CN107937423A - 用于治疗变态反应的核酸 - Google Patents

用于治疗变态反应的核酸 Download PDF

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Publication number
CN107937423A
CN107937423A CN201710999629.5A CN201710999629A CN107937423A CN 107937423 A CN107937423 A CN 107937423A CN 201710999629 A CN201710999629 A CN 201710999629A CN 107937423 A CN107937423 A CN 107937423A
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威廉·赫尔
特瑞·海兰
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Immunomic Therapeutics Inc
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Immunomic Therapeutics Inc
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/35Allergens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/35Allergens
    • A61K39/36Allergens from pollen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/34Antigenic peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596Molecules with a "CD"-designation not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/577Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/06Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/35Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin

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  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Physics & Mathematics (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
CN201710999629.5A 2012-06-15 2012-06-15 用于治疗变态反应的核酸 Pending CN107937423A (zh)

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CN201710999629.5A CN107937423A (zh) 2012-06-15 2012-06-15 用于治疗变态反应的核酸

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2012/042552 WO2013187906A1 (en) 2012-06-15 2012-06-15 Nucleic acids for treatment of allergies
CN201710999629.5A CN107937423A (zh) 2012-06-15 2012-06-15 用于治疗变态反应的核酸
CN201280075163.5A CN104519896B (zh) 2012-06-15 2012-06-15 用于治疗变态反应的核酸

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CN107937423A true CN107937423A (zh) 2018-04-20

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CN201280075163.5A Active CN104519896B (zh) 2012-06-15 2012-06-15 用于治疗变态反应的核酸

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EP (2) EP3808361A1 (enExample)
JP (1) JP5807994B2 (enExample)
KR (2) KR102386481B1 (enExample)
CN (2) CN107937423A (enExample)
AU (3) AU2012382406B2 (enExample)
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CA (1) CA2876824C (enExample)
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HU (1) HUE052481T2 (enExample)
IL (4) IL236174B (enExample)
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PL (1) PL2861240T3 (enExample)
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RS (1) RS61098B1 (enExample)
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Cited By (2)

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CN112119161A (zh) * 2018-05-11 2020-12-22 安斯泰来制药株式会社 用于甲壳类过敏治疗的核酸
CN113631231A (zh) * 2019-03-13 2021-11-09 普梭梅根公司 用于过敏治疗的基于表位的方法和克罗恩病的抑制剂

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PT2861240T (pt) * 2012-06-15 2020-11-09 Immunomic Therapeutics Inc Ácidos nucleicos para tratamento de alergias
PL2914286T3 (pl) 2012-10-30 2022-01-31 Aravax Pty Ltd Nowe cząsteczki immunoterapeutyczne oraz ich zastosowania
KR20160075532A (ko) 2013-09-25 2016-06-29 아라백스 피티와이 엘티디 신규한 면역치료제 조성물 및 이의 용도
KR20170019457A (ko) * 2014-06-23 2017-02-21 이뮤노믹 쎄라퓨틱스, 인크. 땅콩 알레르기의 치료를 위한 핵산
US10166286B2 (en) 2015-02-20 2019-01-01 The Board Of Trustees Of The Leland Stanford Junior University Mixed allergen compositions and methods for using the same
US10149904B2 (en) 2015-02-20 2018-12-11 The Board Of Trusteees Of The Leland Stanford Junior University Mixed allergen compositions and methods for using the same
US11452774B2 (en) 2015-02-20 2022-09-27 The Board Of Trustees Of The Leland Stanford Junior University Mixed allergen compositions and methods for using the same
US10143742B2 (en) 2015-02-20 2018-12-04 The Board Of Trustees Of The Leland Stanford Junior University Mixed allergen compositions and methods for using the same
AU2016374874B2 (en) 2015-12-23 2020-12-03 Helmholtz Zentrum Munchen Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) Dendritic cell composition
JP7078620B2 (ja) 2016-11-16 2022-05-31 イミュノミック セラピューティックス, インコーポレイテッド アレルギーの治療のための核酸
ES3004084T3 (en) 2017-04-22 2025-03-11 Immunomic Therapeutics Inc Improved lamp constructs
KR20200016224A (ko) * 2017-05-02 2020-02-14 이뮤노믹 쎄라퓨틱스, 인크. 암 항원을 포함하는 lamp (리소솜 연관 막 단백질) 구축물
IL272033B2 (en) 2017-07-18 2023-09-01 Before Brands Inc Methods for the preparation of mixed allergen preparations
WO2019194656A1 (ko) * 2018-04-06 2019-10-10 (주)에스엘에스바이오 신규한 면역글로불린 e의 에피토프, 그와 결합하는 항체 및 상기 항체를 포함하는 시료 중 면역글로불린 e를 분석하기 위한 키트
AR115379A1 (es) * 2018-05-11 2021-01-13 Astellas Pharma Inc Ácido nucleico para tratar alergia a los ácaros
US12398195B2 (en) 2018-05-15 2025-08-26 Immunomic Therapeutics, Inc. Lamp constructs comprising allergens
WO2020154476A1 (en) 2019-01-23 2020-07-30 Before Brands, Inc. Methods for making mixed allergen compositions
KR20240009434A (ko) * 2021-05-04 2024-01-22 소비다 솔루션즈 리미티드 니코틴아미드 아데닌 디뉴클레오티드 (nad) 조성물, 이의 제조 방법 및 이의 사용 방법
EP4382607A4 (en) * 2021-08-06 2025-11-19 Kao Corp NUCLEIC ACID STRUCTURE INVOLVING SNARE PROTEINS
FI20237105A1 (en) 2023-05-29 2024-11-30 Onni Biotechnologies Oy Modified natural killer cells with enhanced cytotoxic action and greater survival

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112119161A (zh) * 2018-05-11 2020-12-22 安斯泰来制药株式会社 用于甲壳类过敏治疗的核酸
CN113631231A (zh) * 2019-03-13 2021-11-09 普梭梅根公司 用于过敏治疗的基于表位的方法和克罗恩病的抑制剂

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US10072053B2 (en) 2018-09-11
HRP20201815T1 (hr) 2021-02-19
AU2019250227A1 (en) 2019-11-07
AU2018200625A1 (en) 2018-02-15
EP3808361A1 (en) 2021-04-21
IL270260B (en) 2020-08-31
HUE052481T2 (hu) 2021-04-28
US20160271245A1 (en) 2016-09-22
CN104519896B (zh) 2017-11-10
EP2861240A1 (en) 2015-04-22
BR112014031327B1 (pt) 2022-02-01
AU2018200625B2 (en) 2019-09-19
IL236174A0 (en) 2015-01-29
JP2015521467A (ja) 2015-07-30
IL270262A (en) 2019-12-31
JP5807994B2 (ja) 2015-11-10
RS61098B1 (sr) 2020-12-31
KR102386481B1 (ko) 2022-04-14
PT2861240T (pt) 2020-11-09
EP2861240A4 (en) 2016-03-16
KR102107646B1 (ko) 2020-05-08
CA2876824C (en) 2020-07-21
EP2861240B1 (en) 2020-09-09
ES2831723T3 (es) 2021-06-09
AU2012382406A2 (en) 2015-04-16
US9744230B2 (en) 2017-08-29
CY1123769T1 (el) 2022-05-27
IL270261B (en) 2021-03-25
PL2861240T3 (pl) 2021-07-05
WO2013187906A1 (en) 2013-12-19
KR20200047792A (ko) 2020-05-07
BR112014031327A2 (pt) 2017-06-27
AU2012382406A1 (en) 2014-12-18
CA2876824A1 (en) 2013-12-19
CN104519896A (zh) 2015-04-15
LT2861240T (lt) 2021-01-25
US20220081474A1 (en) 2022-03-17
US20180009857A1 (en) 2018-01-11
IL236174B (en) 2019-11-28
SI2861240T1 (sl) 2021-04-30
AU2012382406B2 (en) 2017-12-07

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