KR20170139060A - Bace1 억제제로서의 화합물 및 이의 용도 - Google Patents

Bace1 억제제로서의 화합물 및 이의 용도 Download PDF

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KR20170139060A
KR20170139060A KR1020177032701A KR20177032701A KR20170139060A KR 20170139060 A KR20170139060 A KR 20170139060A KR 1020177032701 A KR1020177032701 A KR 1020177032701A KR 20177032701 A KR20177032701 A KR 20177032701A KR 20170139060 A KR20170139060 A KR 20170139060A
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hydrogen
alkyl
halogen
deuterium
group
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마드흐 췌커리
시아오-웬 린
슈 치 유
리핑 팽
예스도스 크리츄 라잔
디앤 댄-시야 탕-리우
앤드류 디. 화이트
토마스 말론
리차드 베레시스
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올제네시스 바이오테라퓨틱스 아이엔씨.
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Biomedical Technology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020177032701A 2015-04-21 2016-04-20 Bace1 억제제로서의 화합물 및 이의 용도 Withdrawn KR20170139060A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562150715P 2015-04-21 2015-04-21
US62/150,715 2015-04-21
US201662274791P 2016-01-05 2016-01-05
US62/274,791 2016-01-05
PCT/US2016/028502 WO2016172255A1 (en) 2015-04-21 2016-04-20 Compounds and their use as bace1 inhibitors

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KR20170139060A true KR20170139060A (ko) 2017-12-18

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KR1020177032701A Withdrawn KR20170139060A (ko) 2015-04-21 2016-04-20 Bace1 억제제로서의 화합물 및 이의 용도

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Country Link
US (1) US10870635B2 (enExample)
EP (1) EP3250035B1 (enExample)
JP (1) JP6765681B2 (enExample)
KR (1) KR20170139060A (enExample)
CN (1) CN107613771B (enExample)
AU (1) AU2016250519A1 (enExample)
BR (1) BR112017022568A2 (enExample)
CA (1) CA2979905A1 (enExample)
ES (1) ES2942308T3 (enExample)
MX (1) MX2017013483A (enExample)
SG (1) SG11201708027XA (enExample)
TW (1) TWI680971B (enExample)
WO (1) WO2016172255A1 (enExample)

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CN109796447B (zh) * 2019-01-07 2020-03-13 广东东阳光药业有限公司 亚氨基噻二嗪二氧化物衍生物及其用途
GB201906804D0 (en) 2019-05-14 2019-06-26 Ucb Biopharma Sprl Therapeutic agents
JP7592069B2 (ja) 2019-08-19 2024-11-29 ユーシービー バイオファルマ エスアールエル 抗マラリア性ヘキサヒドロピリミジン類似体
GB202010606D0 (en) 2020-07-10 2020-08-26 Ucb Biopharma Sprl Therapeutic agents
IL309232A (en) 2021-06-14 2024-02-01 Scorpion Therapeutics Inc Urea derivatives which can be used to treat cancer
US20250134890A1 (en) 2022-02-08 2025-05-01 UCB Biopharma SRL Antimalarial hexahydropyrimidine analogues

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EP3250035B1 (en) 2023-01-25
US20180201604A1 (en) 2018-07-19
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JP6765681B2 (ja) 2020-10-07
TWI680971B (zh) 2020-01-01
ES2942308T3 (es) 2023-05-31
JP2018513191A (ja) 2018-05-24
WO2016172255A1 (en) 2016-10-27
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