CN107753929A - 一种含麦胚球蛋白的保健口服液及其制备方法 - Google Patents
一种含麦胚球蛋白的保健口服液及其制备方法 Download PDFInfo
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- CN107753929A CN107753929A CN201711106666.5A CN201711106666A CN107753929A CN 107753929 A CN107753929 A CN 107753929A CN 201711106666 A CN201711106666 A CN 201711106666A CN 107753929 A CN107753929 A CN 107753929A
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- wheat germ
- root
- globulin
- oral liquid
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Abstract
本发明公开了一种含麦胚球蛋白的保健口服液,由麦胚球蛋白、白花蛇舌草、竹茹多糖、香菇多糖、秋葵多糖、脱脂麦胚、灵芝、蜂王浆、牛蒡子、柴胡、鱼腥草、葛根、川芎、夏枯草、穿心莲、黄芩、蒲公英、贯众、虎杖、牛膝、甘草和小球藻组成,通过麦胚芽蛋白、白花蛇舌草、灵芝、蜂王浆、牛蒡子、鱼腥草、葛根、川芎、黄柏、穿心莲、蒲公英、枸杞、贯众、虎杖、牛膝、甘草、小球藻等中草药彼此间存在复杂的相互作用关系,君臣佐使合理配比,配以功能多糖,采用“快速固态糖化发酵+高温炒制+二次固态螯合发酵+中温水提”的工艺,多菌协同,充分糅合麦胚球蛋白和中草药中的抗肿瘤提高免疫力的功能活性成分,取得了较好的技术效果。
Description
技术领域
本发明涉及一种口服液,尤其是涉及一种含麦胚球蛋白的保健口服液及其制备方法,属于保健领域。
背景技术
人血丙种球蛋白,主要用于预防麻疹或减轻症状。用于传染性肝炎、麻疹、水痘、腮腺炎、带状疱疹等病毒性感染的防治。用于哮喘、过敏性鼻炎、湿疹等内源性过敏性疾病。用于提高机体的免疫功能:原发性免疫球蛋白缺乏症,常见变异性免疫缺陷病,免疫球蛋白G亚型缺陷病等。继发性免疫球蛋白缺陷病,如重症感染,新生儿败血症等。自身免疫性疾病,如原发性血小板减少性紫癜,川崎病。麦胚球蛋白与人血丙种球蛋白功能类似,是从小麦中提取出来的一类植物源球蛋白。
麦胚球蛋白在麦胚总蛋白中占比20%左右,是麦胚中除白蛋白外含量最高、功能最全的蛋白质。Danielson采用超速离心技术分离并研究了小麦籽粒和谷物胚芽中的球蛋白组分,结果证明麦胚球蛋白是一种相对分子量为213kD的单一蛋白;Burgess等研究证明麦胚球蛋白主要是一种8S球蛋白,包括两个非二硫键连接的亚基,其相对分子量分别为50和40kD;周显青在对麦胚球蛋白的提取研究中,通过SDS-PAGE电泳分析由α、γ、δ三种球蛋白组成;朱科学等对比于前人的研究,发现麦胚球蛋白主要包含单一的γ型8S球蛋白,并通过CD光谱分析二级结构组成及含量,显示其中包含54.9%的β-折叠结构、25.3%的无规卷曲结构和19.8%α-螺旋,未有β-转角结构;同时还发现麦胚球蛋白中还可能含有类似于“Triticins”蛋白的11S球蛋白;其相对分子质量范围为12~60kD。
基于LC/MS对麦胚球蛋白组分鉴定、代谢通路分析,经GO功能注释和KEGG Pathway分析发现麦胚球蛋白共涉及分子功能31种、细胞组成47种和生物过程调控87种,参与到代谢通路调控104条。蛋白质互作网络(PPI)分析,共包含具有统计学特征的蛋白质互作子网络5个,枢纽蛋白23个。对鉴定所得的蛋白质进行KEGG Pathway分析,发现麦胚球蛋白参与到了104条通路,其中系统性红斑狼疮(Systemic lupus erythematosus)相关蛋白12%,酒精中毒(Alcoholism)相关蛋白12%,核糖体(Ribosome)相关蛋白10% ,剪接体(Spliceosome)相关蛋白7%,RNA转运(RNA transport)相关蛋白4%,蛋白质在内质网形成过程蛋白(Protein processing in endoplasmic reticulum)4%,碳代谢(Carbonmetabolism)4%,在真核生物核糖体生物起源(Ribosome biogenesis in eukaryotes)4%,氨基糖和核苷酸糖代谢(Amino sugar and nucleotide sugar metabolism)4%等。
白花蛇舌草,其成药味苦、淡,性寒。具有清热解毒、消痛散结、利尿除湿功效。尤善治疗各种类型炎症。在临床实践中,发现白花蛇舌草若与球蛋白配伍得当,具有抑瘤、抗癌功能。竹茹多糖、香菇多糖、秋葵多糖为天然的功能多糖,是一种宿主免疫增强剂(hostdefense potentiator,HDP),临床与药理研究表明,其具有抗病毒、抗肿瘤、调节免疫功能和刺激干扰素形成等作用;三者结合具有缓解不能手术或复发性胃癌、肝癌、膀胱癌症状,提高病人免疫功能,纠正微量元素失调功能;另外功能糖组合与麦胚球蛋白配合使用,能够保护蛋白活性,增强麦胚球蛋白功效。灵芝、蜂王浆具有提高免疫力、增强细胞活性之功效;牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、小球藻联用具有提高免疫力、抑制肿瘤细胞的功效;夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草具有清热解毒、抗病毒之功效,与上述中草药搭配合理,具有增强药效的作用。
麦胚球蛋白具有抑瘤、增强免疫力的功能,目前常用于食品、保健品、医药等,具有较好的应用开发价值。本发明利用麦胚球蛋白的抑瘤、增强免疫力功能特性和中草药抑制肿瘤、提高免疫的特性相配比,提供一种一种含麦胚球蛋白的保健口服液及其制备方法。
发明内容
本发明的目的是提供一种含麦胚球蛋白的保健口服液及其制备方法,可以提高人们的免疫功能,增强体质,保障人们的健康。
本发明提供一种含麦胚球蛋白的保健口服液,由麦胚球蛋白、白花蛇舌草、竹茹多糖、香菇多糖、秋葵多糖、脱脂麦胚、灵芝、蜂王浆、牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草和小球藻组成。
作为本发明的一种优选技术方案,每1000份口服液中中药原料及质量配比为:麦胚球蛋白3~12份、白花蛇舌草15~30份、竹茹多糖10~15份、香菇多糖10~15份、秋葵多糖10~15份、脱脂麦胚30~50份、灵芝4~8份、蜂王浆2~6份、牛蒡子10~15份、柴胡10~15份、鱼腥草8~12份、葛根10~15份、川芎15~20份、黄柏10~13份、夏枯草10~13份、穿心莲8~12份、黄芩8~12份、蒲公英10~15份、枸杞10~16份、贯众10~18份、虎杖5~10份、牛膝5~10份、甘草10~15份、小球藻10~15份称重;
作为本发明的一种优选技术方案,其中药原料及质量配比为:麦胚球蛋白7份、白花蛇舌草23份、竹茹多糖13份、香菇多糖13份、秋葵多糖13份、脱脂麦胚40份、灵芝6份、蜂王浆4份、牛蒡子13份、柴胡13份、鱼腥草10份、葛根12份、川芎16份、黄柏12份、夏枯草12份、穿心莲10份、黄芩10份、蒲公英13份、枸杞15份、贯众15份、虎杖7份、牛膝7份、甘草12份、小球藻13份。
本发明提供一种含麦胚球蛋白的保健口服液的制备方法,通过以下步骤制备:
(1)分拣称量:将所用中草药分拣,去除杂质等,按照上述比例称重;
(2)原料预处理:将白花蛇舌草、脱脂麦胚、灵芝、牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草和小球藻混合后进行粉碎处理,过30目筛;
(3)向粉碎后的混合物中加入0.3倍灭菌纯净水,接种米曲霉孢子粉和毛霉孢子粉,平摊在发酵浅盘中,厚度0.6 cm。发酵温度32 ℃,好氧发酵时间12 h后,立即50℃烘干至水分在8%左右,并进行炒制后,自然冷却至室温,得前发酵固体混合物;所述米曲霉接种为0.01%,含孢子120亿/克,毛霉接种量为0.01%,含孢子120亿/克;所述炒制温度200℃,时间30min,翻动频率在120次/分钟;
(4)将前发酵固体混合物,加0.3倍灭菌纯净水,接种0.01%红曲霉干粉,平摊在发酵浅盘中,厚度0.6cm。发酵温度37℃,发酵时间144 h,颜色为玫红色后,立即50℃烘干至水分在8%左右,得后发酵固体混合物;
(5)添加辅料:加入蜂王浆和质量分数为1~2%的甜味剂,加水搅拌定容,加热至70℃,30min;
(6)静置:将口服液半成品常温下静置48h以上;
(7)离心:将口服液半成品5000r/min离心20 min;加入麦胚球蛋白、竹茹多糖、香菇多糖、秋葵多糖;
(8)定容分装:将离心后的口服液定容、分装即得口服液成品。
作为本发明的一种优选技术方案,上述甜味剂的组成为三氯蔗糖1份;果糖2.5份;高果糖浆1.5份。
本发明的有益效果是:本发明提供一种含麦胚球蛋白的保健口服液及其制备方法,一是在传统中医理论和实践指导下精选药方,科学配伍麦胚球蛋白和多种中草药,药物组分经辨证配伍,在作用上相互佐助,能显著抗肿瘤提高免疫力;二是在口服液的制备过程中采用“快速固态糖化发酵+高温炒制+二次固态螯合发酵+中温水提”的工艺,多菌协同,充分糅合麦胚球蛋白和中草药中的抗肿瘤提高免疫力的功能活性成分,提高保健效果;三是来源植物天然成分,口服液安全无副作用,饮用方便。
本发明提供一种含麦胚球蛋白的保健口服液及其制备方法,不同的中草药性味各异,功效存在着巨大的差异,不同的中草药组合后存在复杂的相互作用关系,且中草药之间的配比比较密切,不同配比也将使君臣佐使关系发生实质性的变化,从而使复合中草药的关系发生实质性改变。白花蛇舌草具有清热解毒、消痛散结、利尿除湿功效。竹茹多糖、香菇多糖、秋葵多糖具有抗病毒、抗肿瘤、调节免疫功能和刺激干扰素形成等作用;灵芝、蜂王浆具有提高免疫力、增强细胞活性之功效;牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、小球藻联用具有提高免疫力、抑制肿瘤细胞的功效;夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草具有清热解毒、抗病毒之功效。本申请通过将白花蛇舌草、灵芝、蜂王浆、河豚鱼油、牛蒡子、鱼腥草、葛根、川芎、黄柏、穿心莲、蒲公英、枸杞、贯众、虎杖、牛膝、甘草、小球藻等中草药彼此间存在复杂的相互作用关系与麦胚球蛋白和功能多糖,君臣佐使,合理配比,取得了预料不到的技术效果,使麦胚球蛋白保健口服液抗肿瘤提高免疫力的关系发生实质性改变。
具体实施方式
下面结合实施例对本发明做进一步描述:
实施例1
本发明提供一种含麦胚球蛋白的保健口服液,由麦胚球蛋白、白花蛇舌草、竹茹多糖、香菇多糖、秋葵多糖、脱脂麦胚、灵芝、蜂王浆、牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草和小球藻组成。
通过以下步骤制备:
(1)分拣称量:将所用中草药分拣,去除杂质等,按照每1000份口服液中麦胚球蛋白7份、白花蛇舌草23份、竹茹多糖13份、香菇多糖13份、秋葵多糖13份、脱脂麦胚40份、灵芝6份、蜂王浆4份、牛蒡子13份、柴胡13份、鱼腥草10份、葛根12份、川芎16份、黄柏12份、夏枯草12份、穿心莲10份、黄芩10份、蒲公英13份、枸杞15份、贯众15份、虎杖7份、牛膝7份、甘草12份、小球藻13份比例称重;
(2)原料预处理:将白花蛇舌草、脱脂麦胚、灵芝、牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草和小球藻处理,过30目筛;
(3)向粉碎后的混合物中加入0.3倍灭菌纯净水,接种米曲霉孢子粉和毛霉孢子粉,平摊在发酵浅盘中,厚度0.6 cm。发酵温度32 ℃,好氧发酵时间12 h后,立即50℃烘干至水分在8%左右,并进行炒制后,自然冷却至室温,得前发酵固体混合物;所述米曲霉接种为0.01%,含孢子120亿/克,毛霉接种量为0.01%,含孢子120亿/克;所述炒制温度200℃,时间30min,翻动频率在120次/分钟。
(4)将前发酵固体混合物,加0.3倍灭菌纯净水,接种0.01%红曲霉干粉,平摊在发酵浅盘中,厚度0.6cm。发酵温度37℃,发酵时间144 h,颜色为玫红色后,立即50℃烘干至水分在8%左右,得后发酵固体混合物;
(5)添加辅料:加入蜂王浆和质量分数为1~2%的甜味剂,加水搅拌定容,加热至50℃,30min;
(6)静置:将口服液半成品常温下静置48h以上;
(7)离心:将口服液半成品5000r/min离心20 min;加入麦胚球蛋白、竹茹多糖、香菇多糖、秋葵多糖;
(8)定容分装:将离心后的口服液定容、分装即得口服液成品。
实施例2
本发明提供一种含麦胚球蛋白的保健口服液,由麦胚球蛋白、白花蛇舌草、竹茹多糖、香菇多糖、秋葵多糖、脱脂麦胚、灵芝、蜂王浆、牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草和小球藻组成。
通过以下步骤制备:
(1)分拣称量:将所用中草药分拣,去除杂质等,按照每1000份口服液中麦胚球蛋白3份、白花蛇舌草15份、竹茹多糖10份、香菇多糖10份、秋葵多糖10份、脱脂麦胚30份、灵芝4份、蜂王浆6份、牛蒡子15份、柴胡10份、鱼腥草12份、葛根15份、川芎15份、黄柏13份、夏枯草13份、穿心莲8份、蒲公英15份、枸杞10份、贯众10份、虎杖5份、牛膝10份、甘草15份、小球藻10份比例称重;
(2)原料预处理:将白花蛇舌草、脱脂麦胚、灵芝、牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草和小球藻混合后进行粉碎处理,过30目筛;
(3)向粉碎后的混合物中加入0.3倍灭菌纯净水,接种米曲霉孢子粉和毛霉孢子粉,平摊在发酵浅盘中,厚度0.6 cm。发酵温度32 ℃,好氧发酵时间12 h后,立即50℃烘干至水分在8%左右,并进行炒制后,自然冷却至室温,得前发酵固体混合物;所述米曲霉接种为0.01%,含孢子120亿/克,毛霉接种量为0.01%,含孢子120亿/克;所述炒制温度200℃,时间30min,翻动频率在120次/分钟;
(4)将前发酵固体混合物,加0.3倍灭菌纯净水,接种0.01%红曲霉干粉,平摊在发酵浅盘中,厚度0.6cm。发酵温度37℃,发酵时间144 h,颜色为玫红色后,立即50℃烘干至水分在8%左右,得后发酵固体混合物;
(5)添加辅料:加入蜂王浆和质量分数为1~2%的甜味剂,加水搅拌定容,加热至70℃,30min;
(6)静置:将口服液半成品常温下静置48h以上;
(7)离心:将口服液半成品5000r/min离心20 min;加入麦胚球蛋白、竹茹多糖、香菇多糖、秋葵多糖;
(8)定容分装:将离心后的口服液定容、分装即得口服液成品。
实施例3
本发明提供一种含麦胚球蛋白的保健口服液,由麦胚球蛋白、白花蛇舌草、竹茹多糖、香菇多糖、秋葵多糖、脱脂麦胚、灵芝、蜂王浆、河豚鱼油、牛蒡子、柴胡、鱼腥草、葛根、川芎、夏枯草、穿心莲、黄芩、蒲公英、贯众、虎杖、牛膝、甘草和小球藻组成。
通过以下步骤制备:
(1)分拣称量:将所用中草药分拣,去除杂质等,按照每1000份口服液中麦胚球蛋白12份、白花蛇舌草30份、竹茹多糖15份、香菇多糖15份、秋葵多糖15份、脱脂麦胚50份、灵芝8份、蜂王浆2份、牛蒡子10份、柴胡15份、鱼腥草8份、葛根10份、川芎20份、黄柏10份、夏枯草10份、穿心莲12份、蒲公英10份、枸杞16份、贯众18份、虎杖10份、牛膝5份、甘草10份、小球藻15份比例称重;
(2)原料预处理:将白花蛇舌草、脱脂麦胚、灵芝、牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草和小球藻混合后进行粉碎处理,过30目筛;
(3)向粉碎后的混合物中加入0.3倍灭菌纯净水,接种米曲霉孢子粉和毛霉孢子粉,平摊在发酵浅盘中,厚度0.6 cm。发酵温度32 ℃,好氧发酵时间12 h后,立即50℃烘干至水分在8%左右,并进行炒制后,自然冷却至室温,得前发酵固体混合物;所述米曲霉接种为0.01%,含孢子120亿/克,毛霉接种量为0.01%,含孢子120亿/克;所述炒制温度200℃,时间30min,翻动频率在120次/分钟;
(4)将前发酵固体混合物,加0.3倍灭菌纯净水,接种0.01%红曲霉干粉,平摊在发酵浅盘中,厚度0.6cm。发酵温度37℃,发酵时间144 h,颜色为玫红色后,立即50℃烘干至水分在8%左右,得后发酵固体混合物;
(5)添加辅料:加入蜂王浆和质量分数为1~2%的甜味剂,加水搅拌定容,加热至70℃,30min;
(6)静置:将口服液半成品常温下静置48h以上;
(7)离心:将口服液半成品5000r/min离心20 min;加入麦胚球蛋白、竹茹多糖、香菇多糖、秋葵多糖;
(8)定容分装:将离心后的口服液定容、分装即得口服液成品。
以上所述仅为本发明的一实施例,并不限制本发明,凡采用等同替换或等效变换的方式所获得的技术方案,均落在本发明的保护范围内。
Claims (3)
1.一种含麦胚球蛋白的保健口服液,其特征在于由麦胚球蛋白、白花蛇舌草、竹茹多糖、香菇多糖、秋葵多糖、脱脂麦胚、灵芝、蜂王浆、牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草和小球藻组成。
2.根据权利要求1所述的一种含麦胚球蛋白的保健口服液的制备方法,其特征在于,通过以下步骤制备:
(1)分拣称量:将所用中草药分拣,去除杂质等,按照每1000份口服液中原料质量配比:麦胚球蛋白3~12份、白花蛇舌草15~30份、竹茹多糖10~15份、香菇多糖10~15份、秋葵多糖10~15份、脱脂麦胚30~50份、灵芝4~8份、蜂王浆2~6份、牛蒡子10~15份、柴胡10~15份、鱼腥草8~12份、葛根10~15份、川芎15~20份、黄柏10~13份、夏枯草10~13份、穿心莲8~12份、黄芩8~12份、蒲公英10~15份、枸杞10~16份、贯众10~18份、虎杖5~10份、牛膝5~10份、甘草10~15份、小球藻10~15份称重;
(2)原料预处理:将白花蛇舌草、脱脂麦胚、灵芝、牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草和小球藻混合后进行粉碎处理,过30目筛;
(3)向粉碎后的混合物中加入0.3倍灭菌纯净水,接种米曲霉孢子粉和毛霉孢子粉,平摊在发酵浅盘中,厚度0.6 cm;发酵温度32 ℃,好氧发酵时间12 h后,立即50℃烘干至水分在8%左右,并进行炒制后,自然冷却至室温,得前发酵固体混合物;所述米曲霉接种为质量分数0.01%,含孢子120亿/克,毛霉接种量为质量分数0.01%,含孢子120亿/克;所述炒制温度200℃,时间30min,翻动频率在120次/分钟;
(4)将前发酵固体混合物,加0.3倍灭菌纯净水,接种红曲霉干粉,平摊在发酵浅盘中,厚度0.6cm;发酵温度37℃,发酵时间144 h,颜色为玫红色后,立即50℃烘干至水分在8%左右,得后发酵固体混合物;所述红曲霉接种为质量分数0.01%,含孢子80亿/克;
(5)添加辅料:加入蜂王浆和质量分数为1~2%的甜味剂,加水搅拌定容,加热至70℃,30min;
(6)静置:将口服液半成品常温下静置48h以上;
(7)离心:将口服液半成品5000r/min离心20 min;加入麦胚球蛋白、竹茹多糖、香菇多糖、秋葵多糖;
(8)定容分装:将离心后的口服液定容、分装即得口服液成品。
3.根据权利要求书1所述的一种含麦胚球蛋白的保健口服液,其特征在于,所述甜味剂的组成为三氯蔗糖1份、果糖2.5份、高果糖浆1.5份。
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