DE69226931T2 - Guanidinothiazolederivate und ihre Anwendung als H2-Rezeptor-Antagonisten - Google Patents

Guanidinothiazolederivate und ihre Anwendung als H2-Rezeptor-Antagonisten

Info

Publication number
DE69226931T2
DE69226931T2 DE69226931T DE69226931T DE69226931T2 DE 69226931 T2 DE69226931 T2 DE 69226931T2 DE 69226931 T DE69226931 T DE 69226931T DE 69226931 T DE69226931 T DE 69226931T DE 69226931 T2 DE69226931 T2 DE 69226931T2
Authority
DE
Germany
Prior art keywords
alkyl
salt
compound
amino
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69226931T
Other languages
German (de)
English (en)
Other versions
DE69226931D1 (de
Inventor
Yoshikazu Amagasaki-Shi Hyogo 661 Inoue
Yousuke Toyonaka-Shi Osaka 560 Katsura
Hisashi Sakai-Shi Osaka 591 Takasugi
Tetsuo Minoo-Shi Osaka 562 Tomishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of DE69226931D1 publication Critical patent/DE69226931D1/de
Application granted granted Critical
Publication of DE69226931T2 publication Critical patent/DE69226931T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69226931T 1991-12-06 1992-12-02 Guanidinothiazolederivate und ihre Anwendung als H2-Rezeptor-Antagonisten Expired - Fee Related DE69226931T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919125970A GB9125970D0 (en) 1991-12-06 1991-12-06 New compounds

Publications (2)

Publication Number Publication Date
DE69226931D1 DE69226931D1 (de) 1998-10-15
DE69226931T2 true DE69226931T2 (de) 1999-03-18

Family

ID=10705819

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69226931T Expired - Fee Related DE69226931T2 (de) 1991-12-06 1992-12-02 Guanidinothiazolederivate und ihre Anwendung als H2-Rezeptor-Antagonisten

Country Status (14)

Country Link
US (1) US5532258A (enExample)
EP (1) EP0545376B1 (enExample)
JP (1) JP2531329B2 (enExample)
CN (1) CN1079469A (enExample)
AT (1) ATE170851T1 (enExample)
AU (1) AU666893B2 (enExample)
CA (1) CA2084640A1 (enExample)
DE (1) DE69226931T2 (enExample)
GB (1) GB9125970D0 (enExample)
HU (3) HU9203849D0 (enExample)
IL (1) IL103826A0 (enExample)
MX (1) MX9206930A (enExample)
TW (1) TW211565B (enExample)
ZA (1) ZA928876B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4427539A1 (de) * 1994-08-04 1996-02-08 Sueddeutsche Kalkstickstoff Verfahren zur Herstellung von 2-Cyaniminothiazolidin
GB9416459D0 (en) * 1994-08-15 1994-10-05 Fujisawa Pharmaceutical Co New compounds
US6288091B1 (en) 1995-12-29 2001-09-11 Boehringer Ingelheim Ltd. Antiherpes virus compounds and methods for their preparation and use
NZ331104A (en) * 1995-12-29 2000-03-27 Boehringer Ingelheim Ca Ltd Phenyl thiazole derivatives that inhibit herpes replication by inhibiting the herpes helicase primase enzyme complex
DE19719053A1 (de) * 1997-05-06 1998-11-12 Bayer Ag Substituierte Aminothiazole
US6100282A (en) * 1998-01-02 2000-08-08 Hoffman-La Roche Inc. Thiazole derivatives
WO2003050261A2 (en) * 2001-12-10 2003-06-19 Bristol-Myers Squibb Company (1-phenyl-2-heteroaryl)ethyl-guanidine compounds as inhibitors of mitochondrial f1f0 atp hydrolase
DE102004008141A1 (de) * 2004-02-19 2005-09-01 Abbott Gmbh & Co. Kg Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren
CN116406816B (zh) * 2021-12-31 2026-03-31 湖南中烟工业有限责任公司 一种水溶性芯材烟用爆珠及其制备方法
CN116406817B (zh) * 2021-12-31 2026-03-27 湖南中烟工业有限责任公司 一种水溶性芯材烟用爆珠材料及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54132566A (en) * 1978-01-18 1979-10-15 Ici Ltd Guanidine derivative*its manufacture and secretion controlling pharmaceutical composition containing it
CA1233818A (en) * 1981-03-09 1988-03-08 David J. Gilman Guanidine derivatives as histamine h-2 receptor antagonists
IT1200371B (it) * 1982-03-24 1989-01-18 Angeli Inst Spa Guanidino eterociclifenilamidine,processi per la loro preparazione e loro impiego farmaceutico
US4452985A (en) * 1983-02-14 1984-06-05 American Home Products Corporation 2-Guanyl-4-(substituted phenyl) thiazole derivatives

Also Published As

Publication number Publication date
EP0545376A1 (en) 1993-06-09
JPH06321921A (ja) 1994-11-22
ZA928876B (en) 1993-07-15
JP2531329B2 (ja) 1996-09-04
US5532258A (en) 1996-07-02
IL103826A0 (en) 1993-04-04
EP0545376B1 (en) 1998-09-09
DE69226931D1 (de) 1998-10-15
GB9125970D0 (en) 1992-02-05
MX9206930A (es) 1993-06-01
TW211565B (enExample) 1993-08-21
HU9203849D0 (en) 1993-03-29
HU211604A9 (en) 1995-12-28
AU2983792A (en) 1993-06-10
ATE170851T1 (de) 1998-09-15
CA2084640A1 (en) 1993-06-07
HUT65776A (en) 1994-07-28
AU666893B2 (en) 1996-02-29
CN1079469A (zh) 1993-12-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee