CN108136218B - 用于治疗轻链淀粉样变性及其它cd38阳性血液恶性肿瘤的抗cd38抗体 - Google Patents

用于治疗轻链淀粉样变性及其它cd38阳性血液恶性肿瘤的抗cd38抗体 Download PDF

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CN108136218B
CN108136218B CN201680042671.1A CN201680042671A CN108136218B CN 108136218 B CN108136218 B CN 108136218B CN 201680042671 A CN201680042671 A CN 201680042671A CN 108136218 B CN108136218 B CN 108136218B
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antibody
seq
ser
amino acid
acid sequence
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CN108136218A (zh
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P.多斯
A.萨斯塞
C.朝拉加恩
R.科门佐
X.马
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Tufts Medical Center Inc
Janssen Biotech Inc
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Janssen Biotech Inc
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • C12Y302/01035—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
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CN201680042671.1A 2015-05-20 2016-05-20 用于治疗轻链淀粉样变性及其它cd38阳性血液恶性肿瘤的抗cd38抗体 Active CN108136218B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562164206P 2015-05-20 2015-05-20
US62/164206 2015-05-20
US201562214586P 2015-09-04 2015-09-04
US62/214586 2015-09-04
PCT/US2016/033544 WO2016187546A1 (en) 2015-05-20 2016-05-20 Anti-cd38 antibodies for treatment of light chain amyloidosis and other cd38-positive hematological malignancies

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CN108136218A CN108136218A (zh) 2018-06-08
CN108136218B true CN108136218B (zh) 2022-12-13

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US (3) US10766965B2 (https=)
EP (3) EP3297729A4 (https=)
JP (1) JP6827426B2 (https=)
KR (2) KR102602754B1 (https=)
CN (1) CN108136218B (https=)
AR (1) AR106534A1 (https=)
AU (3) AU2016264725B2 (https=)
BR (1) BR112017024877A2 (https=)
CA (2) CA3256477A1 (https=)
CL (1) CL2017002909A1 (https=)
CR (1) CR20170526A (https=)
EA (1) EA201792546A1 (https=)
EC (1) ECSP17083788A (https=)
GT (1) GT201700247A (https=)
HK (1) HK1253242A1 (https=)
IL (3) IL300548A (https=)
MA (2) MA42136A (https=)
MX (1) MX389805B (https=)
MY (1) MY198983A (https=)
NI (1) NI201700142A (https=)
PE (1) PE20180671A1 (https=)
PH (1) PH12017502104A1 (https=)
TW (3) TWI737642B (https=)
UA (1) UA124143C2 (https=)
WO (1) WO2016187546A1 (https=)
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