CN108066283A - 一种盐酸左倍他洛尔滴眼液的制备方法 - Google Patents
一种盐酸左倍他洛尔滴眼液的制备方法 Download PDFInfo
- Publication number
- CN108066283A CN108066283A CN201711461666.7A CN201711461666A CN108066283A CN 108066283 A CN108066283 A CN 108066283A CN 201711461666 A CN201711461666 A CN 201711461666A CN 108066283 A CN108066283 A CN 108066283A
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- CN
- China
- Prior art keywords
- hydrochloric acid
- eye drops
- preparation
- levobetaxolol
- injection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711461666.7A CN108066283B (zh) | 2017-12-28 | 2017-12-28 | 一种盐酸左倍他洛尔滴眼液的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711461666.7A CN108066283B (zh) | 2017-12-28 | 2017-12-28 | 一种盐酸左倍他洛尔滴眼液的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN108066283A true CN108066283A (zh) | 2018-05-25 |
CN108066283B CN108066283B (zh) | 2020-03-24 |
Family
ID=62155854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711461666.7A Active CN108066283B (zh) | 2017-12-28 | 2017-12-28 | 一种盐酸左倍他洛尔滴眼液的制备方法 |
Country Status (1)
Country | Link |
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CN (1) | CN108066283B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111689868A (zh) * | 2020-07-03 | 2020-09-22 | 山东省食品药品检验研究院 | 1-【(4-羟乙基)苯氧基】-3-(异丙基氨基)丙-2-醇的制备方法与应用 |
CN111732517A (zh) * | 2020-07-03 | 2020-10-02 | 山东省食品药品检验研究院 | 1-(4-(2-环丁氧基乙基)苯氧基)-3-(异丙基氨基)丙基-2-醇及制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000018316A2 (en) * | 1998-09-25 | 2000-04-06 | Alcon Laboratories, Inc. | Sustained release, and comfortable ophthalmic composition and method for ocular therapy |
WO2000024425A1 (en) * | 1998-10-27 | 2000-05-04 | Alcon Laboratories, Inc. | Preservative system for topically administrable pharmaceutical compositions |
WO2002040030A1 (en) * | 2000-11-16 | 2002-05-23 | Alcon Manufacturing, Ltd. | Combination therapy for lowering and controlling intraocular pressure |
CN1374873A (zh) * | 1999-09-21 | 2002-10-16 | 爱尔康实验室公司 | 用于提高局部药物组合物的抗菌效力的阴离子氨基酸基表面活性剂 |
US6743439B1 (en) * | 2001-06-27 | 2004-06-01 | Alcon, Inc. | Ophthalmic compositions containing copolymers of sulfonated styrene and maleic anhydride |
-
2017
- 2017-12-28 CN CN201711461666.7A patent/CN108066283B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000018316A2 (en) * | 1998-09-25 | 2000-04-06 | Alcon Laboratories, Inc. | Sustained release, and comfortable ophthalmic composition and method for ocular therapy |
WO2000024425A1 (en) * | 1998-10-27 | 2000-05-04 | Alcon Laboratories, Inc. | Preservative system for topically administrable pharmaceutical compositions |
CN1374873A (zh) * | 1999-09-21 | 2002-10-16 | 爱尔康实验室公司 | 用于提高局部药物组合物的抗菌效力的阴离子氨基酸基表面活性剂 |
WO2002040030A1 (en) * | 2000-11-16 | 2002-05-23 | Alcon Manufacturing, Ltd. | Combination therapy for lowering and controlling intraocular pressure |
US6743439B1 (en) * | 2001-06-27 | 2004-06-01 | Alcon, Inc. | Ophthalmic compositions containing copolymers of sulfonated styrene and maleic anhydride |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111689868A (zh) * | 2020-07-03 | 2020-09-22 | 山东省食品药品检验研究院 | 1-【(4-羟乙基)苯氧基】-3-(异丙基氨基)丙-2-醇的制备方法与应用 |
CN111732517A (zh) * | 2020-07-03 | 2020-10-02 | 山东省食品药品检验研究院 | 1-(4-(2-环丁氧基乙基)苯氧基)-3-(异丙基氨基)丙基-2-醇及制备方法 |
Also Published As
Publication number | Publication date |
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CN108066283B (zh) | 2020-03-24 |
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Legal Events
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PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20180913 Address after: 230088 30 Tian Zhi Road, hi tech Industrial Development Zone, Hefei, Anhui Applicant after: Zhaoke Pharmaceutical (Hefei) Co., Ltd. Address before: 511466 No. three virtue road three, Zhujiang Industrial Park, Nansha District, Guangzhou, Guangdong. Applicant before: ZHAOKE PHARMACEUTICAL (HONGKONG) CO., LTD. |
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TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20190308 Address after: 511466 Room 501, 5th Floor, Area A, No. 1 Meide No. 3 Road, Pearl River Industrial Park, Nansha District, Guangzhou City, Guangdong Province (Office only) Applicant after: Mega eye (Guangzhou) ophthalmic drug Co., Ltd. Address before: 230088 30 Tian Zhi Road, hi tech Industrial Development Zone, Hefei, Anhui Applicant before: Zhaoke Pharmaceutical (Hefei) Co., Ltd. |
|
GR01 | Patent grant | ||
GR01 | Patent grant |