CN1081437A - 抗溃疡的吡啶氧衍生物，它们的制备方法和用途 - Google Patents

抗溃疡的吡啶氧衍生物，它们的制备方法和用途 Download PDF

Info

Publication number
CN1081437A
CN1081437A CN93105481A CN93105481A CN1081437A CN 1081437 A CN1081437 A CN 1081437A CN 93105481 A CN93105481 A CN 93105481A CN 93105481 A CN93105481 A CN 93105481A CN 1081437 A CN1081437 A CN 1081437A
Authority
CN
China
Prior art keywords
pip
group
substituent
methyl
pyr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN93105481A
Other languages
English (en)
Chinese (zh)
Inventor
福见宏
杉山充男
田端敬一
小岛孝一
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of CN1081437A publication Critical patent/CN1081437A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Cleaning And De-Greasing Of Metallic Materials By Chemical Methods (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
CN93105481A 1992-03-23 1993-03-23 抗溃疡的吡啶氧衍生物，它们的制备方法和用途 Pending CN1081437A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP6532492 1992-03-23
JP65324/92 1992-03-23
JP10139292 1992-04-21
JP101392/92 1992-04-21
JP175707/92 1992-07-02
JP17570792 1992-07-02
JP34903592 1992-12-28
JP349035/92 1992-12-28

Publications (1)

Publication Number Publication Date
CN1081437A true CN1081437A (zh) 1994-02-02

Family

ID=27464571

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93105481A Pending CN1081437A (zh) 1992-03-23 1993-03-23 抗溃疡的吡啶氧衍生物，它们的制备方法和用途

Country Status (19)

Country Link
US (1) US5616579A (cg-RX-API-DMAC10.html)
EP (1) EP0562833B1 (cg-RX-API-DMAC10.html)
JP (1) JPH06247933A (cg-RX-API-DMAC10.html)
CN (1) CN1081437A (cg-RX-API-DMAC10.html)
AT (1) ATE137748T1 (cg-RX-API-DMAC10.html)
AU (1) AU659922B2 (cg-RX-API-DMAC10.html)
CA (1) CA2092111A1 (cg-RX-API-DMAC10.html)
CZ (1) CZ47493A3 (cg-RX-API-DMAC10.html)
DE (1) DE69302515T2 (cg-RX-API-DMAC10.html)
DK (1) DK0562833T3 (cg-RX-API-DMAC10.html)
ES (1) ES2090859T3 (cg-RX-API-DMAC10.html)
FI (1) FI931292A7 (cg-RX-API-DMAC10.html)
GR (1) GR3020069T3 (cg-RX-API-DMAC10.html)
HK (1) HK159796A (cg-RX-API-DMAC10.html)
HU (1) HUT64053A (cg-RX-API-DMAC10.html)
IL (1) IL105140A (cg-RX-API-DMAC10.html)
NO (1) NO931041L (cg-RX-API-DMAC10.html)
NZ (1) NZ247229A (cg-RX-API-DMAC10.html)
TW (1) TW240222B (cg-RX-API-DMAC10.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1251474B (it) * 1991-09-13 1995-05-15 Mini Ricerca Scient Tecnolog Derivati ossimici ad attivita' fungicida
JP4058129B2 (ja) * 1996-03-18 2008-03-05 株式会社資生堂 ピリジン誘導体及び抗潰瘍剤、抗菌剤

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS568352A (en) * 1979-07-03 1981-01-28 Shionogi & Co Ltd Aminoalkylvenzene derivative
US4300549A (en) * 1980-01-07 1981-11-17 Surgikos Operating room face mask
JPS6185365A (ja) 1984-10-02 1986-04-30 Ikeda Mohandou:Kk アミノアルキルピリジルオキシ誘導体
US4837316A (en) * 1985-08-29 1989-06-06 Fujirebio Kabushiki Kaisha Alkylamide derivatives with H2 -receptor antagonistic and cytoprotective action
JPS63225371A (ja) 1987-03-13 1988-09-20 Fujirebio Inc ピリジルオキシ誘導体
US4912101A (en) * 1987-03-13 1990-03-27 Fujirebio Kabushiki Kaisha 4-aminomethyl-pyridyl-2-oxy derivatives having anti-ulcer activity
JPH0639466B2 (ja) * 1987-08-03 1994-05-25 杏林製薬株式会社 ウレア誘導体
JPH0193247A (ja) * 1987-10-05 1989-04-12 Toshiba Corp マルチノードシステム
JPH0637472B2 (ja) 1988-01-29 1994-05-18 富士レビオ株式会社 ピリジルオキシ誘導体
KR900701749A (ko) * 1988-07-05 1990-12-04 이베 사치아끼 치환 아세트아미드 유도체, 그의 제조법 및 이를 함유하는 항궤양제
DE69106172D1 (de) * 1990-03-06 1995-02-09 Akzo Nobel Nv Wässrige Hybridpolymerdispersion und Beschichtungszusammensetzung.
JPH04257581A (ja) * 1991-02-08 1992-09-11 Kyorin Pharmaceut Co Ltd ピペリジノメチルピリジン誘導体

Also Published As

Publication number Publication date
EP0562833A1 (en) 1993-09-29
DE69302515T2 (de) 1997-01-09
IL105140A0 (en) 1993-07-08
ATE137748T1 (de) 1996-05-15
HK159796A (en) 1996-08-30
CA2092111A1 (en) 1993-09-24
EP0562833B1 (en) 1996-05-08
GR3020069T3 (en) 1996-08-31
HU9300827D0 (en) 1993-06-28
NZ247229A (en) 1994-10-26
IL105140A (en) 1997-01-10
NO931041D0 (no) 1993-03-23
FI931292L (fi) 1993-09-24
HUT64053A (en) 1993-11-29
CZ47493A3 (en) 1993-12-15
DK0562833T3 (da) 1996-09-09
ES2090859T3 (es) 1996-10-16
US5616579A (en) 1997-04-01
DE69302515D1 (de) 1996-06-13
FI931292A7 (fi) 1993-09-24
TW240222B (cg-RX-API-DMAC10.html) 1995-02-11
AU659922B2 (en) 1995-06-01
FI931292A0 (fi) 1993-03-23
JPH06247933A (ja) 1994-09-06
NO931041L (no) 1993-09-24
AU3537993A (en) 1993-09-30

Similar Documents

Publication Publication Date Title
CN1142932C (zh) 具有速激肽受体拮抗活性的杂环化合物,其制备及用途
US6013663A (en) Dithiolan derivatives, their preparation and their therapeutic effect
CN1117083C (zh) 哒嗪－3－酮衍生物,它们的应用,以及制备它们所用的中间体
CN1255386C (zh) 有取代稠合杂环化合物
CA2500225C (en) Pyrazole compounds
US20170096402A1 (en) 5-(hetero)arylpyridazinones and their use as herbicides
US20070031514A1 (en) Use of isoindolinone derivatives as insecticides
JP2000169371A (ja) ジチオラン誘導体を含有する医薬
JPH11269170A (ja) ジチオラン誘導体
US20050032858A1 (en) Novel heterocyclic compound and anti-inflamatory agent
JP3192631B2 (ja) 飽和複素環化合物からなる医薬
TW200409757A (en) 1-aralkyl-N-(3-quinolyl)-1-cyclohexancarboxamide derivatives
US5616579A (en) Anti-ulcer pyridyloxy derivatives, their preparation and uses
US6869913B1 (en) Pyridazin-3-one derivatives, their use and intermediates for their production
HK1019061A (en) Dithiolan derivatices, their preparation and their therapeutic effect
HK1002279A (en) Heterocyclic compounds having tachykinin receptor antagonist activity, their preparation and their use
JP2000178188A (ja) 回腸型胆汁酸トランスポ−タ−阻害剤
JPH11286443A (ja) 飽和複素環化合物からなる医薬
AU6669100A (en) Dithiolan derivatives, their preparation and their therapeutic effect
JPH1160548A (ja) ベンジルアミン類
AU2005214274A1 (en) Indanol derivative

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication