CN107744519A - 改良神经传导速度的方法和组合物 - Google Patents
改良神经传导速度的方法和组合物 Download PDFInfo
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- CN107744519A CN107744519A CN201711036658.8A CN201711036658A CN107744519A CN 107744519 A CN107744519 A CN 107744519A CN 201711036658 A CN201711036658 A CN 201711036658A CN 107744519 A CN107744519 A CN 107744519A
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
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- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| CN2011800145791A CN102821765A (zh) | 2010-01-19 | 2011-01-19 | 改良神经传导速度的方法和组合物 |
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| US (1) | US9095587B2 (https=) |
| EP (1) | EP2525795B1 (https=) |
| JP (2) | JP6232184B2 (https=) |
| CN (2) | CN107744519A (https=) |
| AU (1) | AU2011207104C1 (https=) |
| CA (1) | CA2787173C (https=) |
| ES (1) | ES2560327T3 (https=) |
| NZ (1) | NZ601383A (https=) |
| WO (1) | WO2011088504A1 (https=) |
| ZA (1) | ZA201205375B (https=) |
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| AU2011281381B2 (en) * | 2010-07-21 | 2015-07-16 | Novartis Ag | Salt and solvates of a tetrahydroisoquinoline derivative |
| WO2012135365A2 (en) * | 2011-03-29 | 2012-10-04 | Biolyst, Llc | Systems and methods for use in treating sensory impairment |
| ES2802251T3 (es) | 2012-01-06 | 2021-01-18 | Novartis Ag | Compuestos heterocíclicos y métodos para su uso |
| PT2807171T (pt) * | 2012-01-25 | 2020-11-03 | Novartis Ag | Compostos heterocíclicos e métodos para a sua utilização |
| ES2798289T3 (es) | 2012-01-25 | 2020-12-10 | Novartis Ag | Compuestos heterocíclicos y métodos para su uso |
| ES2883155T3 (es) * | 2013-07-08 | 2021-12-07 | Novartis Ag | Compuestos heterocíclicos y métodos para su uso |
| JP6667551B2 (ja) | 2015-01-13 | 2020-03-18 | ノバルティス アーゲー | アンジオテンシンｉｉ２型拮抗薬としてのピロリジン誘導体 |
| US10308628B2 (en) | 2015-03-12 | 2019-06-04 | Novartis Ag | Heterocyclic compounds and methods for their use |
| CN106478502B (zh) * | 2015-08-29 | 2021-04-27 | 上海翰森生物医药科技有限公司 | 1,2,3,4-四氢异喹啉衍生物、其制备方法和应用 |
| PT3620454T (pt) * | 2017-06-09 | 2021-09-10 | Shandong Danhong Pharmaceutical Co Ltd | Derivado de ácido carboxílico como antagonista do recetor at2r |
| KR102619333B1 (ko) * | 2018-11-02 | 2023-12-28 | 산동 단홍 파머수티컬 컴퍼니., 리미티드. | 안지오텐신ii 수용체2 길항제의 염 형태, 결정형 및 그 제조방법 |
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| US5091390A (en) * | 1990-09-20 | 1992-02-25 | E. I. Du Pont De Nemours And Company | Treatment of CNS disorders with 4,5,6,7-tetrahydro-1H-imidazo (4,5-)-pyridines and analogs |
| CN101087619A (zh) * | 2004-12-24 | 2007-12-12 | 昆士兰大学 | 治疗或预防的方法 |
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| AU675935B2 (en) | 1992-04-13 | 1997-02-27 | Astrazeneca Ab | Angiotensin II antagonists against disorders associated withimpaired neuronal conduction velocity, especially diabetic neuropathy |
| US5246943A (en) | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
| US5236934A (en) | 1992-08-26 | 1993-08-17 | E. I. Du Pont De Nemours And Company | 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders |
| GB2337701A (en) * | 1998-05-26 | 1999-12-01 | United Medical And Dental Schools Of Guys St Thomas Hospitals | Treatment of ischemia with an angiotensin II antagonist |
| CA2866540A1 (en) * | 2006-03-20 | 2007-09-27 | Spinifex Pharmaceuticals Pty Ltd. | Method of treatment or prophylaxis of inflammatory pain |
| US7828840B2 (en) | 2007-11-15 | 2010-11-09 | Med Institute, Inc. | Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists |
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- 2011-01-19 CA CA2787173A patent/CA2787173C/en not_active Expired - Fee Related
- 2011-01-19 AU AU2011207104A patent/AU2011207104C1/en not_active Ceased
- 2011-01-19 ES ES11734246.9T patent/ES2560327T3/es active Active
- 2011-01-19 JP JP2012549209A patent/JP6232184B2/ja not_active Expired - Fee Related
- 2011-01-19 EP EP11734246.9A patent/EP2525795B1/en active Active
- 2011-01-19 WO PCT/AU2011/000051 patent/WO2011088504A1/en not_active Ceased
- 2011-01-19 CN CN201711036658.8A patent/CN107744519A/zh active Pending
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- 2011-01-19 CN CN2011800145791A patent/CN102821765A/zh active Pending
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2012
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2016
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091390A (en) * | 1990-09-20 | 1992-02-25 | E. I. Du Pont De Nemours And Company | Treatment of CNS disorders with 4,5,6,7-tetrahydro-1H-imidazo (4,5-)-pyridines and analogs |
| CN101087619A (zh) * | 2004-12-24 | 2007-12-12 | 昆士兰大学 | 治疗或预防的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2525795A1 (en) | 2012-11-28 |
| JP2013517300A (ja) | 2013-05-16 |
| CN102821765A (zh) | 2012-12-12 |
| HK1176554A1 (en) | 2013-08-02 |
| JP2016155846A (ja) | 2016-09-01 |
| EP2525795B1 (en) | 2015-10-21 |
| CA2787173A1 (en) | 2011-07-28 |
| WO2011088504A1 (en) | 2011-07-28 |
| US20130131103A1 (en) | 2013-05-23 |
| US9095587B2 (en) | 2015-08-04 |
| JP6232184B2 (ja) | 2017-11-15 |
| ES2560327T3 (es) | 2016-02-18 |
| CA2787173C (en) | 2018-05-01 |
| AU2011207104A1 (en) | 2012-07-26 |
| NZ601383A (en) | 2014-07-25 |
| AU2011207104B2 (en) | 2015-07-02 |
| AU2011207104C1 (en) | 2015-10-08 |
| ZA201205375B (en) | 2013-09-25 |
| EP2525795A4 (en) | 2013-07-24 |
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