CN108186746A - Drug for livestock body surface expelling parasite and preparation method thereof - Google Patents
Drug for livestock body surface expelling parasite and preparation method thereof Download PDFInfo
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- CN108186746A CN108186746A CN201810101104.XA CN201810101104A CN108186746A CN 108186746 A CN108186746 A CN 108186746A CN 201810101104 A CN201810101104 A CN 201810101104A CN 108186746 A CN108186746 A CN 108186746A
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- body surface
- bentonite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The invention discloses a kind of for drug of livestock body surface expelling parasite and preparation method thereof, which includes:1)Chinese herbal medicine, ethyl alcohol and ethyl acetate are decocted, then filter to take filtrate so that extracting solution is made;2)Under ultrasound condition, extracting solution, nano-bentonite, rotenone, Albendazole are subjected to adsorption treatment, then filter that modified Nano bentonite is made;3)Modified Nano bentonite, cyclodextrin and water are subjected to ultrasonic vibration so that the drug for livestock body surface expelling parasite is made;Wherein, Chinese herbal medicine is azedarach, radix ranunculi ternati, manyleaf meadowure rhizome and root, semen momordicae, raw Radix Astragali, buckeye and cacumen biotae.The drug for being used for livestock body surface expelling parasite has excellent anthelminthic effect, and milder, nuisanceless to environment and livestock for the body surface of livestock;The preparation method has the advantages that process is simple and raw material is easy to get simultaneously.
Description
Technical field
The present invention relates to drugs, and in particular, to a kind of for drug of livestock body surface expelling parasite and preparation method thereof.
Background technology
Animal husbandry refers to that with the mode herded, stable breeding or the two combine, raising livestock and poultry are to obtain animal product or the draught animal
Production division.It include livestock raise herd, home poultry raising, economic beasts are raised and train.Animal husbandry has important in national economy
Status and effect, predominantly:1. provide the animal foods such as meat, milk, eggs;2. for industry provide wool, cashmere, skin,
The raw materials such as hair on the neck, beast bone, casing;3. export acquisition of foreign currency by livestock products;4. the industry of animal husbandry input and livestock products is promoted to add
Industrial expansion increases labour employment chance;5. provide organic fertilizer for production estimation;6. it increases farmers' income;7. for agriculture
Industry and transportation provide animal power;8. promoting the economy and cultural development in vast pastoral area, strengthen the unity among nationalities.Thus
As it can be seen that the development of country is to be unable to do without the support of animal husbandry.
During developing animal husbandry, often need to livestock carry out expelling parasite processing, wherein be divided into internal expelling parasite and
Body surface area worm.At present, body surface area worm is generally to carry out expelling parasite using the organic reagent of chemical synthesis, although can obtain certain
Anthelminthic effect;But on the one hand the health of livestock can be adversely affected, and then affect domestic animal by being chemical synthesis reagent
The meat and pelage quality of poultry, the reagent of another aspect chemical synthesis can cause environmental pollution.
Invention content
The object of the present invention is to provide a kind of for drug of livestock body surface expelling parasite and preparation method thereof, this is used for livestock body
The drug of table expelling parasite has excellent anthelminthic effect, and milder, nuisanceless to environment and livestock for the body surface of livestock;
The preparation method has the advantages that process is simple and raw material is easy to get simultaneously.
To achieve these goals, the present invention provides a kind of preparation method of the drug for livestock body surface expelling parasite, packets
It includes:
1)Chinese herbal medicine, ethyl alcohol and ethyl acetate are decocted, then filter to take filtrate so that extracting solution is made;
2)Under ultrasound condition, extracting solution, nano-bentonite, rotenone, Albendazole are subjected to adsorption treatment, then filtered
Modified Nano bentonite is made;
3)Modified Nano bentonite, cyclodextrin and water are subjected to ultrasonic vibration so that the drug for livestock body surface expelling parasite is made;
Wherein, Chinese herbal medicine is azedarach, radix ranunculi ternati, manyleaf meadowure rhizome and root, semen momordicae, raw Radix Astragali, buckeye and cacumen biotae.
The present invention also provides a kind of drug for livestock body surface expelling parasite, which passes through
Above-mentioned preparation method is prepared.
In the above-mentioned technical solutions, the present invention by the mixed liquor that is made up of first ethyl alcohol and ethyl acetate to Chinese herbal medicine
It is decocted and then obtains extracting solution;Then, extracting solution, rotenone, Albendazole are adsorbed by nano-bentonite
And then modified Nano bentonite is made;Then, modified Nano bentonite is coated by cyclodextrin, while utilizes cyclodextrin
Outer rim is hydrophilic and characteristic that inner cavity is hydrophobic is so as to soluble in water and then drug for livestock body surface expelling parasite is made.It should
Drug has excellent anthelminthic effect, while milder, nuisanceless to environment and livestock not only for the body surface of livestock;Together
When the preparation method have the advantages that process is simple and be easy to get with raw material.
Other features and advantages of the present invention will be described in detail in subsequent specific embodiment part.
Specific embodiment
The specific embodiment of the present invention is described in detail below.It is it should be understood that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to restrict the invention.
The present invention provides a kind of preparation method of the drug for livestock body surface expelling parasite, including:
1)Chinese herbal medicine, ethyl alcohol and ethyl acetate are decocted, then filter to take filtrate so that extracting solution is made;
2)Under ultrasound condition, extracting solution, nano-bentonite, rotenone, Albendazole are subjected to adsorption treatment, then filtered
Modified Nano bentonite is made;
3)Modified Nano bentonite, cyclodextrin and water are subjected to ultrasonic vibration so that the drug for livestock body surface expelling parasite is made;
Wherein, Chinese herbal medicine is azedarach, radix ranunculi ternati, manyleaf meadowure rhizome and root, semen momordicae, raw Radix Astragali, buckeye and cacumen biotae.
In the step 1 of the present invention)In, the dosage of each material can select in wide range, but in order to make the drug
With superior anthelminthic effect and mildness, it is preferable that in step 1)In, the weight of Chinese herbal medicine, ethyl alcohol and ethyl acetate
Than being 10:35-45:10-15;In Chinese herbal medicine, azedarach, radix ranunculi ternati, manyleaf meadowure rhizome and root, semen momordicae, raw Radix Astragali, buckeye and arbor-vitae
The weight ratio of leaf is 10:5-8:15-20:8-12:3-6:10-12:8-15.
In the step 1 of the present invention)In, the condition of decoction can select in wide range, but in order to have the drug
There are superior anthelminthic effect and mildness, it is preferable that decoction meets the following conditions:It is 79-83 DEG C to decoct temperature, during decoction
Between be 2-4h.
In the step 2 of the present invention)In, the dosage of each substance can select in wide range, but in order to make the drug
With superior anthelminthic effect and mildness, it is preferable that in step 2)In, extracting solution, nano-bentonite, rotenone, third
The weight ratio of thibenzazoline is 100:30-40:5-8:2-6.
In the step 2 of the present invention)In, the condition of adsorption treatment can select in wide range, but in order to make the medicine
Object has superior anthelminthic effect and mildness, it is preferable that in step 2)In, adsorption treatment meets the following conditions:Processing
Temperature is 40-50 DEG C, processing time 6-8h, supersonic frequency 25-30KHz.
In the step 3 of the present invention)In, the dosage of each substance can select in wide range, but in order to make the drug
With superior anthelminthic effect and mildness, it is preferable that in step 3)In, modified Nano bentonite, cyclodextrin and water
Weight ratio is 10:4-6:200-220.
In the step 3 of the present invention)In, the condition of ultrasonic vibration can select in wide range, but in order to make the medicine
Object has superior anthelminthic effect and mildness, it is preferable that in step 3)In, ultrasonic vibration meets the following conditions:Concussion
Temperature is 15-35 DEG C, and the concussion time is 3-5h, supersonic frequency 35-40KHz.
In the present invention, the average grain diameter of nano-bentonite can select in wide range, but in order to make the drug
With superior anthelminthic effect and mildness, it is preferable that the average grain diameter of nano-bentonite is 15-30nm.
The present invention also provides a kind of drug for livestock body surface expelling parasite, which passes through
Above-mentioned preparation method is prepared.
The present invention will be described in detail by way of examples below.
Embodiment 1
1)By Chinese herbal medicine(Azedarach, radix ranunculi ternati, manyleaf meadowure rhizome and root, semen momordicae, raw Radix Astragali, buckeye and the weight ratio of cacumen biotae are 10:
7:35:10:5:11:12), ethyl alcohol and ethyl acetate is according to 10:40:13 weight ratio is decocted(It is 80 DEG C to decoct temperature, is decocted
The time is boiled as 3h), filtrate is then filtered to take so that extracting solution is made;
2)Under ultrasound condition, by extracting solution, nano-bentonite(Average grain diameter is 20nm), rotenone, Albendazole according to
100:35:7:4 weight ratio carries out adsorption treatment(Treatment temperature is 45 DEG C, processing time 7h, supersonic frequency 28KHz),
Then it filters that modified Nano bentonite is made;
3)By modified Nano bentonite, cyclodextrin and water according to 10:5:200 weight ratio carries out ultrasonic vibration(Shaking temperature is
25 DEG C, the concussion time is 4h, supersonic frequency 38KHz)The drug A1 for livestock body surface expelling parasite is made.
Embodiment 2
1)By Chinese herbal medicine(Azedarach, radix ranunculi ternati, manyleaf meadowure rhizome and root, semen momordicae, raw Radix Astragali, buckeye and the weight ratio of cacumen biotae are 10:
5:15:8:3:10:8), ethyl alcohol and ethyl acetate is according to 10:35:10 weight ratio is decocted(It is 79 DEG C to decoct temperature, is decocted
Time is 2h), filtrate is then filtered to take so that extracting solution is made;
2)Under ultrasound condition, by extracting solution, nano-bentonite(Average grain diameter is 15nm), rotenone, Albendazole according to
100:30:5:2 weight ratio carries out adsorption treatment(Treatment temperature is 40 DEG C, processing time 6h, supersonic frequency 25KHz),
Then it filters that modified Nano bentonite is made;
3)By modified Nano bentonite, cyclodextrin and water according to 10:4:210 weight ratio carries out ultrasonic vibration(Shaking temperature is
15 DEG C, the concussion time is 3h, supersonic frequency 35KHz)The drug A2 for livestock body surface expelling parasite is made.
Embodiment 3
1)By Chinese herbal medicine(Azedarach, radix ranunculi ternati, manyleaf meadowure rhizome and root, semen momordicae, raw Radix Astragali, buckeye and the weight ratio of cacumen biotae are 10:
8:20:12:6:12:15), ethyl alcohol and ethyl acetate is according to 10:45:15 weight ratio is decocted(It is 83 DEG C to decoct temperature, is decocted
The time is boiled as 4h), filtrate is then filtered to take so that extracting solution is made;
2)Under ultrasound condition, by extracting solution, nano-bentonite(Average grain diameter is 30nm), rotenone, Albendazole according to
100:40:8:6 weight ratio carries out adsorption treatment(Treatment temperature is 50 DEG C, processing time 8h, supersonic frequency 30KHz),
Then it filters that modified Nano bentonite is made;
3)By modified Nano bentonite, cyclodextrin and water according to 10:6:220 weight ratio carries out ultrasonic vibration(Shaking temperature is
35 DEG C, the concussion time is 5h, supersonic frequency 40KHz)The drug A3 for livestock body surface expelling parasite is made.
Comparative example 1
Method according to embodiment 1 carries out that drug B1 is made, unlike, step 2)Extracting solution is not used.
Comparative example 2
Method according to embodiment 1 carries out that drug B2 is made, unlike, step 3)Cyclodextrin is not used.
Detect example 1
Using flea as experiment made on the living in this test example, enough food is provided during experiment made on the living.6 groups of work are chosen respectively
Body flea(It is sexually matured), every group 10(Each half of male and female), above-mentioned drug periodically then is sprayed to every group of flea, is sprayed daily
Spill 3 times, each every group of sprinkling 10mL, continuous sprinkling 7 days, after right the latter moon in every group live body flea quantity;Wherein blank
Control group spray water;Concrete outcome is shown in Table 1.
Table 1
The substance of sprinkling | After one month in every group live body flea quantity/only |
A1 | 0 |
A2 | 0 |
A3 | 0 |
B1 | 153 |
B2 | 42 |
Water | 456 |
The preferred embodiment of the present invention has been described above in detail, still, the tool during present invention is not limited to the embodiments described above
Body details within the scope of the technical concept of the present invention, can carry out a variety of simple variants, these letters to technical scheme of the present invention
Monotropic type all belongs to the scope of protection of the present invention.
It is further to note that specific technical features described in the above specific embodiments, in not lance
In the case of shield, can be combined by any suitable means, in order to avoid unnecessary repetition, the present invention to it is various can
The combination of energy no longer separately illustrates.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally
The thought of invention, it should also be regarded as the disclosure of the present invention.
Claims (9)
1. a kind of preparation method of drug for livestock body surface expelling parasite, which is characterized in that including:
1)Chinese herbal medicine, ethyl alcohol and ethyl acetate are decocted, then filter to take filtrate so that extracting solution is made;
2)Under ultrasound condition, the extracting solution, nano-bentonite, rotenone, Albendazole are subjected to adsorption treatment, then
Filtering is with obtained modified Nano bentonite;
3)The modified Nano bentonite, cyclodextrin and water are subjected to ultrasonic vibration to be made described for livestock body surface expelling parasite
Drug;
Wherein, the Chinese herbal medicine is azedarach, radix ranunculi ternati, manyleaf meadowure rhizome and root, semen momordicae, raw Radix Astragali, buckeye and cacumen biotae.
2. preparation method according to claim 1, wherein, in step 1)In, the Chinese herbal medicine, ethyl alcohol and ethyl acetate
Weight ratio is 10:35-45:10-15;
In the Chinese herbal medicine, the azedarach, radix ranunculi ternati, manyleaf meadowure rhizome and root, semen momordicae, raw Radix Astragali, buckeye and the weight of cacumen biotae
Amount is than being 10:5-8:15-20:8-12:3-6:10-12:8-15.
3. preparation method according to claim 1, wherein, the decoction meets the following conditions:Decoction temperature is 79-83
DEG C, decocting time 2-4h.
4. according to the preparation method described in any one in claim 1-3, wherein, in step 2)In, the extracting solution, nanometer
Bentonite, rotenone, Albendazole weight ratio be 100:30-40:5-8:2-6.
5. preparation method according to claim 4, wherein, in step 2)In, the adsorption treatment meets the following conditions:Place
It is 40-50 DEG C, processing time 6-8h, supersonic frequency 25-30KHz to manage temperature.
6. according to the preparation method described in any one in claim 1-3,5, wherein, in step 3)In, the modified Nano
The weight ratio of bentonite, cyclodextrin and water is 10:4-6:200-220.
7. according to the preparation method described in any one in claim 1-3,5, wherein, in step 3)In, the ultrasonic vibration
Meet the following conditions:It is 15-35 DEG C to shake temperature, and the concussion time is 3-5h, supersonic frequency 35-40KHz.
8. according to the preparation method described in any one in claim 1-3,5, wherein, the average grain diameter of the nano-bentonite
For 15-30nm.
9. a kind of drug for livestock body surface expelling parasite, which is characterized in that the drug for livestock body surface expelling parasite passes through power
Profit requires the preparation method in 1-8 described in any one to be prepared.
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CN102100661A (en) * | 2009-12-17 | 2011-06-22 | 苏州知微堂生物科技有限公司 | Process for preparing novel formulation of integrative traditional Chinese medicine and production method thereof |
CN103341053A (en) * | 2013-07-26 | 2013-10-09 | 广东药学院 | Purification method for large ligusticum wallichii oral liquid |
CN105418217A (en) * | 2015-11-27 | 2016-03-23 | 颍上县永祥旱粮研究所 | Corn compound fertilizer with slow-release and insect-resistant effects |
CN106377656A (en) * | 2016-10-21 | 2017-02-08 | 江西正邦动物保健品有限公司 | Traditional Chinese medicine pre-mixing agent for expelling parasites and preparation method thereof |
CN106490026A (en) * | 2016-10-31 | 2017-03-15 | 郑州思辩科技有限公司 | A kind of storage pest insecticide and preparation method thereof |
CN106857726A (en) * | 2017-01-23 | 2017-06-20 | 嵊州市派特普科技开发有限公司 | Pure natural insecticide and preparation method thereof |
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2018
- 2018-02-01 CN CN201810101104.XA patent/CN108186746A/en active Pending
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Publication number | Priority date | Publication date | Assignee | Title |
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CN102100661A (en) * | 2009-12-17 | 2011-06-22 | 苏州知微堂生物科技有限公司 | Process for preparing novel formulation of integrative traditional Chinese medicine and production method thereof |
CN101732336A (en) * | 2009-12-18 | 2010-06-16 | 华中师范大学 | Antiparasitic solution for external use |
CN103341053A (en) * | 2013-07-26 | 2013-10-09 | 广东药学院 | Purification method for large ligusticum wallichii oral liquid |
CN105418217A (en) * | 2015-11-27 | 2016-03-23 | 颍上县永祥旱粮研究所 | Corn compound fertilizer with slow-release and insect-resistant effects |
CN106377656A (en) * | 2016-10-21 | 2017-02-08 | 江西正邦动物保健品有限公司 | Traditional Chinese medicine pre-mixing agent for expelling parasites and preparation method thereof |
CN106490026A (en) * | 2016-10-31 | 2017-03-15 | 郑州思辩科技有限公司 | A kind of storage pest insecticide and preparation method thereof |
CN106857726A (en) * | 2017-01-23 | 2017-06-20 | 嵊州市派特普科技开发有限公司 | Pure natural insecticide and preparation method thereof |
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