CN108130373A - 在人pi3kca (pik3ca)基因中检测突变的方法和组合物 - Google Patents

在人pi3kca (pik3ca)基因中检测突变的方法和组合物 Download PDF

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Publication number
CN108130373A
CN108130373A CN201810088883.4A CN201810088883A CN108130373A CN 108130373 A CN108130373 A CN 108130373A CN 201810088883 A CN201810088883 A CN 201810088883A CN 108130373 A CN108130373 A CN 108130373A
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China
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artificial sequence
dna
annotation
source
sequence description
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Chinese (zh)
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A.詹
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201810088883.4A 2013-03-13 2014-03-12 在人pi3kca (pik3ca)基因中检测突变的方法和组合物 Pending CN108130373A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361780017P 2013-03-13 2013-03-13
US61/780017 2013-03-13
CN201480013282.7A CN105229171A (zh) 2013-03-13 2014-03-12 在人pi3kca (pik3ca)基因中检测突变的方法和组合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201480013282.7A Division CN105229171A (zh) 2013-03-13 2014-03-12 在人pi3kca (pik3ca)基因中检测突变的方法和组合物

Publications (1)

Publication Number Publication Date
CN108130373A true CN108130373A (zh) 2018-06-08

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Family Applications (2)

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CN201810088883.4A Pending CN108130373A (zh) 2013-03-13 2014-03-12 在人pi3kca (pik3ca)基因中检测突变的方法和组合物
CN201480013282.7A Pending CN105229171A (zh) 2013-03-13 2014-03-12 在人pi3kca (pik3ca)基因中检测突变的方法和组合物

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Country Link
US (2) US20140272961A1 (https=)
EP (1) EP2971075B1 (https=)
JP (1) JP6453781B2 (https=)
CN (2) CN108130373A (https=)
CA (1) CA2899712C (https=)
ES (1) ES2691306T3 (https=)
WO (1) WO2014140061A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109913481A (zh) * 2019-04-24 2019-06-21 无锡市第五人民医院 PIK3CA基因g.1792224821G>A突变及其在乳腺癌辅助诊断中的应用
CN114410790A (zh) * 2022-01-27 2022-04-29 湖南大学 一种用于检测ctDNA的生物传感检测系统及其检测方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201206486D0 (en) * 2012-04-12 2012-05-30 Sequessome Technology Holdings Ltd Vesicular formulations and uses thereof
WO2018094569A1 (zh) * 2016-11-22 2018-05-31 深圳华大基因研究院 多肽及其应用
KR102813811B1 (ko) * 2020-03-27 2025-05-30 주식회사 젠큐릭스 Pik3ca 돌연변이 검출용 조성물 및 이를 포함하는 키트
CN111363827A (zh) * 2020-04-30 2020-07-03 北京和合医学诊断技术股份有限公司 用于检测pik3ca基因突变的引物组及其应用方法

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CN102119222A (zh) * 2007-09-28 2011-07-06 Dxs有限公司 多核苷酸引物
WO2012020965A2 (ko) * 2010-08-13 2012-02-16 주식회사 파나진 Ｐｎａ의 실시간 ｐｃｒ 클램핑을 이용한 ｐｉｋ3ｃａ 돌연변이 검출 방법 및 키트

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SI3296407T1 (sl) * 2004-03-02 2019-09-30 The Johns Hopkins University Mutacije gena PIK3CA pri rakih pri ljudeh
ES2527653T3 (es) * 2008-10-20 2015-01-28 F. Hoffmann-La Roche Ag Amplificación específica de alelo usando un cebador con un nucleótido modificado
US20100286143A1 (en) * 2009-04-24 2010-11-11 Dora Dias-Santagata Methods and materials for genetic analysis of tumors
US9238832B2 (en) * 2009-12-11 2016-01-19 Roche Molecular Systems, Inc. Allele-specific amplification of nucleic acids
CA2786696C (en) * 2010-01-12 2021-05-25 Jill Detmer Oligonucleotides and methods for detecting pik3ca mutations
CN102234685B (zh) * 2010-04-23 2014-08-27 益善生物技术股份有限公司 一种pik3ca基因突变检测液相芯片
JP6050820B2 (ja) * 2011-09-23 2016-12-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 改良された対立遺伝子特異的ｐｃｒのためのｇ−クランプの使用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102119222A (zh) * 2007-09-28 2011-07-06 Dxs有限公司 多核苷酸引物
WO2012020965A2 (ko) * 2010-08-13 2012-02-16 주식회사 파나진 Ｐｎａ의 실시간 ｐｃｒ 클램핑을 이용한 ｐｉｋ3ｃａ 돌연변이 검출 방법 및 키트

Non-Patent Citations (4)

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Title
DBSNP: "ss275515117", 《DBSNP》 *
RAJESH PATEL等: "Mutation Scanning Using MUT-MAP, a High-Throughput,Microfluidic Chip-Based, Multi-Analyte Panel", 《PLOS ONE》 *
余多慰等: "《分子生物学》", 31 July 2007, 南京师范大学出版社 *
蒋健坤等: "结直肠癌组织中PIK3CA基因突变与AKT1/2蛋白的表达及其意义", 《广西医学》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109913481A (zh) * 2019-04-24 2019-06-21 无锡市第五人民医院 PIK3CA基因g.1792224821G>A突变及其在乳腺癌辅助诊断中的应用
CN114410790A (zh) * 2022-01-27 2022-04-29 湖南大学 一种用于检测ctDNA的生物传感检测系统及其检测方法
CN114410790B (zh) * 2022-01-27 2024-04-12 湖南大学 一种用于检测ctDNA的生物传感检测系统及其检测方法

Also Published As

Publication number Publication date
CA2899712A1 (en) 2014-09-18
WO2014140061A2 (en) 2014-09-18
CA2899712C (en) 2021-01-05
US20160160297A1 (en) 2016-06-09
JP2016510982A (ja) 2016-04-14
EP2971075A2 (en) 2016-01-20
CN105229171A (zh) 2016-01-06
JP6453781B2 (ja) 2019-01-16
EP2971075B1 (en) 2018-08-15
ES2691306T3 (es) 2018-11-26
WO2014140061A3 (en) 2014-10-30
US20140272961A1 (en) 2014-09-18

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