DK2861240T3 - Nukleinsyrer til behandling af allergier - Google Patents
Nukleinsyrer til behandling af allergier Download PDFInfo
- Publication number
- DK2861240T3 DK2861240T3 DK12878776.9T DK12878776T DK2861240T3 DK 2861240 T3 DK2861240 T3 DK 2861240T3 DK 12878776 T DK12878776 T DK 12878776T DK 2861240 T3 DK2861240 T3 DK 2861240T3
- Authority
- DK
- Denmark
- Prior art keywords
- allergies
- treatment
- nucleic acids
- nucleic
- acids
- Prior art date
Links
- 230000007815 allergy Effects 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/34—Antigenic peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2012/042552 WO2013187906A1 (en) | 2012-06-15 | 2012-06-15 | Nucleic acids for treatment of allergies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2861240T3 true DK2861240T3 (da) | 2020-09-28 |
Family
ID=49758576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12878776.9T DK2861240T3 (da) | 2012-06-15 | 2012-06-15 | Nukleinsyrer til behandling af allergier |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US9744230B2 (enExample) |
| EP (2) | EP3808361A1 (enExample) |
| JP (1) | JP5807994B2 (enExample) |
| KR (2) | KR102107646B1 (enExample) |
| CN (2) | CN107937423A (enExample) |
| AU (3) | AU2012382406B2 (enExample) |
| BR (1) | BR112014031327B1 (enExample) |
| CA (1) | CA2876824C (enExample) |
| CY (1) | CY1123769T1 (enExample) |
| DK (1) | DK2861240T3 (enExample) |
| ES (1) | ES2831723T3 (enExample) |
| HR (1) | HRP20201815T1 (enExample) |
| HU (1) | HUE052481T2 (enExample) |
| IL (4) | IL236174B (enExample) |
| LT (1) | LT2861240T (enExample) |
| PL (1) | PL2861240T3 (enExample) |
| PT (1) | PT2861240T (enExample) |
| RS (1) | RS61098B1 (enExample) |
| SI (1) | SI2861240T1 (enExample) |
| WO (1) | WO2013187906A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160185831A1 (en) * | 2011-06-14 | 2016-06-30 | Immunomic Therapeutics, Inc. | Nucleic acids for treatment of allergies |
| PL2861240T3 (pl) * | 2012-06-15 | 2021-07-05 | Immunomic Therapeutics, Inc. | Kwasy nukleinowe do leczenia alergii |
| NZ707615A (en) | 2012-10-30 | 2019-01-25 | Aravax Pty Ltd | Novel immunotherapeutic molecules and uses thereof |
| WO2015042664A1 (en) | 2013-09-25 | 2015-04-02 | Monash University | Novel immunotherapeutic composition and uses thereof |
| EP3157558A2 (en) * | 2014-06-23 | 2017-04-26 | Immunomic Therapeutics, Inc. | Nucleic acids for treatment of peanut allergies |
| US10149904B2 (en) | 2015-02-20 | 2018-12-11 | The Board Of Trusteees Of The Leland Stanford Junior University | Mixed allergen compositions and methods for using the same |
| US10166286B2 (en) | 2015-02-20 | 2019-01-01 | The Board Of Trustees Of The Leland Stanford Junior University | Mixed allergen compositions and methods for using the same |
| US10143742B2 (en) | 2015-02-20 | 2018-12-04 | The Board Of Trustees Of The Leland Stanford Junior University | Mixed allergen compositions and methods for using the same |
| US11452774B2 (en) | 2015-02-20 | 2022-09-27 | The Board Of Trustees Of The Leland Stanford Junior University | Mixed allergen compositions and methods for using the same |
| TWI752930B (zh) | 2015-12-23 | 2022-01-21 | 德商梅迪基因免疫治療公司 | 抗原特異性ｔｃｒ的新生成 |
| CN110418650A (zh) * | 2016-11-16 | 2019-11-05 | 免疫治疗有限公司 | 用于治疗过敏的核酸 |
| EP3612556B8 (en) * | 2017-04-22 | 2024-11-20 | Immunomic Therapeutics, Inc. | Improved lamp constructs |
| WO2018204534A1 (en) * | 2017-05-02 | 2018-11-08 | Immunomic Therapeutics, Inc. | Lamp (lysosomal associated membrane protein) constructs comprising cancer antigens |
| CN111465328A (zh) | 2017-07-18 | 2020-07-28 | 前品牌股份有限公司 | 制备混合型变应原组合物的方法 |
| EP3779443A4 (en) * | 2018-04-06 | 2022-05-04 | Slsbio Co., Ltd. | NEW IMMUNOGLOBULIN E EPITOPE, BINDING ANTIBODY AND KIT FOR THE ANALYSIS OF IMMUNOGLOBULIN E IN A SAMPLE CONTAINING IT |
| WO2019216394A1 (ja) * | 2018-05-11 | 2019-11-14 | アステラス製薬株式会社 | ダニアレルギー治療のための核酸 |
| CA3099505A1 (en) * | 2018-05-11 | 2019-11-14 | Astellas Pharma Inc. | Nucleic acid for treating crustacean allergy |
| JP2021523185A (ja) | 2018-05-15 | 2021-09-02 | イミュノミック セラピューティックス， インコーポレイテッドＩｍｍｕｎｏｍｉｃ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | アレルゲンを含む改善されたｌａｍｐ構築物 |
| US11766477B2 (en) | 2019-01-23 | 2023-09-26 | Societe Des Produits Nestle S.A. | Methods for making mixed allergen compositions |
| CN113631231A (zh) * | 2019-03-13 | 2021-11-09 | 普梭梅根公司 | 用于过敏治疗的基于表位的方法和克罗恩病的抑制剂 |
| KR20220083773A (ko) | 2019-10-18 | 2022-06-20 | 이뮤노믹 쎄라퓨틱스, 인크. | 암 항원을 포함하는 개선된 lamp 구축물 |
| JP2024517463A (ja) * | 2021-05-04 | 2024-04-22 | ソヴィダ ソリューションズ リミテッド | ニコチンアミドアデニンジヌクレオチド（ｎａｄ）組成物、それらの製造方法、及びそれらの使用方法 |
| CN117795081A (zh) * | 2021-08-06 | 2024-03-29 | 花王株式会社 | 利用snare的核酸构建体 |
| FI131854B1 (en) | 2023-05-29 | 2026-01-12 | Onni Biotechnologies Oy | Modified natural killer cells with enhanced cytotoxic activity and greater survival |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USD335810S (en) | 1990-07-02 | 1993-05-25 | Dick-Ming Asien | Handle for luggage or similar article |
| US6982326B1 (en) | 1991-07-12 | 2006-01-03 | Immulogic Pharmaceutical Corporation | Allergenic proteins and peptides from Japanese cedar pollen |
| US6090386A (en) | 1991-07-12 | 2000-07-18 | Griffith; Irwin J. | T cell peptides of the CRX JII allergen |
| WO1994024281A1 (en) * | 1993-04-14 | 1994-10-27 | Immulogic Pharmaceutical Corporation | T cell epitopes of the major allergens from dermatophagoides (house dust mite) |
| AU5668194A (en) * | 1992-11-12 | 1994-06-08 | Immulogic Pharmaceutical Corporation | Allergenic proteins and peptides from japanese cedar pollen |
| US5633234A (en) | 1993-01-22 | 1997-05-27 | The Johns Hopkins University | Lysosomal targeting of immunogens |
| JP3649460B2 (ja) | 1993-11-05 | 2005-05-18 | 明治乳業株式会社 | スギ花粉アレルゲンＣｒｙ ｊ ＩＩエピトープ |
| GB9516760D0 (en) | 1995-08-16 | 1995-10-18 | Sandoz Ltd | Organic compounds |
| CA2241918C (en) | 1995-12-29 | 2008-12-02 | University Of Arkansas | Peanut allergens and methods |
| CA2258125C (en) | 1996-06-14 | 2010-11-23 | Meiji Milk Products Co., Ltd. | T-cell epitope peptides |
| US20020142978A1 (en) * | 2000-04-07 | 2002-10-03 | Eyal Raz | Synergistic improvements to polynucleotide vaccines |
| WO2002074250A2 (en) | 2001-03-16 | 2002-09-26 | Panacea Pharmaceuticals | Methods and reagents for decreasing clinical reaction to allergy |
| ES2404689T3 (es) * | 2001-04-05 | 2013-05-28 | The Johns Hopkins University | Vacunas quiméricas que comprenden el dominio lumenal de LAMP-1 o LAMP-2 |
| US20060003148A1 (en) | 2004-06-30 | 2006-01-05 | Zwynenburg James L | Interlocking polymeric foam floor underlayment and process for making |
| US20060216315A1 (en) * | 2005-03-16 | 2006-09-28 | Yoo Tai J | Cockroach allergen gene expression and delivery systems and uses |
| US20090304738A1 (en) | 2005-06-16 | 2009-12-10 | Moran Thomas M | Methods for Enhancing Immune Responses |
| US7566456B2 (en) | 2005-06-23 | 2009-07-28 | Haiming Chen | Allergen vaccine proteins for the treatment and prevention of allergic diseases |
| WO2007024026A1 (ja) * | 2005-08-25 | 2007-03-01 | Taiho Pharmaceutical Co., Ltd. | Ｔ細胞認識エピトープペプチドを固定化又は内包化した生分解性ナノ粒子 |
| US20080006554A1 (en) | 2006-07-07 | 2008-01-10 | Medtronic Vascular, Inc. | Packaging assembly for a catheter |
| EP2042193A1 (en) * | 2007-09-28 | 2009-04-01 | Biomay AG | RNA Vaccines |
| EP2331568B1 (en) * | 2008-09-10 | 2014-09-03 | ITH Immune Therapy Holdings AB | Treating inflammatory conditions |
| PL2861240T3 (pl) * | 2012-06-15 | 2021-07-05 | Immunomic Therapeutics, Inc. | Kwasy nukleinowe do leczenia alergii |
| CN110418650A (zh) * | 2016-11-16 | 2019-11-05 | 免疫治疗有限公司 | 用于治疗过敏的核酸 |
| EP3612556B8 (en) * | 2017-04-22 | 2024-11-20 | Immunomic Therapeutics, Inc. | Improved lamp constructs |
-
2012
- 2012-06-15 PL PL12878776T patent/PL2861240T3/pl unknown
- 2012-06-15 HR HRP20201815TT patent/HRP20201815T1/hr unknown
- 2012-06-15 EP EP20194785.0A patent/EP3808361A1/en not_active Withdrawn
- 2012-06-15 KR KR1020157000696A patent/KR102107646B1/ko active Active
- 2012-06-15 LT LTEP12878776.9T patent/LT2861240T/lt unknown
- 2012-06-15 JP JP2015517226A patent/JP5807994B2/ja active Active
- 2012-06-15 DK DK12878776.9T patent/DK2861240T3/da active
- 2012-06-15 EP EP12878776.9A patent/EP2861240B1/en active Active
- 2012-06-15 CA CA2876824A patent/CA2876824C/en active Active
- 2012-06-15 BR BR112014031327-0A patent/BR112014031327B1/pt active IP Right Grant
- 2012-06-15 CN CN201710999629.5A patent/CN107937423A/zh active Pending
- 2012-06-15 HU HUE12878776A patent/HUE052481T2/hu unknown
- 2012-06-15 AU AU2012382406A patent/AU2012382406B2/en active Active
- 2012-06-15 ES ES12878776T patent/ES2831723T3/es active Active
- 2012-06-15 CN CN201280075163.5A patent/CN104519896B/zh active Active
- 2012-06-15 PT PT128787769T patent/PT2861240T/pt unknown
- 2012-06-15 WO PCT/US2012/042552 patent/WO2013187906A1/en not_active Ceased
- 2012-06-15 SI SI201231855T patent/SI2861240T1/sl unknown
- 2012-06-15 RS RS20201379A patent/RS61098B1/sr unknown
- 2012-06-15 KR KR1020207012427A patent/KR102386481B1/ko active Active
-
2014
- 2014-12-11 IL IL23617414A patent/IL236174B/en active IP Right Grant
-
2016
- 2016-03-02 US US15/058,224 patent/US9744230B2/en active Active
-
2017
- 2017-07-31 US US15/663,871 patent/US10072053B2/en active Active
-
2018
- 2018-01-25 AU AU2018200625A patent/AU2018200625B2/en active Active
-
2019
- 2019-10-18 AU AU2019250227A patent/AU2019250227B2/en active Active
- 2019-10-29 IL IL270261A patent/IL270261B/en active IP Right Grant
- 2019-10-29 IL IL270262A patent/IL270262A/en unknown
- 2019-10-29 IL IL270260A patent/IL270260B/en active IP Right Grant
-
2020
- 2020-09-22 US US17/028,762 patent/US20220081474A1/en active Pending
- 2020-11-23 CY CY20201101107T patent/CY1123769T1/el unknown
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