CN1079469A - 具有抗溃疡活性及组胺受体拮抗作用的噻唑衍生物的制备方法 - Google Patents

具有抗溃疡活性及组胺受体拮抗作用的噻唑衍生物的制备方法 Download PDF

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Publication number
CN1079469A
CN1079469A CN92114939A CN92114939A CN1079469A CN 1079469 A CN1079469 A CN 1079469A CN 92114939 A CN92114939 A CN 92114939A CN 92114939 A CN92114939 A CN 92114939A CN 1079469 A CN1079469 A CN 1079469A
Authority
CN
China
Prior art keywords
alkyl
compound
amino
general formula
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN92114939A
Other languages
English (en)
Chinese (zh)
Inventor
桂洋介
富士哲男
井上善一
高杉寿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of CN1079469A publication Critical patent/CN1079469A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN92114939A 1991-12-06 1992-12-05 具有抗溃疡活性及组胺受体拮抗作用的噻唑衍生物的制备方法 Pending CN1079469A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9125970.5 1991-12-06
GB919125970A GB9125970D0 (en) 1991-12-06 1991-12-06 New compounds

Publications (1)

Publication Number Publication Date
CN1079469A true CN1079469A (zh) 1993-12-15

Family

ID=10705819

Family Applications (1)

Application Number Title Priority Date Filing Date
CN92114939A Pending CN1079469A (zh) 1991-12-06 1992-12-05 具有抗溃疡活性及组胺受体拮抗作用的噻唑衍生物的制备方法

Country Status (14)

Country Link
US (1) US5532258A (enExample)
EP (1) EP0545376B1 (enExample)
JP (1) JP2531329B2 (enExample)
CN (1) CN1079469A (enExample)
AT (1) ATE170851T1 (enExample)
AU (1) AU666893B2 (enExample)
CA (1) CA2084640A1 (enExample)
DE (1) DE69226931T2 (enExample)
GB (1) GB9125970D0 (enExample)
HU (3) HU9203849D0 (enExample)
IL (1) IL103826A0 (enExample)
MX (1) MX9206930A (enExample)
TW (1) TW211565B (enExample)
ZA (1) ZA928876B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116406816A (zh) * 2021-12-31 2023-07-11 湖南中烟工业有限责任公司 一种水溶性芯材烟用爆珠及其制备方法
CN116406817A (zh) * 2021-12-31 2023-07-11 湖南中烟工业有限责任公司 一种水溶性芯材烟用爆珠材料及其制备方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4427539A1 (de) * 1994-08-04 1996-02-08 Sueddeutsche Kalkstickstoff Verfahren zur Herstellung von 2-Cyaniminothiazolidin
GB9416459D0 (en) * 1994-08-15 1994-10-05 Fujisawa Pharmaceutical Co New compounds
US6288091B1 (en) 1995-12-29 2001-09-11 Boehringer Ingelheim Ltd. Antiherpes virus compounds and methods for their preparation and use
NZ331104A (en) * 1995-12-29 2000-03-27 Boehringer Ingelheim Ca Ltd Phenyl thiazole derivatives that inhibit herpes replication by inhibiting the herpes helicase primase enzyme complex
DE19719053A1 (de) * 1997-05-06 1998-11-12 Bayer Ag Substituierte Aminothiazole
US6100282A (en) * 1998-01-02 2000-08-08 Hoffman-La Roche Inc. Thiazole derivatives
WO2003050261A2 (en) * 2001-12-10 2003-06-19 Bristol-Myers Squibb Company (1-phenyl-2-heteroaryl)ethyl-guanidine compounds as inhibitors of mitochondrial f1f0 atp hydrolase
DE102004008141A1 (de) * 2004-02-19 2005-09-01 Abbott Gmbh & Co. Kg Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54132566A (en) * 1978-01-18 1979-10-15 Ici Ltd Guanidine derivative*its manufacture and secretion controlling pharmaceutical composition containing it
CA1233818A (en) * 1981-03-09 1988-03-08 David J. Gilman Guanidine derivatives as histamine h-2 receptor antagonists
IT1200371B (it) * 1982-03-24 1989-01-18 Angeli Inst Spa Guanidino eterociclifenilamidine,processi per la loro preparazione e loro impiego farmaceutico
US4452985A (en) * 1983-02-14 1984-06-05 American Home Products Corporation 2-Guanyl-4-(substituted phenyl) thiazole derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116406816A (zh) * 2021-12-31 2023-07-11 湖南中烟工业有限责任公司 一种水溶性芯材烟用爆珠及其制备方法
CN116406817A (zh) * 2021-12-31 2023-07-11 湖南中烟工业有限责任公司 一种水溶性芯材烟用爆珠材料及其制备方法

Also Published As

Publication number Publication date
EP0545376A1 (en) 1993-06-09
JPH06321921A (ja) 1994-11-22
ZA928876B (en) 1993-07-15
JP2531329B2 (ja) 1996-09-04
US5532258A (en) 1996-07-02
IL103826A0 (en) 1993-04-04
EP0545376B1 (en) 1998-09-09
DE69226931D1 (de) 1998-10-15
GB9125970D0 (en) 1992-02-05
MX9206930A (es) 1993-06-01
TW211565B (enExample) 1993-08-21
HU9203849D0 (en) 1993-03-29
HU211604A9 (en) 1995-12-28
AU2983792A (en) 1993-06-10
ATE170851T1 (de) 1998-09-15
CA2084640A1 (en) 1993-06-07
DE69226931T2 (de) 1999-03-18
HUT65776A (en) 1994-07-28
AU666893B2 (en) 1996-02-29

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PB01 Publication
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C01 Deemed withdrawal of patent application (patent law 1993)
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