CN107857817A - 胶原特异结合能力的egfr抗体及在脊髓损伤修复中的应用 - Google Patents
胶原特异结合能力的egfr抗体及在脊髓损伤修复中的应用 Download PDFInfo
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- CN107857817A CN107857817A CN201610841518.7A CN201610841518A CN107857817A CN 107857817 A CN107857817 A CN 107857817A CN 201610841518 A CN201610841518 A CN 201610841518A CN 107857817 A CN107857817 A CN 107857817A
- Authority
- CN
- China
- Prior art keywords
- collagen
- based materials
- binding ability
- fab
- egfr antibody
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L2300/256—Antibodies, e.g. immunoglobulins, vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Claims (11)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610841518.7A CN107857817B (zh) | 2016-09-22 | 2016-09-22 | 胶原特异结合能力的egfr抗体及在脊髓损伤修复中的应用 |
Applications Claiming Priority (1)
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---|---|---|---|
CN201610841518.7A CN107857817B (zh) | 2016-09-22 | 2016-09-22 | 胶原特异结合能力的egfr抗体及在脊髓损伤修复中的应用 |
Publications (2)
Publication Number | Publication Date |
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CN107857817A true CN107857817A (zh) | 2018-03-30 |
CN107857817B CN107857817B (zh) | 2021-06-22 |
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CN201610841518.7A Active CN107857817B (zh) | 2016-09-22 | 2016-09-22 | 胶原特异结合能力的egfr抗体及在脊髓损伤修复中的应用 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110051840A (zh) * | 2019-04-24 | 2019-07-26 | 中国科学院遗传与发育生物学研究所 | Egfr/erk/trim32信号通路在促进脊髓损伤后脊髓神经干细胞分化中的应用 |
CN111978405A (zh) * | 2019-05-21 | 2020-11-24 | 中国科学院苏州纳米技术与纳米仿生研究所 | 功能多肽、可特异结合胶原的红细胞载药体系及其应用 |
CN111978406A (zh) * | 2019-05-21 | 2020-11-24 | 中国科学院苏州纳米技术与纳米仿生研究所 | 功能连接多肽、可特异性结合胶原的外泌体载药体系及其应用 |
Citations (4)
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---|---|---|---|---|
US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
CN101979106A (zh) * | 2010-09-10 | 2011-02-23 | 中国科学院遗传与发育生物学研究所 | 修复脊髓损伤的生物材料及其制备方法与应用 |
CN103127552A (zh) * | 2013-02-05 | 2013-06-05 | 中国科学院苏州纳米技术与纳米仿生研究所 | 一种用于修复脊髓损伤的圆柱体支架及其应用方法 |
CN105327392A (zh) * | 2014-08-08 | 2016-02-17 | 中国科学院遗传与发育生物学研究所 | 一种有序胶原材料及其制备方法与应用 |
-
2016
- 2016-09-22 CN CN201610841518.7A patent/CN107857817B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
CN101979106A (zh) * | 2010-09-10 | 2011-02-23 | 中国科学院遗传与发育生物学研究所 | 修复脊髓损伤的生物材料及其制备方法与应用 |
CN103127552A (zh) * | 2013-02-05 | 2013-06-05 | 中国科学院苏州纳米技术与纳米仿生研究所 | 一种用于修复脊髓损伤的圆柱体支架及其应用方法 |
CN105327392A (zh) * | 2014-08-08 | 2016-02-17 | 中国科学院遗传与发育生物学研究所 | 一种有序胶原材料及其制备方法与应用 |
Non-Patent Citations (3)
Title |
---|
FAN C, LI X, XIAO Z, ET AL: "《A modified collagen scaffold facilitates endogenous neurogenesis for acute spinal cord injury repair》", 《ACTA BIOMATERIALIA》 * |
HAN Q等: "《The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an EGFR neutralizing antibody》", 《BIOMATERIALS》 * |
LIANG, H等: "《A collagen-binding EGFR antibody fragment targeting tumors with a collagen-rich extracellular matrix》", 《SCIENTIFIC REPORTS》 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110051840A (zh) * | 2019-04-24 | 2019-07-26 | 中国科学院遗传与发育生物学研究所 | Egfr/erk/trim32信号通路在促进脊髓损伤后脊髓神经干细胞分化中的应用 |
CN110051840B (zh) * | 2019-04-24 | 2021-04-13 | 中国科学院遗传与发育生物学研究所 | Egfr/erk/trim32信号通路在促进脊髓损伤后脊髓神经干细胞分化中的应用 |
CN111978405A (zh) * | 2019-05-21 | 2020-11-24 | 中国科学院苏州纳米技术与纳米仿生研究所 | 功能多肽、可特异结合胶原的红细胞载药体系及其应用 |
CN111978406A (zh) * | 2019-05-21 | 2020-11-24 | 中国科学院苏州纳米技术与纳米仿生研究所 | 功能连接多肽、可特异性结合胶原的外泌体载药体系及其应用 |
CN111978406B (zh) * | 2019-05-21 | 2022-06-17 | 中国科学院苏州纳米技术与纳米仿生研究所 | 功能连接多肽、可特异性结合胶原的外泌体载药体系及其应用 |
CN111978405B (zh) * | 2019-05-21 | 2023-01-03 | 中国科学院苏州纳米技术与纳米仿生研究所 | 功能多肽、可特异结合胶原的红细胞载药体系及其应用 |
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Effective date of registration: 20220129 Address after: 100000 b-1608-029, 16th floor, building 1, No. 18, Zhongguancun East Road, Haidian District, Beijing Patentee after: BEIJING TONGJIAN REGENERATION MEDICAL TECHNOLOGY Co.,Ltd. Address before: 215123, Suzhou, Jiangsu province Suzhou Industrial Park alone villa lake high Parish, if the waterway 398 Patentee before: SUZHOU INSTITUTE OF NANO-TECH AND NANO-BIONICS (SINANO), CHINESE ACADEMY OF SCIENCES |
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Effective date of registration: 20220330 Address after: No.99, Chuqiao Road, New District, Zhenjiang City, Jiangsu Province, 212000 Patentee after: Jiangsu dubu Biotechnology Co.,Ltd. Address before: 100000 b-1608-029, 16th floor, building 1, No. 18, Zhongguancun East Road, Haidian District, Beijing Patentee before: BEIJING TONGJIAN REGENERATION MEDICAL TECHNOLOGY Co.,Ltd. |
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Application publication date: 20180330 Assignee: Dubu Wuqi Biomedical Technology (Jiangsu) Co.,Ltd. Assignor: Jiangsu dubu Biotechnology Co.,Ltd. Contract record no.: X2023980035226 Denomination of invention: EGFR antibody with collagen specific binding ability and its application in the repair of spinal cord injury Granted publication date: 20210622 License type: Exclusive License Record date: 20230504 |
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