CN107801936A - 一种分散均匀、促进泌乳的组合物及其制备方法 - Google Patents
一种分散均匀、促进泌乳的组合物及其制备方法 Download PDFInfo
- Publication number
- CN107801936A CN107801936A CN201710860003.6A CN201710860003A CN107801936A CN 107801936 A CN107801936 A CN 107801936A CN 201710860003 A CN201710860003 A CN 201710860003A CN 107801936 A CN107801936 A CN 107801936A
- Authority
- CN
- China
- Prior art keywords
- parts
- powder
- composition
- lactation
- uniformly dispersed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000006651 lactation Effects 0.000 title claims abstract description 54
- 239000000203 mixture Substances 0.000 title claims abstract description 43
- 230000001737 promoting effect Effects 0.000 title claims abstract description 10
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000000843 powder Substances 0.000 claims abstract description 59
- 235000009467 Carica papaya Nutrition 0.000 claims abstract description 28
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 23
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 23
- 240000006432 Carica papaya Species 0.000 claims abstract description 21
- 239000002994 raw material Substances 0.000 claims abstract description 19
- 241000195493 Cryptophyta Species 0.000 claims abstract description 14
- 235000013305 food Nutrition 0.000 claims abstract description 13
- 235000013361 beverage Nutrition 0.000 claims abstract description 9
- 239000003814 drug Substances 0.000 claims abstract description 9
- 230000036541 health Effects 0.000 claims abstract description 8
- 239000007787 solid Substances 0.000 claims abstract description 6
- 235000013336 milk Nutrition 0.000 claims description 14
- 239000008267 milk Substances 0.000 claims description 14
- 210000004080 milk Anatomy 0.000 claims description 14
- -1 congee class Substances 0.000 claims description 12
- 235000006264 Asimina triloba Nutrition 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 241000237502 Ostreidae Species 0.000 claims description 5
- 238000010521 absorption reaction Methods 0.000 claims description 5
- 238000004140 cleaning Methods 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 235000020636 oyster Nutrition 0.000 claims description 5
- 230000000295 complement effect Effects 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 238000005360 mashing Methods 0.000 claims description 4
- 238000001694 spray drying Methods 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- 235000013616 tea Nutrition 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 206010033546 Pallor Diseases 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000000853 adhesive Substances 0.000 claims description 2
- 230000001070 adhesive effect Effects 0.000 claims description 2
- 235000012970 cakes Nutrition 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000000945 filler Substances 0.000 claims description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 235000013402 health food Nutrition 0.000 claims description 2
- 238000007654 immersion Methods 0.000 claims description 2
- 235000015110 jellies Nutrition 0.000 claims description 2
- 239000008274 jelly Substances 0.000 claims description 2
- 239000000314 lubricant Substances 0.000 claims description 2
- 239000006072 paste Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 239000000080 wetting agent Substances 0.000 claims description 2
- 241000219173 Carica Species 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 102000003946 Prolactin Human genes 0.000 abstract description 13
- 108010057464 Prolactin Proteins 0.000 abstract description 13
- 229940097325 prolactin Drugs 0.000 abstract description 13
- 235000016709 nutrition Nutrition 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 7
- 235000019640 taste Nutrition 0.000 abstract description 4
- 230000000474 nursing effect Effects 0.000 abstract description 3
- 230000009469 supplementation Effects 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 2
- 230000007774 longterm Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 210000000481 breast Anatomy 0.000 description 13
- 230000015572 biosynthetic process Effects 0.000 description 12
- 230000028327 secretion Effects 0.000 description 12
- 238000003786 synthesis reaction Methods 0.000 description 12
- 239000000047 product Substances 0.000 description 11
- 108090000623 proteins and genes Proteins 0.000 description 10
- 210000004027 cell Anatomy 0.000 description 8
- 235000018102 proteins Nutrition 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 8
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 7
- 239000008101 lactose Substances 0.000 description 7
- 235000020256 human milk Nutrition 0.000 description 6
- 210000004251 human milk Anatomy 0.000 description 6
- 229910052500 inorganic mineral Inorganic materials 0.000 description 6
- 239000011707 mineral Substances 0.000 description 6
- 235000010755 mineral Nutrition 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 235000019197 fats Nutrition 0.000 description 5
- 235000015097 nutrients Nutrition 0.000 description 5
- 230000035764 nutrition Effects 0.000 description 5
- 102000004407 Lactalbumin Human genes 0.000 description 4
- 108090000942 Lactalbumin Proteins 0.000 description 4
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 210000002919 epithelial cell Anatomy 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 150000003722 vitamin derivatives Chemical class 0.000 description 4
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- ZQSIJRDFPHDXIC-UHFFFAOYSA-N daidzein Chemical compound C1=CC(O)=CC=C1C1=COC2=CC(O)=CC=C2C1=O ZQSIJRDFPHDXIC-UHFFFAOYSA-N 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 229930003944 flavone Natural products 0.000 description 3
- 235000011949 flavones Nutrition 0.000 description 3
- 230000000762 glandular Effects 0.000 description 3
- 210000005229 liver cell Anatomy 0.000 description 3
- 210000005075 mammary gland Anatomy 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 240000009087 Crescentia cujete Species 0.000 description 2
- 235000005983 Crescentia cujete Nutrition 0.000 description 2
- 206010062767 Hypophysitis Diseases 0.000 description 2
- 108010070158 Lactose synthase Proteins 0.000 description 2
- 235000009797 Lagenaria vulgaris Nutrition 0.000 description 2
- 108010011756 Milk Proteins Proteins 0.000 description 2
- 235000014676 Phragmites communis Nutrition 0.000 description 2
- 102000001253 Protein Kinase Human genes 0.000 description 2
- 102000003923 Protein Kinase C Human genes 0.000 description 2
- 108090000315 Protein Kinase C Proteins 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 102000014384 Type C Phospholipases Human genes 0.000 description 2
- 108010079194 Type C Phospholipases Proteins 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 108060000200 adenylate cyclase Proteins 0.000 description 2
- 102000030621 adenylate cyclase Human genes 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000005018 casein Substances 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- ZZIALNLLNHEQPJ-UHFFFAOYSA-N coumestrol Chemical compound C1=C(O)C=CC2=C1OC(=O)C1=C2OC2=CC(O)=CC=C12 ZZIALNLLNHEQPJ-UHFFFAOYSA-N 0.000 description 2
- 229940011871 estrogen Drugs 0.000 description 2
- 239000000262 estrogen Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000001983 lactogenic effect Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 235000008935 nutritious Nutrition 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 230000001817 pituitary effect Effects 0.000 description 2
- 235000021395 porridge Nutrition 0.000 description 2
- 239000000186 progesterone Substances 0.000 description 2
- 229960003387 progesterone Drugs 0.000 description 2
- 108060006633 protein kinase Proteins 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 210000001525 retina Anatomy 0.000 description 2
- 230000019491 signal transduction Effects 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 150000005856 steroid saponins Chemical class 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- 235000021241 α-lactalbumin Nutrition 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- HDXIQHTUNGFJIC-UHFFFAOYSA-N (25R)-spirost-5-en-3beta-ol 3-O-<O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside> Natural products O1C2(OCC(C)CC2)C(C)C(C2(CCC3C4(C)CC5)C)C1CC2C3CC=C4CC5OC1OC(CO)C(O)C(O)C1OC1OC(C)C(O)C(O)C1O HDXIQHTUNGFJIC-UHFFFAOYSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- FTVWIRXFELQLPI-ZDUSSCGKSA-N (S)-naringenin Chemical compound C1=CC(O)=CC=C1[C@H]1OC2=CC(O)=CC(O)=C2C(=O)C1 FTVWIRXFELQLPI-ZDUSSCGKSA-N 0.000 description 1
- 241000173529 Aconitum napellus Species 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 102100026189 Beta-galactosidase Human genes 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- VNONINPVFQTJOC-RXEYMUOJSA-N Collettiside III Natural products O([C@@H]1[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O2)[C@H](CO)O[C@@H]1O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]5[C@H](C)[C@@]6(O[C@H]5C4)OC[C@H](C)CC6)CC3)CC=2)CC1)[C@H]1[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O1 VNONINPVFQTJOC-RXEYMUOJSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- GMTUGPYJRUMVTC-UHFFFAOYSA-N Daidzin Natural products OC(COc1ccc2C(=O)C(=COc2c1)c3ccc(O)cc3)C(O)C(O)C(O)C=O GMTUGPYJRUMVTC-UHFFFAOYSA-N 0.000 description 1
- KYQZWONCHDNPDP-UHFFFAOYSA-N Daidzoside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 KYQZWONCHDNPDP-UHFFFAOYSA-N 0.000 description 1
- 102000015554 Dopamine receptor Human genes 0.000 description 1
- 108050004812 Dopamine receptor Proteins 0.000 description 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 108010059881 Lactase Proteins 0.000 description 1
- 208000019395 Lactation disease Diseases 0.000 description 1
- 101710094902 Legumin Proteins 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 108010070551 Meat Proteins Proteins 0.000 description 1
- 235000005135 Micromeria juliana Nutrition 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 201000009916 Postpartum depression Diseases 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- 102000001712 STAT5 Transcription Factor Human genes 0.000 description 1
- 108010029477 STAT5 Transcription Factor Proteins 0.000 description 1
- 240000002114 Satureja hortensis Species 0.000 description 1
- 235000007315 Satureja hortensis Nutrition 0.000 description 1
- 102000008078 Sterol Regulatory Element Binding Protein 1 Human genes 0.000 description 1
- 108010074436 Sterol Regulatory Element Binding Protein 1 Proteins 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 206010042576 Suppressed lactation Diseases 0.000 description 1
- 108700005078 Synthetic Genes Proteins 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- DWCSNWXARWMZTG-UHFFFAOYSA-N Trigonegenin A Natural products CC1C(C2(CCC3C4(C)CCC(O)C=C4CCC3C2C2)C)C2OC11CCC(C)CO1 DWCSNWXARWMZTG-UHFFFAOYSA-N 0.000 description 1
- 244000250129 Trigonella foenum graecum Species 0.000 description 1
- 235000001484 Trigonella foenum graecum Nutrition 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- CNHOGQMRRDHYGI-NJCGARBWSA-N beta-onocerin Chemical compound C([C@@]12C)C[C@H](O)C(C)(C)[C@@H]1CCC(C)=C2CCC1=C(C)CC[C@@H]2[C@]1(C)CC[C@H](O)C2(C)C CNHOGQMRRDHYGI-NJCGARBWSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 235000019636 bitter flavor Nutrition 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 102000014823 calbindin Human genes 0.000 description 1
- 108060001061 calbindin Proteins 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 230000008131 children development Effects 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 210000003022 colostrum Anatomy 0.000 description 1
- 235000021277 colostrum Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 235000007240 daidzein Nutrition 0.000 description 1
- KYQZWONCHDNPDP-QNDFHXLGSA-N daidzein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 KYQZWONCHDNPDP-QNDFHXLGSA-N 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- VNONINPVFQTJOC-ZGXDEBHDSA-N dioscin Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O[C@H]1[C@@H]([C@H](O)[C@@H](O)[C@H](C)O1)O)O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@H]5[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@@H]([C@]1(OC[C@H](C)CC1)O5)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O VNONINPVFQTJOC-ZGXDEBHDSA-N 0.000 description 1
- CJNUQCDDINHHHD-APRUHSSNSA-N dioscin Natural products C[C@@H]1CC[C@@]2(OC1)O[C@H]3C[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@H]6[C@H]5CC[C@]4(C)[C@H]3[C@@H]2C)O[C@@H]7O[C@H](CO)[C@@H](O[C@@H]8O[C@@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@H](O)[C@H]7O[C@@H]9O[C@@H](C)[C@H](O)[C@@H](O)[C@H]9O CJNUQCDDINHHHD-APRUHSSNSA-N 0.000 description 1
- WQLVFSAGQJTQCK-VKROHFNGSA-N diosgenin Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)CC[C@H](O)CC4=CC[C@H]3[C@@H]2C1)C)[C@@H]1C)[C@]11CC[C@@H](C)CO1 WQLVFSAGQJTQCK-VKROHFNGSA-N 0.000 description 1
- WQLVFSAGQJTQCK-UHFFFAOYSA-N diosgenin Natural products CC1C(C2(CCC3C4(C)CCC(O)CC4=CCC3C2C2)C)C2OC11CCC(C)CO1 WQLVFSAGQJTQCK-UHFFFAOYSA-N 0.000 description 1
- 208000016097 disease of metabolism Diseases 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- NEKNNCABDXGBEN-UHFFFAOYSA-L disodium;4-(4-chloro-2-methylphenoxy)butanoate;4-(2,4-dichlorophenoxy)butanoate Chemical compound [Na+].[Na+].CC1=CC(Cl)=CC=C1OCCCC([O-])=O.[O-]C(=O)CCCOC1=CC=C(Cl)C=C1Cl NEKNNCABDXGBEN-UHFFFAOYSA-L 0.000 description 1
- 235000011869 dried fruits Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 230000001076 estrogenic effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 235000006539 genistein Nutrition 0.000 description 1
- 229940045109 genistein Drugs 0.000 description 1
- TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000009229 glucose formation Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 235000021125 infant nutrition Nutrition 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 229940116108 lactase Drugs 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 230000023247 mammary gland development Effects 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 235000007625 naringenin Nutrition 0.000 description 1
- 229940117954 naringenin Drugs 0.000 description 1
- WGEYAGZBLYNDFV-UHFFFAOYSA-N naringenin Natural products C1(=O)C2=C(O)C=C(O)C=C2OC(C1)C1=CC=C(CC1)O WGEYAGZBLYNDFV-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 239000000813 peptide hormone Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- SBNFWQZLDJGRLK-UHFFFAOYSA-N phenothrin Chemical compound CC1(C)C(C=C(C)C)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 SBNFWQZLDJGRLK-UHFFFAOYSA-N 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 239000003075 phytoestrogen Substances 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- VNONINPVFQTJOC-UHFFFAOYSA-N polyphyllin III Natural products O1C2(OCC(C)CC2)C(C)C(C2(CCC3C4(C)CC5)C)C1CC2C3CC=C4CC5OC(C(C1O)OC2C(C(O)C(O)C(C)O2)O)OC(CO)C1OC1OC(C)C(O)C(O)C1O VNONINPVFQTJOC-UHFFFAOYSA-N 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 description 1
- 210000003456 pulmonary alveoli Anatomy 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 230000001835 salubrious effect Effects 0.000 description 1
- 210000002955 secretory cell Anatomy 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 235000001019 trigonella foenum-graecum Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
- A23L17/50—Molluscs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/10—Products from fruits or vegetables; Preparation or treatment thereof of tuberous or like starch containing root crops
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/035—Organic compounds containing oxygen as heteroatom
- A23L29/04—Fatty acids or derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Pediatric Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开一种促进泌乳的组合物，由下述重量份的原料制成：葫芦巴粉2‑10份、葛根粉30‑40份、木瓜粉40‑50份、牡蛎粉10‑20份、藻油(DHA含量70％)0.1‑0.6份。本发明公开的促进泌乳组合物优点在于：通过多种原料的合理配制，不仅可以提高产妇体内催乳素水平促进泌乳，还可以有效地增加产妇的营养补充，保证其乳汁的分泌；口感好，不油腻，可制备成饮料、固体饮料、粥类、面食、糕点等多种产品形式的食品、保健品或药品，实际应用价值较强；组合物所用原料大多被列入药食两用目录，安全有效，无毒副作用，适合哺乳期产妇长期服用。
Description
技术领域
本发明涉及一种分散均匀、促进泌乳的组合物及其制备方法，属于医药保健品技术领域。
背景技术
一直以来，母乳都被人们认为是婴儿营养的黄金标准，是0-6个月婴儿最合理的“营养配餐”，能够提供6个月内婴儿所需的所有营养。母乳含有3％-5％的脂肪，0.8％-0.9％的蛋白质，6.9％-7.2％的碳水化合物(乳糖)，0.2％的矿物质，以及其他生理活性物质等，提供60-75kcal/100ml的能量。母乳中丰富的抗体和免疫蛋白等物质可增强婴儿的抗感染能力；母乳中的消化酶、乳糖酶、脂肪酶等能够促进婴儿的胃肠道消化与吸收；母乳喂养还可以减少婴儿成年后患代谢性疾病如肥胖、高血压等的几率。研究表明，母乳喂养不仅有益于婴儿的生长发育，还可以降低母亲患乳腺癌和卵巢癌的危险。
世卫组织和儿童基金会建议：产后一小时即开始母乳喂养；生命最初6个月应进行纯母乳喂养；在婴儿6个月龄时增加有足够营养和安全的补充(固体)食品，同时持续进行母乳喂养至两岁或两岁以上。《2011-2020年中国妇女儿童发展纲要》也提出健康标准：0-6个月婴儿纯母乳喂养率达到50％以上。然而，许多婴幼儿都得不到最佳喂养。比如，世界范围内，2007年至2014年只有大约36％的年龄不足六个月的婴儿得到纯母乳喂养。产后缺乳、少乳是纯母乳喂养率比较低的主要原因。
泌乳期可分为3个时期：泌乳Ⅰ期或称泌乳分化期，始于孕中期，是乳腺细胞为泌乳准备的时期；泌乳Ⅱ期也称泌乳活化期，始于产后30-40小时左右，是乳腺细胞开始大量泌乳的时期；建立泌乳(从少量初乳增加至足量泌乳)和维持泌乳阶段(足量泌乳直到停止哺乳)。其中泌乳Ⅱ期是决定能否顺利开始母乳喂养的关键，泌乳Ⅱ期的启动有3个必要条件：胎盘娩出，孕酮撤退；催乳素水平上升并维持；乳房中乳汁有效排空。
孕酮撤退是泌乳的触发点。乳汁的分泌水平主要取决于产妇体内催乳素的高低。催乳素由脑垂体前叶及某些垂体外组织器官合成分泌的多肽类激素，由199个氨基酸残基所组成，分子量为22000。其主要作用为促进乳腺发育生长，启动并维持泌乳。催乳素可以调控机体内肝脏、脂肪组织和肌肉等外周组织的营养元素优先流向乳腺，用于乳糖、乳脂和乳蛋白等营养物质的合成，增强乳腺上皮细胞的泌乳功能。适量的雌激素能够增加产妇体内催乳素的释放。
另外，摄入足够的营养对于哺乳期妇女的重要性也是不容忽视。在哺乳期产生大量乳汁的时候，蛋白质、糖类化合物、脂质、矿物质等的摄入需要明显增加。营养不足会影响乳汁的分泌量而不是乳汁的组成成分。当营样摄入不足时乳汁中的基本成分的含量不变，但是这些营养成分是来自于产妇自身的储备。例如当膳食中的钙不足时，骨骼中储备的钙会被发掘直至分泌的乳汁达到正常水平。当产妇营养不足时乳汁的分泌量会明显降低。
对于促进泌乳的产品来说，只有被机体吸收了，才有发挥作用的可能，吸收率的高低直接关系到生物学效应的发挥，因此，吸收率是评价促进泌乳效果的关键，现有的促进泌乳的产品普遍存在吸收不理想的缺陷。同时现有促进泌乳的产品只是单纯地促进垂体催乳素的分泌，通过减少泌乳抑制因子(PIF)的分泌来增加垂体催乳素(PRL)的分泌，进而激活乳腺细胞,使乳腺细胞分泌乳汁，对于哺乳期妇女营养达不到一样影响乳汁的产量，同时现有的促进泌乳的产品分散性差，容易结块。
发明内容
针对现有技术的不足，本发明提供一种分散均匀、促进泌乳的组合物及其制备方法。
一种分散均匀、促进泌乳的组合物，原料重量份组成如下：葫芦巴粉2-10份、葛根粉30-40份、木瓜粉40-50份、牡蛎粉10-20份、藻油0.1-0.6份。
根据本发明优选的，所述的藻油中DHA含量70-80％。
根据本发明优选的，一种分散均匀、促进泌乳的组合物，原料重量份组成如下：葫芦巴粉4-7份、葛根粉30-36份、木瓜粉42-47份、牡蛎粉16-20份、藻油0.2-0.5份。
根据本发明优选的，一种分散均匀、促进泌乳的组合物，原料重量份组成如下：葫芦巴粉6份、葛根粉32份、木瓜粉45份、牡蛎粉16.6份、藻油0.4份。
根据本发明优选的，所述的葫芦巴粉是将葫芦巴炒制后清水浸泡、烘干、粉碎制得。
根据本发明优选的，所述的葛根粉是将葛根经除杂、去皮、洗涤、切块、打浆、静置、分离、烘干制得的。
根据本发明优选的，所述的木瓜粉是将木瓜除杂、去皮、去籽、切片、热烫、打浆、过滤、喷雾干燥制得的。
根据本发明优选的，所述的木瓜粉为番木瓜粉。
根据本发明优选的，所述的牡蛎粉是将牡蛎去皮清洗、匀浆、酶解、过滤、浓缩、喷雾干燥制得的。去皮清洗、匀浆、酶解、过滤、浓缩、喷雾干燥按本领域的常规技术进行。
本发明的第二个目的在于提供一种促进泌乳的保健品、食品或药品，以上述促进泌乳的组合物为有效成分，加入相应的配料、辅料或辅助性成分制成饮料、固体饮料、鲜汁、冲剂、颗粒剂、散剂、干粉、胶囊、软胶囊、片剂、口服液、糖浆、粥类、果冻、面食、糕点、茶类、丸剂、膏剂、奶粉、保健食品或药品。
所述辅料或辅助性成分包括食品或药学领域的稀释剂、赋形剂、填充剂、粘合剂、湿润剂、崩解剂、吸收促进剂、表面活性剂、吸附载体、润滑剂等。
根据本发明，一种分散均匀、促进泌乳的组合物的制备方法，包括步骤如下：
按配比将葫芦巴粉、葛根粉、木瓜粉、牡蛎粉、藻油混合均匀，然后辐照灭菌即得。
根据本发明，一种分散均匀、促进泌乳的组合物，口服使用，每日服用2-3次，每次30-40g。
葫芦巴为豆科植物葫芦巴(Trigonella foenum-graecum)的干燥成熟种子，据李时珍编撰的《本草纲目》一书中记载：味苦，大温，无毒；主治元脏虚冷气；得附子、硫黄，治肾虚冷，腹胁胀满，面色青黑；得香子、桃仁，治膀胱气甚效(嘉)；治冷气疝瘕，寒湿香港脚，益右肾，暖丹田。作为一种民间传统药物，葫芦巴常作为滋补、强壮药物，开胃药和解热药使用，从未用于产妇促进泌乳。葫芦巴含有丰富的蛋白质、淀粉、维生素、甾体皂苷、生物碱、香豆素等。研究发现，薯蓣皂苷元是葫芦巴甾体皂苷的主要成份。薯蓣皂苷元结构与17β-雌二醇结构非常类似，具有雌激素样功能，可以通过两条路线诱导脑垂体前叶催乳素细胞中催乳素基因的表达。一条路线是直接通过与细胞内雌激素受体相结合来刺激脑垂体前叶催乳素的合成与分泌。第二条路线是通过抑制多巴胺受体的活性来增强腺苷酸环化酶(AC)活性，增加单磷酸腺苷的浓度(cAMP)，增强cAMP依存性蛋白激酶(PKA)活性，同时增强磷脂酶C(PLC)和蛋白激酶C(PKC)的活性，最终刺激催乳素的分泌和催乳素细胞的增殖。
适量葫芦巴能够促进脑垂体催乳素的分泌，进而促进乳蛋白、乳糖和乳脂的合成。1分子的催乳素可与2分子乳腺上皮细胞膜结合型催乳素受体相结合激活受体，启动非受体型酪氨酸激酶2-信号传导及转录激活5(JAK2-STAT5)信号传导途径,最终激活反式作用因子STAT5,使其作用于乳蛋白基因启动子区的靶序列,启动或增强以乳蛋白基因启动子为作用元件的靶基因的表达，增加乳蛋白-酪蛋白的合成；刺激腺泡细胞内α乳白蛋白的合成，α乳白蛋白既是乳清蛋白中主要的钙结合蛋白，也是乳糖合成酶的一个亚基，α乳白蛋白的量增加，可以增加乳糖合成酶的合成量，使更多的半乳糖和葡萄糖合成乳糖。催乳素还可以激活肝细胞磷脂酰肌醇3激酶-蛋白激酶B(PI3K-Akt)信号通路，促进调控脂合成和转运的重要转录因子胆固醇元件结合蛋白-1c(SREBP-1c)的表达和转录活性，进而促进脂合成基因和转运基因的表达，使肝细胞甘油三酯(TG)和极低密度脂蛋白(VLDL)的合成和分泌增多，促进肝细胞的脂合成和转运作用，为乳脂的合成提供更多的前体物。
葛根富含黄酮类化合物，比普通食物高出40倍，种类多达13种，葛根素、大豆苷元、大豆苷、金雀异黄素苷、拟雌内酯和芒柄花素等；木瓜也含有芦丁、槲皮素、柚皮素、儿茶素等黄酮类化合物。葛根和木瓜含有的黄酮类化合物都属于植物雌激素，能够与葫芦巴协同促进脑垂体前叶催乳素的合成与分泌，促进乳汁的分泌。
本发明促进泌乳组合物中的牡蛎、木瓜、葛根都具有丰富的营养物质。番木瓜是一种营养丰富的“果之珍品”，含有比鲜橙更丰富的维生素C,每100g番木瓜果肉中含有50mg维生素C,是苹果的48倍；牡蛎素有“海底牛奶”之美称，干牡蛎肉蛋白质含量高达45％～57％，牛磺酸含量高达1.3％，有助于婴幼儿脑组织和智力发育；葛根含有大量的淀粉、多糖及17种必须氨基酸、矿物质等，葛根粉中的碳水化合物能达到80％，必须氨基酸含量为316mg/100g，人体不能合成的必须氨基酸含量为62mg/100g。另外木瓜中还含有木瓜蛋白酶，能帮助消化、吸收，还可以分解蛋白质、糖类等营养素。三者相互配合可以大大提高产妇蛋白质、糖类化合物、脂质、矿物质、维生素等营养元素的补充吸收。
本发明促进泌乳组合物中的藻油中二十二碳六稀酸(DHA)含量为70％，提取自海洋微藻，未经食物链的传递，相对更安全，其EPA含量非常低，且有利于婴幼儿的吸收。DHA是大脑和视网膜的重要构成脂肪酸，在人体大脑皮层中含量高达20％，在眼睛视网膜中所占比例最大，约占50％。婴幼儿如果缺乏DHA，会影响其智力、行为、精细动作等神经功能发育及视觉发育。产妇补充充足的DHA，才能保证婴幼儿大脑和视力更好地发育。世界卫生组织建议，哺乳期妇女每日DHA摄取量为300mg。
产妇充足的营养补充也有利于保证大量乳汁的分泌。母乳中含有乳蛋白、乳糖、乳脂、维生素及矿物质等营养物质。乳中的蛋白质是由酪蛋白和乳清蛋白组成，由乳腺上皮细胞合成的，原料来自血液中的游离氨基酸，其中必须氨基酸全部从血液中摄取。乳糖是以血液中的葡萄糖为原料，在乳腺腺泡细胞中合成，分泌到腺泡腔内。乳糖是调节渗透压的重要组成部分，它可以从周围的细胞质内汲取水而维持乳汁的体积。乳脂中大部分为甘油三脂，还含有少量磷脂、胆固醇、游离脂肪酸等。乳脂中的脂肪酸一部分是由乳腺上皮细胞合成，一部分是直接从血液中摄取。乳汁中的花生四烯酸(AA)、二十二碳六稀酸(DHA)、亚油酸、亚麻酸等都是从血液中摄取的；维生素和矿物质等营养元素都是由乳腺分泌上皮细胞从血液中选择性吸收而来。
本发明促进泌乳组合物中的葫芦巴味微苦；葛根味甘甜，气清香；木瓜粉具有果味清香，味香甜；牡蛎粉食用后也常有清爽宜人的感觉。葫芦巴粉、葛根粉、木瓜粉、牡蛎粉相互组合不仅可以消除葫芦巴粉的苦味，达到入口细腻柔滑,味道清香爽口的效果，还可以调节产妇情绪，缓解产后忧郁。
本发明的有益效果在于：1)通过多种原料的合理配制，不仅可以提高产妇体内催乳素水平促进泌乳，还可以有效地增加产妇的营养补充，保证其乳汁的分泌；2)口感好，不油腻，可制备成饮料、固体饮料、粥类、面食、糕点等多种产品形式的食品、保健品或药品，实际应用价值较强；3)组合物所用原料大多被列入药食两用目录，安全有效，无毒副作用，适合哺乳期产妇长期服用。
具体实施方式
下面通过具体实施例对本发明做进一步说明，但不限于此。
实施例中的原料为市购产品，
实施例1
一种分散均匀、促进泌乳的组合物，原料重量份组成如下：葫芦巴粉6g，葛根粉32g、木瓜粉45g、牡蛎粉16.6g、藻油(DHA含量70％)0.4g，将上述原料100g送入混料机里，充分混匀后进行微波灭菌，得到组合物。
组合物作为固体饮料使用，食用量：每日2次，每次35g，取适量80-100度开水冲调均匀后即可食用。
实施例2
一种分散均匀、促进泌乳的组合物，原料重量份组成如下：葫芦巴粉5份、葛根粉33份、木瓜粉45份、牡蛎粉16.6份、藻油(DHA含量70％)0.4份，共70g，取上述原料70g与燕麦片20g，水果干10g，将原料送入混料机里，充分混匀后进行微波灭菌，制得营养粥。
营养粥后的食用量：每日2-3次，每次50g，取适量80-100度开水冲调均匀后即可食用。
实验例：
一、不同促进泌乳产品的泌乳效果
随机选取200名产妇进行对比实验，年龄段为25～40岁，分为5组，每组40人，实验周期为2周。记录产妇每天的泌乳次数，实验结果如下1：
注：1.数据显示为平均值(标准偏差)；2.研究表明，葫芦巴粉每人每日的安全剂量最高为9g。
二、不同促进泌乳产品的分散性及口感
取实施例1的组合物、葫芦巴粉、葛根粉、木瓜粉、牡蛎粉各35g，分别用100ml 80-100度开水冲调，观察其冲调效果。选20位志愿者品尝并对其口感进行评分，满分为10分，20名志愿者取平均分。结果如下表：
以上所述仅是本发明的优选实施方式，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以做出若干改进和润饰，这些改进和润饰也应视为本发明的保护范围。
Claims (10)
1.一种分散均匀、促进泌乳的组合物，原料重量份组成如下：葫芦巴粉2-10份、葛根粉30-40份、木瓜粉40-50份、牡蛎粉10-20份、藻油0.1-0.6份。
2.根据权利要求1所述的分散均匀、促进泌乳的组合物，其特征在于，所述的藻油中DHA含量70-80％。
3.根据权利要求1所述的分散均匀、促进泌乳的组合物，其特征在于，原料重量份组成如下：葫芦巴粉4-7份、葛根粉30-36份、木瓜粉42-47份、牡蛎粉16-20份、藻油0.2-0.5份。
4.根据权利要求1所述的分散均匀、促进泌乳的组合物，其特征在于，原料重量份组成如下：葫芦巴粉6份、葛根粉32份、木瓜粉45份、牡蛎粉16.6份、藻油0.4份。
5.根据权利要求1所述的分散均匀、促进泌乳的组合物，其特征在于，所述的葫芦巴粉是将葫芦巴炒制后清水浸泡、烘干、粉碎制得。
6.根据权利要求1所述的分散均匀、促进泌乳的组合物，其特征在于，所述的葛根粉是将葛根经除杂、去皮、洗涤、切块、打浆、静置、分离、烘干制得的。
7.根据权利要求1所述的分散均匀、促进泌乳的组合物，其特征在于，所述的木瓜粉是将木瓜除杂、去皮、去籽、切片、热烫、打浆、过滤、喷雾干燥制得的；所述的木瓜粉为番木瓜粉，所述的牡蛎粉是将牡蛎去皮清洗、匀浆、酶解、过滤、浓缩、喷雾干燥制得。
8.一种促进泌乳的保健品、食品或药品，以上述促进泌乳的组合物为有效成分，加入相应的配料、辅料或辅助性成分制成饮料、固体饮料、鲜汁、冲剂、颗粒剂、散剂、干粉、胶囊、软胶囊、片剂、口服液、糖浆、粥类、果冻、面食、糕点、茶类、丸剂、膏剂、奶粉、保健食品或药品；所述辅料或辅助性成分包括食品或药学领域的稀释剂、赋形剂、填充剂、粘合剂、湿润剂、崩解剂、吸收促进剂、表面活性剂、吸附载体、润滑剂等。
9.一种分散均匀、促进泌乳的组合物的制备方法，包括步骤如下：
按配比将葫芦巴粉、葛根粉、木瓜粉、牡蛎粉、藻油混合均匀，然后辐照灭菌即得。
10.根据权利要求1所述的分散均匀、促进泌乳的组合物，其特征在于，口服使用，每日服用2-3次，每次30-40g。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710860003.6A CN107801936A (zh) | 2017-09-21 | 2017-09-21 | 一种分散均匀、促进泌乳的组合物及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710860003.6A CN107801936A (zh) | 2017-09-21 | 2017-09-21 | 一种分散均匀、促进泌乳的组合物及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107801936A true CN107801936A (zh) | 2018-03-16 |
Family
ID=61584355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710860003.6A Pending CN107801936A (zh) | 2017-09-21 | 2017-09-21 | 一种分散均匀、促进泌乳的组合物及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107801936A (zh) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020153908A3 (en) * | 2019-01-23 | 2020-09-17 | Agency For Science, Technology And Research (A*Star) | Pre-natal beta-cryptoxanthin benefits children |
| CN111685318A (zh) * | 2020-06-24 | 2020-09-22 | 南京玉鹤鸣医学营养研究院有限公司 | 一种促进产后泌乳的配方食品 |
| CN111973635A (zh) * | 2020-08-31 | 2020-11-24 | 广东海洋大学 | 一种牡蛎促进泌乳作用研究方法 |
| CN114246220A (zh) * | 2020-09-24 | 2022-03-29 | 沈阳美生药物研究所 | 一种适合哺乳期女性的风味植物蛋白饮料的配方 |
| CN114271335A (zh) * | 2021-11-30 | 2022-04-05 | 倍恩喜(湖南)乳业有限公司 | 乳制品及其制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB488932A (en) * | 1936-01-15 | 1938-07-15 | Ig Farbenindustrie Ag | Manufacture of the substance promoting lactation from the anterior lobes of the hypophysis |
| CN101919518A (zh) * | 2009-06-15 | 2010-12-22 | 徐善峰 | 一种木瓜葛根粉及其制作方法 |
| CN102497788A (zh) * | 2009-07-29 | 2012-06-13 | 法国婴儿营养实验室 | 适用于哺乳期女性的营养组合物 |
-
2017
- 2017-09-21 CN CN201710860003.6A patent/CN107801936A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB488932A (en) * | 1936-01-15 | 1938-07-15 | Ig Farbenindustrie Ag | Manufacture of the substance promoting lactation from the anterior lobes of the hypophysis |
| CN101919518A (zh) * | 2009-06-15 | 2010-12-22 | 徐善峰 | 一种木瓜葛根粉及其制作方法 |
| CN102497788A (zh) * | 2009-07-29 | 2012-06-13 | 法国婴儿营养实验室 | 适用于哺乳期女性的营养组合物 |
Non-Patent Citations (1)
| Title |
|---|
| 张军合，等: "《食品机械与设备》", 31 August 2012, 中国科学技术出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020153908A3 (en) * | 2019-01-23 | 2020-09-17 | Agency For Science, Technology And Research (A*Star) | Pre-natal beta-cryptoxanthin benefits children |
| CN111685318A (zh) * | 2020-06-24 | 2020-09-22 | 南京玉鹤鸣医学营养研究院有限公司 | 一种促进产后泌乳的配方食品 |
| CN111973635A (zh) * | 2020-08-31 | 2020-11-24 | 广东海洋大学 | 一种牡蛎促进泌乳作用研究方法 |
| CN114246220A (zh) * | 2020-09-24 | 2022-03-29 | 沈阳美生药物研究所 | 一种适合哺乳期女性的风味植物蛋白饮料的配方 |
| CN114271335A (zh) * | 2021-11-30 | 2022-04-05 | 倍恩喜(湖南)乳业有限公司 | 乳制品及其制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107801936A (zh) | 一种分散均匀、促进泌乳的组合物及其制备方法 | |
| CN102919836B (zh) | 一种降糖、降压、降脂、通便养颜、减肥、抗疲劳保健品及其生产工艺 | |
| CN109645320A (zh) | 一种轻断食全营养配方可冲泡即食棒及其制备方法 | |
| CN102524659A (zh) | 一种具有营养保健功能的粮食配方 | |
| CN110447902B (zh) | 一种具有减肥功效的组合物 | |
| CN104643250A (zh) | 一种可双向调节体重改善亚健康的固体饮料 | |
| CN102511861A (zh) | 一种添加低聚糖的红枣浓浆 | |
| CN102511864B (zh) | 一种红枣浓浆 | |
| CN102511869A (zh) | 红枣生姜浓浆 | |
| CN110547470A (zh) | 一种可提高男性性功能的营养组合物及其制备方法 | |
| CN104336144A (zh) | 一种同步调节高血糖高血压高血脂及免疫功能的食用饼干 | |
| CN108770941A (zh) | 一种罗汉果奇亚籽豆奶及其制备方法 | |
| CN108936601A (zh) | 一种预防小儿厌食、偏食的保健食品及其制备方法 | |
| CN108308621A (zh) | 一种富含大米低聚肽的减肥代餐粉 | |
| CN102511876B (zh) | 山楂红枣浓浆及其生产工艺 | |
| CN104757689A (zh) | 一种松黄维生素固体饮料及其制备方法 | |
| CN102511875A (zh) | 一种适合术后人群饮用的红枣浓浆 | |
| CN106472680A (zh) | 一种乳制品 | |
| CN102511871A (zh) | 补肾强身红枣浓浆 | |
| CN105995980B (zh) | 一种具有体重管理作用的组合物及其制备方法 | |
| CN102511882A (zh) | 一种有助于改善生长发育的红枣浓浆 | |
| CN113925172A (zh) | 一种适用于儿童的大鲵肽营养组合物 | |
| CN102511870A (zh) | 一种利于减肥的红枣浓浆 | |
| CN102511860B (zh) | 一种添加植物甾醇适合孕妇食用的红枣浓浆 | |
| CN102511868A (zh) | 一种添加维生素的红枣阿胶浓浆 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180316 |