CN107827893B - 一种4-氯-7H-吡咯并[2,3-d]嘧啶的制备方法 - Google Patents
一种4-氯-7H-吡咯并[2,3-d]嘧啶的制备方法 Download PDFInfo
- Publication number
- CN107827893B CN107827893B CN201711105043.6A CN201711105043A CN107827893B CN 107827893 B CN107827893 B CN 107827893B CN 201711105043 A CN201711105043 A CN 201711105043A CN 107827893 B CN107827893 B CN 107827893B
- Authority
- CN
- China
- Prior art keywords
- pyrrolo
- pyrimidine
- chloro
- carrying
- organic solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711105043.6A CN107827893B (zh) | 2017-11-10 | 2017-11-10 | 一种4-氯-7H-吡咯并[2,3-d]嘧啶的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711105043.6A CN107827893B (zh) | 2017-11-10 | 2017-11-10 | 一种4-氯-7H-吡咯并[2,3-d]嘧啶的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107827893A CN107827893A (zh) | 2018-03-23 |
CN107827893B true CN107827893B (zh) | 2020-03-27 |
Family
ID=61655028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711105043.6A Active CN107827893B (zh) | 2017-11-10 | 2017-11-10 | 一种4-氯-7H-吡咯并[2,3-d]嘧啶的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107827893B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108409745A (zh) * | 2018-04-09 | 2018-08-17 | 华东师范大学 | 一种4-氯-7H-吡咯并[2,3-d]嘧啶的合成方法 |
CN110790768A (zh) * | 2019-11-01 | 2020-02-14 | 廖文杰 | 一种医药中间体4-氯吡咯并嘧啶的生产系统 |
CN110724145A (zh) * | 2019-11-01 | 2020-01-24 | 廖文杰 | 一种医药中间体4-氯吡咯并嘧啶的合成方法 |
CN111533748A (zh) * | 2020-06-02 | 2020-08-14 | 江苏恒沛药物科技有限公司 | 一种采用非磷氯化试剂制备4-氯-7H-吡咯并[2,3-d]嘧啶的方法 |
CN115684424A (zh) * | 2022-11-11 | 2023-02-03 | 贵州健安德科技有限公司 | 基于LC-MS/MS检测土壤和水中4-氯-7H-吡咯并[2,3-d]嘧啶的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102006016426A1 (de) * | 2006-04-07 | 2007-10-11 | Merck Patent Gmbh | Neuartige Cyclobutyl-Verbindungen als Kinase-Inhibitoren |
CN101602766A (zh) * | 2009-07-02 | 2009-12-16 | 浙江工业大学 | 一种6-氯嘌呤的合成方法 |
CN101914069A (zh) * | 2010-07-29 | 2010-12-15 | 安徽丰乐农化有限责任公司 | 6-氯-2-羟基喹喔啉的氯化新工艺 |
CN102432547A (zh) * | 2011-11-22 | 2012-05-02 | 太仓市运通化工厂 | 一种4,6-二氯-2-甲基嘧啶的合成方法 |
CN105622616A (zh) * | 2016-02-25 | 2016-06-01 | 上海雅本化学有限公司 | 一种4-氯吡咯并嘧啶的制备方法 |
-
2017
- 2017-11-10 CN CN201711105043.6A patent/CN107827893B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
CN107827893A (zh) | 2018-03-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN107827893B (zh) | 一种4-氯-7H-吡咯并[2,3-d]嘧啶的制备方法 | |
CN111315742B (zh) | 制备氨基嘧啶衍生物的方法 | |
CN111440188B (zh) | 一种瑞卢戈利(Relugolix)关键中间体的制备方法 | |
CN111205304A (zh) | 一种巴洛沙韦中间体的制备方法 | |
CN101619034B (zh) | 一种二硒化物的合成方法 | |
CN111362939B (zh) | 一种帕布昔利布母核结构化合物的制备方法 | |
CN113683571A (zh) | 一种2-甲基-5-溴嘧啶的制备方法 | |
CN105801535A (zh) | 一种芳香类衍生物的工业生产方法 | |
IE873229L (en) | Imidazole derivatives | |
CN115141147B (zh) | 一种n-甲基-3-取代甲基-4-吡唑甲酰胺衍生物的合成方法 | |
CN111233673A (zh) | 一种手性芳香族环丙胺及其盐的制备方法及所用中间体 | |
CN113651827B (zh) | 一种无需金属催化剂制备吡喃并[2,3-b]吲哚-2-酮的方法 | |
CN111423437B (zh) | 一种帕博西尼中间体的制备方法 | |
CN104447758A (zh) | 吡唑并[3,4-d]嘧啶类化合物的合成工艺 | |
CN104804008B (zh) | 一种工业化生产甲磺酸特拉替尼的方法 | |
CN109608493B (zh) | 一种制备α-氨基磷酸酯类化合物的方法 | |
Heyman | Preparation of isatoates from isatoic anhydride | |
CN112209947A (zh) | 一种手性吲哚并噁嗪酮化合物及其合成方法 | |
CN112062705A (zh) | 7-甲基色氨酸的合成方法 | |
CN109384753B (zh) | 一种2-苯基-3-甲基苯并呋喃类化合物的合成方法 | |
CN114105903B (zh) | 一种高纯度去甲基氨噻肟酸乙酯的制备方法 | |
CN109796348B (zh) | 一种9-苄基萘胺及其合成方法 | |
CN116283776A (zh) | 一种合成三苯并[b,d,f]氮杂卓衍生物的方法 | |
KR20180081276A (ko) | 5-(3,6-다이하이드로-2,6-다이옥소-4-트리플루오로메틸-1(2h)-피리미디닐)페닐싸이올 화합물의 제조 방법 | |
CN116768697B (zh) | 一种氯丙烷作烷化剂制备二丙基丙二酸的方法与应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20200120 Address after: 213127, Jinlong Road, Xinbei Town, Xinbei District, Jiangsu, Changzhou, 18 Applicant after: Changzhou Qi Hui pharmaceutcal corporation, Ltd Applicant after: Inner Mongolia Qihui Chemical Co., Ltd. Address before: 213127, Jinlong Road, Xinbei Town, Xinbei District, Jiangsu, Changzhou, 18 Applicant before: Changzhou Qi Hui pharmaceutcal corporation, Ltd |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: 213127, Jinlong Road, Xinbei Town, Xinbei District, Jiangsu, Changzhou, 18 Patentee after: CHANGZHOU YABANG-QH PHARMACHEM Co.,Ltd. Patentee after: Inner Mongolia Qihui Pharmaceutical Co., Ltd Address before: 213127, Jinlong Road, Xinbei Town, Xinbei District, Jiangsu, Changzhou, 18 Patentee before: CHANGZHOU YABANG-QH PHARMACHEM Co.,Ltd. Patentee before: INNER MONGOLIA QIHUI CHEMICAL Co.,Ltd. |