CN108137579B - 桥连哌啶衍生物 - Google Patents

桥连哌啶衍生物 Download PDF

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Publication number
CN108137579B
CN108137579B CN201680057010.6A CN201680057010A CN108137579B CN 108137579 B CN108137579 B CN 108137579B CN 201680057010 A CN201680057010 A CN 201680057010A CN 108137579 B CN108137579 B CN 108137579B
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CN
China
Prior art keywords
triazolo
azabicyclo
pyridin
amine
octan
Prior art date
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Active
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CN201680057010.6A
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English (en)
Chinese (zh)
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CN108137579A (zh
Inventor
比约恩·巴特尔斯
卡尔海因茨·博伊曼
吉多·加利
乔治·耶施克
罗兰·雅各布-勒特
安雅·林贝格
维尔纳·奈德哈特
哈萨内·拉特尼
罗莎·马丽亚·罗得里格斯-萨尔米恩托
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN108137579A publication Critical patent/CN108137579A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201680057010.6A 2015-12-10 2016-12-06 桥连哌啶衍生物 Active CN108137579B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15199260 2015-12-10
EP15199260.9 2015-12-10
PCT/EP2016/079816 WO2017097728A1 (en) 2015-12-10 2016-12-06 Bridged piperidine derivatives

Publications (2)

Publication Number Publication Date
CN108137579A CN108137579A (zh) 2018-06-08
CN108137579B true CN108137579B (zh) 2022-01-07

Family

ID=54848457

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680057010.6A Active CN108137579B (zh) 2015-12-10 2016-12-06 桥连哌啶衍生物

Country Status (7)

Country Link
US (2) US10562903B2 (https=)
EP (1) EP3386978B1 (https=)
JP (1) JP6872550B2 (https=)
CN (1) CN108137579B (https=)
AR (1) AR107010A1 (https=)
TW (1) TWI629278B (https=)
WO (1) WO2017097728A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
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NZ739090A (en) 2015-10-02 2025-06-27 Hoffmann La Roche Bispecific antibodies specific for pd1 and tim3
EA201800367A1 (ru) 2015-12-10 2019-02-28 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Способы лечения болезни хантингтона
JP7012715B2 (ja) * 2016-06-27 2022-01-28 エフ．ホフマン－ラ ロシュ アーゲー γ－セクレターゼモジュレーターとしてのトリアゾロピリジン
AR109829A1 (es) * 2016-09-29 2019-01-30 Hoffmann La Roche Derivados de piperidina puenteados
WO2018083050A1 (en) * 2016-11-01 2018-05-11 F. Hoffmann-La Roche Ag Bicyclic heteroaryl derivatives
RU2761377C2 (ru) 2017-04-03 2021-12-07 Ф. Хоффманн-Ля Рош Аг Иммуноконъюгаты антитела к pd-1 с мутантом il-2 или с il-15
TWI690538B (zh) 2017-04-05 2020-04-11 瑞士商赫孚孟拉羅股份公司 特異性結合至pd1至lag3的雙特異性抗體
EP3634953B1 (en) 2017-06-05 2024-01-03 PTC Therapeutics, Inc. Compounds for treating huntington's disease
MX2019015580A (es) 2017-06-28 2020-07-28 Ptc Therapeutics Inc Metodos para tratar la enfermedad de huntington.
CN111182898B (zh) 2017-06-28 2024-04-16 Ptc医疗公司 用于治疗亨廷顿氏病的方法
EA202092001A1 (ru) 2018-03-27 2021-01-29 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Соединения для лечения болезни гентингтона
WO2020005877A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
HRP20240935T1 (hr) 2018-06-27 2024-11-22 Ptc Therapeutics, Inc. Heterociklični i heteroaril spojevi za liječenje huntingtonove bolesti
DK3846903T3 (da) 2018-09-03 2024-01-02 Hoffmann La Roche Bicykliske heteroarylderivater
CN117946116A (zh) 2018-12-13 2024-04-30 豪夫迈·罗氏有限公司 6,7-二氢-5h-吡咯并[1,2-b][1,2,4]三唑-2-胺衍生物
ES2940185T3 (es) 2018-12-27 2023-05-04 Hoffmann La Roche Procedimiento para la preparación de exo-N-(3-azabiciclo[3.2.1]octan-8-il)carbamato de terc-butilo
JP7649257B2 (ja) 2019-05-13 2025-03-19 ピーティーシー セラピューティクス， インコーポレイテッド ハンチントン病を処置するための化合物
CN117396490A (zh) * 2021-05-14 2024-01-12 Bm医药咨询有限公司 用于预防和治疗病毒感染的双环杂环化合物

Citations (3)

* Cited by examiner, † Cited by third party
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EP1947098A1 (en) * 2005-10-06 2008-07-23 Nippon Soda Co., Ltd. Cyclic amine compounds and pest control agent
CN103025724A (zh) * 2010-02-17 2013-04-03 霍夫曼-拉罗奇有限公司 哌啶衍生物
CN103403003A (zh) * 2011-03-02 2013-11-20 霍夫曼-拉罗奇有限公司 桥连哌啶衍生物

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GB1383409A (en) 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US6774134B2 (en) 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
BRPI0418127A (pt) 2003-12-24 2007-04-27 Biota Scient Management uso de um composto, seus sais, e derivados farmaceuticamente aceitáveis dos mesmos, método para o tratamento de infecções envolvendo vìrus da sub-famìlia pneumovirinae, formulação farmacêutica, métodos para tratar mamìferos infectados e para prevenir a infecção de mamìferos com vìrus da sub-famìlia pneumovirinae, composto, seus sais, e derivados farmaceuticamente aceitáveis dos mesmos, composto e a forma n-óxido e sal piridìnio do mesmo, e, método de separação de enantiÈmeros de um composto
FR2914188B1 (fr) 2007-03-28 2012-06-22 Trophos Nouvelle composition a base d'oxime de cholest-4-en-3-one
WO2009151546A2 (en) 2008-05-27 2009-12-17 Ptc Therapeutics, Inc. Methods for treating spinal muscular atrophy
EP2337609B1 (en) 2008-08-14 2016-08-17 Cardiac Pacemakers, Inc. Performance assessment and adaptation of an acoustic communication link
US8871756B2 (en) 2011-08-11 2014-10-28 Hoffmann-La Roche Inc. Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease
GB201119538D0 (en) 2011-11-10 2011-12-21 Viral Ltd Pharmaceutical compounds
MX352861B (es) 2011-12-30 2017-12-13 Ptc Therapeutics Inc Compuestos para tratar la atrofia muscular espinal.
MX357834B (es) 2012-01-26 2018-07-26 Ptc Therapeutics Inc Compuestos de tipo isocumarina sustituidos para tratar la atrofia muscular espinal.
EP2812004B1 (en) 2012-02-10 2018-06-27 PTC Therapeutics, Inc. Compounds for treating spinal muscular atrophy
US9212209B2 (en) 2012-07-13 2015-12-15 Indiana University Research And Technology Corporation Screening methods for spinal muscular atrophy
EP2997028A1 (en) 2013-05-14 2016-03-23 F.Hoffmann-La Roche Ag Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
CA2913785C (en) 2013-06-25 2021-08-31 F. Hoffmann-La Roche Ag Compounds for treating spinal muscular atrophy
AR099134A1 (es) 2014-01-24 2016-06-29 Hoffmann La Roche Procedimiento para la preparación de n-[(3-aminooxetán-3-il)metil]-2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepín-4-il)-6-metil-quinazolín-4-amina
ES2761423T3 (es) 2014-05-15 2020-05-19 Hoffmann La Roche Compuestos para tratar la atrofia muscular espinal
EA036399B1 (ru) 2015-11-12 2020-11-06 Ф. Хоффманн-Ля Рош Аг Композиции для лечения спинальной мышечной атрофии

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1947098A1 (en) * 2005-10-06 2008-07-23 Nippon Soda Co., Ltd. Cyclic amine compounds and pest control agent
CN103025724A (zh) * 2010-02-17 2013-04-03 霍夫曼-拉罗奇有限公司 哌啶衍生物
CN103403003A (zh) * 2011-03-02 2013-11-20 霍夫曼-拉罗奇有限公司 桥连哌啶衍生物

Also Published As

Publication number Publication date
EP3386978B1 (en) 2021-01-27
US10562903B2 (en) 2020-02-18
JP6872550B2 (ja) 2021-05-19
CN108137579A (zh) 2018-06-08
US20200291034A1 (en) 2020-09-17
TW201725209A (zh) 2017-07-16
AR107010A1 (es) 2018-03-14
WO2017097728A1 (en) 2017-06-15
EP3386978A1 (en) 2018-10-17
US20190010156A1 (en) 2019-01-10
TWI629278B (zh) 2018-07-11
JP2018536671A (ja) 2018-12-13

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