CN107949388B - 吡咯并嘧啶激酶抑制剂的药用盐、物理形态和组合物及其制备方法 - Google Patents

吡咯并嘧啶激酶抑制剂的药用盐、物理形态和组合物及其制备方法 Download PDF

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CN107949388B
CN107949388B CN201680021771.6A CN201680021771A CN107949388B CN 107949388 B CN107949388 B CN 107949388B CN 201680021771 A CN201680021771 A CN 201680021771A CN 107949388 B CN107949388 B CN 107949388B
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pharmaceutically acceptable
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mixture
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CN107949388A (zh
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毛龙
刘佳
陈以乐
华宇宁
代孔恩
包益梅
翁波杰
莫小鹏
吴健
徐晓
徐万红
王小波
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Essen Pharmaceuticals
Hangzhou Acea Pharmaceutical Research Co Ltd
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Hangzhou Acea Medicine Research Co ltd
Essen Pharmaceuticals
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201680021771.6A 2015-10-09 2016-06-30 吡咯并嘧啶激酶抑制剂的药用盐、物理形态和组合物及其制备方法 Active CN107949388B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2015091536 2015-10-09
CNPCT/CN2015/091536 2015-10-09
PCT/CN2016/087857 WO2017059702A1 (en) 2015-10-09 2016-06-30 Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same

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CN107949388A CN107949388A (zh) 2018-04-20
CN107949388B true CN107949388B (zh) 2021-10-26

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EP (1) EP3359159B1 (enExample)
JP (1) JP6889494B2 (enExample)
KR (1) KR20180067584A (enExample)
CN (1) CN107949388B (enExample)
AR (1) AR106301A1 (enExample)
AU (1) AU2016334141B2 (enExample)
BR (1) BR112018006939A2 (enExample)
CA (1) CA3001744C (enExample)
MX (1) MX2018004332A (enExample)
RU (1) RU2018115334A (enExample)
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CN111848631B (zh) * 2020-08-28 2022-04-19 四川大学华西医院 一种靶向EGFR突变的吡咯并[2,3-d]嘧啶衍生物及其制备方法和用途
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BR112018006939A2 (en) 2018-10-16
EP3359159A1 (en) 2018-08-15
AU2016334141A1 (en) 2018-04-26
RU2018115334A (ru) 2019-11-11
AU2016334141B2 (en) 2019-12-19
EP3359159A4 (en) 2019-06-05
KR20180067584A (ko) 2018-06-20
US20180312510A1 (en) 2018-11-01
EP3359159B1 (en) 2023-06-07
CN107949388A (zh) 2018-04-20
US10533011B2 (en) 2020-01-14
MX2018004332A (es) 2019-01-10
WO2017059702A1 (en) 2017-04-13
AR106301A1 (es) 2018-01-03
JP6889494B2 (ja) 2021-06-18
HK1253537A1 (en) 2019-06-21
CA3001744C (en) 2024-09-27
TW201722431A (zh) 2017-07-01
RU2018115334A3 (enExample) 2019-11-29
CA3001744A1 (en) 2017-04-13
JP2018530610A (ja) 2018-10-18

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