BR112018006939A2 - pharmaceutical salts, physical forms, and compositions of pyrrole-pyrimidine kinase inhibitors, and methods for producing them - Google Patents

pharmaceutical salts, physical forms, and compositions of pyrrole-pyrimidine kinase inhibitors, and methods for producing them

Info

Publication number
BR112018006939A2
BR112018006939A2 BR112018006939-6A BR112018006939A BR112018006939A2 BR 112018006939 A2 BR112018006939 A2 BR 112018006939A2 BR 112018006939 A BR112018006939 A BR 112018006939A BR 112018006939 A2 BR112018006939 A2 BR 112018006939A2
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
compound
salt
pharmaceutically acceptable
mixture
Prior art date
Application number
BR112018006939-6A
Other languages
English (en)
Portuguese (pt)
Inventor
Mao Long
Liu Jia
Chen Yile
Hua Yuning
Dai Kongen
Bao Yimei
Weng Bojie
Mo Xiaopeng
Wu Jian
Xu Xiao
Xu Wanhong
Wang Xiaobo
Original Assignee
ACEA Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ACEA Therapeutics, Inc. filed Critical ACEA Therapeutics, Inc.
Publication of BR112018006939A2 publication Critical patent/BR112018006939A2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BR112018006939-6A 2015-10-09 2016-06-30 pharmaceutical salts, physical forms, and compositions of pyrrole-pyrimidine kinase inhibitors, and methods for producing them BR112018006939A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2015091536 2015-10-09
CNPCT/CN2015/091536 2015-10-09
PCT/CN2016/087857 WO2017059702A1 (en) 2015-10-09 2016-06-30 Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same

Publications (1)

Publication Number Publication Date
BR112018006939A2 true BR112018006939A2 (en) 2018-10-16

Family

ID=58487279

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018006939-6A BR112018006939A2 (en) 2015-10-09 2016-06-30 pharmaceutical salts, physical forms, and compositions of pyrrole-pyrimidine kinase inhibitors, and methods for producing them

Country Status (13)

Country Link
US (1) US10533011B2 (enExample)
EP (1) EP3359159B1 (enExample)
JP (1) JP6889494B2 (enExample)
KR (1) KR20180067584A (enExample)
CN (1) CN107949388B (enExample)
AR (1) AR106301A1 (enExample)
AU (1) AU2016334141B2 (enExample)
BR (1) BR112018006939A2 (enExample)
CA (1) CA3001744C (enExample)
MX (1) MX2018004332A (enExample)
RU (1) RU2018115334A (enExample)
TW (1) TW201722431A (enExample)
WO (1) WO2017059702A1 (enExample)

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Also Published As

Publication number Publication date
EP3359159A1 (en) 2018-08-15
AU2016334141A1 (en) 2018-04-26
RU2018115334A (ru) 2019-11-11
AU2016334141B2 (en) 2019-12-19
EP3359159A4 (en) 2019-06-05
KR20180067584A (ko) 2018-06-20
US20180312510A1 (en) 2018-11-01
EP3359159B1 (en) 2023-06-07
CN107949388A (zh) 2018-04-20
US10533011B2 (en) 2020-01-14
CN107949388B (zh) 2021-10-26
MX2018004332A (es) 2019-01-10
WO2017059702A1 (en) 2017-04-13
AR106301A1 (es) 2018-01-03
JP6889494B2 (ja) 2021-06-18
HK1253537A1 (en) 2019-06-21
CA3001744C (en) 2024-09-27
TW201722431A (zh) 2017-07-01
RU2018115334A3 (enExample) 2019-11-29
CA3001744A1 (en) 2017-04-13
JP2018530610A (ja) 2018-10-18

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