CN108299425B - 稠环衍生物、其制备方法、中间体、药物组合物及应用 - Google Patents

稠环衍生物、其制备方法、中间体、药物组合物及应用 Download PDF

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CN108299425B
CN108299425B CN201810188235.6A CN201810188235A CN108299425B CN 108299425 B CN108299425 B CN 108299425B CN 201810188235 A CN201810188235 A CN 201810188235A CN 108299425 B CN108299425 B CN 108299425B
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CN108299425A (zh
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许祖盛
张农
孙庆瑞
吴添智
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Shanghai Yingli Pharmaceutical Co Ltd
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Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108299425B (zh) 2015-03-24 2020-09-18 上海璎黎药业有限公司 稠环衍生物、其制备方法、中间体、药物组合物及应用
US10494378B2 (en) * 2015-07-21 2019-12-03 Guangzhou Maxinovel Pharmaceuticals Co., Ltd. Fused ring pyrimidine compound, intermediate, and preparation method, composition and use thereof
CN107286156A (zh) * 2016-04-05 2017-10-24 江苏新元素医药科技有限公司 新型urat1抑制剂及其在医药上的应用
NZ749427A (en) * 2016-05-23 2019-11-29 Cstone Pharmaceutical Suzhou Co Ltd Thiophene, manufacturing method thereof, and pharmaceutical application of same
CN106146533B (zh) * 2016-07-14 2018-04-03 华润赛科药业有限责任公司 含硫杂环羧酸类衍生物、其制备方法和应用
CN106083847B (zh) * 2016-08-03 2018-10-30 山东大学 一种咪唑并吡啶巯乙酸类衍生物及其制备方法与应用
CN108084186B (zh) * 2016-11-16 2021-06-25 江苏新元素医药科技有限公司 Urat1抑制剂及其应用
WO2018090921A1 (zh) * 2016-11-16 2018-05-24 江苏新元素医药科技有限公司 Urat1抑制剂及其应用
CN108033909A (zh) * 2017-12-20 2018-05-15 北京六合宁远科技有限公司 一种6-甲基-4-溴-异喹啉的制备方法
CN109608432B (zh) * 2018-12-17 2022-10-11 江苏艾立康医药科技有限公司 作为urat1抑制剂的噻吩类衍生物
CN111943957B (zh) * 2019-05-17 2023-01-06 中国医学科学院药物研究所 喹啉甲酰胺类化合物及其制备方法和用途
CN111303161B (zh) * 2020-04-14 2021-01-05 遵义医科大学珠海校区 嘧啶并氮杂环类化合物及其用途
CN111763218B (zh) * 2020-07-14 2021-05-28 山东大学 一种噻吩并嘧啶酮巯乙酸类衍生物及其制备方法与应用
CA3246483A1 (en) * 2022-01-04 2025-06-13 Shanghai Yingli Pharmaceutical Co., Ltd Crystal form of a fused ring derivative, a prepartion method therefor and use thereof
CN116465985B (zh) * 2023-03-03 2024-12-10 连云港杰瑞药业有限公司 一种气相色谱法检测α-核糖甲磺酸酯中残留溶剂的方法
WO2024209363A1 (en) 2023-04-06 2024-10-10 Pfizer Inc. Substituted indazole propionic acid derivative compounds and uses thereof as ampk activators
CN118955327A (zh) * 2024-06-26 2024-11-15 安徽大学 一种4-溴-1-萘甲腈的合成方法
CN118878551B (zh) * 2024-07-08 2026-04-28 安徽大学 一种4-溴噻吩并[2,3-c]吡啶-2-羧酸乙酯的制备方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558655A (en) 1969-06-25 1971-01-26 Parke Davis & Co Benzo(b)thiopheneacetic acid compounds
US4224330A (en) 1979-09-13 1980-09-23 Zoecon Corporation Esters and thiolesters of benzothienyl acids
AUPO282896A0 (en) 1996-10-07 1996-10-31 Fujisawa Pharmaceutical Co., Ltd. Novel compounds
ES2270867T3 (es) 1999-09-23 2007-04-16 Astrazeneca Ab Compuestos de quinazolina terapeuticos.
US6987118B2 (en) * 2003-05-21 2006-01-17 Pfizer Inc. Tetrahydroisoquinoline derivatives as PPAR-alpha activators
TWI328009B (en) * 2003-05-21 2010-08-01 Glaxo Group Ltd Quinoline derivatives as phosphodiesterase inhibitors
WO2005051940A2 (en) * 2003-11-20 2005-06-09 Eli Lilly And Company Vitamin d receptor modulators
ATE418567T1 (de) * 2003-12-22 2009-01-15 Basell Polyolefine Gmbh Metallocenverbindungen
SE0400440D0 (sv) * 2004-02-25 2004-02-25 Active Biotech Ab Novel Cinnamic Amides
GB0426313D0 (en) * 2004-12-01 2005-01-05 Merck Sharp & Dohme Therapeutic agents
US8916550B2 (en) * 2005-05-09 2014-12-23 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
AU2007210076A1 (en) * 2006-01-30 2007-08-09 Irm Llc Polycyclic 1, 2, 3, 4 -tetrahydro- isoquinoline derivatives and compositions comprising them as PPAR modulators
MX2008011723A (es) 2006-03-16 2008-09-26 Astellas Pharma Inc Derivado de triazol o su sal.
US7960567B2 (en) * 2007-05-02 2011-06-14 Amgen Inc. Compounds and methods useful for treating asthma and allergic inflammation
JP2011520809A (ja) 2008-05-05 2011-07-21 アムジエン・インコーポレーテツド γセクレターゼモジュレーターとしての尿素化合物
EP2427430B1 (en) * 2009-05-04 2014-09-10 The Royal Institution for the Advancement of Learning/McGill University 5-oxo-ete receptor antagonist compounds
TW201116281A (en) 2009-08-06 2011-05-16 Astellas Pharma Inc N atom containing ring acylguanidine derivatives
WO2011150156A2 (en) * 2010-05-26 2011-12-01 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
TWI499412B (zh) * 2010-06-16 2015-09-11 亞德生化公司 苯基硫乙酸酯組合物及其使用方法
EP2632922B1 (de) 2010-10-27 2019-02-27 Bayer CropScience Aktiengesellschaft Heteroarylpiperidin und -piperazinderivate als fungizide
JP5990106B2 (ja) * 2011-01-28 2016-09-07 佐藤製薬株式会社 縮環化合物
US8957203B2 (en) * 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2013047813A1 (ja) 2011-09-30 2013-04-04 大鵬薬品工業株式会社 1,2,4-トリアジン-6-カルボキサミド誘導体
WO2014017643A1 (ja) 2012-07-27 2014-01-30 佐藤製薬株式会社 ジフルオロメチレン化合物
RU2015120217A (ru) * 2012-11-20 2017-01-10 Ф. Хоффманн-Ля Рош Аг Замещенные 1,6-нафтиридины
JP6113354B2 (ja) * 2013-05-03 2017-04-12 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 神経新生刺激イソキノリン誘導体
ES3069593T3 (en) 2013-08-23 2026-06-09 Neupharma Inc Quinazolin-8-yl derivatives for use in methods of treating melanoma, non-small cell lung cancer, thyroid cancer, ovarian cancer, or colon cancer
MX385777B (es) * 2014-12-24 2025-03-04 Lg Chemical Ltd Derivado de biarilo como agonista de gpr120.
CN108299425B (zh) 2015-03-24 2020-09-18 上海璎黎药业有限公司 稠环衍生物、其制备方法、中间体、药物组合物及应用

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