CN108114276A - 慢病毒基因转移载体及其医学应用 - Google Patents

慢病毒基因转移载体及其医学应用 Download PDF

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Publication number
CN108114276A
CN108114276A CN201511036366.5A CN201511036366A CN108114276A CN 108114276 A CN108114276 A CN 108114276A CN 201511036366 A CN201511036366 A CN 201511036366A CN 108114276 A CN108114276 A CN 108114276A
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Prior art keywords
vsv
gag
combination
hiv
lentiviral
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Pending
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CN201511036366.5A
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English (en)
Chinese (zh)
Inventor
P·沙尔诺
A-S·贝尼翁
F·P·库唐
K·库贝雷泰
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Centre National de la Recherche Scientifique CNRS
Theravectys SA
Institut Pasteur
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Centre National de la Recherche Scientifique CNRS
Theravectys SA
Institut Pasteur
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Priority claimed from EP07290980.7A external-priority patent/EP2020444B1/en
Priority claimed from EP07291251.2A external-priority patent/EP2047861B1/en
Application filed by Centre National de la Recherche Scientifique CNRS, Theravectys SA, Institut Pasteur filed Critical Centre National de la Recherche Scientifique CNRS
Publication of CN108114276A publication Critical patent/CN108114276A/zh
Pending legal-status Critical Current

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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C12N2740/10011—Retroviridae
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CN201511036366.5A 2007-08-03 2008-08-01 慢病毒基因转移载体及其医学应用 Pending CN108114276A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP07290980.7 2007-08-03
EP07290980.7A EP2020444B1 (en) 2007-08-03 2007-08-03 Defective non-integrative lentiviral transfer vectors for vaccines
EP07290979 2007-08-03
EP07290979.9 2007-08-03
EP07291251.2A EP2047861B1 (en) 2007-10-12 2007-10-12 Lentiviral gene transfer vectors suitable for iterative administration and their medicinal applications
EP07291251.2 2007-10-12
EP08156405 2008-05-16
EP08156405.6 2008-05-16
CN200880110278.7A CN102083462B (zh) 2007-08-03 2008-08-01 慢病毒基因转移载体及其医学应用

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200880110278.7A Division CN102083462B (zh) 2007-08-03 2008-08-01 慢病毒基因转移载体及其医学应用

Publications (1)

Publication Number Publication Date
CN108114276A true CN108114276A (zh) 2018-06-05

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CN201511036366.5A Pending CN108114276A (zh) 2007-08-03 2008-08-01 慢病毒基因转移载体及其医学应用
CN200880110278.7A Active CN102083462B (zh) 2007-08-03 2008-08-01 慢病毒基因转移载体及其医学应用

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US (3) US8420104B2 (enExample)
EP (1) EP2185192B1 (enExample)
JP (3) JP5773648B2 (enExample)
CN (2) CN108114276A (enExample)
AU (1) AU2008285224B2 (enExample)
BR (1) BRPI0813194B8 (enExample)
CA (1) CA2695433C (enExample)
DK (1) DK2185192T3 (enExample)
ES (1) ES2708856T3 (enExample)
HK (1) HK1252608A1 (enExample)
IL (1) IL243569A (enExample)
MX (2) MX342449B (enExample)
PT (1) PT2185192T (enExample)
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Cited By (4)

* Cited by examiner, † Cited by third party
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CN108040484A (zh) * 2014-12-11 2018-05-15 巴斯德研究院 基于慢病毒载体的日本脑炎免疫原性组合物
CN113631703A (zh) * 2018-12-04 2021-11-09 西瑞恩生物科技股份有限公司 使用泊洛沙胺的病毒传导
CN115247190A (zh) * 2021-04-28 2022-10-28 沛尔生技医药股份有限公司 慢病毒包装系统、其所制得的慢病毒及经该慢病毒转导的细胞及其应用
US11993782B2 (en) 2021-04-28 2024-05-28 PELL Bio-Med Technology Co., Ltd. Lentivirus packaging system, lentivirus produced by the same, cell transduced by the lentivirus, method for improving lentivirus production in a host cell, and method of using the cell for treating cancer

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
AU2008285224B2 (en) 2007-08-03 2015-01-22 Centre National De La Recherche Scientifique (Cnrs) Lentiviral gene transfer vectors and their medicinal applications
WO2010129602A2 (en) * 2009-05-04 2010-11-11 Fred Hutchinson Cancer Research Center Cocal vesiculovirus envelope pseudotyped retroviral vectors
EP2366776A1 (en) * 2010-03-01 2011-09-21 Epixis A method for measuring viral infectivity
EP2385107B1 (en) 2010-05-03 2016-08-24 Institut Pasteur Lentiviral vector based immunological compounds against malaria
EP2666477A1 (en) 2012-05-23 2013-11-27 Theravectys Lentiviral vectors containing an MHC class I promoter
WO2011147622A1 (en) 2010-05-26 2011-12-01 Deutsches Rheuma-Forschungszentrum Berlin Antigen-presenting modified naïve b cells for immune suppression and a method for producing said modified cells
CN102277380B (zh) * 2010-06-08 2013-03-27 齐鲁制药有限公司 一种dhfr互补表达的共转染真核表达载体及其制备方法与应用
CA2803543A1 (en) 2010-06-25 2011-12-29 Omarco Network Solutions Limited Security improvements for flexible substrates
US9403880B2 (en) 2010-11-26 2016-08-02 Institut Pasteur Identification of a human gyrovirus and applications
EP3632463A1 (en) 2011-04-08 2020-04-08 Immune Design Corp. Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
EP2788477A2 (en) 2011-12-07 2014-10-15 Institut Pasteur Identification of a swine parecho-like virus and applications
GB201202516D0 (en) 2012-02-13 2012-03-28 Ucl Business Plc Materials and methods relating to packaging cell lines
WO2013140169A1 (en) * 2012-03-20 2013-09-26 Isis Innovation Limited Immunogenic composition and methods of use thereof
US9713635B2 (en) 2012-03-30 2017-07-25 Immune Design Corp. Materials and methods for producing improved lentiviral vector particles
ES2707288T3 (es) 2012-03-30 2019-04-03 Immune Design Corp Partículas de vectores lentivíricos que tienen eficiencia de transducción mejorada para células que expresan DC-SIGN
US20150182617A1 (en) 2012-07-25 2015-07-02 Theravectys Glycoproteins for pseudotyping lentivectors
FR2996856B1 (fr) * 2012-10-15 2015-06-05 Agronomique Inst Nat Rech Novirhabdovirus recombinant utilisable comme vecteur d'antigenes
EP2931903B1 (en) * 2012-12-14 2021-07-28 The Regents of the University of California Viral vector nanocapsule for targeting gene therapy and its preparation
SG11201509743WA (en) * 2013-06-03 2015-12-30 Theravectys Lentiviral vectors containing an mhc class i, mhc class ii, or beta-2 microglobulin upstream promoter sequence
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
EP3009144A1 (en) * 2014-10-15 2016-04-20 Theravectys Lentiviral vectors for inducing CD4+ and CD8+ immune responses in vaccination of humans
WO2015063707A1 (en) * 2013-10-31 2015-05-07 Theravectys LENTIVIRAL VECTORS FOR INDUCING CD4+ and CD8+ IMMUNE RESPONSES IN VACCINATION OF HUMANS
EP2878674A1 (en) * 2013-11-28 2015-06-03 Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) Stable episomes based on non-integrative lentiviral vectors
EP2878667A1 (en) 2013-11-29 2015-06-03 Institut Pasteur TAL effector means useful for partial or full deletion of DNA tandem repeats
CA2937741A1 (en) 2014-01-27 2015-07-30 Theravectys Lentiviral vectors for generating immune responses against human t lymphotrophic virus type 1
EP3113795B1 (en) * 2014-03-01 2019-07-10 The Board of Regents of The University of Texas System Recombinant isfahan viral vectors
KR20170045344A (ko) 2014-09-07 2017-04-26 셀렉타 바이오사이언시즈, 인크. 항-바이러스 전달 벡터 면역 반응을 약화시키기 위한 방법 및 조성물
EP3211003A1 (en) 2016-02-24 2017-08-30 Institut Pasteur T cell receptors from the hiv-specific repertoire, means for their production and therapeutic uses thereof
US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
WO2017180587A2 (en) 2016-04-11 2017-10-19 Obsidian Therapeutics, Inc. Regulated biocircuit systems
US11185555B2 (en) 2016-04-11 2021-11-30 Noah James Harrison Method to kill pathogenic microbes in a patient
EP3235828A1 (en) 2016-04-21 2017-10-25 Genethon Stable pseudotyped lentiviral particles and uses thereof
JP6982001B2 (ja) * 2016-05-13 2021-12-17 フラッシュ セラピューティクス ゲノム工学システムのカプシド形成のための粒子
CN106399376A (zh) * 2016-08-31 2017-02-15 河南省华隆生物技术有限公司 一种整合缺陷型慢病毒载体、其制备方法及应用
AU2018205496A1 (en) 2017-01-07 2019-07-25 Selecta Biosciences, Inc. Patterned dosing of immunosuppressants coupled to synthetic nanocarriers
US20190367944A1 (en) 2017-01-30 2019-12-05 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Recombinant virus vectors for the treatment of glycogen storage disease
WO2018165631A1 (en) 2017-03-09 2018-09-13 President And Fellows Of Harvard College Cancer vaccine
PL3601367T3 (pl) 2017-03-30 2025-03-31 The University Of Queensland Cząsteczki chimeryczne i ich zastosowania
FR3065967B1 (fr) * 2017-05-05 2022-06-03 Univ Paris Descartes Procede in vitro de detection et de quantification de l'adn du vih-2
JP2020534795A (ja) 2017-07-28 2020-12-03 プレジデント アンド フェローズ オブ ハーバード カレッジ ファージによって支援される連続的進化（ｐａｃｅ）を用いて塩基編集因子を進化させるための方法および組成物
US12076369B2 (en) 2017-09-01 2024-09-03 The Frances Crick Institute Limited Immunoregulatory molecules and uses therefor
EP4446337A3 (en) 2017-09-22 2025-01-08 Centre National de la Recherche Scientifique Mutated glycoprotein of vesicular stomatitis virus
KR102215475B1 (ko) * 2017-09-28 2021-02-15 주식회사 탠덤 암 치료용 신규 재조합 원형질막-기반 소포체
JP6994714B2 (ja) 2017-10-03 2022-01-14 東亞合成株式会社 抗ウイルス性ペプチドおよびその利用
BR112020007157A2 (pt) 2017-10-13 2020-09-24 Selecta Biosciences, Inc. métodos e composições para a atenuação de respostas de igm antivetor de transferência viral
CN111225682A (zh) * 2017-10-20 2020-06-02 吉尼松公司 合胞素用于将药物和基因靶向递送至肺组织的用途
AU2018365296B2 (en) 2017-11-09 2023-11-23 Institut Pasteur A Zika virus chimeric polyepitope comprising non-structural proteins and its use in an immunogenic composition
CN112384204B (zh) 2018-02-26 2023-03-14 安托瑞斯公司 致耐受性脂质体及其使用方法
JP6917942B2 (ja) 2018-04-11 2021-08-11 株式会社日立製作所 データ分析サーバ、データ分析システム、及びデータ分析方法
CN110577585A (zh) * 2018-06-07 2019-12-17 中国医学科学院基础医学研究所 水泡型口炎病毒包膜糖蛋白变体及其构建方法和应用
EP3806888B1 (en) 2018-06-12 2024-01-31 Obsidian Therapeutics, Inc. Pde5 derived regulatory constructs and methods of use in immunotherapy
US20210386788A1 (en) 2018-10-24 2021-12-16 Obsidian Therapeutics, Inc. Er tunable protein regulation
US12351837B2 (en) 2019-01-23 2025-07-08 The Broad Institute, Inc. Supernegatively charged proteins and uses thereof
CN113966397A (zh) 2019-03-08 2022-01-21 黑曜石疗法公司 人碳酸酐酶2组合物和用于可调调节的方法
EP3708176A1 (en) * 2019-03-15 2020-09-16 Centre National De La Recherche Scientifique -Cnrs- Mutant vsv ectodomain polypeptide and uses thereof
WO2020214842A1 (en) 2019-04-17 2020-10-22 The Broad Institute, Inc. Adenine base editors with reduced off-target effects
JP2022531201A (ja) 2019-04-28 2022-07-06 セレクタ バイオサイエンシーズ インコーポレーテッド ウイルス導入ベクターに対する既存の免疫を伴う対象の処置のための方法
WO2020227515A1 (en) 2019-05-07 2020-11-12 Voyager Therapeutics, Inc. Compositions and methods for the vectored augmentation of protein destruction, expression and/or regulation
AU2020284555A1 (en) 2019-05-28 2021-12-23 Selecta Biosciences, Inc. Methods and compositions for attenuated anti-viral transfer vector immune response
JP2022536364A (ja) 2019-06-13 2022-08-15 ザ ジェネラル ホスピタル コーポレイション 操作されたヒト内在性ウイルス様粒子および細胞への送達のためのその使用方法
EP3770264A1 (en) 2019-07-22 2021-01-27 Genethon Precise integration using nuclease targeted idlv
US20230092895A1 (en) 2019-08-30 2023-03-23 Obsidian Therapeutics, Inc. Tandem cd19 car-based compositions and methods for immunotherapy
WO2021046451A1 (en) 2019-09-06 2021-03-11 Obsidian Therapeutics, Inc. Compositions and methods for dhfr tunable protein regulation
US20210332448A1 (en) * 2020-03-09 2021-10-28 Janssen Pharmaceutica Nv Compositions and methods for quantifying integration of recombinant vector nucleic acid
CN111593073B (zh) * 2020-03-18 2022-03-08 睿丰康生物医药科技(浙江)有限公司 双报告基因骨架载体、四质粒假病毒包装系统、包装新冠肺炎假病毒
WO2021188996A1 (en) * 2020-03-20 2021-09-23 The Broad Institute, Inc. Compositions and methods for enhanced lentiviral production
WO2022020800A2 (en) 2020-07-24 2022-01-27 The General Hospital Corporation Enhanced virus-like particles and methods of use thereof for delivery to cells
US20230323394A1 (en) * 2020-09-01 2023-10-12 The Trustees Of The University Of Pennsylvania Improved generation of lentiviral vectors for t cell transduction using cocal envelope
KR102379144B1 (ko) * 2020-09-29 2022-03-28 한국표준과학연구원 SARS-CoV-2의 RNA 표준물질 및 이를 이용한 코로나19바이러스(SARS-CoV-2) 감염 진단 정보의 제공방법
KR102283733B1 (ko) * 2020-12-22 2021-08-02 한국표준과학연구원 ＣＯＶＩＤ-19 바이러스 진단을 위한, ＳＡＲＳ-ＣｏＶ-2 포장 ＲＮＡ 표준물질, 이의 제조방법 및 이의 용도
EP4284931A4 (en) * 2021-01-28 2025-06-04 The Broad Institute, Inc. Compositions and methods for cargo delivery to a target cell
CN114107393A (zh) 2021-04-07 2022-03-01 上海劲威生物科技有限公司 一种治疗乙型肝炎的慢病毒载体、慢病毒颗粒及其制备方法和应用
WO2022235929A1 (en) 2021-05-05 2022-11-10 Radius Pharmaceuticals, Inc. Animal model having homologous recombination of mouse pth1 receptor
AU2022301302A1 (en) 2021-07-01 2024-01-25 Indapta Therapeutics, Inc. Engineered natural killer (nk) cells and related methods
WO2023019225A2 (en) 2021-08-11 2023-02-16 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions
AU2022326565A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy
JP2024534771A (ja) 2021-08-11 2024-09-26 サナ バイオテクノロジー，インコーポレイテッド 補体媒介性炎症反応を低減するための同種異系細胞療法のための遺伝子改変細胞
MX2024001208A (es) 2021-08-11 2024-04-22 Sana Biotechnology Inc Celulas primarias geneticamente modificadas para terapia celular alogenica.
WO2023064367A1 (en) 2021-10-12 2023-04-20 Selecta Biosciences, Inc. Methods and compositions for attenuating anti-viral transfer vector igm responses
CA3238020A1 (en) * 2021-11-15 2023-05-19 Theravectys Lentiviral vectors for expression of human papillomavirus (hpv) antigens and its implementation in the treatment of hpv induced cancers
CN114181972A (zh) * 2021-11-23 2022-03-15 上海本导基因技术有限公司 适用于难治性血管新生性眼疾病基因治疗的慢病毒载体
US20250009802A1 (en) 2021-12-16 2025-01-09 Ludwig Institute For Cancer Research Ltd Antisense transfer vectors and methods of use thereof
EP4463135A2 (en) 2022-01-10 2024-11-20 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
EP4473097A1 (en) 2022-02-02 2024-12-11 Sana Biotechnology, Inc. Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses
AU2023220128A1 (en) 2022-02-17 2024-08-22 Sana Biotechnology, Inc. Engineered cd47 proteins and uses thereof
US20230357437A1 (en) 2022-03-09 2023-11-09 Selecta Biosciences, Inc. Immunosuppressants in combination with anti-igm agents and related dosing
WO2023173123A1 (en) 2022-03-11 2023-09-14 Sana Biotechnology, Inc. Genetically modified cells and compositions and uses thereof
CA3259982A1 (en) 2022-06-30 2024-01-04 Indapta Therapeutics, Inc. COMBINATION OF MODIFIED NATURAL KILLER (NK) CELLS AND ANTIBODY THERAPY AND ASSOCIATED METHODS
WO2024026377A1 (en) 2022-07-27 2024-02-01 Sana Biotechnology, Inc. Methods of transduction using a viral vector and inhibitors of antiviral restriction factors
EP4561619A1 (en) * 2022-07-27 2025-06-04 Theravectys Lentiviral vectors for expression of human papillomavirus (hpv) antigens and its implementation in the treatment of hpv induced cancers
CN116024269B (zh) * 2022-11-18 2024-02-02 复百澳(苏州)生物医药科技有限公司 一种冠状病毒假病毒颗粒的制备方法
WO2024129696A1 (en) 2022-12-12 2024-06-20 Retromer Therapeutics Corp. Aav and lentiviral constructs comprising a sorl1 mini-gene for use in treating neurodegenerative diseases
WO2024151541A1 (en) 2023-01-09 2024-07-18 Sana Biotechnology, Inc. Type-1 diabetes autoimmune mouse
CN120187857A (zh) * 2023-01-10 2025-06-20 南京传奇生物科技有限公司 调控序列及其用途
WO2024178386A1 (en) 2023-02-24 2024-08-29 Aarhus Universitet Methods of treating endosomal trafficking diseases
CN121001739A (zh) * 2023-04-13 2025-11-21 深圳市济因生物科技有限公司 一种载体及其应用
US20240390474A1 (en) * 2023-04-27 2024-11-28 Genvivo, Inc. Compositions and methods for therapeutic or vaccine delivery
WO2024229302A1 (en) 2023-05-03 2024-11-07 Sana Biotechnology, Inc. Methods of dosing and administration of engineered islet cells
WO2024243236A2 (en) 2023-05-22 2024-11-28 Sana Biotechnology, Inc. Methods of delivery of islet cells and related methods
US12403194B2 (en) 2023-09-25 2025-09-02 Kelonia Therapeutics, Inc. Compositions for treating cancer
CN119639818A (zh) * 2025-02-18 2025-03-18 南京市计量监督检测院 一种假病毒颗粒的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1840204A (zh) * 1999-10-11 2006-10-04 巴斯德研究所 用于制备免疫治疗性组合物的慢病毒载体

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001092508A1 (en) * 2000-06-01 2001-12-06 Dnavec Research Inc. Pseudo-type retrovirus vector containing membrane protein having hemagglutinin activity
WO2002022080A2 (en) 2000-09-15 2002-03-21 Merck & Co., Inc. Enhanced first generation adenovirus vaccines expressing codon optimized hiv1-gag, pol, nef and modifications
US7575924B2 (en) * 2000-11-13 2009-08-18 Research Development Foundation Methods and compositions relating to improved lentiviral vectors and their applications
ATE426035T1 (de) 2001-05-03 2009-04-15 Fit Biotech Oy Neue expressionsvektoren und deren verwendungen
CN100557023C (zh) 2001-06-08 2009-11-04 株式会社载体研究所 利用vsv-g假型化猴免疫缺陷病毒载体将基因导入灵长类胚胎干细胞
CN1606625A (zh) 2001-10-31 2005-04-13 南非医学研究会 Hiv－1亚型分离株调节/附加基因及其修饰物和衍生物
WO2004110485A1 (en) * 2003-06-13 2004-12-23 Palmowski Michael J Materials and methods for improved vaccination
EP1678292A4 (en) 2003-09-18 2008-05-07 Univ Emory IMPROVED MVA VACCINES
FR2872170B1 (fr) 2004-06-25 2006-11-10 Centre Nat Rech Scient Cnrse Lentivirus non interactif et non replicatif, preparation et utilisations
AU2005293568B2 (en) * 2004-10-13 2010-10-28 Beth Israel Deaconess Medical Center Inc. Improved adenoviral vectors and uses thereof
JP2008539796A (ja) * 2005-05-20 2008-11-20 バイレクシス コーポレイション 初代細胞の形質導入
EP1885186B1 (en) * 2005-06-01 2015-09-02 California Institute Of Technology Method of targeted gene delivery using viral vectors
ES2281252B1 (es) * 2005-07-27 2009-02-16 Consejo Superior De Investigaciones Cientificas Vectores recombinantes basados en el virus modificado de ankara (mva) como vacunas preventivas y terapeuticas contra el sida.
WO2007054792A1 (en) 2005-11-08 2007-05-18 South African Medical Research Council Chimaeric hiv-1 subtype c gag-virus-like particles
JP2009520790A (ja) 2005-12-21 2009-05-28 グラクソ グループ リミテッド 免疫応答を惹起する方法
GB0526211D0 (en) 2005-12-22 2006-02-01 Oxford Biomedica Ltd Viral vectors
WO2007091066A1 (en) 2006-02-07 2007-08-16 Ucl Business Plc Applications of non-integrating lentiviral vectors
AU2008285224B2 (en) * 2007-08-03 2015-01-22 Centre National De La Recherche Scientifique (Cnrs) Lentiviral gene transfer vectors and their medicinal applications

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1840204A (zh) * 1999-10-11 2006-10-04 巴斯德研究所 用于制备免疫治疗性组合物的慢病毒载体

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DONATELLA RM NEGRI等: "Successful Immunization with a Single Injection of Non-integrating Lentiviral Vector", 《MOLECULAR THERAPY》 *
NICOLA J. PHILPOTT等: "Use of Nonintegrating Lentiviral Vectors for Gene Therapy", 《HUMAN GENE THERAPY》 *
RENATA STRIPECKE等: "The use of lentiviral vectors in gene therapy of leukemia: combinatorial gene delivery of immunomodulators into leukemia cells by state-of-the-art vectors", 《BLOOD CELLS, MOLECULES, AND DISEASES》 *
VIVIANA BUFFA等: "Evaluation of a Self-Inactivating Lentiviral Vector Expressing Simian Immunodeficiency Virus Gag for Induction of Specific Immune Responses in Vitro and in Vivo", 《VIRAL IMMUNOLOGY》 *
WEI WANG等: "A Role for Nuclear Factor I in the Intrinsic Control of Cerebellar Granule Neuron Gene Expression", 《THE JOURNAL OF BIOLOGICAL CHEMISTRY》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108040484A (zh) * 2014-12-11 2018-05-15 巴斯德研究院 基于慢病毒载体的日本脑炎免疫原性组合物
CN113631703A (zh) * 2018-12-04 2021-11-09 西瑞恩生物科技股份有限公司 使用泊洛沙胺的病毒传导
CN115247190A (zh) * 2021-04-28 2022-10-28 沛尔生技医药股份有限公司 慢病毒包装系统、其所制得的慢病毒及经该慢病毒转导的细胞及其应用
US11993782B2 (en) 2021-04-28 2024-05-28 PELL Bio-Med Technology Co., Ltd. Lentivirus packaging system, lentivirus produced by the same, cell transduced by the lentivirus, method for improving lentivirus production in a host cell, and method of using the cell for treating cancer

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