CN108137579B - 桥连哌啶衍生物 - Google Patents

桥连哌啶衍生物 Download PDF

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Publication number
CN108137579B
CN108137579B CN201680057010.6A CN201680057010A CN108137579B CN 108137579 B CN108137579 B CN 108137579B CN 201680057010 A CN201680057010 A CN 201680057010A CN 108137579 B CN108137579 B CN 108137579B
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CN
China
Prior art keywords
triazolo
azabicyclo
pyridin
amine
octan
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CN201680057010.6A
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English (en)
Chinese (zh)
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CN108137579A (zh
Inventor
比约恩·巴特尔斯
卡尔海因茨·博伊曼
吉多·加利
乔治·耶施克
罗兰·雅各布-勒特
安雅·林贝格
维尔纳·奈德哈特
哈萨内·拉特尼
罗莎·马丽亚·罗得里格斯-萨尔米恩托
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN108137579A publication Critical patent/CN108137579A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201680057010.6A 2015-12-10 2016-12-06 桥连哌啶衍生物 Active CN108137579B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15199260.9 2015-12-10
EP15199260 2015-12-10
PCT/EP2016/079816 WO2017097728A1 (en) 2015-12-10 2016-12-06 Bridged piperidine derivatives

Publications (2)

Publication Number Publication Date
CN108137579A CN108137579A (zh) 2018-06-08
CN108137579B true CN108137579B (zh) 2022-01-07

Family

ID=54848457

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680057010.6A Active CN108137579B (zh) 2015-12-10 2016-12-06 桥连哌啶衍生物

Country Status (7)

Country Link
US (2) US10562903B2 (https=)
EP (1) EP3386978B1 (https=)
JP (1) JP6872550B2 (https=)
CN (1) CN108137579B (https=)
AR (1) AR107010A1 (https=)
TW (1) TWI629278B (https=)
WO (1) WO2017097728A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
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WO2017055404A1 (en) 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Bispecific antibodies specific for pd1 and tim3
IL294124B2 (en) 2015-12-10 2024-02-01 Ptc Therapeutics Inc Methods for treating huntington's disease
CN109311878B (zh) * 2016-06-27 2022-05-24 豪夫迈·罗氏有限公司 作为γ-分泌酶调节剂的三唑并吡啶类化合物
AR109829A1 (es) * 2016-09-29 2019-01-30 Hoffmann La Roche Derivados de piperidina puenteados
EP3535266B1 (en) * 2016-11-01 2021-12-29 F. Hoffmann-La Roche AG Bicyclic heteroaryl derivatives
MY201482A (en) 2017-04-03 2024-02-26 Hoffmann La Roche Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15
EP4516809A3 (en) 2017-04-05 2025-09-03 F. Hoffmann-La Roche AG Bispecific antibodies specifically binding to pd1 and lag3
US11407753B2 (en) 2017-06-05 2022-08-09 Ptc Therapeutics, Inc. Compounds for treating Huntington's disease
WO2019005993A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. METHODS OF TREATING HUNTINGTON'S DISEASE
US11382918B2 (en) 2017-06-28 2022-07-12 Ptc Therapeutics, Inc. Methods for treating Huntington's Disease
MX2020009957A (es) 2018-03-27 2021-01-15 Ptc Therapeutics Inc Compuestos para el tratamiento de enfermedad de hungtinton.
PL3814357T3 (pl) 2018-06-27 2024-09-16 Ptc Therapeutics, Inc. Związki heterocykliczne i heteroarylowe do leczenia choroby huntingtona
EP3814345B8 (en) 2018-06-27 2024-10-30 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
US12084461B2 (en) 2018-09-03 2024-09-10 Hoffmann-La Roche Inc. Bicyclic heteroaryl derivatives
BR112021009443A2 (pt) 2018-12-13 2021-08-17 F. Hoffmann-La Roche Ag derivados de 7-fenóxi-n-(3-azabiciclo[3.2.1]octan-8-il)-6,7-di-hidro-5h-pirrolo[1,2-b][1,2,4]triazol-2-amina e compostos relacionados como moduladores de gama-secretase para o tratamento da doença de alzheimer.
US12275709B2 (en) 2018-12-27 2025-04-15 Hoffmann-La Roche Inc. Process for the preparation of exo-tert-butyl N-(3-azabicyclo[3.2.1]octan-8-yl)carbamate
WO2020231977A1 (en) 2019-05-13 2020-11-19 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
WO2022238816A1 (en) * 2021-05-14 2022-11-17 Bm Pharma Consulting Pty. Ltd Bicyclic heterocyclic compounds for prophylaxis and treatment of viral infections

Citations (3)

* Cited by examiner, † Cited by third party
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EP1947098A1 (en) * 2005-10-06 2008-07-23 Nippon Soda Co., Ltd. Cyclic amine compounds and pest control agent
CN103025724A (zh) * 2010-02-17 2013-04-03 霍夫曼-拉罗奇有限公司 哌啶衍生物
CN103403003A (zh) * 2011-03-02 2013-11-20 霍夫曼-拉罗奇有限公司 桥连哌啶衍生物

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GB1383409A (en) 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US6774134B2 (en) 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
NZ551468A (en) 2003-12-24 2010-05-28 Biota Scient Management Polycyclic agents for the treatment of respiratory syncytial virus infections
FR2914188B1 (fr) 2007-03-28 2012-06-22 Trophos Nouvelle composition a base d'oxime de cholest-4-en-3-one
WO2009151546A2 (en) 2008-05-27 2009-12-17 Ptc Therapeutics, Inc. Methods for treating spinal muscular atrophy
EP2337609B1 (en) 2008-08-14 2016-08-17 Cardiac Pacemakers, Inc. Performance assessment and adaptation of an acoustic communication link
US8871756B2 (en) 2011-08-11 2014-10-28 Hoffmann-La Roche Inc. Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease
GB201119538D0 (en) 2011-11-10 2011-12-21 Viral Ltd Pharmaceutical compounds
KR102057351B1 (ko) 2011-12-30 2019-12-18 피티씨 테라퓨틱스, 인크. 척수성 근위축증을 치료하기 위한 화합물
PL2809322T3 (pl) 2012-01-26 2019-11-29 Ptc Therapeutics Inc Związki do leczenia zaniku mięśni pochodzenia rdzeniowego
DK2812004T3 (en) 2012-02-10 2018-10-15 Ptc Therapeutics Inc COMPOUNDS FOR TREATMENT OF SPINAL MUSCLE DROPHY
US9212209B2 (en) 2012-07-13 2015-12-15 Indiana University Research And Technology Corporation Screening methods for spinal muscular atrophy
EP2997028A1 (en) 2013-05-14 2016-03-23 F.Hoffmann-La Roche Ag Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
WO2014209841A2 (en) 2013-06-25 2014-12-31 F. Hoffmann-La Roche Ag Compounds for treating spinal muscular atrophy
AR099134A1 (es) 2014-01-24 2016-06-29 Hoffmann La Roche Procedimiento para la preparación de n-[(3-aminooxetán-3-il)metil]-2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepín-4-il)-6-metil-quinazolín-4-amina
SI3143025T1 (sl) 2014-05-15 2020-01-31 F. Hoffmann-La Roche Ag Spojine za zdravljenje spinalne mišične atrofije
JP6659841B2 (ja) 2015-11-12 2020-03-04 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 脊髄性筋萎縮症を処置するための組成物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1947098A1 (en) * 2005-10-06 2008-07-23 Nippon Soda Co., Ltd. Cyclic amine compounds and pest control agent
CN103025724A (zh) * 2010-02-17 2013-04-03 霍夫曼-拉罗奇有限公司 哌啶衍生物
CN103403003A (zh) * 2011-03-02 2013-11-20 霍夫曼-拉罗奇有限公司 桥连哌啶衍生物

Also Published As

Publication number Publication date
EP3386978A1 (en) 2018-10-17
WO2017097728A1 (en) 2017-06-15
CN108137579A (zh) 2018-06-08
JP6872550B2 (ja) 2021-05-19
US20200291034A1 (en) 2020-09-17
AR107010A1 (es) 2018-03-14
US10562903B2 (en) 2020-02-18
EP3386978B1 (en) 2021-01-27
JP2018536671A (ja) 2018-12-13
TW201725209A (zh) 2017-07-16
TWI629278B (zh) 2018-07-11
US20190010156A1 (en) 2019-01-10

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