CN107625818A - A kind of pharmaceutical composition for treating chordapsus and preparation method thereof, preparation and application - Google Patents

Abstract

The invention discloses a kind of pharmaceutical composition for treating chordapsus and preparation method thereof, preparation and application.The pharmaceutical composition of described treatment chordapsus includes Huanglong's tail 0.1 ~ 99% of raw material weight percentage, manages secondary 0.1 ~ 99%, rodgersflower rhizome 0.1 ~ 99%, beggar-ticks 0.1 ~ 99% and chenopodium ambrosiodies 0.1 ~ 99%, is prepared through pre-treatment, extraction and post-processing step.Preparation is to add the auxiliary material pharmaceutically received in described pharmaceutical composition to be prepared into granule, tablet, capsule, soft capsule, mixture, supensoid agent and pill etc.；Prophylactic treatment chordapsus is being prepared using for described pharmaceutical composition.Pharmaceutical composition of the present invention has a special effect, Small side effects, no toxicity, can prevent, alleviate, treating chordapsus and have good therapeutic effect.

Description

A kind of pharmaceutical composition for treating chordapsus and preparation method thereof, preparation and application

Technical field

The invention belongs to pharmaceutical technology field, and in particular to a kind of pharmaceutical composition for treating chordapsus and its preparation side Method, preparation and application.

Background technology

Traditional Chinese medical science small intestine disease is more to be associated with navel abdominal pain, turgor, borborygmus and vomiting, diarrhea.《Arteries and veins Yi Jianmo volume eight》 Say：" small intestine ... is navel abdomen as skin.”《In volumes of medicine origin》Say：" when navel and few abdomen are by pain, heresy is in small intestine.”《Card is controlled Criterion miscellaneous diseases the 6th》Say：" small intestine-QI ... attacks thorn around navel walking, few abdomen." secondly, stomachache, diarrhea can reflect small intestine disease Become.《Plain Questions lifts pain and discussed》Say：" cold air visitor in small intestine, small intestine must not be into poly-, therefore diarrhea with abdominal pain.Hot gas is stayed in small intestine, intestines Bitterly, fear heat is terribly thirsty, and heavily fortified point is dry not to be drawn, therefore abdominal pain with constipation is obstructed.”《On volumes of Fahrenheit Huatuo's Zhongzang classic》Say：" flatulence of the small intestine, then underbelly stare at It is swollen, draw abdomen and pain.”《Cure rock diarrheas》Say：" diet enters stomach, lower small intestine, bring about the desired sensation operation then it is pure and impure with point ... or affection of cold, The cold then airsetting of lid, is difficult transporting and transforming nutrients from foodstuff, therefore let out.”

The traditional Chinese medical science proposes eight kinds of card types of small intestine：" depression and stagnation of QI ", " phlegm stagnation ", " fever and chills imbalance ", " bleeding, hemostasis ", " lifting mistake Department ", " imbalance of yin and yang "., can be by gas and blood, by through entering network, influenceing blood system, qi and blood is all sick, and network road is not if the small intestine stagnation of the circulation of vital energy is with the passing of time Profit, form syndrome of qi stagnation and blood stasis；Wet to draw heresy, its property is sticky, easily hinders mechanism of qi, so as to form retention of damp leading to blockage of QI card.

" small intestine syndrome of dampness-heat " feature that the present invention studies：Navel week turgor, pain, navel abdomen is scorching hot, borborygmus, dry, and mouth glues, limb The tired weight of body, inhibited defecation, tongue is red, yellow tongue fur, slippery and rapid pulse；" small intestine syndrome of qi stagnation（Temper virtual loss）" feature：Navel week pain, turgor, intestines Ring, distending pain are aggravated with emotional discomfort, mitigated after fart, and happiness is sighed, and pink tongue, tongue is white, veins string.《The ten of volumes of the General Treatise on the Cause and Symptoms of Diseases Five》Say：" small intestine deficiency, then cold air visitor, enteropathy, startles and does not say, first first goes, is the void for small intestine-QI, then preferably mends it.”

The common chordapsus patient of modern clinic is more in summer and autumn sudden onset, and has the medical history for eating unclean food by mistake more, has The characteristics of break out and spread, it is first that patient shows as Nausea and vomiting more, after with diarrhoea, daily 3~5 times, in addition tens of times not Deng stool is in water sample, buff or with green, and stench can be with symptoms such as cramp, heating, Muscular stiffness.Stool routine examination Check and coproculture, Leukocyte Counts can be normally or abnormal, patient claims acute gastritis by shower of Nausea and vomiting;With Stomachache, diarrhoea are frequently referred to chordapsus for shower；Clinically often Nausea and vomiting, stomachache, diarrhoea simultaneously and see, therefore also known as Acute gastroenteritis.

The content of the invention

The first object of the present invention is to provide a kind of pharmaceutical composition for treating chordapsus；Second purpose is to provide The preparation method of the pharmaceutical composition of described treatment chordapsus；3rd purpose is to provide described treatment chordapsus The preparation of pharmaceutical composition；4th purpose is the application for providing the pharmaceutical composition of described treatment chordapsus.

The first object of the present invention is achieved in that Huanglong's tail 0.1 ~ 99%, Guan Zhong including raw material weight percentage 0.1 ~ 99%, rodgersflower rhizome 0.1 ~ 99%, beggar-ticks 0.1 ~ 99% and chenopodium ambrosiodies 0.1 ~ 99%, through pre-treatment, extraction and post-processing step system It is standby to obtain.

The second object of the present invention is achieved in that including pre-treatment, extraction and post-processing step, is specifically included：

A, pre-treatment：Each bulk drug is weighed by formulation ratio, crushed 20 ~ 100 mesh sieves respectively, to be uniformly mixed so as to obtain material a standby；

B, extract：The alcoholic solution that the concentration expressed in percentage by volume 30 ~ 70% of 8 ~ 12 times of material a weight is added in material a extract To extract solution b, it is concentrated into relative density and obtains target medicine composition liquid extract c for 1.01 ~ 1.07；

C, post-process：Target medicine composition liquid extract c is dried to obtain target medicine composition dry extract d.

The third object of the present invention, which is achieved in that in the pharmaceutical composition of described treatment chordapsus, adds pharmacy Upper acceptable auxiliary material is prepared into granule, tablet, capsule, soft capsule, solution, syrup, supensoid agent and pill.

The fourth object of the present invention is achieved in that the pharmaceutical composition of described treatment chordapsus is being prepared in advance Anti-/treatment enteron aisle is damp and hot, the purport caused by temper virtual loss is the application in the medicine of chordapsus.It is mainly shown as that stomachache is rushed down, Lower urgent, the just yellowish-brown dirty smelly of color is rushed down, burning sensation of the anus can be with heating, the diseases such as serious acute gastritis can also cause spitting blood, have blood in stool Shape, tongue is red, yellow and greasy fur, soft and rapid pulse.This cause of disease being invaded by exogenous pathogen,invasion of exogenous pathogen, or diet internal injury, the cause dysfunction of the spleen in transport are conducted caused by mistake department.Acute stomach The disease categories such as scorching more category traditional Chinese medical science epigastric pains, stomach ruffian, vomiting.

Huanglong's tail in pharmaceutical composition of the present inventionAgrimonia pilosa Ledeb.var.nepalensisFor the rose family The drying herb of plant.《The southern regions of the Yunnan Province book on Chinese herbal medicine》、《It is herbal in Yunnan》、《Chinese Hani's medicine》It is recited as " hairyvein agrimony ".Other claim Call and cut medicine, Ma Lingan, water for Agrimony, Herba Salviae Chinensis, letter grass, knife and help digestion.It is bitter in taste, puckery, tepor.The thoughts of returning home, liver, the spleen channel. Cure mainly hemostasis convergence, menstruation regulating stop dysentery.For spitting blood, spitting blood, metrostaxis, band under, red white diarrhea, carbuncle sore tumefacting virus, de-power internal lesion caused by overexertion. 《National Chinese herbal medicine compilation》The agents area for listing Huanglong's tail is herb or eastern bud, bitter, puckery, mild-natured.Major function herb：Receive Hold back hemostasis, anti-inflammtory anti-dysentery.Spitting blood is treated, spitting of blood, bleeding from five sense organs or subcutaneous tissue, hematuria, is had blood in stool, functional uterine bleeding, gastroenteritis, dysentery, enteron aisle Trichomonad；Carbuncle boils boils, Trichomonas vaginalis are controlled in external application.Bar bud：Expelling parasite.Cure mainly taeniasis.《The southern regions of the Yunnan Province book on Chinese herbal medicine》Notebook medicine enters for herb Medicine, bitter, puckery, slightly warm in nature, major function：Control married woman's menstruation it is preceding or after, red to collapse leukorrhea, the cold back of the body in face is cold, stomachache, pain in the back, hair Hot gas is swollen, red, white dysentery.Modern study show Huanglong's tail containing agrimonine, agrimonolide, catechol, tannin, vitamin C, K and volatile oil, primary treatment internal heat anticance, cooling blood and hemostasis, detumescence of healing the wounds.

Guan Zhongwei rosaceous plant Potentilla fuigens Potentilla fulgens Wall.ex Hook dry root or band Root herb.Other appellations：Guan Zhong, turn over white garden burnet, ground tube, horse dung root, white garden burnet, betel nut（《Yunnan Chinese herbal medicine》）.Nature and flavor With channel tropism：It is bitter, puckery.It is cold in nature.Return stomach, lung, large intestine, Liver Channel.Function is with curing mainly：Clearing away heat to stop bleeding, astringing to arrest diarrhea.For dyspepsia abdomen Bitterly, enteritis, diarrhea, dysentery, spit blood, spit blood, bleeding from five sense organs or subcutaneous tissue, hemorrhoid hemorrhage；Uterine bleeding, with, dysmenorrhoea；Burn and scald.《Chinese Yi pharmacy》 Notebook medicine root or whole herb with root are used as medicine, and are mainly used in regulating qi-flowing for relieving pain, and help digestion antidiarrheal, cooling blood and hemostasis.Treatment stomachache, stomachache, diaphragm Food, diarrhoea, dysentery, nose is bled, in poor health, and diet is ill, wound swelling and pain, nameless gall.《The southern regions of the Yunnan Province book on Chinese herbal medicine》Described in be used for Control blood under metrorrhagia leukorrhea, large intestine.《National Chinese herbal medicine compilation》：" cure mainly hemoptysis of pulmonary tuberculosis, upper respiratory tract hemorrhage, enteritis.”《Guizhou Folk medicine》It is fresh to turn over the white careless 30g of the back of the body with the secondary treatment dysentery of pipe.Decocting, appropriate brown sugar is put in pot, wine 60g, burnt, and be blended into The liquid medicine decocted, then takes.

Rodgersflower rhizome be Saxifragaceae Rodgersia sambucifolia Hemsl. herb, different name Mao Qinghong, rock in September Top, crimsoned ginger sweetened《Yunnan Chinese herbal medicine choosing》, wild yellow ginger《Guizhou herbal medicine》, XUESANQI, burr seven, hair seven, burr pseudo-ginseng《Chinese medicinal herbal》Deng. Nature and flavor and channel tropism：It is bitter, puckery, it is cool in nature.《Yunnan Chinese herbal medicine》" bitter, micro-puckery, tepor.”《The southern regions of the Yunnan Province book on Chinese herbal medicine》Record its function and master Control：Promoting blood circulation for regulating menstruation, dispelling wind and eliminating dampness, astringing to arrest diarrhea.Traumatic injury is cured mainly, is fractured, irregular menstruation, dysmenorrhoea, rheumatalgia pain, wound goes out Blood, enteritis, dysentery.《National Chinese herbal medicine compilation》：" clearing heat and cooling blood, menstruction regulating and pain relieving.Control enteritis, dysentery, dysmenorrhoea, menorrhalgia, wind Wet arthritis.Traumatism and bleeding, eczema of scrotum are controlled in external application.”

Beggar-ticks Bidens pilosa are different name ghost hairpin grass《Bencao Shiyi》, small Bidens bipinnata《Jiangsu medicinal material will》, pierce Bidens bipinnata《The whole nation Chinese herbal medicine collects》.《Chinese book on Chinese herbal medicine》：" bitter, cold nature ".Function is with curing mainly：It is clearing heat and detoxicating, dispelling wind and eliminating dampness, activating blood circulation and reducing swelling.It is main Control abscess of throat, diarrhea, dysentery, jaundice, acute appendicitis, furunculosis distending pain, snake bite and insect sting, arthralgia pain due to rheumatism, traumatic injury.

Modern study：Herb contains hyperin（hyperoside）, isookanin -7-O- glycosides（isookanin- 7-O-βDglucopyranoside）, okanin（okanin）, maritimetin（maritimetin）, salicylic acid（salicylic acid）, protocatechuic acid（pro-tocatechuic acid）, unreal son acid（gallic acid）And fatty acid compound.Again Containing micro polyacetylene class compound（polyacetylene）Ⅹ I V and a variety of highly polar acetylene compounds].Another report herb contains General flavone 4.035%, its middle period contain 6.26%, seed 0.84%, stem 0.74%, root 0.67%；Herb also contains aspartic acid（aspat- tic acid）1.86%, threonine（threonine）0.82%, serine（setine）0.72%, glutamic acid（glucamic acid）2.20%, glycine（glucine）0.96% etc..Beggar-ticks can act on and central nervous system, there is analgesic activity, but by force Degree does not enter morphine.Beggar-ticks can also lipidemia and thrombosis effect simultaneously；Antiulcer action.

Chenopodium ambrosiodies：Chenopodium ambrosioides L.For the dry ground with fruit ear of chenopod chenopodium ambrosiodies Upper part.Different name：Goose pin grass《New Compendium of Materia Medica》, day celestial grass, stinkweed《Fujian medicine will》.Chenopodium ambrosiodies：Acrid flavour, hardship, slightly warm in nature, Return lung passes through, slightly poisonous.There is wind-dispelling promoting the circulation of qi, dehumidifying desinsection and other effects with fruit ear stem branch aerial part.Function is with curing mainly：Wind-dispelling Dehumidifying, desinsection is antipruritic, activating blood circulation and reducing swelling.Cure mainly hookworm disease, roundworm disease, head louse, skin eczema, mange, arthralgia pain due to rheumatism, Amenorrhea, pain Through, aphthae, abscess of throat, traumatic injury, snake bite and insect sting.《Fujian Province's Chinese medicine standard》" rheumatic arthralgia, bruise damage Wound, eczema, scabies, tinea, dysentery, rheumatic arthritis, leukorrhea, postpartum anemic fainting, traumatic injury ".This product has wind-dispelling promoting the circulation of qi, dehumidifying The effect of desinsection.

Modern study shows that herb contains volatilization Chinese pine 0.5-1%, is carvol, aritasone, triterpenoid saponin, native chaste tree Mustard glycosides, ascaridole, also containing the rhamnose infantile malnutrition due to digestive disturbances or intestinalparasites of Kaempferol -7, volatile oil is so that at most, leaf takes second place, and stem is minimum in fruit；Clinical main use It is also effective to amoebic dysentery in anticancer and treatment intractable jock itch and antiulcer and the effect for suppressing helicobacter pylori, can For chronic or carrier.

Chordapsus belongs to the illness scopes such as traditional Chinese medicine vomiting, stomachache, diarrhea, cholera.The traditional Chinese medical science thinks that this sick generation is more Caused by kidney, stomach, spleen yin and yang imbalance and qi and blood are against unrest.Wherein enteron aisle syndrome of dampness-heat enteritis is due to that chronic dietary is irregular more, Perverse trend violates intestines, and moisture stagnates, and makes the dysfunction of the spleen in transport, and it is damp and hot to accumulate life, damp and hot to invade liver, is invaded in temper virtual loss or damp and hot heresy, wet turbid resistance Stagnant passages through which vital energy circulates, and lead stomachache and rush down, rush down lower urgent, the disease such as stomachache borborygmus.For the above-mentioned interpretation of the cause, onset and process of an illness, the master for the treatment of enteron aisle syndrome of dampness-heat enteritis Want principle for invigorating the spleen except damp and hot.Huanglong's tail, Guan Zhong, rodgersflower rhizome, beggar-ticks and the soil based on Yi nationality, distributed over Yunnan, Sichuan and Guizhou's traditional medicine are selected in the invention of this class Schizonepeta assembles research.We are using Huanglong's tail as monarch drug in a prescription；Guan Zhong, rodgersflower rhizome, beggar-ticks are ministerial drug.Wherein chenopodium ambrosiodies is that ministerial drug and assistant make Medicine.

Primary treatment of the present invention is because enteron aisle is damp and hot, the chordapsus caused by temper virtual loss.Show as stomachache to rush down, under rushing down Urgently, big loose stool is thin accompanies indigestion food, just the yellowish-brown dirty smelly of color, burning sensation of the anus, can be with heating, spiritlessness and weakness.Tongue is red, tongue Yellow greasy, soft and rapid pulse.This is more common in being invaded by exogenous pathogen,invasion of exogenous pathogen, or diet internal injury, causes the dysfunction of the spleen in transport, conduction mistake department, is increased with times of defecation.Control Suitable invigorating the spleen, dehumidifying, hold back puckery solid intestines.

Brief description of the drawings

Fig. 1 is present invention process schematic flow sheet；

Fig. 2 is invention formulation process flow diagram.

Embodiment

With reference to embodiment and accompanying drawing, the present invention is further illustrated, but the present invention is not subject in any way Limitation, based on present invention teach that any conversion or replacement made, belong to protection scope of the present invention.

It is of the present invention treatment chordapsus pharmaceutical composition, including raw material weight percentage Huanglong's tail 0.1 ~ 99%th, secondary 0.1 ~ 99%, rodgersflower rhizome 0.1 ~ 99%, beggar-ticks 0.1 ~ 99% and chenopodium ambrosiodies 0.1 ~ 99% are managed, through pre-treatment, extraction and after locate Reason step is prepared.

The pharmaceutical composition of described treatment chordapsus includes Huanglong's tail 32~40%, the Guan Zhong of raw material weight percentage 14~20%, rodgersflower rhizome 15~19%, beggar-ticks 12~15% and chenopodium ambrosiodies 13~15%, prepared through pre-treatment, extraction, post-processing step Obtain.

The pharmaceutical composition of described treatment chordapsus includes Huanglong's tail 30~37%, the Guan Zhong of raw material weight percentage 13~19%, rodgersflower rhizome 15~18%, beggar-ticks 13~14% and chenopodium ambrosiodies 13~14%, prepared through pre-treatment, extraction, post-processing step Obtain.

The preparation method of the pharmaceutical composition for the treatment of chordapsus of the present invention, including pre-treatment, extraction and rear place Step is managed, is specifically included：

A, pre-treatment：Each bulk drug is weighed by formulation ratio, crushed 20 ~ 100 mesh sieves respectively, to be uniformly mixed so as to obtain material a standby；

B, extract：The alcoholic solution that the concentration expressed in percentage by volume 30 ~ 70% of 8 ~ 12 times of material a weight is added in material a extract To extract solution b, it is concentrated into relative density and obtains target medicine composition liquid extract c for 1.01 ~ 1.07；

C, post-process：Target medicine composition liquid extract c is dried to obtain target medicine composition dry extract d.

Step B also includes clarification steps, and the concentration expressed in percentage by volume of 8 ~ 12 times of material a weight is added specially in material a 30 ~ 70% alcoholic solution is extracted to obtain extract solution b, is concentrated into relative density and is obtained object medicine group for 1.01 ~ 1.07 Compound liquid extract first product, then add the fining agent clarification of pharmaceutical composition liquid extract percetage by weight 0.15 ~ 0.25 ‰ or use The ethanol solution of concentration expressed in percentage by volume 60 ~ 75% carries out alcohol precipitation clarification or clarified with water is heavy, and 25 ~ 35 DEG C are incubated 0.5 ~ 1.5h with temperature, Then more than 8h is stood below 10 DEG C of temperature, takes supernatant liquid filtering, filtrate decompression is concentrated to give target medicine composition stream Medicinal extract c.

Described fining agent is diatomite or chitosan.

Described is extracted as circumfluence method extraction, decocting method extraction, Microwave Extraction, ultrasonic wave extraction or temperature leaching hair extraction.

First, for treating the liquid extract preparation method of chordapsus

Circumfluence method is extracted

Huanglong's tail, Guan Zhong, rodgersflower rhizome, beggar-ticks, chenopodium ambrosiodies gomi herbs medicine materical crude slice are cleaned, crushes and is measured for coarse powder, 8-12 times of addition Water immersion 2-4h, supplies water by water absorption rate before backflow, flow back 1-2h for the first time, second, third time respectively plus 8 times of amount water return 0.5-1h is flowed, filtration, merges filtrate three times, is concentrated into relative density to 1.2, adds ethanol to be clarified to content 40-75%, 40- 60 DEG C of insulation 20-60min, in less than 10 DEG C left undisturbed overnights, filtering, add preservative and obtain liquid extract.

Decocting method extracts

Huanglong's tail, Guan Zhong, rodgersflower rhizome, beggar-ticks, chenopodium ambrosiodies gomi herbs medicine materical crude slice are cleaned, crushes and is measured for coarse powder, 8-12 times of addition Water immersion 2-4h, supplies water by water absorption rate before decocting, decocts 1-2h for the first time, second, third time respectively plus 8 times of amount decoctings 0.5-1h is boiled, is filtered, merges filtrate three times, is concentrated into solid-liquid ratio as 1：6, clarified with 0.03-0.06 ‰ fining agent chitosan, 40-60 DEG C of insulation 20-60min, in less than 10 DEG C left undisturbed overnights, filtering, add preservative and obtain liquid extract.

Ultrasonic wave extraction

Huanglong's tail, Guan Zhong, rodgersflower rhizome, beggar-ticks, chenopodium ambrosiodies gomi herbs medicine materical crude slice are cleaned, crushes and is measured for coarse powder, 8-12 times of addition 30-70% water immersion 2-4h, supply water by water absorption rate before ultrasonic extraction, for the first time ultrasonic 10-40min, second, the Three times respectively plus 8 times of amount water 50HZ ultrasound 0.5h, filtration, merge filtrate three times, be concentrated into relative density to 1.2, add ethanol to containing Measure 40-75% to be clarified, at room temperature left undisturbed overnight, filter, add preservative and obtain liquid extract.

2nd, for treating the liquid extract preparation method of chordapsus

Circumfluence method is extracted

Huanglong's tail, Guan Zhong, rodgersflower rhizome, beggar-ticks, chenopodium ambrosiodies gomi herbs medicine materical crude slice are cleaned, crushed as coarse powder, with 8-12 times of water Infiltrate 2-4h；Supplies water by water absorption rate before backflow, flow back 1-2h for the first time, second, third time respectively plus 8 times of amount water backflows 0.5-1h, filtration, merge filtrate three times, be concentrated into relative density to 1.2, add ethanol to 40-75% amount to clarify, it is small to stand 24 When more than, Aspirate supernatant filtering, filtrate decompression is concentrated to give liquid extract, continues to be condensed into dry extract.

Decocting method extracts

Huanglong's tail, Guan Zhong, rodgersflower rhizome, beggar-ticks, chenopodium ambrosiodies gomi herbs medicine materical crude slice are cleaned, crushed as coarse powder, with 8-12 times of water Infiltrate 2-4h；Decoction is preceding to supply water by water absorption rate, decocts 1-2h for the first time, respectively adds 8 times of amount decoctings to boil for the second time, for the third time 0.5-1h, filtration, merge filtrate three times, be concentrated into relative density and filtered for 1.01-1.07, add 0.2-0.5% diatomite, Stir evenly.More than 24 hours are stood, Aspirate supernatant filtering, filtrate decompression is concentrated to give liquid extract, continues to be condensed into dry extract.

Ultrasonic wave extraction

Huanglong's tail, Guan Zhong, rodgersflower rhizome, beggar-ticks, chenopodium ambrosiodies gomi herbs medicine materical crude slice are cleaned, crushed as coarse powder, with 8-12 times of 30- 70% water infiltration 2-4h；Supply water by water absorption rate before ultrasonic extraction, for the first time ultrasonic 10-40min, second, third time it is each Add 8 times of amount water ultrasound 0.5h, filtration, merge filtrate three times, be concentrated into relative density and filtered for 1.01-1.07, add 0.03- 0.06 ‰ chitosan, is stirred evenly.More than 24 hours are stood, Aspirate supernatant filtering, filtrate decompression is concentrated to give liquid extract, continues dense Shorten dry extract into.

It is of the present invention be used to improving, treat can be added in the pharmaceutical composition of chordapsus medicinal fining agent, excipient, Solvent, preservative, PH conditioning agents, isotonic regulator.

Fining agent：101 fruit juice clarifiers：Production unit：Zhengzhou Tian Shuan Year food additives Co., Ltd；Gelatin：Production is single Position：Dongguan City is newly into gelatin Co., Ltd；Chitosan, production unit：Qingdao latent light bioengineering Co., Ltd；Diatomite：Cloud Nan Sheng Tengchong Counties filter aid factory；Preservative：Sodium benzoate, parabens；

Excipient：Gelatin, glycerine, dextrin, starch, silica, magnesium stearate, microcrystalline cellulose, sodium carboxymethylcellulose, second Base cellulose, hydroxypropyl cellulose, polyethylene glycol, polyvinylpyrrolidone, Tween-80.

Solvent：Vegetable oil（Eucalyptus oil, peanut oil, rapeseed oil, walnut oil）, glycerine, propane diols, atoleine, beeswax； Purified water.

Excipient：Gelatin, glycerine, dextrin, starch, silica, magnesium stearate, microcrystalline cellulose, carboxymethyl cellulose Sodium, ethyl cellulose, hydroxypropyl cellulose, activated carbon, beeswax, polyethylene glycol, polyvinylpyrrolidone, tween -80.

Preservative：Salicylic acid, benzoic acid and sodium benzoate, methyl p-hydroxybenzoate, ethyl ester, propyl ester, butyl ester（Nipalgin Class）, eucalyptus oil.

Flavouring：Honey, stevioside glycosides, saccharin sodium.

Isotonic regulator：Sodium chloride, glucose.

The fining agent of addition, excipient, solvent, preservative, the quantity of PH conditioning agents are carried out by medicinal standard requirement above.

The preparation of pharmaceutical composition of the present invention is to add the auxiliary material pharmaceutically received in described pharmaceutical composition It is prepared into granule, tablet, capsule, soft capsule, mixture, supensoid agent or pill.

The preparation method of the granule for chordapsus is：Medicine dry extract is crushed, crosses 80-100 mesh sieves, with The auxiliary materials and mixings such as starch, dextrin, superfine silica gel powder, carboxymethyl cellulose-Na, magnesium stearate, granulation, drying, whole grain, packing are .

The preparation method of the tablet for chordapsus is：Each supplementary material for being formulated dosage is weighed, mixed, system Grain, dry, tabletting produce；

The preparation method of the capsule for chordapsus is：Medicine dry extract is crushed, 80-100 sieves are crossed, with titanium dioxide Silicon, magnesium stearate, microcrystalline cellulose, ethyl cellulose mix, and granulation, whole grain, are packed into hard shell capsules or capsulae enterosolubilis and produce. Medicine preparation, medicine dry extract is crushed, cross 200 mesh sieves, pelletized, dried with hydroxypropyl cellulose, whole grain, capsule grain is placed in bag In clothing machine, micro-capsule is made in the ethanol solution for adding polyethylene glycol and ethyl cellulose, is packed into hard shell capsules or tabletted, i.e., .

The preparation method of the soft capsule for chordapsus is：Medicine dry extract is crushed, crosses 200 mesh sieves, with The auxiliary materials and mixings such as polyethylene glycol, gelatin, glycerine, water, soft capsule is made and produces；

The preparation method of the dripping pill for acute gastritis is：Medicine dry extract is crushed, cross 200 mesh sieves, with polyethylene glycol, The auxiliary materials and mixings such as glycerine, dripping pill is made and produces.

The syrup preparation technology for chordapsus is：Medicine liquid extract is added into purified water, dissolved by heating, is added Enter honey, activated carbon boils, while hot filter, refrigerate, filtering, filtrate add citric acid, add purified water adjust to amount of preparation, point Dress, sterilizing, are produced.

The purposes that the thing for chordapsus combines：The drug regimen is characterized in that for treating chordapsus disease Disease.It is seen as that enteron aisle is damp and hot, temper virtual loss type from tcm syndrome.

The drug regimen of present invention treatment chordapsus comes from the Yi Nationality Area folk remedy, and formula has special effect, secondary Small, no toxicity is acted on, can prevent, treat chordapsus, there is good therapeutic effect.

Dry extract d moisture content is 5 ~ 7%.

The preparation of the pharmaceutical composition for the treatment of chordapsus of the present invention is the medicine of described treatment chordapsus Pharmaceutically acceptable auxiliary material is added in composition and is prepared into granule, tablet, capsule, soft capsule, solution, syrup Agent, supensoid agent and pill.

The application of the pharmaceutical composition for the treatment of chordapsus of the present invention is the medicine of described treatment chordapsus Preventing/treating enteron aisle is damp and hot, the purport caused by temper virtual loss is the application in the medicine of chordapsus preparing for composition.Main table Now rushed down for stomachache, rush down lower urgent, just the yellowish-brown dirty smelly of color, burning sensation of the anus, be able to can also cause with heating, serious acute gastritis Spitting blood, the symptom such as have blood in stool, tongue is red, yellow and greasy fur, soft and rapid pulse.This cause of disease being invaded by exogenous pathogen,invasion of exogenous pathogen, or diet internal injury, dysfunction of the spleen in transport conduction is caused to lose Caused by department.Acute gastritis belongs to the disease categories such as traditional Chinese medical science epigastric pain, stomach ruffian, vomiting more.

Drug regimen formula essence of the present invention contains Huanglong's tail, Guan Zhong, rodgersflower rhizome, beggar-ticks and chenopodium ambrosiodies, and surplus is medicine Use auxiliary material.Each constituent and its compositional ranges are in the pharmaceutical preparation：Huanglong's tail 0.1~99.9%, pipe secondary 0.1~99.9%, rock Top 0.1~99.9%, beggar-ticks 0.1~99.9%, chenopodium ambrosiodies 0.1~99.9%, medicine auxiliary material 99.9~0.1%.

1. dry extract type：Each constituent and its its composition essence contain medicinal material in pharmaceutical preparation：Huanglong tail 32-40%, pipe secondary 14 ~20%, rodgersflower rhizome 15-19%, beggar-ticks 12-15%, the surplus of chenopodium ambrosiodies 13~15% are medicine auxiliary material.

The essential scope of optimum proportioning containing medicinal material of each constituent and its composition in the pharmaceutical preparation：Huanglong tail 35-38%, Guan Zhong 16~19%, rodgersflower rhizome 16-19%, beggar-ticks 13-14%, the surplus of chenopodium ambrosiodies 13~15% are medicine auxiliary material.

Each constituent and its optimal proportioning components are during solid dosage medicine for treating chordapsus combines：Huanglong Tail：625 grams, Guan Zhong：300 grams, rodgersflower rhizome：300 grams, 240 grams of beggar-ticks, 240 grams of chenopodium ambrosiodies, then amount to by above-mentioned five kinds of medicinal materials 1705 grams, 230 grams of medicinal extract or dry extract can be obtained after extraction process（Active ingredient）.

So that case is embodied, the present invention will be further described below：

Embodiment 1

Huanglong tail 625g, the secondary 300g of pipe, rodgersflower rhizome 300g, beggar-ticks 240g, chenopodium ambrosiodies 240g are weighed, gomi herbs medicine materical crude slice is total to 1705g, crush as coarse powder, mixing.For the first time plus 10 times of amounts water immersion 2h, supply amount of alcohol by water absorption rate before backflow, first Secondary backflow 2h, second and third time is respectively plus 8 times are measured backflow 1h, filtration, merges filtrate three times, is concentrated into relative density as 1.05.Add The chitosan that dosage is 0.2 ‰ is clarified, and 30 DEG C of insulation 1h, less than 10 DEG C stand more than 8h, Aspirate supernatant filtering, filtrate decompression It is concentrated to give liquid extract, dry dry extract.

Embodiment 2

Huanglong tail 625g, the secondary 300g of pipe, rodgersflower rhizome 300g, beggar-ticks 240g, chenopodium ambrosiodies 240g are weighed, gomi herbs medicine materical crude slice is total to 1705g, crush as coarse powder, mixing.For the first time plus 12 times of amount water soak 4h, by the water absorption rate amount of supplying before backflow, flow back for the first time 1.5h, second and third time respectively plus 9 times of amount backflow 1h, filtration, merge filtrate three times, add the content of ethanol to 60% clarification, room temperature bar More than 12h, Aspirate supernatant filtering are stood under part, filtrate decompression is concentrated to give liquid extract, dry dry extract.

Embodiment 3

Huanglong tail 690g, the secondary 340g of pipe, rodgersflower rhizome 335g, beggar-ticks 260g, chenopodium ambrosiodies 256g are weighed, gomi herbs medicine materical crude slice is total to 1881g, crush as coarse powder, mixing.For the first time plus 10 times of water measured soak 1h, container are put into ultrasonic washing instrument, ultrasound Extract 30min, 30min is stood after stirring 1 time, ultrasonic extraction 30min again, stood after stirring 1 time, so ultrasonic extraction repeatedly After 3 times, filtration, merge filtrate three times, be concentrated into relative density as 1.05.Add the chitosan that dosage is 0.3 ‰ to clarify, 30 DEG C 1h, less than 10 DEG C standing more than 8h are incubated, Aspirate supernatant filters, and filtrate decompression is concentrated to give liquid extract, dry dry extract.

Embodiment 4

Huanglong tail 560g, the secondary 260g of pipe, rodgersflower rhizome 265g, beggar-ticks 220g, chenopodium ambrosiodies 224g, the common 1529g of gomi herbs medicine materical crude slice, powder Broken is coarse powder, is mixed.For the first time plus 12 times of amount water soak 2h, container are put into ultrasonic washing instrument, ultrasonic extraction 35min, 30min is stood after stirring 1 time, ultrasonic extraction 20min again, is stood after stirring 1 time, so repeatedly after ultrasonic extraction 3 times, filter Cross, merge filtrate three times, add the content of ethanol to 60% clarification, more than 12h, Aspirate supernatant filtering, filter are stood under room temperature condition Liquid is concentrated under reduced pressure to obtain liquid extract, dry dry extract.

Embodiment 5

The embodiment for treating the granule of chordapsus drug regimen

Embodiment 6

The embodiment for treating the tablet of chordapsus drug regimen

Embodiment 7

The embodiment for treating the capsule of chordapsus drug regimen

Embodiment 8

The embodiment for treating the soft capsule of chordapsus drug regimen

Embodiment 9

Treat the mixture of chordapsus drug regimen（Oral liquid）Embodiment

Embodiment 10

The embodiment for treating the dripping pill of chordapsus drug regimen

Embodiment 11

Choose the therapeutic effect that 80 chordapsus patients observe medicine.Treatment group's drug administration, 0.8g/ times, daily 3 It is secondary；Water is taken in control.It is uninterrupted take 14d after, follow-up patients acuity enteritis improves situation, just under dense blood, tenesmus, body Heat, burning sensation of the anus, gastral cavity ruffian is indigestion and loss of appetite, dirty smelly of defecating, scanty drak urine, and the symptom such as yellowish fur substantially mitigates or disappeared.

The comparison sheet of two groups of patient clinical curative effects

Embodiment 12

Certain male, 53 years old, make a definite diagnosis chronic nonspecific colitis 3 years, during one's sickness intermittent treatment mistake, but it is ineffective.Continue After taking this medicine 15d, with the front lower glutinous jelly of profit or dense blood, hence it is evident that dirty smelly, indistinctly happiness of suffering from abdominal pain are pressed, abdominal swelling, and indigestion and loss of appetite deficiency of food is few The lazy speech of gas, soreness and weakness of waist and knees are obviously improved.This user is fine to drug evaluation provided by the invention.Tested more than：This The medicine that invention provides has remarkable result to improving, treating chronic nonspecific colitis.

Embodiment 13

Certain women, 40 years old, suffer from colitis more than 2 years, be diagnosed as chronic nonspecific colitis.After constantly taking this medicine 20d, abdomen Pain happiness is by reduction, this disappearance of abdominal swelling sensillary base.This user is very good to drug evaluation provided by the invention.Tested more than Understand：Medicine provided by the invention has remarkable result to improving, treating chronic nonspecific colitis, improves diet not to future The chronic colitis of a stack of people of rule has certain market prospects.

Embodiment 14

The pharmaceutical composition being prepared respectively with embodiment 1, embodiment 2, embodiment 3, embodiment 4 is tested, as a result table Bright, prevention, treatment enteron aisle be damp and hot, spleen preparing to the pharmaceutical composition of chordapsus for the pharmaceutical composition that is prepared of the present invention The application in chordapsus medicine caused by gas virtual loss.

Claims (10)

1. A kind of 1. pharmaceutical composition for treating chordapsus, it is characterised in that Huanglong's tail 0.1 including raw material weight percentage ~ 99%th, secondary 0.1 ~ 99%, rodgersflower rhizome 0.1 ~ 99%, beggar-ticks 0.1 ~ 99% and chenopodium ambrosiodies 0.1 ~ 99% are managed, through pre-treatment, extraction and after locate Reason step is prepared.
2. 2. the pharmaceutical composition for the treatment of chordapsus according to claim 1, it is characterised in that including raw material weight percentage Several Huanglong's tail 32~40%, pipe are secondary 14~20%, rodgersflower rhizome 15~19%, beggar-ticks 12~15% and chenopodium ambrosiodies 13~15%, premenstrual place Reason, extraction, post-processing step are prepared.
3. 3. the pharmaceutical composition for the treatment of chordapsus according to claim 1, it is characterised in that including raw material weight percentage Several Huanglong's tail 30~37%, pipe are secondary 13~19%, rodgersflower rhizome 15~18%, beggar-ticks 13~14% and chenopodium ambrosiodies 13~14%, premenstrual place Reason, extraction, post-processing step are prepared.
4. A kind of 4. preparation method of the pharmaceutical composition of any described treatment chordapsus of claim 1 ~ 3, it is characterised in that Including pre-treatment, extraction and post-processing step, specifically include：

   A, pre-treatment：Each bulk drug is weighed by formulation ratio, crushed 20 ~ 100 mesh sieves respectively, to be uniformly mixed so as to obtain material a standby；

   B, extract：The alcoholic solution that the concentration expressed in percentage by volume 30 ~ 70% of 8 ~ 12 times of material a weight is added in material a extract To extract solution b, it is concentrated into relative density and obtains target medicine composition liquid extract c for 1.01 ~ 1.07；

   C, post-process：Target medicine composition liquid extract c is dried to obtain target medicine composition dry extract d.
5. 5. preparation method according to claim 4, it is characterised in that step B also includes clarification steps, specially in material a The alcoholic solution of the concentration expressed in percentage by volume 30 ~ 70% of middle 8 ~ 12 times of addition material a weight is extracted to obtain extract solution b, is concentrated into Relative density obtains target medicine composition liquid extract first product for 1.01 ~ 1.07, then adds pharmaceutical composition liquid extract weight The fining agent clarification of amount percentage 0.15 ~ 0.25 ‰ carries out alcohol precipitation clarification or use with the ethanol solution of concentration expressed in percentage by volume 60 ~ 75% The heavy clarification of water, and 25 ~ 35 DEG C of 0.5 ~ 1.5h of insulation of temperature, then standing more than the 8h below 10 DEG C of temperature, takes supernatant liquid filtering, Filtrate decompression is concentrated to give target medicine composition liquid extract c.
6. 6. preparation method according to claim 5, it is characterised in that described fining agent is diatomite or chitosan.
7. 7. preparation method according to claim 4, it is characterised in that it is described be extracted as circumfluence method extraction, decocting method carries Take, Microwave Extraction, ultrasonic wave extraction or temperature leaching hair are extracted.
8. 8. preparation method according to claim 4, it is characterised in that dry extract d moisture content is 5 ~ 7%.
9. 9. the preparation of the pharmaceutical composition of any described treatment chordapsus of a kind of claim 1 ~ 3, it is characterised in that described Treatment chordapsus pharmaceutical composition in add pharmaceutically acceptable auxiliary material and be prepared into granule, tablet, capsule, soft Capsule, solution, syrup, supensoid agent and pill.
10. 10. the application of the pharmaceutical composition of the treatment chordapsus described in a kind of claim 1 ~ 3, it is characterised in that described controls The pharmaceutical composition for treating chordapsus is preparing the medicine that preventing/treating enteron aisle is damp and hot, the purport caused by temper virtual loss is chordapsus Application in thing.