CN107889489A - 用于骨髓瘤和其他癌症免疫治疗的新型细胞表位和细胞表位组合物 - Google Patents

用于骨髓瘤和其他癌症免疫治疗的新型细胞表位和细胞表位组合物 Download PDF

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CN107889489A
CN107889489A CN201680037125.9A CN201680037125A CN107889489A CN 107889489 A CN107889489 A CN 107889489A CN 201680037125 A CN201680037125 A CN 201680037125A CN 107889489 A CN107889489 A CN 107889489A
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peptide
cells
cell
peptides
seq
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汉斯乔治·罗曼
朱利安·史迪克
丹尼尔·柯华李维斯基丹
史蒂芬·史蒂芬诺维克
西蒙·沃尔兹
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Immatics Biotechnologies GmbH
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01—MEASURING; TESTING
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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CN201680037125.9A 2015-06-25 2016-06-21 用于骨髓瘤和其他癌症免疫治疗的新型细胞表位和细胞表位组合物 Pending CN107889489A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562184500P 2015-06-25 2015-06-25
GB1511191.7 2015-06-25
US62/184,500 2015-06-25
GBGB1511191.7A GB201511191D0 (en) 2015-06-25 2015-06-25 T-cell epitopes for the immunotherapy of myeloma
PCT/EP2016/064317 WO2016207164A2 (en) 2015-06-25 2016-06-21 Novel cell epitopes and combination of cell epitopes for use in the immuno-therapy of myeloma and other cancers

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EP (1) EP3313860A2 (cg-RX-API-DMAC10.html)
JP (1) JP2018520653A (cg-RX-API-DMAC10.html)
KR (1) KR20180012865A (cg-RX-API-DMAC10.html)
CN (1) CN107889489A (cg-RX-API-DMAC10.html)
AU (1) AU2016284857A1 (cg-RX-API-DMAC10.html)
BR (1) BR112017027639A2 (cg-RX-API-DMAC10.html)
CA (1) CA2990507A1 (cg-RX-API-DMAC10.html)
CR (1) CR20180051A (cg-RX-API-DMAC10.html)
EA (1) EA201792484A1 (cg-RX-API-DMAC10.html)
GB (1) GB201511191D0 (cg-RX-API-DMAC10.html)
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MA (5) MA46506A1 (cg-RX-API-DMAC10.html)
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CN110741260A (zh) * 2017-06-09 2020-01-31 生物技术Rna制药有限公司 用于预测疾病特异性氨基酸修饰用于免疫治疗的可用性的方法
CN112639136A (zh) * 2018-08-30 2021-04-09 蒙特利尔大学 用于鉴定肿瘤特异性抗原的基于蛋白质基因组学的方法
CN113150115A (zh) * 2018-05-16 2021-07-23 伊玛提克斯生物技术有限公司 用于抗癌免疫治疗的肽
CN113195715A (zh) * 2018-08-29 2021-07-30 阿迈瑞斯公司 基于选择的测定法的细胞和方法
CN113476619A (zh) * 2021-07-08 2021-10-08 上海交通大学医学院附属仁济医院 一种18f标记纳米抗体探针及其制备方法和应用
CN114026117A (zh) * 2019-06-25 2022-02-08 蒙特利尔大学 用于卵巢癌的新型肿瘤特异性抗原及其用途
CN115485295A (zh) * 2020-03-10 2022-12-16 麻省理工学院 NPM1c阳性癌症的免疫疗法的组合物和方法
CN115968299A (zh) * 2020-02-14 2023-04-14 詹森生物科技公司 在多发性骨髓瘤中表达的新抗原及其用途
CN116097096A (zh) * 2020-03-27 2023-05-09 印地安纳大学理事会 多发性骨髓瘤中的免疫治疗靶点及其鉴定方法
CN116472052A (zh) * 2020-10-19 2023-07-21 南特生物公司 阵列肽新表位生成器

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KR20240007715A (ko) 2016-10-14 2024-01-16 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 핵염기 에디터의 aav 전달
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TW201841937A (zh) 2017-04-10 2018-12-01 德商英麥提克生物技術股份有限公司 用於白血病和其他癌症免疫治療的新穎肽和肽組合物
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DE102018108612A1 (de) 2018-03-21 2019-09-26 Immatics US, Inc. Verfahren zur erhöhung der persistenz von adoptiv infundierten t-zellen
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