CN107596158A - A kind of galic essential oil compound auxiliary blood fat reducing soft capsule and preparation method thereof - Google Patents
A kind of galic essential oil compound auxiliary blood fat reducing soft capsule and preparation method thereof Download PDFInfo
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Abstract
A kind of galic essential oil compound auxiliary blood fat reducing soft capsule of the present invention, including capsule-core and capsule skin, wherein capsule-core include the raw material components of following parts by weight：10 20 parts of galic essential oil, 10 20 parts of deep sea fish oil, 5 15 parts of hawthorn seeds oil, 2 10 parts of fullerene, 30 50 parts of cavings essential oil；The capsule skin is made up of following components of the raw material of following parts by weight：20 40 parts of converted starch natural plant gum, 5 10 parts of sodium alginate, 5 10 parts of potassium citrate, 5 10 parts of dried orange peel polysaccharide, 10 20 parts of glycerine, 50 60 parts of pure water；Wherein the mass ratio of capsule-core and capsule skin is 1:3‑3:1；The simple science of preparation method of soft capsule, mild condition, production cost is low, is suitable for industrialized production, has auxiliary effect for reducing blood fat well.
Description
Technical field
The present invention relates to a kind of soft capsule technical field, more particularly to a kind of galic essential oil compound auxiliary blood fat reducing soft capsule
And preparation method thereof.
Background technology
Garlic is the bulb of Liliaceae allium, and acrid flavour is peppery, there have to be strong garlicky, is that important spice vegetables make
Thing.The many pharmacological actions of garlic come from it and contain abundant chemical composition.Galic essential oil be extracted from garlic it is special
Material, it is multicomponent mixture, the sulfide compound group being made up of allicin, Allicin and a variety of pi-allyls and methyl
Into also containing citral, geraniol, linalool, α-phellandrene, propionic aldehyde, valeral etc., main component has six kinds, belongs to
Allyl sulfide ethers material, it is allyl methyl thioether, allyl sulfide, allyl methyl disulfide, diallyl disulfide
Ether, allyl methyl trisulfide ether, Diallytrisin, Diallytrisin are that galic essential oil has the main of physiologically active
Composition；Modern age medicine and pharmacology, biology, medical science experimental study prove that galic essential oil has following effect：Antibacterial, sterilization；Drop
Blood fat, prevention of arterial hardening, treatment cardiovascular and cerebrovascular disease；It is hypoglycemic；Protect liver；Improve immunity, anti-aging；Near fat-reducing
Deng；Additionally improve glycometabolism effect and treatment impotence effect there are some researches show galic essential oil has.
At present both at home and abroad on most of still using single galic essential oil as primary raw material in garlic P.E product, function
Property is extremely limited.
Blood fat is a kind of important material in human body, plays very important function to the health of human body, but need
Certain scope is kept to ensure the health of human body, if beyond certain limit some will be caused to seriously endanger health
Disease, such as atherosclerosis, coronary heart disease；With the continuous lifting of people's living standard, there is blood fat in increasing people
Higher phenomenon, and increasingly tend to rejuvenation, the physically and mentally healthy problem of China resident is seriously endangered, influences normal life and work
Make；Product in existing patent on galic essential oil compounding other components also has much, and the product for being directed to high fat of blood class also has
A lot, it is but too big there are still production cost, it is formulated unscientific problem.
The content of the invention
To solve above-mentioned problem, it is an object of the invention to provide a kind of auxiliary reducing blood lipid of galic essential oil compound is soft
Capsule and preparation method thereof.
To reach above-mentioned purpose, the technical scheme is that：
A kind of galic essential oil compound aids in blood fat reducing soft capsule, including capsule-core and capsule skin, wherein capsule-core to include following weight
The raw material components of part：Galic essential oil 10-20 parts, deep sea fish oil 10-20 parts, hawthorn seeds oil 5-15 parts, fullerene 2-10 parts, cavings
Essential oil 30-50 parts；The capsule skin is made up of following components of the raw material of following parts by weight：Converted starch natural plant gum 20-40 parts,
Sodium alginate 5-10 parts, potassium citrate 5-10 parts, dried orange peel polysaccharide 5-10 parts, glycerine 10-20 parts, pure water 50-60 parts；Wherein capsule
The mass ratio of core and capsule skin is 1:3-3:1.
Preferably, described galic essential oil preparation method comprises the following steps：
1) selected no insect pest, the fresh garlic head without lesion of going rotten clean up after it is soaked with clear water, smash to pieces in garlic
Mud；
2) cellulase for adding mashed garlic weight 0.03-0.05% is digested, and hydrolysis temperature is 36-40 DEG C, during enzymolysis
Between be 1-2h, enzymolysis liquid is filtered into obtain filter residue and the first filtrate after the completion of enzymolysis, filtering uses 0.2 μm of filtering with microporous membrane；
3) concentration that filter residue addition is accounted for 2-3 times of filter residue weight is molten for 1-3wt% sodium chloride and the mixing of 4-6wt% sodium acetates
Agent carries out ultrasonic extraction, and the ultrasonic extraction time is 20-30min, filters to take filtrate and obtains the second filtrate, filtering uses 0.2 μm of micropore
Membrane filtration；
4) the first filtrate and the second filtrate are merged, using CO2Supercritical extract, pressure 15-20MPa, extraction temperature are
35-40 DEG C, extraction time 1-1.5h, carbon dioxide flow 3500-3600g/h, separate to obtain extract；
5) supernatant, centrifugation rate 10000-12000r/min is collected by centrifugation in extract；
6) step 5) supernatant progress pressure reduction with classification is separated into obtain galic essential oil, pressure 8-10MPa, temperature 35-40
℃。
Preferably, enzymolysis process is additionally added mashed garlic weight 0.05-0.1% antioxidant in the step 2).
Preferably, described antioxidant is one kind in butylated hydroxy anisole or tert-butylhydroquinone.
Preferably, described fullerene is C60 or C70.
Preferably, described cavings essential oil preparation method comprises the following steps：By cavings crude oil below 2 DEG C normal pressure winterization
One week, filter off except being preheated to 50-60 DEG C after wax, add the same warm water of 0.4-0.6 times of cavings crude oil weight while stirring,
20-30min is stirred under 0.05-0.06MPa vacuums, insulation stands 4-6h, sub-cloud water and impurity removed after layering, in 70-
Water content is dried under vacuum at 80 DEG C to produce below 0.1%.
Preferably, described converted starch natural plant gum is made by converted starch, and described converted starch is by cornstarch, horse
One or more in bell sweet potato starch, tapioca mix.
A kind of preparation method of galic essential oil compound auxiliary blood fat reducing soft capsule, comprises the following steps：
(1) extraction separation and purification of galic essential oil：Garlic cleaning filters to obtain filter residue after being digested after smashing to pieces using enzymatic isolation method
With the first filtrate, filter residue adds extract progress ultrasonic extraction and obtains the second filtrate, merges the first filtrate and the second filtrate using super
Critical CO2Extract and separate obtains supernatant re-grading decompression separation and produced；
(2) prepared by capsule-core：Galic essential oil, deep sea fish oil, hawthorn seeds oil, fullerene, cavings essential oil are measured according to formula, is added
Enter ball milling 6-12h in ball mill, being heated to 30-50 DEG C makes material dissolution and be well mixed, and stands 1-3h centrifugal filtrations, deaerates
To mixing capsule-core solution；
(3) capsule leather is standby：According to formula ratio by converted starch natural plant gum, sodium alginate, dried orange peel polysaccharide, glycerine, pure water
Glue is well mixed to obtain, potassium citrate is added in foregoing glue in the form of spraying, lasting stirring increases until gelatin viscosity
Adding to degassing after 2000-6000mPa.s, to obtain composite sac hide glue gelatin standby；
(4) pelleting sizing, cleaning：Capsule-core and capsule skin are placed in after pellet processing machine pelleting to be placed in rolling and shaped, then with 95%
Edible alcohol washs, and removes the fat-soluble burs such as the oily wax on soft capsule surface；
(5) dry：Soft capsule after cleaning is sent into the drying indoor seasoning that temperature is 20-30 DEG C, relative humidity 15-
25%, drying time 12-15h；
(6) finished product detection, packaging：Dried soft capsule is placed in lamp inspection machine, screens out underproof soft capsule, will
Qualified soft capsule bottling, and cased after packing, be put in storage after the assay was approved through quality inspection portion.
Preferably, pellet press rotating speed is 3-4r/min in the step (4), 40-50 DEG C of sprinkler body temperature, and soft capsule specification is
0.5g/ grains, setting temperature are 20-25 DEG C, relative humidity 35-45%.
The beneficial effects of the present invention are：
(1) a kind of galic essential oil compound auxiliary blood fat reducing soft capsule provided by the invention, using galic essential oil, deep-sea fish
Oil, hawthorn seeds oil and fullerene compounding, fullerene are advantageous to improve galic essential oil, deep sea fish oil, the stabilization of hawthorn seeds oil mixing
Property；Galic essential oil can adjust blood fat, reduce blood viscosity, suppress the formation of thrombus, can also suppress low-density lipoprotein and
The effect that triacylglycerol is formed in liver, and conveyed in promoting low-density lipoprotein from blood vessel toward tissue, promote triacylglycerol
Decompose, increase HDL, moreover it is possible to block the cholesterol synthase and aliphatic acid to be played a crucial role in blood fat building-up process
Synzyme, and promote the synthesis of the HDL beneficial to human body；Deep sea fish oil is rich in DHA and EPA, has regulation blood
Fat, it can reduce serum triglyceride in serum, prevent blood clotting；Hawthorn seeds oil is rich in leukotrienes, linoleic acid, leukotrienes tool
There are reducing blood lipid and hypotensive activity, having reduces serum total cholesterol, triglycerides, low-density lipoprotein, VLDL
And the effect of rise serum high-density LP, hawthorn seeds oil can suppress the work of B- hydroxyl-B- methyl the eleventh of the twelve Earthly Branches diacid CoA-reductases
Property, the clever synthesis for suppressing endogenous cholesterol of ear, and energy increasing high density lipoprotein, low-density lipoprotein is reduced, is advantageous to clear
Except the cholesterol that peripheral tissues are excessive, so as to improve HypercholesterolemicRats；Both galic essential oil and deep sea fish oil are monarch in compound,
Deep sea fish oil is the elite of ocean fish, nourishing hepatic yin, galic essential oil reducing blood lipid；Hawthorn seeds oil is minister, is the elite of plant, kidney-replenishing；
Cavings essential oil is assistant, containing several amino acids, its Glutamic Acid, leucine, alanine, proline, aspartic acid equal size compared with
Height, also containing vitamins such as carrotene (vitamin A), vitamin B1, B2 in cavings essential oil, with galic essential oil, deep sea fish oil and
Hawthorn seeds oil compounding, is more beneficial for absorption of human body；Supplemented by fullerene, there is very strong antioxidation, there is very strong removing
Free radical ability；Adjust fat nourishing hepatic yin kidney-replenishing, be anti-oxidant in one, playing auxiliary reducing blood lipid, the health-care effect of promoting blood circulation altogether；
(2) capsule skin of the present invention uses full starch plant capsule, and gel strength is high, and capsule shaping is good, and filming performance is preferable,
Transparency increase, good toughness is with short production cycle, safe, is easy to digest and assimilate；
(3) extracting method of galic essential oil of the present invention is simple, and recovery rate is high, up to 0.40-0.52%, using gentle temperature
Degree condition, the decomposition of galic essential oil under the high temperature conditions is effectively avoided, stability is good, and purity is high, and extraction cost is low, suitable industry
Metaplasia is produced；
(4) dosage form selection soft capsule of the present invention, it is in good taste, easily swallow, not only can be by galic essential oil, deep sea fish oil, mountain
The active ingredient of short, bristly hair or beard seed oil slowly discharges, and improves action time, and can reduce stimulation of the galic essential oil to stomach, takes
Band safety, it is convenient to take；
(5) compound coordinates scientific and reasonable, has the function that to aid in reducing blood lipid, has effective prevention to cardiovascular and cerebrovascular disease
Effect, hence it is evident that suppress platelet aggregation, strengthen red cell deformability, reduce coagulation factor activity, reduce blood viscosity；Prepare
The simple science of method, mild condition, production cost are low.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is further detailed with reference to embodiments
Describe in detail bright.
Embodiment 1
A kind of galic essential oil compound aids in blood fat reducing soft capsule, including capsule-core and capsule skin, wherein capsule-core to include following weight
The raw material components of part：10 parts of galic essential oil, 10 parts of deep sea fish oil, 5 parts of hawthorn seeds oil, 2 parts of fullerene, 30 parts of cavings essential oil；Institute
Capsule skin is stated to be made up of the raw material of following parts by weight of following components：20 parts of converted starch natural plant gum, 5 parts of sodium alginate, lemon
Sour 5 parts of potassium, 5 parts of dried orange peel polysaccharide, 10 parts of glycerine, 50 parts of pure water；Wherein the mass ratio of capsule-core and capsule skin is 1:3.
Described galic essential oil preparation method comprises the following steps：
1) selected no insect pest, the fresh garlic head without lesion of going rotten clean up after it is soaked with clear water, smash to pieces in garlic
Mud；
2) cellulase for adding mashed garlic weight 0.03% is digested, and hydrolysis temperature is 36 DEG C, enzymolysis time 1h, enzyme
Enzymolysis liquid is filtered into obtain filter residue and the first filtrate after the completion of solution, filtering uses 0.2 μm of filtering with microporous membrane；
3) concentration that filter residue addition is accounted for 2 times of filter residue weight is carried out for 1wt% sodium chloride and 4wt% sodium acetates mixed solvent
Ultrasonic extraction, ultrasonic extraction time are 20min, filter to take filtrate and obtain the second filtrate, filtering uses 0.2 μm of filtering with microporous membrane；
4) the first filtrate and the second filtrate are merged, using CO2Supercritical extract, pressure 15MPa, extraction temperature 35
DEG C, extraction time 1h, carbon dioxide flow 3500g/h, separate to obtain extract；
5) supernatant, centrifugation rate 10000r/min is collected by centrifugation in extract；
6) step 5) supernatant progress pressure reduction with classification is separated into obtain galic essential oil, pressure 8MPa, temperature is 35 DEG C.
Enzymolysis process is additionally added the antioxidant of mashed garlic weight 0.05% in the step 2).
Described antioxidant is butylated hydroxy anisole.
Described fullerene is C60.
Described cavings essential oil preparation method comprises the following steps：By cavings crude oil below 2 DEG C normal pressure winterization one week, mistake
Filter off and be preheated to 50 DEG C after removing wax, the same warm water of 0.4 times of cavings crude oil weight is added while stirring, in 0.05MPa vacuum
The lower stirring 20min of degree, insulation stand 4h, sub-cloud water and impurity are removed after layering, water content 0.1% is dried under vacuum at 70 DEG C
Produce below.
Described converted starch natural plant gum is made by converted starch, and described converted starch is cornstarch.
A kind of preparation method of galic essential oil compound auxiliary blood fat reducing soft capsule, comprises the following steps：
(1) extraction separation and purification of galic essential oil：Garlic cleaning filters to obtain filter residue after being digested after smashing to pieces using enzymatic isolation method
With the first filtrate, filter residue adds extract progress ultrasonic extraction and obtains the second filtrate, merges the first filtrate and the second filtrate using super
Critical CO2Extract and separate obtains supernatant re-grading decompression separation and produced；
(2) prepared by capsule-core：Galic essential oil, deep sea fish oil, hawthorn seeds oil, fullerene, cavings essential oil are measured according to formula, is added
Enter ball milling 6h in ball mill, being heated to 30 DEG C makes material dissolution and be well mixed, and stands 1h centrifugal filtrations, degassing obtains mictocystis
Core solution；
(3) capsule leather is standby：According to formula ratio by converted starch natural plant gum, sodium alginate, dried orange peel polysaccharide, glycerine, pure water
Glue is well mixed to obtain, potassium citrate is added in foregoing glue in the form of spraying, lasting stirring increases until gelatin viscosity
Adding to degassing after 2000mPa.s, to obtain composite sac hide glue gelatin standby；
(4) pelleting sizing, cleaning：Capsule-core and capsule skin are placed in after pellet processing machine pelleting to be placed in rolling and shaped, then with 95%
Edible alcohol washs, and removes the fat-soluble burs such as the oily wax on soft capsule surface；
(5) dry：Soft capsule after cleaning is sent into temperature as 20 DEG C of drying indoor seasoning, relative humidity 15%,
Drying time is 12h；
(6) finished product detection, packaging：Dried soft capsule is placed in lamp inspection machine, screens out underproof soft capsule, will
Qualified soft capsule bottling, and cased after packing, be put in storage after the assay was approved through quality inspection portion.
Pellet press rotating speed is 3r/min in the step (4), and 40 DEG C of sprinkler body temperature, soft capsule specification is 0.5g/ grains, sizing
Temperature is 20 DEG C, relative humidity 35%.
Embodiment 2
A kind of galic essential oil compound aids in blood fat reducing soft capsule, including capsule-core and capsule skin, wherein capsule-core to include following weight
The raw material components of part：20 parts of galic essential oil, 20 parts of deep sea fish oil, 15 parts of hawthorn seeds oil, 10 parts of fullerene, 50 parts of cavings essential oil；
The capsule skin is made up of following components of the raw material of following parts by weight：40 parts of converted starch natural plant gum, 10 parts of sodium alginate, lemon
10 parts of lemon acid potassium, 10 parts of dried orange peel polysaccharide, 20 parts of glycerine, 60 parts of pure water；Wherein the mass ratio of capsule-core and capsule skin is 3:1.
Described galic essential oil preparation method comprises the following steps：
1) selected no insect pest, the fresh garlic head without lesion of going rotten clean up after it is soaked with clear water, smash to pieces in garlic
Mud；
2) cellulase for adding mashed garlic weight 0.05% is digested, and hydrolysis temperature is 40 DEG C, enzymolysis time 2h, enzyme
Enzymolysis liquid is filtered into obtain filter residue and the first filtrate after the completion of solution, filtering uses 0.2 μm of filtering with microporous membrane；
3) concentration that filter residue addition is accounted for 3 times of filter residue weight is carried out for 3wt% sodium chloride and 6wt% sodium acetates mixed solvent
Ultrasonic extraction, ultrasonic extraction time are 30min, filter to take filtrate and obtain the second filtrate, filtering uses 0.2 μm of filtering with microporous membrane；
4) the first filtrate and the second filtrate are merged, using CO2Supercritical extract, pressure 20MPa, extraction temperature 40
DEG C, extraction time 1.5h, carbon dioxide flow 3600g/h, separate to obtain extract；
5) supernatant, centrifugation rate 12000r/min is collected by centrifugation in extract；
6) step 5) supernatant progress pressure reduction with classification is separated into obtain galic essential oil, pressure 10MPa, temperature is 40 DEG C.
Enzymolysis process is additionally added the antioxidant of mashed garlic weight 0.1% in the step 2).
Described antioxidant is one kind in tert-butylhydroquinone.
Described fullerene is C70.
Described cavings essential oil preparation method comprises the following steps：By cavings crude oil below 2 DEG C normal pressure winterization one week, mistake
Filter off and be preheated to 60 DEG C after removing wax, the same warm water of 0.6 times of cavings crude oil weight is added while stirring, in 0.06MPa vacuum
The lower stirring 30min of degree, insulation stand 6h, sub-cloud water and impurity are removed after layering, water content 0.1% is dried under vacuum at 80 DEG C
Produce below.
Described converted starch natural plant gum is made by converted starch, and described converted starch is formed sediment by cornstarch, potato
One or more in powder, tapioca mix.
A kind of preparation method of galic essential oil compound auxiliary blood fat reducing soft capsule, comprises the following steps：
(1) extraction separation and purification of galic essential oil：Garlic cleaning filters to obtain filter residue after being digested after smashing to pieces using enzymatic isolation method
With the first filtrate, filter residue adds extract progress ultrasonic extraction and obtains the second filtrate, merges the first filtrate and the second filtrate using super
Critical CO2Extract and separate obtains supernatant re-grading decompression separation and produced；
(2) prepared by capsule-core：Galic essential oil, deep sea fish oil, hawthorn seeds oil, fullerene, cavings essential oil are measured according to formula, is added
Enter ball milling 12h in ball mill, being heated to 50 DEG C makes material dissolution and be well mixed, and stands 3h centrifugal filtrations, degassing is mixed
Capsule-core solution；
(3) capsule leather is standby：According to formula ratio by converted starch natural plant gum, sodium alginate, dried orange peel polysaccharide, glycerine, pure water
Glue is well mixed to obtain, potassium citrate is added in foregoing glue in the form of spraying, lasting stirring increases until gelatin viscosity
Adding to degassing after 6000mPa.s, to obtain composite sac hide glue gelatin standby；
(4) pelleting sizing, cleaning：Capsule-core and capsule skin are placed in after pellet processing machine pelleting to be placed in rolling and shaped, then with 95%
Edible alcohol washs, and removes the fat-soluble burs such as the oily wax on soft capsule surface；
(5) dry：Soft capsule after cleaning is sent into temperature as 30 DEG C of drying indoor seasoning, relative humidity 25%,
Drying time is 15h；
(6) finished product detection, packaging：Dried soft capsule is placed in lamp inspection machine, screens out underproof soft capsule, will
Qualified soft capsule bottling, and cased after packing, be put in storage after the assay was approved through quality inspection portion.
Preferably, pellet press rotating speed is 4r/min in the step (4), and sprinkler body temperature 50 C, soft capsule specification is 0.5g/
Grain, setting temperature are 25 DEG C, relative humidity 45%.
Embodiment 3
A kind of galic essential oil compound aids in blood fat reducing soft capsule, including capsule-core and capsule skin, wherein capsule-core to include following weight
The raw material components of part：15 parts of galic essential oil, 15 parts of deep sea fish oil, 10 parts of hawthorn seeds oil, 6 parts of fullerene, 40 parts of cavings essential oil；Institute
Capsule skin is stated to be made up of the raw material of following parts by weight of following components：30 parts of converted starch natural plant gum, 8 parts of sodium alginate, lemon
Sour 8 parts of potassium, 8 parts of dried orange peel polysaccharide, 15 parts of glycerine, 55 parts of pure water；Wherein the mass ratio of capsule-core and capsule skin is 2:2.
Described galic essential oil preparation method comprises the following steps：
1) selected no insect pest, the fresh garlic head without lesion of going rotten clean up after it is soaked with clear water, smash to pieces in garlic
Mud；
2) cellulase for adding mashed garlic weight 0.04% is digested, and hydrolysis temperature is 38 DEG C, enzymolysis time 1.5h,
Enzymolysis liquid is filtered into obtain filter residue and the first filtrate after the completion of enzymolysis, filtering uses 0.2 μm of filtering with microporous membrane；
3) concentration that filter residue addition is accounted for 2.5 times of filter residue weight is entered for 2wt% sodium chloride and 5wt% sodium acetate mixed solvents
Row ultrasonic extraction, ultrasonic extraction time are 25min, filter to take filtrate and obtain the second filtrate, filtering uses 0.2 μm of miillpore filter mistake
Filter；
4) the first filtrate and the second filtrate are merged, using CO2Supercritical extract, pressure 18MPa, extraction temperature 38
DEG C, extraction time 1.2h, carbon dioxide flow 3550g/h, separate to obtain extract；
5) supernatant, centrifugation rate 11000r/min is collected by centrifugation in extract；
6) step 5) supernatant progress pressure reduction with classification is separated into obtain galic essential oil, pressure 9MPa, temperature is 38 DEG C.
Enzymolysis process is additionally added the antioxidant of mashed garlic weight 0.08% in the step 2).
Described antioxidant is one kind in butylated hydroxy anisole or tert-butylhydroquinone.
Described fullerene is C60.
Described cavings essential oil preparation method comprises the following steps：By cavings crude oil below 2 DEG C normal pressure winterization one week, mistake
Filter off and be preheated to 55 DEG C after removing wax, the same warm water of 0.5 times of cavings crude oil weight is added while stirring, in 0.05MPa vacuum
The lower stirring 25min of degree, insulation stand 5h, sub-cloud water and impurity are removed after layering, water content 0.1% is dried under vacuum at 75 DEG C
Produce below.
Described converted starch natural plant gum is made by converted starch, and described converted starch is formed sediment by cornstarch, potato
One or more in powder, tapioca mix.
A kind of preparation method of galic essential oil compound auxiliary blood fat reducing soft capsule, comprises the following steps：
(1) extraction separation and purification of galic essential oil：Garlic cleaning filters to obtain filter residue after being digested after smashing to pieces using enzymatic isolation method
With the first filtrate, filter residue adds extract progress ultrasonic extraction and obtains the second filtrate, merges the first filtrate and the second filtrate using super
Critical CO2Extract and separate obtains supernatant re-grading decompression separation and produced；
(2) prepared by capsule-core：Galic essential oil, deep sea fish oil, hawthorn seeds oil, fullerene, cavings essential oil are measured according to formula, is added
Enter ball milling 9h in ball mill, being heated to 40 DEG C makes material dissolution and be well mixed, and stands 2h centrifugal filtrations, degassing obtains mictocystis
Core solution；
(3) capsule leather is standby：According to formula ratio by converted starch natural plant gum, sodium alginate, dried orange peel polysaccharide, glycerine, pure water
Glue is well mixed to obtain, potassium citrate is added in foregoing glue in the form of spraying, lasting stirring increases until gelatin viscosity
Adding to degassing after 4000mPa.s, to obtain composite sac hide glue gelatin standby；
(4) pelleting sizing, cleaning：Capsule-core and capsule skin are placed in after pellet processing machine pelleting to be placed in rolling and shaped, then with 95%
Edible alcohol washs, and removes the fat-soluble burs such as the oily wax on soft capsule surface；
(5) dry：Soft capsule after cleaning is sent into temperature as 25 DEG C of drying indoor seasoning, relative humidity 20%,
Drying time is 13h；
(6) finished product detection, packaging：Dried soft capsule is placed in lamp inspection machine, screens out underproof soft capsule, will
Qualified soft capsule bottling, and cased after packing, be put in storage after the assay was approved through quality inspection portion.
Preferably, pellet press rotating speed is 3.5r/min in the step (4), sprinkler body temperature 45 C, and soft capsule specification is
0.5g/ grains, setting temperature are 23 DEG C, relative humidity 40%.
Experimental verification：
1. experiment material and method
Experimental rat, male and female half and half, 6-8 week old, body weight are 250 ± 50g；Test medicine is embodiment 1-3 soft capsule；
Tested rat is 4 groups at random, every group 10, male and female half and half, and high fat is fed before 1 group, 2 groups and 3 groups rat experiment
Feed (1% cholesterol, 50% lard, basal feed 49%), 4 groups are fed using basal feed, and continuous nursing is carried out after 20 days
Experiment, 1 group of daily timing in afternoon gavage the soft capsule core material of the preparation of embodiment 3, each 2mg；2 groups of daily timings in afternoon gavage
Capsule-core material is free of galic essential oil, the capsule-core material that other compositions are prepared with embodiment 3, each 2mg；3 groups are positive controls, are gavaged
Pure water, each 2mg；4 groups are blank control group, conventinal breeding, to rat liver outward appearance and tectology after continuous 20 days
Influence is detected；
Liver cosmetic variation：1 group of rat liver appearance surfaces for gavaging the capsule are in aubergine, and finger pressure is flexible, volume
Normal in size, and 4 groups close；2 groups, liver appearance surfaces are in aubergine, compared to 1 group and 4 groups of somewhat colors are light, and finger pressure has bullet
Property, volume normal in size；3 groups of liver silght enlargements, there is greasy feeling.
Histomorphological changes：3 groups of swelling of liver cell, size is uneven, and the volume that endochylema includes differs in size red small
Fat drips (soudan III dyeing)；Fat drips are pressed against cell edges in liver cell；1 group of liver cell form is normal, in the same size, only few
Number liver cell endochylema has small fat drips；2 groups of liver cell forms are somewhat not good enough compared to 1 group, and size is basically identical, there is a small amount of liver cell
Endochylema has small fat drips, and centrilobular liver cell nuclear is in polygon；4 groups of liver cell forms are normal.
4 groups of experimental rat lungs, spleen, kidney and enteron aisle are showed no exception.
Last time gavages rear 1.5h separation rat blood serum, and TC, TG, T-CHOL (TC) and glycerine are surveyed with kit method
Three esters (TG) measurement result such as following table：
* 3 groups of P ＜ 0.05, * * P ＜ 0.01vs
Show in table, the capsule capsule-core containing galic essential oil compares the capsule capsule-core without galic essential oil to T-CHOL
(TC) to be got well with the improvement of triglycerides (TG), also show galic essential oil and deep sea fish oil, hawthorn seeds oil, fullerene,
Cavings essential oil has synergistic function.
It should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted.Although with reference to compared with
The present invention is described in detail good embodiment, it will be understood by those within the art that, can be to the technology of invention
Scheme is modified or equivalent substitution, and without departing from the scope of technical solution of the present invention, it all should cover the power in the present invention
In sharp claimed range.
Claims (9)
1. a kind of galic essential oil compound aids in blood fat reducing soft capsule, it is characterised in that including capsule-core and capsule skin, wherein capsule-core includes
The raw material components of following parts by weight：Galic essential oil 10-20 parts, deep sea fish oil 10-20 parts, hawthorn seeds oil 5-15 parts, fullerene 2-
10 parts, cavings essential oil 30-50 parts；The capsule skin is made up of following components of the raw material of following parts by weight：Converted starch plant
Glue 20-40 parts, sodium alginate 5-10 parts, potassium citrate 5-10 parts, dried orange peel polysaccharide 5-10 parts, glycerine 10-20 parts, pure water 50-
60 parts；Wherein the mass ratio of capsule-core and capsule skin is 1:3-3:1.
2. a kind of galic essential oil compound auxiliary blood fat reducing soft capsule according to claim 1, it is characterised in that described is big
Garlic essential oil preparation method comprises the following steps：
1）Selected no insect pest, the fresh garlic head without lesion of going rotten clean up after it is soaked with clear water, smash to pieces in mashed garlic；
2）The cellulase for adding mashed garlic weight 0.03-0.05% is digested, and hydrolysis temperature is 36-40 DEG C, enzymolysis time 1-
2h, filters to obtain filter residue and the first filtrate after the completion of enzymolysis by enzymolysis liquid, and filtering uses 0.2 μm of filtering with microporous membrane；
3）The concentration that filter residue addition is accounted for 2-3 times of filter residue weight is carried out for 1-3wt% sodium chloride and 4-6wt% sodium acetates mixed solvent
Ultrasonic extraction, ultrasonic extraction time are 20-30min, filter to take filtrate and obtain the second filtrate, filtering uses 0.2 μm of miillpore filter mistake
Filter；
4）Merge the first filtrate and the second filtrate, using CO2Supercritical extract, pressure 15-20MPa, extraction temperature 35-40
DEG C, extraction time 1-1.5h, carbon dioxide flow 3500-3600g/h, separate to obtain extract；
5）Supernatant, centrifugation rate 10000-12000r/min is collected by centrifugation in extract；
6）By step 5）Supernatant carries out pressure reduction with classification and separates to obtain galic essential oil, pressure 8-10MPa, and temperature is 35-40 DEG C.
A kind of 3. galic essential oil compound auxiliary blood fat reducing soft capsule according to claim 2, it is characterised in that the step
2）Middle enzymolysis process is additionally added mashed garlic weight 0.05-0.1% antioxidant.
4. a kind of galic essential oil compound auxiliary blood fat reducing soft capsule according to claim 3, it is characterised in that described is anti-
Oxidant is one kind in butylated hydroxy anisole or tert-butylhydroquinone.
A kind of 5. galic essential oil compound auxiliary blood fat reducing soft capsule according to claim 1, it is characterised in that described richness
Le alkene is C60 or C70.
A kind of 6. galic essential oil compound auxiliary blood fat reducing soft capsule according to claim 1, it is characterised in that described paddy
Chaff essential oil preparation method comprises the following steps：By cavings crude oil below 2 DEG C normal pressure winterization one week, filter off except being preheated after wax
To 50-60 DEG C, the same warm water of 0.4-0.6 times of cavings crude oil weight is added while stirring, under 0.05-0.06MPa vacuums
20-30min is stirred, insulation stands 4-6h, sub-cloud water and impurity are removed after layering, water content is dried under vacuum at 70-80 DEG C
Less than 0.1% produces.
A kind of 7. galic essential oil compound auxiliary blood fat reducing soft capsule according to claim 1, it is characterised in that described change
Property starch plant glue is made by converted starch, and described converted starch is by one in cornstarch, farina, tapioca
Kind or a variety of mix.
8. a kind of preparation method of galic essential oil compound auxiliary blood fat reducing soft capsule, it is characterised in that comprise the following steps：
（1）The extraction separation and purification of galic essential oil：Garlic cleaning smash to pieces after using filtering to obtain filter residue and the after enzymatic isolation method enzymolysis
One filtrate, filter residue add extract progress ultrasonic extraction and obtain the second filtrate, merge the first filtrate and the second filtrate using overcritical
CO2Extract and separate obtains supernatant re-grading decompression separation and produced；
（2）It is prepared by capsule-core：Galic essential oil, deep sea fish oil, hawthorn seeds oil, fullerene, cavings essential oil are measured according to formula, adds ball
Ball milling 6-12h in grinding machine, being heated to 30-50 DEG C makes material dissolution and is well mixed, and stands 1-3h centrifugal filtrations, degassing is mixed
Close capsule-core solution；
（3）Capsule leather is standby：Converted starch natural plant gum, sodium alginate, dried orange peel polysaccharide, glycerine, pure water are mixed according to formula ratio
It is uniform to obtain glue, potassium citrate is added in foregoing glue in the form of spraying, lasting stirring increases to until gelatin viscosity
It is standby that 2000-6000mPa.s rear degassing obtains composite sac hide glue gelatin；
（4）Pelleting sizing, cleaning：Capsule-core and capsule skin are placed in after pellet processing machine pelleting to be placed in rolling and shaped, then with 95% edible wine
Fine purifiation is washed, and removes the fat-soluble burs such as the oily wax on soft capsule surface；
（5）Dry：Soft capsule after cleaning is sent into temperature as 20-30 DEG C of drying indoor seasoning, relative humidity 15-25%,
Drying time is 12-15h；
（6）Finished product detection, packaging：Dried soft capsule is placed in lamp inspection machine, screens out underproof soft capsule, will be qualified
Soft capsule bottling, and pack after case, be put in storage after the assay was approved through quality inspection portion.
9. a kind of preparation method of galic essential oil compound auxiliary blood fat reducing soft capsule according to claim 8, its feature exist
In the step（4）Middle pellet press rotating speed is 3-4r/min, and 40-50 DEG C of sprinkler body temperature, soft capsule specification is 0.5g/ grains, sizing
Temperature is 20-25 DEG C, relative humidity 35-45%.
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Application publication date: 20180119 |