CN108079257A - 一种肿瘤临床治疗的药物组合及其制备方法 - Google Patents

一种肿瘤临床治疗的药物组合及其制备方法 Download PDF

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CN108079257A
CN108079257A CN201810063474.9A CN201810063474A CN108079257A CN 108079257 A CN108079257 A CN 108079257A CN 201810063474 A CN201810063474 A CN 201810063474A CN 108079257 A CN108079257 A CN 108079257A
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vinegar
pharmaceutical composition
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刘宁
吕静
齐卫卫
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Affiliated Hospital of University of Qingdao
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Abstract

本发明公开了一种肿瘤临床治疗的药物组合，包括下列重量份的原料：桑黄1‑5份、赤芝1‑10份、红豆杉0.5‑3份、丹参1‑5份、莪术0.2‑2份、山楂0.5‑6份、茯苓5‑10份、人参2‑6份、白术3‑5份、三七0.5‑6份、麦芽0.1‑2份、夏枯草1‑5份、青藤香1‑5份、蜘蛛香0.2‑1份、白花蛇舌草1‑3份、醋制制鳖甲0.3‑2份、山茨菇0.5‑3份、白芍2‑5份、甘草3‑10份、醋制干蟾皮0.3‑3份、壁虎0.2‑3份、水蛭0.3‑6份、醋制土鳖虫0.3‑7份、制蜈蚣0.5‑3份、制马钱子0.1‑1份、金银花1‑5份、半枝莲2‑6份、当归1‑5份、乳香0.3‑2份、没药0.3‑5份、白花蛇舌草1‑6份、天龙2‑5份、灵芝0.3‑4份、冰片0.2‑3份、猫爪草0.2‑6份、石斛1‑5份，本发明配方多样，原料多样，有效遏制肿瘤的生长，药效显著，疗效好，能够有效的治疗肿瘤疾病。

Description

一种肿瘤临床治疗的药物组合及其制备方法
技术领域
本发明涉及肿瘤临床治疗技术领域，具体是一种肿瘤临床治疗的药物组合及其制备方法。
背景技术
肿瘤是指机体在各种致瘤因子作用下，局部组织细胞增生所形成的新生物，因为这种新生物多呈占位性块状突起，也称赘生物。
根据新生物的细胞特性及对机体的危害性程度，又将肿瘤分为良性肿瘤和恶性肿瘤两大类，白血病是一种血液系统的恶性肿瘤，它是由骨髓中某型未成熟的白细胞弥漫性恶性生长，取代正常骨髓组织并进入血液中形成的。因在患者的血液中出现大量的这种肿瘤性白细胞，以致血液呈现乳糜样颜色的特征，因此人们便称它为白血病，在极大多数病例中，血液白细胞数量明显增多，但有时也可正常甚至减少。按白血病细胞的类型，可分为粒细胞型、淋巴细胞型、单核细胞型等3种。另外，一如上述，医生是根据肿瘤的病理学形态、生长方式以及对病人的危害程度，将肿瘤分为恶性和良性两大类的。
抗肿瘤药物为治疗肿瘤疾病的一类药物。近年来，分子肿瘤学、分子药理学的发展使肿瘤本质正在逐步阐明；大规模快速筛选、组合化学、基因工程等先进技术的发明和应用加速了药物开发进程；抗肿瘤药物的研究与开发已进入一个崭新的时代。当今抗肿瘤药物的发展战略有以下几点：（1）以占恶性肿瘤90%以上的实体瘤为主攻对象；（2）从天然产物中寻找活性成分；（3）针对肿瘤发生发展的机制，寻找新的分子作用靶点（酶、受体、基因等）；（4）大规模快速筛选；（5）新技术的导入和应用：组合化学、结构生物学、计算机辅助设计、基因工程、DNA芯片、药物基因组学（功能基因组学与药理学结合）等，现在治疗肿瘤的药物一般都为西药，但是治疗效果不佳，不能满足现在的使用要求。
发明内容
本发明的目的在于提供一种肿瘤临床治疗的药物组合及其制备方法，以解决上述背景技术中提出的问题。
为实现上述目的，本发明提供如下技术方案：
一种肿瘤临床治疗的药物组合，包括下列重量份的原料：桑黄1-5份、赤芝1-10份、红豆杉0.5-3份、丹参1-5份、莪术0.2-2份、山楂0.5-6份、茯苓5-10份、人参2-6份、白术3-5份、三七0.5-6份、麦芽0.1-2份、夏枯草1-5份、青藤香1-5份、蜘蛛香0.2-1份、白花蛇舌草1-3份、醋制制鳖甲0.3-2份、山茨菇0.5-3份、白芍2-5份、甘草3-10份、醋制干蟾皮0.3-3份、壁虎0.2-3份、水蛭0.3-6份、醋制土鳖虫0.3-7份、制蜈蚣0.5-3份、制马钱子0.1-1份、金银花1-5份、半枝莲2-6份、当归1-5份、乳香0.3-2份、没药0.3-5份、白花蛇舌草1-6份、天龙2-5份、灵芝0.3-4份、冰片0.2-3份、猫爪草0.2-6份、石斛1-5份。
作为本发明进一步的方案：包括下列重量份的原料：桑黄2份、赤芝3份、红豆杉4份、丹参2份、莪术0.5份、山楂0.8份、茯苓6份、人参3份、白术3份、三七1份、麦芽0.2份、夏枯草2份、青藤香3份、蜘蛛香0.4份、白花蛇舌草1份、醋制制鳖甲0.5份、山茨菇0.5份、白芍3份、甘草4份、醋制干蟾皮0.5份、壁虎0.3份、水蛭0.6份、醋制土鳖虫0.5份、制蜈蚣0.5份、制马钱子0.2份、金银花2份、半枝莲3份、当归2份、乳香1份、没药1份、白花蛇舌草4份、天龙3份、灵芝1份、冰片1份、猫爪草0.5份、石斛3份。
作为本发明进一步的方案：包括下列重量份的原料：桑黄1份、赤芝2份、红豆杉1份、丹参3份、莪术1份、山楂5份、茯苓7份、人参3份、白术4份、三七3份、麦芽1份、夏枯草4份、青藤香5份、蜘蛛香0.6份、白花蛇舌草5份、醋制制鳖甲0.8份、山茨菇0.9份、白芍3份、甘草6份、醋制干蟾皮0.6份、壁虎0.4份、水蛭0.6份、醋制土鳖虫0.8份、制蜈蚣0.9份、制马钱子0.8份、金银花3份、半枝莲5份、当归4份、乳香0.9份、没药0.8份、白花蛇舌草5份、天龙4份、灵芝0.9份、冰片0.9份、猫爪草0.9份、石斛4份。
作为本发明进一步的方案：所述桑黄的炮制方法为：除去杂质，晒干，用时捣碎成粉末。
作为本发明进一步的方案：所述丹参的炮制方法为：除去杂质和残茎，洗净，润透，切厚片，干燥。
作为本发明进一步的方案：所述莪术的炮制方法为：挖掘根部，除去根茎上莪术的泥土，洗净，置锅里蒸或煮约15分钟，晒干或烘干，去除须根即成。
作为本发明进一步的方案：所述茯苓的炮制方法为：取茯苓若干，浸泡，洗净，润后蒸煮，削去外皮，切制成块或切厚片，晒干。
作为本发明进一步的方案：所述夏枯草的炮制方法为：当6月份植株果穗80%现黄渐变成棕褐色时，在晴天挤蔸割下或将果穗割回晒干收籽，干草及干果穗分别储藏。
作为本发明进一步的方案：所述金银花的炮制方法为：5、6月间采收，择晴天早晨露水刚干时摘取花蕾，置于芦席、石棚或场上雄开晾晒或通风阴干，在1-22天内晒干，至九成干时，拣去枝叶杂质，忌在烈日下曝晒，阴天可微火烘干，但花色较暗，不如晒干或阴干为佳。
一种如所述的肿瘤临床治疗的药物组合的制备方法，包括下列步骤：首先秤取定量的各分原料，放入蒸煮釜中进行煎药，加入药材质量的50-200倍的水，首先武火煎煮40-60分钟，文火煎煮1-3小时，浓缩成汤药剂即可。
与现有技术相比，本发明的有益效果是：本发明配方多样，原料多样，通过多种不同中药材的使用，全面提高患者的各项身体机能，有效遏制肿瘤的生长，药效显著，疗效好，能够有效的治疗肿瘤疾病。
具体实施方式
下面将对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
本发明实施例中，一种肿瘤临床治疗的药物组合，包括下列重量份的原料：桑黄1-5份、赤芝1-10份、红豆杉0.5-3份、丹参1-5份、莪术0.2-2份、山楂0.5-6份、茯苓5-10份、人参2-6份、白术3-5份、三七0.5-6份、麦芽0.1-2份、夏枯草1-5份、青藤香1-5份、蜘蛛香0.2-1份、白花蛇舌草1-3份、醋制制鳖甲0.3-2份、山茨菇0.5-3份、白芍2-5份、甘草3-10份、醋制干蟾皮0.3-3份、壁虎0.2-3份、水蛭0.3-6份、醋制土鳖虫0.3-7份、制蜈蚣0.5-3份、制马钱子0.1-1份、金银花1-5份、半枝莲2-6份、当归1-5份、乳香0.3-2份、没药0.3-5份、白花蛇舌草1-6份、天龙2-5份、灵芝0.3-4份、冰片0.2-3份、猫爪草0.2-6份、石斛1-5份。
包括下列重量份的原料：桑黄2份、赤芝3份、红豆杉4份、丹参2份、莪术0.5份、山楂0.8份、茯苓6份、人参3份、白术3份、三七1份、麦芽0.2份、夏枯草2份、青藤香3份、蜘蛛香0.4份、白花蛇舌草1份、醋制制鳖甲0.5份、山茨菇0.5份、白芍3份、甘草4份、醋制干蟾皮0.5份、壁虎0.3份、水蛭0.6份、醋制土鳖虫0.5份、制蜈蚣0.5份、制马钱子0.2份、金银花2份、半枝莲3份、当归2份、乳香1份、没药1份、白花蛇舌草4份、天龙3份、灵芝1份、冰片1份、猫爪草0.5份、石斛3份。
包括下列重量份的原料：桑黄1份、赤芝2份、红豆杉1份、丹参3份、莪术1份、山楂5份、茯苓7份、人参3份、白术4份、三七3份、麦芽1份、夏枯草4份、青藤香5份、蜘蛛香0.6份、白花蛇舌草5份、醋制制鳖甲0.8份、山茨菇0.9份、白芍3份、甘草6份、醋制干蟾皮0.6份、壁虎0.4份、水蛭0.6份、醋制土鳖虫0.8份、制蜈蚣0.9份、制马钱子0.8份、金银花3份、半枝莲5份、当归4份、乳香0.9份、没药0.8份、白花蛇舌草5份、天龙4份、灵芝0.9份、冰片0.9份、猫爪草0.9份、石斛4份。
所述桑黄的炮制方法为：除去杂质，晒干，用时捣碎成粉末。
所述丹参的炮制方法为：除去杂质和残茎，洗净，润透，切厚片，干燥。
所述莪术的炮制方法为：挖掘根部，除去根茎上莪术的泥土，洗净，置锅里蒸或煮约15分钟，晒干或烘干，撞去须根即成。
所述茯苓的炮制方法为：取茯苓个，浸泡，洗净，润后稍蒸，及时削去外皮，切制成块或切厚片，晒干。
所述夏枯草的炮制方法为：当6月份植株果穗80%现黄渐变成棕褐色时，趁晴天可挤蔸割下或将果穗割回晒干收籽。干草及干果穗分别储藏。
所述金银花的炮制方法为：5、6月间采收，择晴天早晨露水刚干时摘取花蕾，置于芦席、石棚或场上雄开晾晒或通风阴干，以1-22天内晒干为好，晒花时切勿翻动，否则花色变黑而降低质量，至九成干，拣去枝叶杂质即可，忌在烈日下曝晒。阴天可微火烘干，但花色较暗，不如晒干或阴干为佳。
一种肿瘤临床治疗的药物组合的制备方法，包括下列步骤：首先秤取定量的各分原料，放入蒸煮釜中进行煎药，加入药材质量的50-200倍的水，首先武火煎煮40-60分钟，文火煎煮1-3小时，浓缩成汤药剂即可。
本发明配方多样，原料多样，通过多种不同中药材的使用，全面提高患者的各项身体机能，有效遏制肿瘤的生长，药效显著，疗效好，能够有效的治疗各类肿瘤疾病。
对于本领域技术人员而言，显然本发明不限于上述示范性实施例的细节，而且在不背离本发明的精神或基本特征的情况下，能够以其他的具体形式实现本发明。因此，无论从哪一点来看，均应将实施例看作是示范性的，而且是非限制性的，本发明的范围由所附权利要求而不是上述说明限定，因此旨在将落在权利要求的等同要件的含义和范围内的所有变化囊括在本发明内。
此外，应当理解，虽然本说明书按照实施方式加以描述，但并非每个实施方式仅包含一个独立的技术方案，说明书的这种叙述方式仅仅是为清楚起见，本领域技术人员应当将说明书作为一个整体，各实施例中的技术方案也可以经适当组合，形成本领域技术人员可以理解的其他实施方式。

Claims (10)

1.一种肿瘤临床治疗的药物组合，其特征在于，包括下列重量份的原料：桑黄1-5份、赤芝1-10份、红豆杉0.5-3份、丹参1-5份、莪术0.2-2份、山楂0.5-6份、茯苓5-10份、人参2-6份、白术3-5份、三七0.5-6份、麦芽0.1-2份、夏枯草1-5份、青藤香1-5份、蜘蛛香0.2-1份、白花蛇舌草1-3份、醋制制鳖甲0.3-2份、山茨菇0.5-3份、白芍2-5份、甘草3-10份、醋制干蟾皮0.3-3份、壁虎0.2-3份、水蛭0.3-6份、醋制土鳖虫0.3-7份、制蜈蚣0.5-3份、制马钱子0.1-1份、金银花1-5份、半枝莲2-6份、当归1-5份、乳香0.3-2份、没药0.3-5份、白花蛇舌草1-6份、天龙2-5份、灵芝0.3-4份、冰片0.2-3份、猫爪草0.2-6份、石斛1-5份。
2.根据权利要求1所述的肿瘤临床治疗的药物组合，其特征在于，包括下列重量份的原料：桑黄2份、赤芝3份、红豆杉4份、丹参2份、莪术0.5份、山楂0.8份、茯苓6份、人参3份、白术3份、三七1份、麦芽0.2份、夏枯草2份、青藤香3份、蜘蛛香0.4份、白花蛇舌草1份、醋制制鳖甲0.5份、山茨菇0.5份、白芍3份、甘草4份、醋制干蟾皮0.5份、壁虎0.3份、水蛭0.6份、醋制土鳖虫0.5份、制蜈蚣0.5份、制马钱子0.2份、金银花2份、半枝莲3份、当归2份、乳香1份、没药1份、白花蛇舌草4份、天龙3份、灵芝1份、冰片1份、猫爪草0.5份、石斛3份。
3.根据权利要求1所述的肿瘤临床治疗的药物组合，其特征在于，包括下列重量份的原料：桑黄1份、赤芝2份、红豆杉1份、丹参3份、莪术1份、山楂5份、茯苓7份、人参3份、白术4份、三七3份、麦芽1份、夏枯草4份、青藤香5份、蜘蛛香0.6份、白花蛇舌草5份、醋制制鳖甲0.8份、山茨菇0.9份、白芍3份、甘草6份、醋制干蟾皮0.6份、壁虎0.4份、水蛭0.6份、醋制土鳖虫0.8份、制蜈蚣0.9份、制马钱子0.8份、金银花3份、半枝莲5份、当归4份、乳香0.9份、没药0.8份、白花蛇舌草5份、天龙4份、灵芝0.9份、冰片0.9份、猫爪草0.9份、石斛4份。
4.根据权利要求1所述的肿瘤临床治疗的药物组合，其特征在于，所述桑黄的炮制方法为：除去杂质，晒干，用时捣碎成粉末。
5.根据权利要求1所述的肿瘤临床治疗的药物组合，其特征在于，所述丹参的炮制方法为：除去杂质和残茎，洗净，润透，切厚片，干燥。
6.根据权利要求1所述的肿瘤临床治疗的药物组合，其特征在于，所述莪术的炮制方法为：挖掘根部，除去根茎上莪术的泥土，洗净，置锅里蒸或煮约15分钟，晒干或烘干，去除须根即成。
7.根据权利要求1所述的肿瘤临床治疗的药物组合，其特征在于，所述茯苓的炮制方法为：取茯苓若干，浸泡，洗净，润后蒸煮，削去外皮，切制成块或切厚片，晒干。
8.根据权利要求1所述的肿瘤临床治疗的药物组合，其特征在于，所述夏枯草的炮制方法为：当6月份植株果穗80%现黄渐变成棕褐色时，在晴天挤蔸割下或将果穗割回晒干收籽，干草及干果穗分别储藏。
9.根据权利要求1所述的肿瘤临床治疗的药物组合，其特征在于，所述金银花的炮制方法为：5、6月间采收，择晴天早晨露水刚干时摘取花蕾，置于芦席、石棚或场上雄开晾晒或通风阴干，在1-22天内晒干，至九成干时，拣去枝叶杂质。
10.一种如权利要求1所述的肿瘤临床治疗的药物组合的制备方法，其特征在于，包括下列步骤：首先秤取定量的各分原料，放入蒸煮釜中进行煎药，加入药材质量的50-200倍的水，首先武火煎煮40-60分钟，文火煎煮1-3小时，浓缩成汤药剂即可。
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