CN107549859B - A kind of galic essential oil compound enhances immune soft capsule and preparation method thereof - Google Patents
A kind of galic essential oil compound enhances immune soft capsule and preparation method thereof Download PDFInfo
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Abstract
A kind of galic essential oil compound of the present invention enhances immune soft capsule, including capsule-core and capsule skin, wherein capsule-core includes the raw material components of following parts by weight: 10-20 parts of galic essential oil, 10-20 parts of Seabuckthorm Seed Oil, 5-15 parts of Purple Perilla Seed Oil, 2-10 parts of fullerene, 30-50 parts of cavings essential oil；The capsule skin is made of following components of the raw material of following parts by weight: 20-40 parts of converted starch natural plant gum, 5-10 parts of sodium alginate, 5-10 parts of potassium citrate, 5-10 parts of sucrose Polyester, 10-20 parts of glycerol, 50-60 parts of pure water；Wherein the mass ratio of capsule-core and capsule skin is 1:3-3:1；The preparation method of soft capsule is simply scientific, and mild condition, production cost is low, is suitable for industrialized production, has the function of that adjusting is immune well, effectively improves rat Ab cellulation number.
Description
Technical field
The present invention relates to a kind of soft capsule technical field, in particular to a kind of galic essential oil compound enhance immune soft capsule and
Preparation method.
Background technique
Garlic is the bulb of Liliaceae allium, and acrid flavour is peppery, there have to be strong garlicky, is important spice vegetables work
Object.The various pharmacological actions of garlic are derived from its chemical component rich in.Galic essential oil be extracted from garlic it is special
Substance is multicomponent mixture, the sulfide compound group being made of allicin, Allicin and a variety of allyls and methyl
At also containing citral, geraniol, linalool, α-phellandrene, propionic aldehyde, valeral etc., main component has six kinds, belongs to
Allyl sulfide ether material is allyl methyl thioether, allyl sulfide, allyl methyl disulfide, diallyl disulfide
Ether, allyl methyl trisulfide ether, Diallytrisin, Diallytrisin are that galic essential oil has the main of physiological activity
Ingredient；Modern age medicine and pharmacology, biology, medical science experimental study proof galic essential oil have effects that following: antibacterial, sterilization；Drop
Blood lipid, prevention of arterial hardening, treatment cardiovascular and cerebrovascular disease；It is hypoglycemic；Protect liver；Improve immunity, anti-aging；Near weight-reducing
Deng；In addition there are research shows that galic essential oil has effects that improve glycometabolism and treats impotence effect.
At present both at home and abroad about most of still using single galic essential oil as primary raw material in garlic P.E product, function
Property is extremely limited.
Immunity is that human body resists extraneous virulence factor and maintains the ability of homoiostasis.Modern society, with life
The quickening that movable joint is played, the increase of survival pressure, sub-health state is extremely widespread, and hypoimmunity is that human body carries out self-protection
One of barrier, hypoimmunity will lead to various diseases, seriously affect normal life and work；About garlic essence in existing patent
The product of oil compounding other components also has the product for being much directed to and improving immunity also to have very much, but there are still be produced into
This is too big, is formulated unscientific problem.
Summary of the invention
Above-mentioned to solve the problems, such as, the purpose of the present invention is to provide a kind of galic essential oil compounds to enhance immune flexible glue
Capsule and preparation method thereof.
In order to achieve the above objectives, the technical scheme is that
A kind of immune soft capsule of galic essential oil compound enhancing, including capsule-core and capsule skin, wherein capsule-core includes following parts by weight
Raw material components: 10-20 parts of galic essential oil, 10-20 parts of Seabuckthorm Seed Oil, 5-15 parts of Purple Perilla Seed Oil, 2-10 parts of fullerene, cavings essence
It is 30-50 parts oily；The capsule skin is made of following components of the raw material of following parts by weight: 20-40 parts of converted starch natural plant gum, sea
5-10 parts of mosanom, 5-10 parts of potassium citrate, 5-10 parts of sucrose Polyester, 10-20 parts of glycerol, 50-60 parts of pure water；Wherein capsule-core
Mass ratio with capsule skin is 1:3-3:1.
Preferably, the galic essential oil preparation method the following steps are included:
1) selected no insect pest, the fresh garlic head without lesion of going rotten clean up after impregnating it with clear water, smash to pieces in garlic
Mud；
2) cellulase that mashed garlic weight 0.03-0.05% is added is digested, and hydrolysis temperature is 36-40 DEG C, when enzymatic hydrolysis
Between be 1-2h, enzymolysis liquid is filtered into obtain filter residue and the first filtrate after the completion of enzymatic hydrolysis, filtering uses 0.2 μm of filtering with microporous membrane；
3) filter residue being added and accounting for the concentration of 2-3 times of filter residue weight is that 1-3wt% sodium chloride and the mixing of 4-6wt% sodium acetate are molten
Agent carries out ultrasonic extraction, and the ultrasonic extraction time is 20-30min, filters to take filtrate and obtains the second filtrate, filtering uses 0.2 μm of micropore
Membrane filtration；
4) merge the first filtrate and the second filtrate, using CO2Supercritical extract, pressure 15-20MPa, extraction temperature are
35-40 DEG C, extraction time 1-1.5h, carbon dioxide flow 3500-3600g/h separates to obtain extract liquor；
5) supernatant, centrifugation rate 10000-12000r/min is collected by centrifugation in extract liquor；
6) step 5) supernatant progress pressure reduction with classification is separated into obtain galic essential oil, pressure 8-10MPa, temperature 35-40
℃。
Preferably, enzymolysis process is additionally added the antioxidant of mashed garlic weight 0.05-0.1% in the step 2).
Preferably, the antioxidant is one of butylated hydroxy anisole or tert-butylhydroquinone.
Preferably, the fullerene is C60 or C70.
Preferably, the cavings essential oil preparation method is the following steps are included: by cavings crude oil in 2 DEG C or less normal pressure winterization
One week, filtering was preheated to 50-60 DEG C after removing wax, and 0.4-0.6 times of weight of cavings crude oil of same warm water is added while stirring,
20-30min is stirred under 0.05-0.06MPa vacuum degree, heat preservation stands 4-6h, lower water and impurity is removed after layering, in 70-
0.1% or less water content is dried under vacuum at 80 DEG C to obtain the final product.
Preferably, the converted starch natural plant gum is made by converted starch, and the converted starch is by cornstarch, horse
One of bell sweet potato starch, tapioca a variety of mix.
A kind of galic essential oil compound enhances the preparation method of immune soft capsule, includes the following steps:
(1) extraction separation and purification of galic essential oil: garlic cleaning filters to obtain filter residue after digesting after smashing to pieces using enzymatic isolation method
With the first filtrate, filter residue is added extract liquor progress ultrasonic extraction and obtains the second filtrate, merges the first filtrate and the second filtrate using super
Critical CO2Extraction and separation obtain supernatant re-grading decompression separation to obtain the final product；
(2) prepared by capsule-core: measuring galic essential oil, Purple Perilla Seed Oil, Seabuckthorm Seed Oil, fullerene, cavings essential oil according to formula, adds
Enter ball milling 6-12h in ball mill, being heated to 30-50 DEG C makes material dissolution and be uniformly mixed, and stands 1-3h centrifugal filtration, deaerates
To mixing capsule-core solution；
(3) capsule leather is standby: according to formula ratio by converted starch natural plant gum, sodium alginate, sucrose Polyester, glycerol, pure water
It is uniformly mixed to obtain glue, potassium citrate is added in aforementioned glue in spraying form, lasting stirring increases until gelatin viscosity
Adding to degassing after 2000-6000mPa.s, to obtain composite sac hide glue gelatin spare；
(4) it pelleting sizing, cleaning: capsule-core and capsule skin is placed in pellet processing machine pelleting is placed in rolling and be formed, then with 95%
Edible alcohol washing, removes the fat-soluble burs such as the oily wax on soft capsule surface；
(5) dry: the soft capsule after cleaning is sent into the drying indoor seasoning that temperature is 20-30 DEG C, relative humidity 15-
25%, drying time 12-15h；
(6) finished product detection, packaging: dried soft capsule is placed in lamp inspection machine, screens out underproof soft capsule, will
Qualified soft capsule bottling, and case after packing, it is put in storage after the assay was approved through quality inspection portion.
Preferably, pellet press revolving speed is 3-4r/min in the step (4), and 40-50 DEG C of sprinkler body temperature, soft capsule specification is
0.5g/, setting temperature is 20-25 DEG C, relative humidity 35-45%.
The beneficial effects of the present invention are:
(1) a kind of galic essential oil compound provided by the invention enhances immune soft capsule, using galic essential oil, Purple Perilla Seed Oil,
Seabuckthorm Seed Oil and fullerene compounding, fullerene are conducive to improve the stability that galic essential oil, Purple Perilla Seed Oil, Seabuckthorm Seed Oil mix；
Galic essential oil can increase T lymphocyte activation, and hemolysin quantity increases, and cellular immunity can be improved, body fluid is exempted from
Epidemic disease and non-specific immune function；Seabuckthorn seeds are formed rich in multiple beneficial fatty acid, and wherein unsaturated fatty acid is up to 70%, class
Carrotene and vitamin E and various trace elements content are also higher, lowly have good adjusting for immunity of organisms
Effect, general flavone have different degrees of regulating power to the too many levels of immune system, have to humoral immunity and cellular immunity
Apparent adjustment effect；Purple Perilla Seed Oil main component is alpha-linolenic acid, and content is up to 67% or so；Galic essential oil and sand in compound
Both spine seed oil is monarch, adjusts immune system, has apparent adjustment effect to humoral immunity and cellular immunity；Purple Perilla Seed Oil is
Minister is the essence of extra large plant, is rich in alpha-linolenic acid；Cavings essential oil is assistant, containing there are many amino acid, Glutamic Acid, leucine,
Alanine, proline, aspartic acid equal size are higher, in cavings essential oil also containing carrotene (vitamin A), vitamin B1,
The vitamins such as B2 compound with galic essential oil, Purple Perilla Seed Oil and Seabuckthorm Seed Oil, are more advantageous to absorption of human body；Supplemented by fullerene, have
Very strong antioxidation has very strong Scavenging ability；Immune system, anti-oxidant in one is adjusted, plays enhancing altogether
Immune, antifatigue health-care effect；
(2) capsule skin of the present invention uses full starch plant capsule, and gel strength is high, and capsule shaping is good, and filming performance is preferable,
Transparency increases, and good toughness is with short production cycle, highly-safe, absorption easy to digest；
(3) extracting method of galic essential oil of the present invention is simple, and recovery rate is high, up to 0.40-0.52%, using mild temperature
Degree condition effectively avoids the decomposition of galic essential oil under the high temperature conditions, and stability is good, and purity is high, extraction cost is low, is suitable for industry
Metaplasia produces；
(4) dosage form selection soft capsule of the present invention, it is in good taste, easily swallow, it not only can be by galic essential oil, Purple Perilla Seed Oil, sand
The effective component of spine seed oil slowly discharges, and improves action time, and can reduce galic essential oil to the stimulation of stomach, takes
Band safety, it is convenient to take, it has no toxic side effect and adverse reaction；
(5) compound cooperation is scientific and reasonable, has and adjusts immune system, improves humoral immunity and Culture in vitro ability；
Preparation method is simply scientific, mild condition, and production cost is low.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, further detailed with reference to embodiments
It describes in detail bright.
Embodiment 1
A kind of immune soft capsule of galic essential oil compound enhancing, including capsule-core and capsule skin, wherein capsule-core includes following parts by weight
Raw material components: 10 parts of galic essential oil, 10 parts of Seabuckthorm Seed Oil, 5 parts of Purple Perilla Seed Oil, 2 parts of fullerene, 30 parts of cavings essential oil；It is described
Capsule skin is made of following components of the raw material of following parts by weight: 20 parts of converted starch natural plant gum, 5 parts of sodium alginate, citric acid
5 parts of potassium, 5 parts of sucrose Polyester, 10 parts of glycerol, 50 parts of pure water；Wherein the mass ratio of capsule-core and capsule skin is 1:3.
The galic essential oil preparation method the following steps are included:
1) selected no insect pest, the fresh garlic head without lesion of going rotten clean up after impregnating it with clear water, smash to pieces in garlic
Mud；
2) cellulase that mashed garlic weight 0.03% is added is digested, and hydrolysis temperature is 36 DEG C, enzymolysis time 1h, enzyme
Enzymolysis liquid is filtered into obtain filter residue and the first filtrate after the completion of solution, filtering uses 0.2 μm of filtering with microporous membrane；
It 3) is that 1wt% sodium chloride and 4wt% sodium acetate mixed solvent carry out by the concentration that filter residue addition accounts for 2 times of filter residue weight
Ultrasonic extraction, ultrasonic extraction time are 20min, filter to take filtrate and obtain the second filtrate, filtering uses 0.2 μm of filtering with microporous membrane；
4) merge the first filtrate and the second filtrate, using CO2Supercritical extract, pressure 15MPa, extraction temperature 35
DEG C, extraction time 1h, carbon dioxide flow 3500g/h separates to obtain extract liquor；
5) supernatant, centrifugation rate 10000r/min is collected by centrifugation in extract liquor；
6) step 5) supernatant progress pressure reduction with classification is separated into obtain galic essential oil, pressure 8MPa, temperature is 35 DEG C.
Enzymolysis process is additionally added the antioxidant of mashed garlic weight 0.05% in the step 2).
The antioxidant is butylated hydroxy anisole.
The fullerene is C60.
The cavings essential oil preparation method the following steps are included: by cavings crude oil 2 DEG C or less normal pressure winterization one week, mistake
It filters off except being preheated to 50 DEG C after wax, the same warm water of 0.4 times of cavings crude oil weight is added while stirring, in 0.05MPa vacuum
Degree is lower to stir 20min, and heat preservation stands 4h, and lower water and impurity are removed after layering, water content 0.1% is dried under vacuum at 70 DEG C
Below to obtain the final product.
The converted starch natural plant gum is made by converted starch, and the converted starch is cornstarch.
A kind of galic essential oil compound enhances the preparation method of immune soft capsule, includes the following steps:
(1) extraction separation and purification of galic essential oil: garlic cleaning filters to obtain filter residue after digesting after smashing to pieces using enzymatic isolation method
With the first filtrate, filter residue is added extract liquor progress ultrasonic extraction and obtains the second filtrate, merges the first filtrate and the second filtrate using super
Critical CO2Extraction and separation obtain supernatant re-grading decompression separation to obtain the final product；
(2) prepared by capsule-core: measuring galic essential oil, Purple Perilla Seed Oil, Seabuckthorm Seed Oil, fullerene, cavings essential oil according to formula, adds
Enter ball milling 6h in ball mill, being heated to 30 DEG C makes material dissolution and be uniformly mixed, and stands 1h centrifugal filtration, degassing obtains mictocystis
Core solution；
(3) capsule leather is standby: according to formula ratio by converted starch natural plant gum, sodium alginate, sucrose Polyester, glycerol, pure water
It is uniformly mixed to obtain glue, potassium citrate is added in aforementioned glue in spraying form, lasting stirring increases until gelatin viscosity
Adding to degassing after 2000mPa.s, to obtain composite sac hide glue gelatin spare；
(4) it pelleting sizing, cleaning: capsule-core and capsule skin is placed in pellet processing machine pelleting is placed in rolling and be formed, then with 95%
Edible alcohol washing, removes the fat-soluble burs such as the oily wax on soft capsule surface；
(5) dry: the drying indoor seasoning for being 20 DEG C by the soft capsule feeding temperature after cleaning, relative humidity 15%,
Drying time is 12h；
(6) finished product detection, packaging: dried soft capsule is placed in lamp inspection machine, screens out underproof soft capsule, will
Qualified soft capsule bottling, and case after packing, it is put in storage after the assay was approved through quality inspection portion.
Pellet press revolving speed is 3r/min in the step (4), and 40 DEG C of sprinkler body temperature, soft capsule specification is 0.5g/, sizing
Temperature is 20 DEG C, relative humidity 35%.
Embodiment 2
A kind of immune soft capsule of galic essential oil compound enhancing, including capsule-core and capsule skin, wherein capsule-core includes following parts by weight
Raw material components: 20 parts of galic essential oil, 20 parts of Seabuckthorm Seed Oil, 15 parts of Purple Perilla Seed Oil, 10 parts of fullerene, 50 parts of cavings essential oil；Institute
It states capsule skin and is made of following components of the raw material of following parts by weight: 40 parts of converted starch natural plant gum, 10 parts of sodium alginate, lemon
10 parts of sour potassium, 10 parts of sucrose Polyester, 20 parts of glycerol, 60 parts of pure water；Wherein the mass ratio of capsule-core and capsule skin is 3:1.
The galic essential oil preparation method the following steps are included:
1) selected no insect pest, the fresh garlic head without lesion of going rotten clean up after impregnating it with clear water, smash to pieces in garlic
Mud；
2) cellulase that mashed garlic weight 0.05% is added is digested, and hydrolysis temperature is 40 DEG C, enzymolysis time 2h, enzyme
Enzymolysis liquid is filtered into obtain filter residue and the first filtrate after the completion of solution, filtering uses 0.2 μm of filtering with microporous membrane；
It 3) is that 3wt% sodium chloride and 6wt% sodium acetate mixed solvent carry out by the concentration that filter residue addition accounts for 3 times of filter residue weight
Ultrasonic extraction, ultrasonic extraction time are 30min, filter to take filtrate and obtain the second filtrate, filtering uses 0.2 μm of filtering with microporous membrane；
4) merge the first filtrate and the second filtrate, using CO2Supercritical extract, pressure 20MPa, extraction temperature 40
DEG C, extraction time 1.5h, carbon dioxide flow 3600g/h separates to obtain extract liquor；
5) supernatant, centrifugation rate 12000r/min is collected by centrifugation in extract liquor；
6) step 5) supernatant progress pressure reduction with classification is separated into obtain galic essential oil, pressure 10MPa, temperature is 40 DEG C.
Enzymolysis process is additionally added the antioxidant of mashed garlic weight 0.1% in the step 2).
The antioxidant is one of tert-butylhydroquinone.
The fullerene is C70.
The cavings essential oil preparation method the following steps are included: by cavings crude oil 2 DEG C or less normal pressure winterization one week, mistake
It filters off except being preheated to 60 DEG C after wax, the same warm water of 0.6 times of cavings crude oil weight is added while stirring, in 0.06MPa vacuum
Degree is lower to stir 30min, and heat preservation stands 6h, and lower water and impurity are removed after layering, water content 0.1% is dried under vacuum at 80 DEG C
Below to obtain the final product.
The converted starch natural plant gum is made by converted starch, and the converted starch is formed sediment by cornstarch, potato
One of powder, tapioca a variety of mix.
A kind of galic essential oil compound enhances the preparation method of immune soft capsule, includes the following steps:
(1) extraction separation and purification of galic essential oil: garlic cleaning filters to obtain filter residue after digesting after smashing to pieces using enzymatic isolation method
With the first filtrate, filter residue is added extract liquor progress ultrasonic extraction and obtains the second filtrate, merges the first filtrate and the second filtrate using super
Critical CO2Extraction and separation obtain supernatant re-grading decompression separation to obtain the final product；
(2) prepared by capsule-core: measuring galic essential oil, Purple Perilla Seed Oil, Seabuckthorm Seed Oil, fullerene, cavings essential oil according to formula, adds
Enter ball milling 12h in ball mill, being heated to 50 DEG C makes material dissolution and be uniformly mixed, and stands 3h centrifugal filtration, degassing is mixed
Capsule-core solution；
(3) capsule leather is standby: according to formula ratio by converted starch natural plant gum, sodium alginate, sucrose Polyester, glycerol, pure water
It is uniformly mixed to obtain glue, potassium citrate is added in aforementioned glue in spraying form, lasting stirring increases until gelatin viscosity
Adding to degassing after 6000mPa.s, to obtain composite sac hide glue gelatin spare；
(4) it pelleting sizing, cleaning: capsule-core and capsule skin is placed in pellet processing machine pelleting is placed in rolling and be formed, then with 95%
Edible alcohol washing, removes the fat-soluble burs such as the oily wax on soft capsule surface；
(5) dry: the drying indoor seasoning for being 30 DEG C by the soft capsule feeding temperature after cleaning, relative humidity 25%,
Drying time is 15h；
(6) finished product detection, packaging: dried soft capsule is placed in lamp inspection machine, screens out underproof soft capsule, will
Qualified soft capsule bottling, and case after packing, it is put in storage after the assay was approved through quality inspection portion.
Preferably, pellet press revolving speed is 4r/min in the step (4), and sprinkler body temperature 50 C, soft capsule specification is 0.5g/
Grain, setting temperature are 25 DEG C, relative humidity 45%.
Embodiment 3
A kind of immune soft capsule of galic essential oil compound enhancing, including capsule-core and capsule skin, wherein capsule-core includes following parts by weight
Raw material components: 15 parts of galic essential oil, 15 parts of Seabuckthorm Seed Oil, 10 parts of Purple Perilla Seed Oil, 6 parts of fullerene, 40 parts of cavings essential oil；It is described
Capsule skin is made of following components of the raw material of following parts by weight: 30 parts of converted starch natural plant gum, 8 parts of sodium alginate, citric acid
8 parts of potassium, 8 parts of sucrose Polyester, 15 parts of glycerol, 55 parts of pure water；Wherein the mass ratio of capsule-core and capsule skin is 2:2.
The galic essential oil preparation method the following steps are included:
1) selected no insect pest, the fresh garlic head without lesion of going rotten clean up after impregnating it with clear water, smash to pieces in garlic
Mud；
2) cellulase that mashed garlic weight 0.04% is added is digested, and hydrolysis temperature is 38 DEG C, enzymolysis time 1.5h,
Enzymolysis liquid is filtered into obtain filter residue and the first filtrate after the completion of enzymatic hydrolysis, filtering uses 0.2 μm of filtering with microporous membrane；
3) filter residue is added account for 2.5 times of filter residue weight of concentration be 2wt% sodium chloride and 5wt% sodium acetate mixed solvent into
Row ultrasonic extraction, ultrasonic extraction time are 25min, filter to take filtrate and obtain the second filtrate, filtering uses 0.2 μm of miillpore filter mistake
Filter；
4) merge the first filtrate and the second filtrate, using CO2Supercritical extract, pressure 18MPa, extraction temperature 38
DEG C, extraction time 1.2h, carbon dioxide flow 3550g/h separates to obtain extract liquor；
5) supernatant, centrifugation rate 11000r/min is collected by centrifugation in extract liquor；
6) step 5) supernatant progress pressure reduction with classification is separated into obtain galic essential oil, pressure 9MPa, temperature is 38 DEG C.
Enzymolysis process is additionally added the antioxidant of mashed garlic weight 0.08% in the step 2).
The antioxidant is one of butylated hydroxy anisole or tert-butylhydroquinone.
The fullerene is C60.
The cavings essential oil preparation method the following steps are included: by cavings crude oil 2 DEG C or less normal pressure winterization one week, mistake
It filters off except being preheated to 55 DEG C after wax, the same warm water of 0.5 times of cavings crude oil weight is added while stirring, in 0.05MPa vacuum
Degree is lower to stir 25min, and heat preservation stands 5h, and lower water and impurity are removed after layering, water content 0.1% is dried under vacuum at 75 DEG C
Below to obtain the final product.
The converted starch natural plant gum is made by converted starch, and the converted starch is formed sediment by cornstarch, potato
One of powder, tapioca a variety of mix.
A kind of galic essential oil compound enhances the preparation method of immune soft capsule, includes the following steps:
(1) extraction separation and purification of galic essential oil: garlic cleaning filters to obtain filter residue after digesting after smashing to pieces using enzymatic isolation method
With the first filtrate, filter residue is added extract liquor progress ultrasonic extraction and obtains the second filtrate, merges the first filtrate and the second filtrate using super
Critical CO2Extraction and separation obtain supernatant re-grading decompression separation to obtain the final product；
(2) prepared by capsule-core: measuring galic essential oil, Purple Perilla Seed Oil, Seabuckthorm Seed Oil, fullerene, cavings essential oil according to formula, adds
Enter ball milling 9h in ball mill, being heated to 40 DEG C makes material dissolution and be uniformly mixed, and stands 2h centrifugal filtration, degassing obtains mictocystis
Core solution；
(3) capsule leather is standby: according to formula ratio by converted starch natural plant gum, sodium alginate, sucrose Polyester, glycerol, pure water
It is uniformly mixed to obtain glue, potassium citrate is added in aforementioned glue in spraying form, lasting stirring increases until gelatin viscosity
Adding to degassing after 4000mPa.s, to obtain composite sac hide glue gelatin spare；
(4) it pelleting sizing, cleaning: capsule-core and capsule skin is placed in pellet processing machine pelleting is placed in rolling and be formed, then with 95%
Edible alcohol washing, removes the fat-soluble burs such as the oily wax on soft capsule surface；
(5) dry: the drying indoor seasoning for being 25 DEG C by the soft capsule feeding temperature after cleaning, relative humidity 20%,
Drying time is 13h；
(6) finished product detection, packaging: dried soft capsule is placed in lamp inspection machine, screens out underproof soft capsule, will
Qualified soft capsule bottling, and case after packing, it is put in storage after the assay was approved through quality inspection portion.
Preferably, pellet press revolving speed is 3.5r/min in the step (4), and sprinkler body temperature 45 C, soft capsule specification is
0.5g/, setting temperature is 23 DEG C, relative humidity 40%.
Experimental verification:
1. experimental material and method
Experimental rat, half male and half female, 6-8 week old, weight are 250 ± 50g；Test medicine is the soft capsule of embodiment 1-3；
Tested rat is 5 groups at random, and every group 10, half male and half female, 1 group is distilled water control group, and 2 groups are embodiment 3
In capsule-core material be free of galic essential oil, the same nursing group of remaining ingredient, 3 groups, 4 groups, 5 groups are respectively the capsule-core in embodiment 3
High dose, middle dosage and low dosage nursing group made of the galic essential oil Seabuckthorm Seed Oil compound capsule-core material of material, the high dose,
Middle dosage and low dosage are respectively 1g/kg.BW, 300mg/kg.BW and 150mg/kg.BW, and daily timing in afternoon stomach-filling once connects
Continuous nursing is tested after 20 days, and control group feeds isometric distilled water, is carried out after continuous 30 days to rat items immune indexes
Detection；
Experimental method:
Antibody-producting cell measurement (Jerne improves slide method), rat charcoal clean up experiment
Experimental result:
Galic essential oil compound enhances immune soft capsule and is as follows: to the influence measurement result of rat Ab cellulation number
* P < 0.05
Show to take the rat of soft capsule and control group without galic essential oil, the equal nothing of antibody-producting cell number in table
Significant difference (P > 0.05), and taking galic essential oil compound enhances the rat of immune soft capsule with significant difference (P <
0.05) rat Ab cellulation number, can be effectively improved, that is, has the function of that enhancing is immune.
It should be noted that the above examples are only used to illustrate the technical scheme of the present invention and are not limiting.Although referring to compared with
Good embodiment describes the invention in detail, those skilled in the art should understand that, it can be to the technology of invention
Scheme is modified or replaced equivalently, and without departing from the range of technical solution of the present invention, should all be covered in power of the invention
In sharp claimed range.
Claims (7)
1. the preparation method that a kind of galic essential oil compound enhances immune soft capsule, which is characterized in that the galic essential oil compound increases
Immune soft capsule includes capsule-core and capsule skin by force, and wherein capsule-core includes the raw material components of following parts by weight: 10-20 parts of galic essential oil,
5-15 parts of Purple Perilla Seed Oil, 10-20 parts of Seabuckthorm Seed Oil, 2-10 parts of fullerene, 30-50 parts of cavings essential oil；The capsule skin is by with the following group
Divide and be made of the raw material of following parts by weight: 20-40 parts of converted starch natural plant gum, 5-10 parts of sodium alginate, potassium citrate 5-10
Part, 5-10 parts of sucrose Polyester, 10-20 parts of glycerol, 50-60 parts of pure water；Wherein the mass ratio of capsule-core and capsule skin is 1:3-3:1；
The galic essential oil compound enhances the preparation method of immune soft capsule, includes the following steps:
(1) extraction separation and purification of galic essential oil: garlic cleaning smash to pieces after using filtering to obtain filter residue and the after enzymatic isolation method enzymatic hydrolysis
One filtrate, filter residue are added extract liquor progress ultrasonic extraction and obtain the second filtrate, merge the first filtrate and the second filtrate using overcritical
CO2Extraction and separation obtain supernatant re-grading decompression separation to obtain the final product；
(2) prepared by capsule-core: measuring galic essential oil, Purple Perilla Seed Oil, Seabuckthorm Seed Oil, fullerene, cavings essential oil according to formula, ball is added
Ball milling 6-12h in grinding machine, being heated to 30-50 DEG C makes material dissolution and is uniformly mixed, and stands 1-3h centrifugal filtration, degassing is mixed
Close capsule-core solution；
(3) capsule leather is standby: mixing converted starch natural plant gum, sodium alginate, sucrose Polyester, glycerol, pure water according to formula ratio
It is uniform to obtain glue, potassium citrate is added in aforementioned glue in spraying form, lasting stirring is increased to until gelatin viscosity
2000-6000mPa.s it is spare that rear degassing obtains composite sac hide glue gelatin；
(4) it pelleting sizing, cleaning: capsule-core and capsule skin is placed in pellet processing machine pelleting is placed in rolling and be formed, then with 95% edible wine
Fine purifiation is washed, and the oily ceride dissolubility bur on soft capsule surface is removed；
(5) dry: the drying indoor seasoning for being 20-30 DEG C by the soft capsule feeding temperature after cleaning, relative humidity 15-25%,
Drying time is 12-15h；
(6) finished product detection, packaging: dried soft capsule is placed in lamp inspection machine, screens out underproof soft capsule, will be qualified
Soft capsule bottling, and pack after case, be put in storage after the assay was approved through quality inspection portion；
The preparation method of the galic essential oil the following steps are included:
1) selected no insect pest, the fresh garlic head without lesion of going rotten clean up after impregnating it with clear water, smash to pieces in mashed garlic；
2) cellulase that mashed garlic weight 0.03-0.05% is added is digested, and hydrolysis temperature is 36-40 DEG C, enzymolysis time 1-
2h, filters to obtain filter residue and the first filtrate for enzymolysis liquid after the completion of enzymatic hydrolysis, and filtering uses 0.2 μm of filtering with microporous membrane；
3) filter residue being added and accounting for the concentration of 2-3 times of filter residue weight is that 1-3wt% sodium chloride and 4-6wt% sodium acetate mixed solvent carry out
Ultrasonic extraction, ultrasonic extraction time are 20-30min, filter to take filtrate and obtain the second filtrate, filtering uses 0.2 μm of miillpore filter mistake
Filter；
4) merge the first filtrate and the second filtrate, using CO2Supercritical extract, pressure 15-20MPa, extraction temperature 35-40
DEG C, extraction time 1-1.5h, carbon dioxide flow 3500-3600g/h separate to obtain extract liquor；
5) supernatant, centrifugation rate 10000-12000r/min is collected by centrifugation in extract liquor；
6) step 5) supernatant progress pressure reduction with classification is separated into obtain galic essential oil, pressure 8-10MPa, temperature is 35-40 DEG C.
2. the preparation method that a kind of galic essential oil compound according to claim 1 enhances immune soft capsule, which is characterized in that
Enzymolysis process is additionally added the antioxidant of mashed garlic weight 0.05-0.1% in the step 2.
3. the preparation method that a kind of galic essential oil compound according to claim 2 enhances immune soft capsule, which is characterized in that
The antioxidant is one of butylated hydroxy anisole or tert-butylhydroquinone.
4. the preparation method that a kind of galic essential oil compound according to claim 1 enhances immune soft capsule, which is characterized in that
The fullerene is C60 or C70.
5. the preparation method that a kind of galic essential oil compound according to claim 1 enhances immune soft capsule, which is characterized in that
The cavings essential oil preparation method the following steps are included: by cavings crude oil 2 DEG C or less normal pressure winterization one week, filter off paraffin removal
It is preheated to 50-60 DEG C after matter, 0.4-0.6 times of weight of cavings crude oil of same warm water is added while stirring, in 0.05-0.06MPa
20-30min is stirred under vacuum degree, heat preservation stands 4-6h, and lower water and impurity are removed after layering, is dried in vacuo at 70-80 DEG C
To 0.1% or less water content to obtain the final product.
6. the preparation method that a kind of galic essential oil compound according to claim 1 enhances immune soft capsule, which is characterized in that
The converted starch natural plant gum is made by converted starch, and the converted starch is cornstarch, potato starch, para arrowroot
One of powder is mixed by a variety of.
7. the preparation method that a kind of galic essential oil compound according to claim 1 enhances immune soft capsule, which is characterized in that
Pellet press revolving speed is 3-4r/min in the step (4), and 40-50 DEG C of sprinkler body temperature, soft capsule specification is 0.5g/, sizing temperature
Degree is 20-25 DEG C, relative humidity 35-45%.
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| CN103404851A (en) * | 2013-07-24 | 2013-11-27 | 新疆庄子实业有限公司 | Garlic oil soft capsules and preparation method thereof |
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| CN107007567A (en) * | 2017-04-20 | 2017-08-04 | 上海应用技术大学 | A kind of galic essential oil soft capsule and preparation method thereof |
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| CN1687203A (en) * | 2005-04-07 | 2005-10-26 | 天津大学 | Vegetable capsule of starch composition and preparation method |
| CN103404851A (en) * | 2013-07-24 | 2013-11-27 | 新疆庄子实业有限公司 | Garlic oil soft capsules and preparation method thereof |
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