodies in cancer treatment |
| US20190263928A1 (en) | 2016-09-30 | 2019-08-29 | Baylor College Of Medicine | Adaptive chimeric antigen receptor t-cell design |
| WO2018071959A1 (en) | 2016-10-21 | 2018-04-26 | Biosceptre (Uk) Limited | Cytotoxic particles |
| JP2021524248A (ja) | 2018-05-21 | 2021-09-13 | バイオセプター・(ユーケー)・リミテッド | 修飾されたリンカードメインを有するキメラ抗原受容体およびその使用 |
| WO2021019222A1 (en) | 2019-07-26 | 2021-02-04 | Biosceptre (Uk) Limited | P2x7 receptor targeted therapy |
-
2016
- 2016-09-10 KR KR1020187010203A patent/KR20180043841A/ko not_active Ceased
- 2016-09-10 ES ES16843305T patent/ES2848478T3/es active Active
- 2016-09-10 KR KR1020257012877A patent/KR20250058773A/ko active Pending
- 2016-09-10 EP EP16843305.0A patent/EP3347474B1/en active Active
- 2016-09-10 CN CN202210429775.5A patent/CN114891116A/zh active Pending
- 2016-09-10 WO PCT/AU2016/050851 patent/WO2017041143A1/en not_active Ceased
- 2016-09-10 AU AU2016318230A patent/AU2016318230B2/en active Active
- 2016-09-10 US US15/759,046 patent/US12121539B2/en active Active
- 2016-09-10 CN CN201680064592.0A patent/CN108350462B/zh active Active
- 2016-09-10 JP JP2018532485A patent/JP6957471B2/ja active Active
- 2016-09-10 EP EP20197564.6A patent/EP3816294A1/en active Pending
-
2020
- 2020-07-28 AU AU2020210185A patent/AU2020210185C1/en active Active
- 2020-10-23 US US17/078,969 patent/US20210038649A1/en not_active Abandoned
-
2021
- 2021-10-05 JP JP2021164222A patent/JP7253020B2/ja active Active
-
2022
- 2022-02-24 AU AU2022201263A patent/AU2022201263B2/en active Active
-
2023
- 2023-03-24 JP JP2023047606A patent/JP2023082052A/ja active Pending
-
2024
- 2024-07-24 US US18/783,109 patent/US20250101080A1/en active Pending
- 2024-08-07 AU AU2024205598A patent/AU2024205598A1/en active Pending
-
2025
- 2025-03-27 JP JP2025052912A patent/JP2025098188A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011020155A1 (en) * | 2009-08-20 | 2011-02-24 | Biosceptre International Limited | Anti p2x7 receptor antibodies and fragments thereof |
| WO2011075789A1 (en) * | 2009-12-24 | 2011-06-30 | Biosceptre International Limited | Antibodies to non-functional oligomeric p2x7 receptors |
| WO2012079000A1 (en) * | 2010-12-09 | 2012-06-14 | The Trustees Of The University Of Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2014055657A1 (en) * | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023082052A (ja) | 2023-06-13 |
| EP3816294A1 (en) | 2021-05-05 |
| JP2025098188A (ja) | 2025-07-01 |
| AU2024205598A1 (en) | 2024-08-29 |
| AU2022201263A1 (en) | 2022-03-17 |
| US20250101080A1 (en) | 2025-03-27 |
| JP2018526033A (ja) | 2018-09-13 |
| AU2022201263B2 (en) | 2024-05-09 |
| JP7253020B2 (ja) | 2023-04-05 |
| WO2017041143A1 (en) | 2017-03-16 |
| KR20250058773A (ko) | 2025-04-30 |
| US20190365805A1 (en) | 2019-12-05 |
| AU2016318230A1 (en) | 2018-04-12 |
| US20210038649A1 (en) | 2021-02-11 |
| EP3347474A1 (en) | 2018-07-18 |
| AU2020210185A1 (en) | 2020-08-13 |
| CN108350462A (zh) | 2018-07-31 |
| NZ740820A (en) | 2022-03-25 |
| ES2848478T3 (es) | 2021-08-09 |
| EP3347474A4 (en) | 2019-03-13 |
| JP2022017256A (ja) | 2022-01-25 |
| EP3347474B1 (en) | 2020-11-04 |
| CN114891116A (zh) | 2022-08-12 |
| KR20180043841A (ko) | 2018-04-30 |
| US12121539B2 (en) | 2024-10-22 |
| AU2020210185C1 (en) | 2022-05-19 |
| AU2020210185B2 (en) | 2021-12-09 |
| JP6957471B2 (ja) | 2021-11-02 |
| AU2016318230B2 (en) | 2020-05-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108350462B (zh) | 嵌合抗原受体及其用途 | |
| AU2019275479B2 (en) | Chimeric antigen receptors with modified linker domains and uses thereof | |
| CN109971712B (zh) | 特异性靶向cd19抗原且高水平稳定表达pd-1抗体的car-t细胞及用途 | |
| CN110461881B (zh) | 嵌合抗原受体 | |
| KR20170012324A (ko) | 키메라 항원 수용체 단백질을 코딩하는 핵산 및 키메라 항원 수용체 단백질을 발현하는 t 림프구 | |
| CN104098698A (zh) | 一种抗cd3抗体及其制法和应用 | |
| US20250197472A1 (en) | Programmable immunocyte receptor complex system | |
| CN115466331B (zh) | 靶向bcma的嵌合抗原受体及其应用 | |
| WO2019128998A1 (zh) | 自表达pd-1抗体并靶向间皮素的嵌合抗原受体修饰t细胞及其用途 | |
| CN115397867A (zh) | Epcam抗体与car-t细胞 | |
| WO2019128996A1 (zh) | 自表达cd47抗体的间皮素特异性car-t细胞及其用途 | |
| WO2019129138A1 (zh) | 靶向ErbB受体家族且自表达PD-1抗体的CAR-T细胞及其用途 | |
| CN114729328B (zh) | Tmem59蛋白二聚体或嵌合表达受体改善t细胞功能 | |
| WO2019129142A1 (zh) | 自分泌CD40抗体且靶向ErbB受体家族的CAR-T细胞及其用途 | |
| RU2804664C2 (ru) | Hpv-специфические связывающие молекулы | |
| WO2024153120A1 (zh) | 突变的pd1胞外域片段及含有该片段的car和nk细胞 | |
| CN120303294A (zh) | 对间皮素具有增加的亲和力的嵌合抗原受体及其用途 | |
| CN116829161A (zh) | 嵌合抗原受体t细胞及方法 | |
| CN117136199A (zh) | 靶向bcma的嵌合抗原受体及其应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20201102 Address after: England Applicant after: BIOSCEPTRE (UK) LTD. Address before: Adelaide Australia Applicant before: CARINA BIOTECH Pty Ltd. |
|
| TA01 | Transfer of patent application right | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220531 Address after: New South Wales Australia Patentee after: BIOSCEPTRE (AUSI) Pty Ltd. Address before: Britain Camb Patentee before: BIOSCEPTRE (UK) LTD. |
|
| TR01 | Transfer of patent right |