CN101087619A - 治疗或预防的方法 - Google Patents
治疗或预防的方法 Download PDFInfo
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- CN101087619A CN101087619A CNA2005800441997A CN200580044199A CN101087619A CN 101087619 A CN101087619 A CN 101087619A CN A2005800441997 A CNA2005800441997 A CN A2005800441997A CN 200580044199 A CN200580044199 A CN 200580044199A CN 101087619 A CN101087619 A CN 101087619A
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- replacement
- alkyl
- phenyl
- benzyl
- aryl
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Abstract
Description
缩写表 | |||
Me | 甲基 | iPn | 异戊基 |
Et | 乙基 | Hex | 正己基 |
Pr | 正丙基 | cHex | 环己基 |
iPr | 异丙基 | Boc | 丁氧基羰基 |
cPr | 环丙基 | Ph | 苯基 |
Bu | 正丁基 | Bn | 苄基 |
iBu | 异丁基 | Bz | 苯甲酰基 |
tBu | 叔丁基 | TET | 四唑-5-基 |
Pn | 正戊基 | PIP | 哌嗪基 |
R6 | R1 | R7 | R4 |
Pr | TET | iBu | Et |
Bu | TET | iBu | Bn |
Bu | TET | tBu | Me |
Pr | TET | iBu | Bu |
Pr | TET | Et | Me |
Pr | TET | iPr | Me |
Pr | TET | Me | Me |
Pr | TET | Bu | Me |
Pr | TET | iBu | Pr |
Pr | TET | iBu | 烯丙基 |
Pr | TET | iBu | Pn |
Pr | TET | iBu | Pn |
Pr | TET | iBu | (CH2)3Ph |
Pr | TET | Me | Bn |
Pr | TET | iBu | Bn |
Pr | TET | Pr | Bn |
Pr | TET | Bu | Bn |
Pr | TET | Bn | Bz |
Pr | TET | Hex | Bn |
Pr | TET | tBu | Bn |
Pr | TET | (CH2)2OMe | Bn |
Pr | TET | Pr | CH2cHex |
Pr | TET | Bu | Bu |
Pr | TET | (CH2)2OEt | (CH2)2OMe |
Et | TET | iBu | Me |
Et | TET | iBu | Bn |
iBu | TET | iBu | Me |
iBu | TET | iBu | Bn |
Me | TET | iBu | Bn |
Me | TET | iBu | Me |
Pr | SO2NHCOPh | iBu | Me |
Pr | TET | Et | Bn |
Pr | TET | Ph | CH2-2-Pyr |
Et | TET | tBu | Bn |
Et | TET | Bn | Bn |
Bu | SO2NHBz | iBu | Bn |
Pr | SO2NHBz | Bu | Bn |
Pr | SO2NHCOcPr | iBu | Bn |
Pr | SO2NHCOcPr | iBu | Me |
Pr | TET | Pr | CH2-4-Pyr |
R6 | R1 | R7 | R4 |
Pr | TET | (CH2)2OMe | Me |
Pr | TET | Pr | CH2-3-Pyr |
Pr | TET | Pr | CH2-2-Pyr |
Pr | TET | (CH2)2OMe | CH2-4-Pyr |
CH2OMe | TET | iBu | Me |
CH2OMe | TET | Pr | CH2-2-Pyr |
Pr | SO2NHBz | Bn | Pn |
Pr | TET | Et | CH2-2-Pyr |
Pr | TET | Pr | Bn-4-NO2 |
Pr | TET | Pr | Bn-4-NH2 |
Pr | TET | Pr | Bn-4-NMe2 |
H | TET | iBu | Me |
R6 | R1 | N(R8)R9 | R4 |
Bu | TET | N(Me)iPr | Me |
Pr | TET | N(Pn)2 | Me |
Pr | TET | N(Me)Pr | Bn |
Pr | TET | N(Me)Et | Bn |
Pr | TET | 吗啉代 | Bn |
Et | TET | NHPr | Bn |
Pr | TET | N(Me)iPr | Bn-4-F |
Pr | TET | N(Me)iPr | CH2-2-Pyr |
R6 | R1 | R10 | R4 |
Pr | TET | Ph | Pn |
Pr | TET | Bn | Pn |
Pr | TET | 4-Pyr | Pn |
Pr | TET | Ph | Bn |
Pr | TET | Ph-4-Cl | Pn |
Pr | TET | Ph-4-Cl | Pn |
Pr | TET | Ph-4-Ome | 4-甲基戊基 |
Pr | TET | 2-呋喃基 | Pn |
Pr | TET | 3-甲基丁基 |
R6 | R1 | R10 | R4 |
Pr | TET | Bu | Bn |
Pr | TET | Ph-4-F | Pn |
Pr | TET | Ph-4-F | Bu |
Pr | TET | Ph-4-Me | Pn |
Pr | TET | Ph-3-Br | Pn |
Pr | TET | 3-甲基丁基 | Bn-4-OH |
Pr | TET | Bu | Bu |
Et | TET | Ph | Bn |
Pr | TET | Ph-4-CF3 | Pn |
Et | TET | Ph-4-F | Pn |
1-甲基戊基 | TET | Ph-4-F | Pn |
Et | TET | Ph-4-F | Bu |
Et | TET | Ph | Bn-4-F |
cPr | TET | Ph | Bn |
cPr | TET | Ph | Pn |
1-甲基-3-苯乙基 | TET | Ph | Bn |
cPr | TET | Ph | Bn |
cPr | TET | Ph | Bn |
Pr | TET | 4-Py | Bu |
Me | TET | Ph | Bn |
iPr | TET | Ph | Bn |
Et | SO2NHBz | Ph | Bn |
Pr | TET | 3-Pyr | Pn |
Pr | SO2NHCOcPr | Ph | Pn |
Pr | SO2NHBz | Ph | Pn |
Et | TET | 4-Pyr | Bn |
Pr | TET | Ph-4-SMe | Pn |
Pr | TET | Ph | Pr |
Et | TET | Ph-2-Cl | Bn |
Et | TET | Ph-2-Cl | Bn-2-Cl |
Pr | TET | Ph-4-SOMe | Pn |
Pr | TET | Ph | (CH2)CHO |
Pr | TET | Ph-4-SO2Me | Pn |
Et | TET | Ph | Bn-2-Cl |
Et | TET | Ph | CH2CH=CMe2 |
Pr | SO2NHCOcPr | Me | Pr |
Pr | SO2NHCOcPr | cPr | Pn |
Pr | SO2NHCOcPr | Me | Pn |
Pr | SO2NHCOPh | cPr | Pr |
Pr | TET | Ph-4-F | Pr |
Et | TET | Ph | iPn |
iPr | TET | Ph | Bn-2-Cl |
iPr | TET | cPr | Bn |
iPr | TET | cPr | Bn-2-Cl |
H | TET | Ph | Bn |
R6 | R1 | R10 | R4 |
H | TET | Ph | Bn-2-Cl |
Et | TET | Ph | Bn-4-Cl |
Et | TET | Ph | Bn-4-F |
Et | TET | Ph | Bn-3-Et |
1-乙基-乙基 | TET | Ph | Bn |
1-乙基-乙基 | TET | Ph | Bn-2-Cl |
Pr | TET | Ph | iBu |
Pr | TET | Ph | (CH2)3CO2Et |
Pr | NHSO2CF3 | Ph | Pn |
Pr | TET | Ph | (CH2)3CO2H |
Me | TET | Ph | Bn-2-Cl |
Me | TET | 4-Pyr | Bn |
Pr | SO2NHCOcPr | Me | Me |
Pr | TET | Ph | CH2CO2Et |
Me | TET | 4-Pyr | Bn-2-Cl |
Me | TET | 4-Pyr | CH2CH=CMe2 |
Et | TET | Ph | Bn-4-I |
Pr | TET | 2-噻吩基 | Pn |
Pr | TET | 2-噻吩基 | Me |
iPr | TET | Ph | Bn-4-I |
Et | TET | Ph-4-I | Bn |
Et | TET | Ph | Bz-2-I |
Et | TET | 2-噻吩基 | Bn |
Pr | TET | 4-Pyr | (CH2)2)OMe |
Pr | TET | Ph | CH2CO2H |
CH2OMe | TET | Ph-4-Cl | Pn |
Et | TET | 2-糠酰 | Bn |
Pr | TET | 2-噻吩基 | Bn |
Pr | TET | 2-噻吩基 | Et |
Pr | TET | 2-糠酰 | Et |
Pr | TET | Ph-2-OMe | Bn |
Pr | TET | Ph-2-OMe | Pr |
Pr | TET | Ph-4-OBn | Pn |
Pr | TET | Ph-4-OBn | Pr |
Pr | TET | Ph-4-OH | Pn |
Pr | TET | Ph-4-OH | Pr |
Pr | TET | CH2咪唑 | Bn |
Pr | TET | CH2PIPBoc | Bn |
Pr | TET | 3-Pyr | Bn |
Pr | TET | 2-Pyr | Bn |
Pr | TET | Ph | CH2-2-Pyr |
Pr | TET | Ph | CH2-4-Pyr |
Pr | TET | 4-Pyr | Bn |
Pr | TET | 2-Pyr | Bn |
R6 | R1 | R10 | R4 |
Pr | TET | Ph | CH2-3-Pyr |
Pr | TET | Ph | CH2-2-Pyr |
Pr | TET | Ph-4-OPO(OBn)2 | Pn |
Pr | TET | Ph-4-OH | Bu |
Pr | TET | 4-Pyr | CH2-2-Pyr |
Pr | TET | Ph-4-OP(OH)2 | Pn |
Pr | TET | Ph-4-OH | Bn |
Pr | TET | 2-糠酰 | CH2-2-Pyr |
Pr | TET | Ph-4-OPO(ONa)2 | Bu |
R6 | R1 | R10 | R4 |
Pr | TET | Bu | Bn |
Et | TET | Pr | Pn |
Et | TET | Bu | Pn |
Et | TET | Pr | (CH2)3NHBoc |
Et | TET | Pr | Bn |
R23 | R3 | R6 | R8 |
iPn | F | Pr | Ph |
iPn | F | Pr | -2-糠酰 |
iPn | F | Bu | Et |
iPn | F | Bu | Pr |
iPn | F | Pr | CH2OCH2CH3 |
iPn | F | Et | -2-糠酰 |
iPn | F | Et | Ph |
iPn | F | Et | -3-吡啶基 |
iPn | F | Et | -4-吡啶基 |
iPn | F | Et | -2-吡啶基 |
(CH2)2cPr | F | Et | Ph |
(CH2)2cPr | F | Et | -2-糠酰 |
R23 | R3 | R6 | R23’ | R24 |
iPn | Me | Pr | iPr | H |
Bu | Me | Pr | iPr | H |
Bu | F | Pr | iPr | H |
iPn | F | Pr | iPr | H |
iPn | Me | Pr | iPr | H |
Bu | F | Bu | iPr | Me |
iPn | F | Pr | iPr | H |
(CH2)2cPr | F | Bu | iPr | Me |
(CH2)2cPr | F | Et | Et | H |
Me | F | Et | Et | H |
iPn | F | Pr | 吗啉代 | |
iPn | F | Bu | iPr | Me |
iPn | F | Et | iPr | Me |
iPn | F | Et | 吗啉代 | |
Bu | F | Et | 吗啉代 | |
iPn | F | Bu | 哌嗪基-4-甲基 | |
Bu | F | Et | iPr | Me |
(CH2)2tBu | F | Pr | iPr | H |
tBu | F | Pr | iPr | H |
iPr | F | Pr | Me | Me |
iHex | F | Et | 吗啉代 | |
iPn | F | Et | Me | Me |
(CH2)2cPr | F | Et | iPr | H |
(CH2)2cPr | F | Et | iPr | Me |
iPn | F | Me | iPr | H |
iPn | F | Me | iPr | Me |
(CH2)2cPr | F | Me | Me | Me |
iBu | F | Et | iPr | Me |
iPn | F | Et | iPr | Me |
Claims (40)
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CN201210208621.XA CN102861019B (zh) | 2004-12-24 | 2005-12-23 | 治疗或预防神经性疼痛的药物 |
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AU2004907332A AU2004907332A0 (en) | 2004-12-24 | Method of Treatment or Prophylaxis | |
AU2004907332 | 2004-12-24 | ||
PCT/AU2005/001975 WO2006066361A1 (en) | 2004-12-24 | 2005-12-23 | Method of treatment or prophylaxis |
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CN2010105444424A Division CN102049048B (zh) | 2004-12-24 | 2005-12-23 | 治疗或预防的方法 |
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CN201210208621.XA Expired - Fee Related CN102861019B (zh) | 2004-12-24 | 2005-12-23 | 治疗或预防神经性疼痛的药物 |
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EP (3) | EP2650011A1 (zh) |
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CN (3) | CN101087619B (zh) |
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PL (1) | PL1830869T3 (zh) |
PT (1) | PT1830869E (zh) |
RS (1) | RS52927B (zh) |
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CN102821765A (zh) * | 2010-01-19 | 2012-12-12 | 西芬克斯医药有限公司 | 改良神经传导速度的方法和组合物 |
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CN107922340A (zh) * | 2015-08-29 | 2018-04-17 | 上海翰森生物医药科技有限公司 | 1,2,3,4‑四氢异喹啉衍生物、其制备方法和应用 |
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CN111902401B (zh) * | 2018-02-23 | 2023-06-13 | 北京泰德制药股份有限公司 | 受体抑制剂、包含其的药物组合物及其用途 |
US11905274B2 (en) | 2018-02-23 | 2024-02-20 | Beijing Tide Pharmaceutical Co., Ltd. | Receptor inhibitors, pharmaceutical compositions comprising the same and use thereof |
US11453690B2 (en) | 2018-03-23 | 2022-09-27 | Beijing Tide Pharmaceutical Co., Ltd. | Receptor inhibitor, pharmaceutical composition comprising same, and use thereof |
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