CN107613771B - 化合物及其作为β-分泌酶1抑制剂的用途 - Google Patents

化合物及其作为β-分泌酶1抑制剂的用途 Download PDF

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CN107613771B
CN107613771B CN201680021454.4A CN201680021454A CN107613771B CN 107613771 B CN107613771 B CN 107613771B CN 201680021454 A CN201680021454 A CN 201680021454A CN 107613771 B CN107613771 B CN 107613771B
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dibenzo
alkyl
thiophen
mmol
prop
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CN107613771A (zh
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马渡·彻如库瑞
林晓汶
游书杰
彭日平
叶苏度斯·克里斯杜·拉詹
戴安·丹霞·汤刘
安德鲁·D·怀特
托马斯·马隆
理查·贝瑞希斯
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Allgenesis Biotherapeutics Inc
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201680021454.4A 2015-04-21 2016-04-20 化合物及其作为β-分泌酶1抑制剂的用途 Active CN107613771B (zh)

Applications Claiming Priority (5)

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US201562150715P 2015-04-21 2015-04-21
US62/150,715 2015-04-21
US201662274791P 2016-01-05 2016-01-05
US62/274,791 2016-01-05
PCT/US2016/028502 WO2016172255A1 (en) 2015-04-21 2016-04-20 Compounds and their use as bace1 inhibitors

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US (1) US10870635B2 (enExample)
EP (1) EP3250035B1 (enExample)
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KR (1) KR20170139060A (enExample)
CN (1) CN107613771B (enExample)
AU (1) AU2016250519A1 (enExample)
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JP7148518B2 (ja) 2016-12-15 2022-10-05 アムジエン・インコーポレーテツド β－セクレターゼ阻害剤としての二環式チアジンおよびオキサジン誘導体ならびに使用方法
MX387729B (es) * 2016-12-15 2025-03-18 Amgen Inc Derivados de dióxido de 1,4-tiazina y dióxido 1,2,4-tiadiazina como inhibidores de beta-secretasa y métodos de uso.
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CN109180670A (zh) * 2018-09-17 2019-01-11 广东东阳光药业有限公司 亚氨基噻二嗪二氧化物衍生物及其用途
CN109180672A (zh) * 2018-09-29 2019-01-11 广东东阳光药业有限公司 亚氨基噻二嗪二氧化物衍生物及其用途
CN109796447B (zh) * 2019-01-07 2020-03-13 广东东阳光药业有限公司 亚氨基噻二嗪二氧化物衍生物及其用途
GB201906804D0 (en) 2019-05-14 2019-06-26 Ucb Biopharma Sprl Therapeutic agents
US20220289685A1 (en) 2019-08-19 2022-09-15 UCB Biopharma SRL Antimalarial hexahydropyrimidine analogues
GB202010606D0 (en) 2020-07-10 2020-08-26 Ucb Biopharma Sprl Therapeutic agents
CR20230576A (es) 2021-06-14 2024-04-05 Scorpion Therapeutics Inc Derivados de la urea que pueden ser utilizados para tratar el cáncer
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