CN107549859A - A kind of immune soft capsule of galic essential oil compound enhancing and preparation method thereof - Google Patents
A kind of immune soft capsule of galic essential oil compound enhancing and preparation method thereof Download PDFInfo
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Abstract
A kind of immune soft capsule of galic essential oil compound enhancing of the present invention, including capsule-core and capsule skin, wherein capsule-core include the raw material components of following parts by weight：10 20 parts of galic essential oil, 10 20 parts of Seabuckthorm Seed Oil, 5 15 parts of Purple Perilla Seed Oil, 2 10 parts of fullerene, 30 50 parts of cavings essential oil；The capsule skin is made up of following components of the raw material of following parts by weight：20 40 parts of converted starch natural plant gum, 5 10 parts of sodium alginate, 5 10 parts of potassium citrate, 5 10 parts of sucrose Polyester, 10 20 parts of glycerine, 50 60 parts of pure water；Wherein the mass ratio of capsule-core and capsule skin is 1:3‑3:1；The simple science of preparation method of soft capsule, mild condition, production cost is low, is suitable for industrialized production, has the function that regulation is immune well, effectively improves rat Ab cellulation number.
Description
Technical field
The present invention relates to a kind of soft capsule technical field, the immune soft capsule of more particularly to a kind of galic essential oil compound enhancing and
Its preparation method.
Background technology
Garlic is the bulb of Liliaceae allium, and acrid flavour is peppery, there have to be strong garlicky, is that important spice vegetables make
Thing.The many pharmacological actions of garlic come from it and contain abundant chemical composition.Galic essential oil be extracted from garlic it is special
Material, it is multicomponent mixture, the sulfide compound group being made up of allicin, Allicin and a variety of pi-allyls and methyl
Into also containing citral, geraniol, linalool, α-phellandrene, propionic aldehyde, valeral etc., main component has six kinds, belongs to
Allyl sulfide ethers material, it is allyl methyl thioether, allyl sulfide, allyl methyl disulfide, diallyl disulfide
Ether, allyl methyl trisulfide ether, Diallytrisin, Diallytrisin are that galic essential oil has the main of physiologically active
Composition；Modern age medicine and pharmacology, biology, medical science experimental study prove that galic essential oil has following effect：Antibacterial, sterilization；Drop
Blood fat, prevention of arterial hardening, treatment cardiovascular and cerebrovascular disease；It is hypoglycemic；Protect liver；Improve immunity, anti-aging；Near fat-reducing
Deng；Additionally improve glycometabolism effect and treatment impotence effect there are some researches show galic essential oil has.
At present both at home and abroad on most of still using single galic essential oil as primary raw material in garlic P.E product, function
Property is extremely limited.
Immunity is that human body resists extraneous virulence factor and maintains the ability of homoiostasis.Modern society, with life
The quickening that movable joint is played, the increase of survival pressure, sub-health state is extremely widespread, and hypoimmunity is that human body carries out self-protection
One of barrier, hypoimmunity can cause various diseases, have a strong impact on normal life and work；On garlic essence in existing patent
The product of oil compounding other components also has the product for much, being directed to raising immunity also to have a lot, but there are still be produced into
This is too big, is formulated unscientific problem.
The content of the invention
To solve above-mentioned problem, it is an object of the invention to provide a kind of galic essential oil compound to strengthen immune flexible glue
Capsule and preparation method thereof.
To reach above-mentioned purpose, the technical scheme is that：
A kind of immune soft capsule of galic essential oil compound enhancing, including capsule-core and capsule skin, wherein capsule-core include following parts by weight
Raw material components：Galic essential oil 10-20 parts, Seabuckthorm Seed Oil 10-20 parts, Purple Perilla Seed Oil 5-15 parts, fullerene 2-10 parts, cavings essence
Oily 30-50 parts；The capsule skin is made up of following components of the raw material of following parts by weight：Converted starch natural plant gum 20-40 parts, sea
Mosanom 5-10 parts, potassium citrate 5-10 parts, sucrose Polyester 5-10 parts, glycerine 10-20 parts, pure water 50-60 parts；Wherein capsule-core
Mass ratio with capsule skin is 1:3-3:1.
Preferably, described galic essential oil preparation method comprises the following steps：
1) selected no insect pest, the fresh garlic head without lesion of going rotten clean up after it is soaked with clear water, smash to pieces in garlic
Mud；
2) cellulase for adding mashed garlic weight 0.03-0.05% is digested, and hydrolysis temperature is 36-40 DEG C, during enzymolysis
Between be 1-2h, enzymolysis liquid is filtered into obtain filter residue and the first filtrate after the completion of enzymolysis, filtering uses 0.2 μm of filtering with microporous membrane；
3) concentration that filter residue addition is accounted for 2-3 times of filter residue weight is molten for 1-3wt% sodium chloride and the mixing of 4-6wt% sodium acetates
Agent carries out ultrasonic extraction, and the ultrasonic extraction time is 20-30min, filters to take filtrate and obtains the second filtrate, filtering uses 0.2 μm of micropore
Membrane filtration；
4) the first filtrate and the second filtrate are merged, using CO2Supercritical extract, pressure 15-20MPa, extraction temperature are
35-40 DEG C, extraction time 1-1.5h, carbon dioxide flow 3500-3600g/h, separate to obtain extract；
5) supernatant, centrifugation rate 10000-12000r/min is collected by centrifugation in extract；
6) step 5) supernatant progress pressure reduction with classification is separated into obtain galic essential oil, pressure 8-10MPa, temperature 35-40
℃。
Preferably, enzymolysis process is additionally added mashed garlic weight 0.05-0.1% antioxidant in the step 2).
Preferably, described antioxidant is one kind in butylated hydroxy anisole or tert-butylhydroquinone.
Preferably, described fullerene is C60 or C70.
Preferably, described cavings essential oil preparation method comprises the following steps：By cavings crude oil below 2 DEG C normal pressure winterization
One week, filter off except being preheated to 50-60 DEG C after wax, add the same warm water of 0.4-0.6 times of cavings crude oil weight while stirring,
20-30min is stirred under 0.05-0.06MPa vacuums, insulation stands 4-6h, sub-cloud water and impurity removed after layering, in 70-
Water content is dried under vacuum at 80 DEG C to produce below 0.1%.
Preferably, described converted starch natural plant gum is made by converted starch, and described converted starch is by cornstarch, horse
One or more in bell sweet potato starch, tapioca mix.
A kind of preparation method of the immune soft capsule of galic essential oil compound enhancing, comprises the following steps：
(1) extraction separation and purification of galic essential oil：Garlic cleaning filters to obtain filter residue after being digested after smashing to pieces using enzymatic isolation method
With the first filtrate, filter residue adds extract progress ultrasonic extraction and obtains the second filtrate, merges the first filtrate and the second filtrate using super
Critical CO2Extract and separate obtains supernatant re-grading decompression separation and produced；
(2) prepared by capsule-core：Galic essential oil, Purple Perilla Seed Oil, Seabuckthorm Seed Oil, fullerene, cavings essential oil are measured according to formula, is added
Enter ball milling 6-12h in ball mill, being heated to 30-50 DEG C makes material dissolution and be well mixed, and stands 1-3h centrifugal filtrations, deaerates
To mixing capsule-core solution；
(3) capsule leather is standby：According to formula ratio by converted starch natural plant gum, sodium alginate, sucrose Polyester, glycerine, pure water
Glue is well mixed to obtain, potassium citrate is added in foregoing glue in the form of spraying, lasting stirring increases until gelatin viscosity
Adding to degassing after 2000-6000mPa.s, to obtain composite sac hide glue gelatin standby；
(4) pelleting sizing, cleaning：Capsule-core and capsule skin are placed in after pellet processing machine pelleting to be placed in rolling and shaped, then with 95%
Edible alcohol washs, and removes the fat-soluble burs such as the oily wax on soft capsule surface；
(5) dry：Soft capsule after cleaning is sent into the drying indoor seasoning that temperature is 20-30 DEG C, relative humidity 15-
25%, drying time 12-15h；
(6) finished product detection, packaging：Dried soft capsule is placed in lamp inspection machine, screens out underproof soft capsule, will
Qualified soft capsule bottling, and cased after packing, be put in storage after the assay was approved through quality inspection portion.
Preferably, pellet press rotating speed is 3-4r/min in the step (4), 40-50 DEG C of sprinkler body temperature, and soft capsule specification is
0.5g/ grains, setting temperature are 20-25 DEG C, relative humidity 35-45%.
The beneficial effects of the present invention are：
(1) the immune soft capsule of a kind of galic essential oil compound enhancing provided by the invention, using galic essential oil, Purple Perilla Seed Oil,
Seabuckthorm Seed Oil and fullerene compounding, fullerene are advantageous to improve galic essential oil, Purple Perilla Seed Oil, the stability of Seabuckthorm Seed Oil mixing；
Galic essential oil can increase T lymphocyte activators, the increase of hemolysin quantity, can improve cellular immunity, body fluid is exempted from
Epidemic disease and non-specific immune function；Seabuckthorn seeds form rich in multiple beneficial aliphatic acid, and wherein unrighted acid is up to 70%, class
Carrotene and vitamin E and various trace elements content are also higher, for immunity of organisms lowly there is regulation well to make
With general flavone has different degrees of regulating power to the too many levels of immune system, has to humoral immunity and cellular immunity bright
Aobvious adjustment effect；Purple Perilla Seed Oil main component is alpha-linolenic acid, and content is up to 67% or so；Galic essential oil and sea-buckthorn in compound
The two is monarch to seed oil, adjusts immune system, has obvious adjustment effect to humoral immunity and cellular immunity；Purple Perilla Seed Oil is
Minister, it is the elite of extra large plant, rich in alpha-linolenic acid；Cavings essential oil is assistant, containing several amino acids, its Glutamic Acid, leucine,
Alanine, proline, aspartic acid equal size are higher, also containing carrotene (vitamin A), vitamin B1, B2 in cavings essential oil
Deng vitamin, compounded with galic essential oil, Purple Perilla Seed Oil and Seabuckthorm Seed Oil, be more beneficial for absorption of human body；Supplemented by fullerene, have very
Strong antioxidation, there is very strong Scavenging ability；Immune system, anti-oxidant in one is adjusted, enhancing is played altogether and exempts from
Epidemic disease, antifatigue health-care effect；
(2) capsule skin of the present invention uses full starch plant capsule, and gel strength is high, and capsule shaping is good, and filming performance is preferable,
Transparency increase, good toughness is with short production cycle, safe, is easy to digest and assimilate；
(3) extracting method of galic essential oil of the present invention is simple, and recovery rate is high, up to 0.40-0.52%, using gentle temperature
Degree condition, the decomposition of galic essential oil under the high temperature conditions is effectively avoided, stability is good, and purity is high, and extraction cost is low, suitable industry
Metaplasia is produced；
(4) dosage form selection soft capsule of the present invention, it is in good taste, easily swallow, not only can be by galic essential oil, Purple Perilla Seed Oil, sand
The active ingredient of spine seed oil slowly discharges, and improves action time, and can reduce stimulation of the galic essential oil to stomach, takes
Band safety, it is convenient to take, have no toxic side effect and adverse reaction；
(5) compound coordinates scientific and reasonable, has regulation immune system, improves humoral immunity and Culture in vitro ability；
The simple science of preparation method, mild condition, production cost are low.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is further detailed with reference to embodiments
Describe in detail bright.
Embodiment 1
A kind of immune soft capsule of galic essential oil compound enhancing, including capsule-core and capsule skin, wherein capsule-core include following parts by weight
Raw material components：10 parts of galic essential oil, 10 parts of Seabuckthorm Seed Oil, 5 parts of Purple Perilla Seed Oil, 2 parts of fullerene, 30 parts of cavings essential oil；It is described
Capsule skin is made up of following components of the raw material of following parts by weight：20 parts of converted starch natural plant gum, 5 parts of sodium alginate, citric acid
5 parts of potassium, 5 parts of sucrose Polyester, 10 parts of glycerine, 50 parts of pure water；Wherein the mass ratio of capsule-core and capsule skin is 1:3.
Described galic essential oil preparation method comprises the following steps：
1) selected no insect pest, the fresh garlic head without lesion of going rotten clean up after it is soaked with clear water, smash to pieces in garlic
Mud；
2) cellulase for adding mashed garlic weight 0.03% is digested, and hydrolysis temperature is 36 DEG C, enzymolysis time 1h, enzyme
Enzymolysis liquid is filtered into obtain filter residue and the first filtrate after the completion of solution, filtering uses 0.2 μm of filtering with microporous membrane；
3) concentration that filter residue addition is accounted for 2 times of filter residue weight is carried out for 1wt% sodium chloride and 4wt% sodium acetates mixed solvent
Ultrasonic extraction, ultrasonic extraction time are 20min, filter to take filtrate and obtain the second filtrate, filtering uses 0.2 μm of filtering with microporous membrane；
4) the first filtrate and the second filtrate are merged, using CO2Supercritical extract, pressure 15MPa, extraction temperature 35
DEG C, extraction time 1h, carbon dioxide flow 3500g/h, separate to obtain extract；
5) supernatant, centrifugation rate 10000r/min is collected by centrifugation in extract；
6) step 5) supernatant progress pressure reduction with classification is separated into obtain galic essential oil, pressure 8MPa, temperature is 35 DEG C.
Enzymolysis process is additionally added the antioxidant of mashed garlic weight 0.05% in the step 2).
Described antioxidant is butylated hydroxy anisole.
Described fullerene is C60.
Described cavings essential oil preparation method comprises the following steps：By cavings crude oil below 2 DEG C normal pressure winterization one week, mistake
Filter off and be preheated to 50 DEG C after removing wax, the same warm water of 0.4 times of cavings crude oil weight is added while stirring, in 0.05MPa vacuum
The lower stirring 20min of degree, insulation stand 4h, sub-cloud water and impurity are removed after layering, water content 0.1% is dried under vacuum at 70 DEG C
Produce below.
Described converted starch natural plant gum is made by converted starch, and described converted starch is cornstarch.
A kind of preparation method of the immune soft capsule of galic essential oil compound enhancing, comprises the following steps：
(1) extraction separation and purification of galic essential oil：Garlic cleaning filters to obtain filter residue after being digested after smashing to pieces using enzymatic isolation method
With the first filtrate, filter residue adds extract progress ultrasonic extraction and obtains the second filtrate, merges the first filtrate and the second filtrate using super
Critical CO2Extract and separate obtains supernatant re-grading decompression separation and produced；
(2) prepared by capsule-core：Galic essential oil, Purple Perilla Seed Oil, Seabuckthorm Seed Oil, fullerene, cavings essential oil are measured according to formula, is added
Enter ball milling 6h in ball mill, being heated to 30 DEG C makes material dissolution and be well mixed, and stands 1h centrifugal filtrations, degassing obtains mictocystis
Core solution；
(3) capsule leather is standby：According to formula ratio by converted starch natural plant gum, sodium alginate, sucrose Polyester, glycerine, pure water
Glue is well mixed to obtain, potassium citrate is added in foregoing glue in the form of spraying, lasting stirring increases until gelatin viscosity
Adding to degassing after 2000mPa.s, to obtain composite sac hide glue gelatin standby；
(4) pelleting sizing, cleaning：Capsule-core and capsule skin are placed in after pellet processing machine pelleting to be placed in rolling and shaped, then with 95%
Edible alcohol washs, and removes the fat-soluble burs such as the oily wax on soft capsule surface；
(5) dry：Soft capsule after cleaning is sent into temperature as 20 DEG C of drying indoor seasoning, relative humidity 15%,
Drying time is 12h；
(6) finished product detection, packaging：Dried soft capsule is placed in lamp inspection machine, screens out underproof soft capsule, will
Qualified soft capsule bottling, and cased after packing, be put in storage after the assay was approved through quality inspection portion.
Pellet press rotating speed is 3r/min in the step (4), and 40 DEG C of sprinkler body temperature, soft capsule specification is 0.5g/ grains, sizing
Temperature is 20 DEG C, relative humidity 35%.
Embodiment 2
A kind of immune soft capsule of galic essential oil compound enhancing, including capsule-core and capsule skin, wherein capsule-core include following parts by weight
Raw material components：20 parts of galic essential oil, 20 parts of Seabuckthorm Seed Oil, 15 parts of Purple Perilla Seed Oil, 10 parts of fullerene, 50 parts of cavings essential oil；Institute
Capsule skin is stated to be made up of the raw material of following parts by weight of following components：40 parts of converted starch natural plant gum, 10 parts of sodium alginate, lemon
Sour 10 parts of potassium, 10 parts of sucrose Polyester, 20 parts of glycerine, 60 parts of pure water；Wherein the mass ratio of capsule-core and capsule skin is 3:1.
Described galic essential oil preparation method comprises the following steps：
1) selected no insect pest, the fresh garlic head without lesion of going rotten clean up after it is soaked with clear water, smash to pieces in garlic
Mud；
2) cellulase for adding mashed garlic weight 0.05% is digested, and hydrolysis temperature is 40 DEG C, enzymolysis time 2h, enzyme
Enzymolysis liquid is filtered into obtain filter residue and the first filtrate after the completion of solution, filtering uses 0.2 μm of filtering with microporous membrane；
3) concentration that filter residue addition is accounted for 3 times of filter residue weight is carried out for 3wt% sodium chloride and 6wt% sodium acetates mixed solvent
Ultrasonic extraction, ultrasonic extraction time are 30min, filter to take filtrate and obtain the second filtrate, filtering uses 0.2 μm of filtering with microporous membrane；
4) the first filtrate and the second filtrate are merged, using CO2Supercritical extract, pressure 20MPa, extraction temperature 40
DEG C, extraction time 1.5h, carbon dioxide flow 3600g/h, separate to obtain extract；
5) supernatant, centrifugation rate 12000r/min is collected by centrifugation in extract；
6) step 5) supernatant progress pressure reduction with classification is separated into obtain galic essential oil, pressure 10MPa, temperature is 40 DEG C.
Enzymolysis process is additionally added the antioxidant of mashed garlic weight 0.1% in the step 2).
Described antioxidant is one kind in tert-butylhydroquinone.
Described fullerene is C70.
Described cavings essential oil preparation method comprises the following steps：By cavings crude oil below 2 DEG C normal pressure winterization one week, mistake
Filter off and be preheated to 60 DEG C after removing wax, the same warm water of 0.6 times of cavings crude oil weight is added while stirring, in 0.06MPa vacuum
The lower stirring 30min of degree, insulation stand 6h, sub-cloud water and impurity are removed after layering, water content 0.1% is dried under vacuum at 80 DEG C
Produce below.
Described converted starch natural plant gum is made by converted starch, and described converted starch is formed sediment by cornstarch, potato
One or more in powder, tapioca mix.
A kind of preparation method of the immune soft capsule of galic essential oil compound enhancing, comprises the following steps：
(1) extraction separation and purification of galic essential oil：Garlic cleaning filters to obtain filter residue after being digested after smashing to pieces using enzymatic isolation method
With the first filtrate, filter residue adds extract progress ultrasonic extraction and obtains the second filtrate, merges the first filtrate and the second filtrate using super
Critical CO2Extract and separate obtains supernatant re-grading decompression separation and produced；
(2) prepared by capsule-core：Galic essential oil, Purple Perilla Seed Oil, Seabuckthorm Seed Oil, fullerene, cavings essential oil are measured according to formula, is added
Enter ball milling 12h in ball mill, being heated to 50 DEG C makes material dissolution and be well mixed, and stands 3h centrifugal filtrations, degassing is mixed
Capsule-core solution；
(3) capsule leather is standby：According to formula ratio by converted starch natural plant gum, sodium alginate, sucrose Polyester, glycerine, pure water
Glue is well mixed to obtain, potassium citrate is added in foregoing glue in the form of spraying, lasting stirring increases until gelatin viscosity
Adding to degassing after 6000mPa.s, to obtain composite sac hide glue gelatin standby；
(4) pelleting sizing, cleaning：Capsule-core and capsule skin are placed in after pellet processing machine pelleting to be placed in rolling and shaped, then with 95%
Edible alcohol washs, and removes the fat-soluble burs such as the oily wax on soft capsule surface；
(5) dry：Soft capsule after cleaning is sent into temperature as 30 DEG C of drying indoor seasoning, relative humidity 25%,
Drying time is 15h；
(6) finished product detection, packaging：Dried soft capsule is placed in lamp inspection machine, screens out underproof soft capsule, will
Qualified soft capsule bottling, and cased after packing, be put in storage after the assay was approved through quality inspection portion.
Preferably, pellet press rotating speed is 4r/min in the step (4), and sprinkler body temperature 50 C, soft capsule specification is 0.5g/
Grain, setting temperature are 25 DEG C, relative humidity 45%.
Embodiment 3
A kind of immune soft capsule of galic essential oil compound enhancing, including capsule-core and capsule skin, wherein capsule-core include following parts by weight
Raw material components：15 parts of galic essential oil, 15 parts of Seabuckthorm Seed Oil, 10 parts of Purple Perilla Seed Oil, 6 parts of fullerene, 40 parts of cavings essential oil；It is described
Capsule skin is made up of following components of the raw material of following parts by weight：30 parts of converted starch natural plant gum, 8 parts of sodium alginate, citric acid
8 parts of potassium, 8 parts of sucrose Polyester, 15 parts of glycerine, 55 parts of pure water；Wherein the mass ratio of capsule-core and capsule skin is 2:2.
Described galic essential oil preparation method comprises the following steps：
1) selected no insect pest, the fresh garlic head without lesion of going rotten clean up after it is soaked with clear water, smash to pieces in garlic
Mud；
2) cellulase for adding mashed garlic weight 0.04% is digested, and hydrolysis temperature is 38 DEG C, enzymolysis time 1.5h,
Enzymolysis liquid is filtered into obtain filter residue and the first filtrate after the completion of enzymolysis, filtering uses 0.2 μm of filtering with microporous membrane；
3) concentration that filter residue addition is accounted for 2.5 times of filter residue weight is entered for 2wt% sodium chloride and 5wt% sodium acetate mixed solvents
Row ultrasonic extraction, ultrasonic extraction time are 25min, filter to take filtrate and obtain the second filtrate, filtering uses 0.2 μm of miillpore filter mistake
Filter；
4) the first filtrate and the second filtrate are merged, using CO2Supercritical extract, pressure 18MPa, extraction temperature 38
DEG C, extraction time 1.2h, carbon dioxide flow 3550g/h, separate to obtain extract；
5) supernatant, centrifugation rate 11000r/min is collected by centrifugation in extract；
6) step 5) supernatant progress pressure reduction with classification is separated into obtain galic essential oil, pressure 9MPa, temperature is 38 DEG C.
Enzymolysis process is additionally added the antioxidant of mashed garlic weight 0.08% in the step 2).
Described antioxidant is one kind in butylated hydroxy anisole or tert-butylhydroquinone.
Described fullerene is C60.
Described cavings essential oil preparation method comprises the following steps：By cavings crude oil below 2 DEG C normal pressure winterization one week, mistake
Filter off and be preheated to 55 DEG C after removing wax, the same warm water of 0.5 times of cavings crude oil weight is added while stirring, in 0.05MPa vacuum
The lower stirring 25min of degree, insulation stand 5h, sub-cloud water and impurity are removed after layering, water content 0.1% is dried under vacuum at 75 DEG C
Produce below.
Described converted starch natural plant gum is made by converted starch, and described converted starch is formed sediment by cornstarch, potato
One or more in powder, tapioca mix.
A kind of preparation method of the immune soft capsule of galic essential oil compound enhancing, comprises the following steps：
(1) extraction separation and purification of galic essential oil：Garlic cleaning filters to obtain filter residue after being digested after smashing to pieces using enzymatic isolation method
With the first filtrate, filter residue adds extract progress ultrasonic extraction and obtains the second filtrate, merges the first filtrate and the second filtrate using super
Critical CO2Extract and separate obtains supernatant re-grading decompression separation and produced；
(2) prepared by capsule-core：Galic essential oil, Purple Perilla Seed Oil, Seabuckthorm Seed Oil, fullerene, cavings essential oil are measured according to formula, is added
Enter ball milling 9h in ball mill, being heated to 40 DEG C makes material dissolution and be well mixed, and stands 2h centrifugal filtrations, degassing obtains mictocystis
Core solution；
(3) capsule leather is standby：According to formula ratio by converted starch natural plant gum, sodium alginate, sucrose Polyester, glycerine, pure water
Glue is well mixed to obtain, potassium citrate is added in foregoing glue in the form of spraying, lasting stirring increases until gelatin viscosity
Adding to degassing after 4000mPa.s, to obtain composite sac hide glue gelatin standby；
(4) pelleting sizing, cleaning：Capsule-core and capsule skin are placed in after pellet processing machine pelleting to be placed in rolling and shaped, then with 95%
Edible alcohol washs, and removes the fat-soluble burs such as the oily wax on soft capsule surface；
(5) dry：Soft capsule after cleaning is sent into temperature as 25 DEG C of drying indoor seasoning, relative humidity 20%,
Drying time is 13h；
(6) finished product detection, packaging：Dried soft capsule is placed in lamp inspection machine, screens out underproof soft capsule, will
Qualified soft capsule bottling, and cased after packing, be put in storage after the assay was approved through quality inspection portion.
Preferably, pellet press rotating speed is 3.5r/min in the step (4), sprinkler body temperature 45 C, and soft capsule specification is
0.5g/ grains, setting temperature are 23 DEG C, relative humidity 40%.
Experimental verification：
1. experiment material and method
Experimental rat, male and female half and half, 6-8 week old, body weight are 250 ± 50g；Test medicine is embodiment 1-3 soft capsule；
Tested rat is 5 groups at random, and every group 10, male and female half and half, 1 group is distilled water control group, and 2 groups are embodiment 3
In capsule-core material be free of galic essential oil, the same nursing group of remaining composition, 3 groups, 4 groups, 5 groups are respectively the capsule-core in embodiment 3
High dose, middle dosage and low dosage nursing group made of the galic essential oil Seabuckthorm Seed Oil compound capsule-core material of material, described high dose,
Middle dosage and low dosage are respectively 1g/kg.BW, 300mg/kg.BW and 150mg/kg.BW, and daily timing in afternoon gavage once connects
Continuous nursing is tested after 20 days, and control group feeds isometric distilled water, and rat items immune indexes are carried out after continuous 30 days
Detection；
Experimental method：
Antibody-producting cell measure (Jerne improves slide methods), rat charcoal clean up experiment
Experimental result：
Influence measurement result such as following table of the immune soft capsule of galic essential oil compound enhancing to rat Ab cellulation number：
* P ＜ 0.05
Show in table, take the rat of soft capsule and control group without galic essential oil, its equal nothing of antibody-producting cell number
Significant difference (P ＞ 0.05), and the rat for taking the immune soft capsule of galic essential oil compound enhancing has significant difference (P ＜
0.05) rat Ab cellulation number, can be effectively improved, that is, has the function that enhancing is immune.
It should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted.Although with reference to compared with
The present invention is described in detail good embodiment, it will be understood by those within the art that, can be to the technology of invention
Scheme is modified or equivalent substitution, and without departing from the scope of technical solution of the present invention, it all should cover the power in the present invention
In sharp claimed range.
Claims (9)
- A kind of 1. immune soft capsule of galic essential oil compound enhancing, it is characterised in that including capsule-core and capsule skin, wherein capsule-core include with The raw material components of lower parts by weight：Galic essential oil 10-20 parts, Purple Perilla Seed Oil 5-15 parts, Seabuckthorm Seed Oil 10-20 parts, fullerene 2-10 Part, cavings essential oil 30-50 parts；The capsule skin is made up of following components of the raw material of following parts by weight：Converted starch natural plant gum 20-40 parts, sodium alginate 5-10 parts, potassium citrate 5-10 parts, sucrose Polyester 5-10 parts, glycerine 10-20 parts, pure water 50-60 Part；Wherein the mass ratio of capsule-core and capsule skin is 1:3-3:1.
- A kind of 2. immune soft capsule of galic essential oil compound enhancing according to claim 1, it is characterised in that described garlic Essential oil preparation method comprises the following steps：1）Selected no insect pest, the fresh garlic head without lesion of going rotten clean up after it is soaked with clear water, smash to pieces in mashed garlic；2）The cellulase for adding mashed garlic weight 0.03-0.05% is digested, and hydrolysis temperature is 36-40 DEG C, enzymolysis time 1- 2h, filters to obtain filter residue and the first filtrate after the completion of enzymolysis by enzymolysis liquid, and filtering uses 0.2 μm of filtering with microporous membrane；3）The concentration that filter residue addition is accounted for 2-3 times of filter residue weight is carried out for 1-3wt% sodium chloride and 4-6wt% sodium acetates mixed solvent Ultrasonic extraction, ultrasonic extraction time are 20-30min, filter to take filtrate and obtain the second filtrate, filtering uses 0.2 μm of miillpore filter mistake Filter；4）Merge the first filtrate and the second filtrate, using CO2Supercritical extract, pressure 15-20MPa, extraction temperature 35-40 DEG C, extraction time 1-1.5h, carbon dioxide flow 3500-3600g/h, separate to obtain extract；5）Supernatant, centrifugation rate 10000-12000r/min is collected by centrifugation in extract；6）By step 5）Supernatant carries out pressure reduction with classification and separates to obtain galic essential oil, pressure 8-10MPa, and temperature is 35-40 DEG C.
- A kind of 3. immune soft capsule of galic essential oil compound enhancing according to claim 2, it is characterised in that the step 2） Middle enzymolysis process is additionally added mashed garlic weight 0.05-0.1% antioxidant.
- A kind of 4. immune soft capsule of galic essential oil compound enhancing according to claim 3, it is characterised in that described antioxygen Agent is one kind in butylated hydroxy anisole or tert-butylhydroquinone.
- A kind of 5. immune soft capsule of galic essential oil compound enhancing according to claim 1, it is characterised in that described fowler Alkene is C60 or C70.
- A kind of 6. immune soft capsule of galic essential oil compound enhancing according to claim 1, it is characterised in that described cavings Essential oil preparation method comprises the following steps：By cavings crude oil below 2 DEG C normal pressure winterization one week, filter off except being preheated to after wax 50-60 DEG C, the same warm water of 0.4-0.6 times of cavings crude oil weight is added while stirring, is stirred under 0.05-0.06MPa vacuums 20-30min is mixed, insulation stands 4-6h, sub-cloud water and impurity are removed after layering, water content is dried under vacuum at 70-80 DEG C Less than 0.1% produces.
- A kind of 7. immune soft capsule of galic essential oil compound enhancing according to claim 1, it is characterised in that described denaturation Starch plant glue is made by converted starch, and described converted starch is by one kind in cornstarch, farina, tapioca Or a variety of mix.
- 8. a kind of preparation method of the immune soft capsule of galic essential oil compound enhancing, it is characterised in that comprise the following steps：（1）The extraction separation and purification of galic essential oil：Garlic cleaning smash to pieces after using filtering to obtain filter residue and the after enzymatic isolation method enzymolysis One filtrate, filter residue add extract progress ultrasonic extraction and obtain the second filtrate, merge the first filtrate and the second filtrate using overcritical CO2Extract and separate obtains supernatant re-grading decompression separation and produced；（2）It is prepared by capsule-core：Galic essential oil, Purple Perilla Seed Oil, Seabuckthorm Seed Oil, fullerene, cavings essential oil are measured according to formula, adds ball Ball milling 6-12h in grinding machine, being heated to 30-50 DEG C makes material dissolution and is well mixed, and stands 1-3h centrifugal filtrations, degassing is mixed Close capsule-core solution；（3）Capsule leather is standby：Converted starch natural plant gum, sodium alginate, sucrose Polyester, glycerine, pure water are mixed according to formula ratio It is uniform to obtain glue, potassium citrate is added in foregoing glue in the form of spraying, lasting stirring increases to until gelatin viscosity It is standby that 2000-6000mPa.s rear degassing obtains composite sac hide glue gelatin；（4）Pelleting sizing, cleaning：Capsule-core and capsule skin are placed in after pellet processing machine pelleting to be placed in rolling and shaped, then with 95% edible wine Fine purifiation is washed, and removes the fat-soluble burs such as the oily wax on soft capsule surface；（5）Dry：Soft capsule after cleaning is sent into temperature as 20-30 DEG C of drying indoor seasoning, relative humidity 15-25%, Drying time is 12-15h；（6）Finished product detection, packaging：Dried soft capsule is placed in lamp inspection machine, screens out underproof soft capsule, will be qualified Soft capsule bottling, and pack after case, be put in storage after the assay was approved through quality inspection portion.
- A kind of 9. preparation method of immune soft capsule of galic essential oil compound enhancing according to claim 8, it is characterised in that The step（4）Middle pellet press rotating speed is 3-4r/min, and 40-50 DEG C of sprinkler body temperature, soft capsule specification is 0.5g/ grains, sizing temperature Spend for 20-25 DEG C, relative humidity 35-45%.
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