CN106692105A - Plant soft capsule shell and ganoderma lucidum spores oil plant soft capsule and preparation methods thereof - Google Patents
Plant soft capsule shell and ganoderma lucidum spores oil plant soft capsule and preparation methods thereof Download PDFInfo
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- CN106692105A CN106692105A CN201710045534.XA CN201710045534A CN106692105A CN 106692105 A CN106692105 A CN 106692105A CN 201710045534 A CN201710045534 A CN 201710045534A CN 106692105 A CN106692105 A CN 106692105A
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- soft capsule
- ganoderma lucidum
- antioxidant
- weight portion
- spore oil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
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- Natural Medicines & Medicinal Plants (AREA)
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- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Alternative & Traditional Medicine (AREA)
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- Medicines Containing Plant Substances (AREA)
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Abstract
The invention discloses a plant soft capsule shell and a ganoderma lucidum spores oil plant soft capsule and preparation methods thereof. The capsule shell is prepared from hydrophilic gel, an adhesive, a coagulant aid, plasticizer, a first antioxidant and water. The ganoderma lucidum spores oil plant soft capsule is composed of contents and the capsule shell, and the contents comprise, by weight, 85-99 parts of ganoderma lucidum spores oil, 1-15 parts of a second antioxidant which is prepared from one or more of natural vitamin E, BQT and haematococcus pluvialis. Accordingly, materials which adopt a green plant source and are safe, reliable and stable in chemical property are adopted to prepare the soft capsule, good chemical stability is achieved, and the dietary habits of vegetarians are met.
Description
Technical field
The present invention relates to traditional Chinese medicine health care product field, more particularly to a kind of soft capsule softgel shell and ganoderma lucidum spore oil plant soft
Capsule and preparation method.
Background technology
Ganoderma lucidum is the general name of Basidiomycetes Polyporaceae Ganoderma fungi red sesame and purple sesame, the effects such as with strengthening the body resistance to consolidate the constitution,
Quilt《Sheng Nong's herbal classic》Referred to as top grade.Reishi sporule is that ganoderma lucidum growth and maturity phase is ejected and its tiny spore from cap,
It is the reproduction cell of ganoderma lucidum, the whole genetic activities material with ganoderma lucidum.The complex chemical composition of Reishi sporule, document report
There are following a few classes：Sterols, triterpenes, alkaloids, fatty acid, lactone, protein and amino acids, glycopeptide class, dimension life
Plain class, carrotene and inorganic ions etc..
Ganoderma lucidum spore oil is a kind of hydrophobicity oily substance extracted from Reishi sporule, accounts for Reishi sporule weight
20%, wherein containing abundant triterpene substance, there is extensive physiologically active because of the diversity of its chemical constitution, for carrying
The aspects such as immunity of organisms high, hypoxia-bearing capability, reduction cholesterol have obvious effect.Recent studies have shown that, ganoderma lucidum spore oil
The active material of middle lipid also has the significant activity for suppressing tumour and anti AIDS virus.
Reishi sporule oil product has turned into the treasure in high-grade health products in recent years, with highly important value and
Economic worth, such as wide medicine board G. lucidum spores Softgel, middle section innovate board G. lucidum spores Softgel, infinitely energy ganoderma lucidum spore oil
Soft capsule, the micro- board G. lucidum spores Softgel in Guangdong etc..But such soft capsule capsule shells are more with gelatin as primary raw material is prepared
Into, and gelatin-based sheet derives from the bone and skin of animal, this easily causes animal sources infectious disease, poor chemical stability, does not meet vegetarian diet
The problems such as doctrine crowd's eating habit, this increased difficulty, therefore ganoderma lucidum spore oil to the sale of existing G. lucidum spores Softgel
The exploitation of soft capsule is extremely urgent.
The content of the invention
In view of this, it is necessary to for above-mentioned problem, there is provided a kind of soft capsule softgel shell and ganoderma lucidum spore oil plant
Soft capsule and preparation method.
A kind of soft capsule softgel shell, following components of its raw material comprising following weight percentage：
A kind of soft capsule softgel shell, following components of its raw material comprising following weight percentage：
A kind of soft capsule softgel shell, following components of its raw material comprising following weight percentage：
Preferably, the hydrophilic gel is Arabic gum, carragheen, agar, yellow glue original, acetylation gellan gum, sweet
One or more in holiday, sodium alginate, algin.
Preferably, described adhesive is in maltose, modified starch, dextrin, Hydroxypropyl methylcellulose, sodium carboxymethylcellulose
One or more.
Preferably, the flocculation aid is one or more in potassium chloride, calcium chloride, potassium phosphate, potassium citrate.
Preferably, the plasticizer is one or more in calcium gluconae, glycerine, D-sorbite, polyethylene glycol.
Preferably, first antioxidant is in Tea Polyphenols, soybean lecithin, L-AA, propylgallate
One or more.
A kind of ganoderma lucidum spore oil soft capsule, is made up of content and above-mentioned softgel shell, and the content contains comprising following
Following components of amount：
The weight portion of ganoderma lucidum spore oil 85~99.9,
The weight portion of second antioxidant 0.1~15,
Second antioxidant is one or more in natural VE, BQT, haematococcus pluvialis.
Preferably, following components of the content comprising following contents：
The weight portion of ganoderma lucidum spore oil 90~99,
The weight portion of second antioxidant 0.2~10.
A kind of ganoderma lucidum spore oil soft capsule preparation method, comprises the following steps：
S1, ganoderma lucidum spore oil and the second antioxidant are well mixed, are prepared into the content of stable homogeneous；
S2, by hydrophilic gel, adhesive, flocculation aid, plasticizer, antioxidant and water mix, mixture is heated
To 80~90 DEG C, colloid is completely dissolved, is then made soft capsule；
S3, by the content and soft capsule of preparation through pelleting, shape, wash ball, drying be made ganoderma lucidum spore oil vegetalitas
Soft capsule.
Compared with prior art, the present invention has the advantages that：
The present invention prepares soft capsule using green plants source, safe and reliable, chemical stabilization material, with good change
Stability is learned, meets the eating habit of vegetarianism crowd.The present invention do not use the animal source material such as gelatin, it is to avoid animal
The propagation of garden infectious disease, the defect of poor chemical stability.Preparation method of the present invention is simple, is easy to prepare ganoderma lucidum spore oil on a large scale
Soft capsule.
Specific embodiment
In order to better illustrate the present invention, it is described further with reference to specific embodiment.
Embodiment 1
A kind of soft capsule softgel shell, following components of its raw material comprising following weight parts：The weight of hydrophilic gel 15
Part, the weight portion of adhesive 55, the weight portion of flocculation aid 1.5, the weight portion of plasticizer 25, the weight portion of the first antioxidant 0.15, water 15
Weight portion.
The hydrophilic gel is the weight portion of Arabic gum 10, the weight portion of carragheen 5；Described adhesive is modified shallow lake
Powder；The flocculation aid is potassium phosphate；The plasticizer is the weight portion of calcium gluconae 10, the weight portion of glycerine 15；Described first resists
Oxidant is Tea Polyphenols.
A kind of ganoderma lucidum spore oil soft capsule is made up of content and above-mentioned softgel shell.The content includes following contents
Following components：The weight portion of ganoderma lucidum spore oil 85, the weight portion of the second antioxidant 15；Second antioxidant is natural dimension life
Plain E2 weight portions, the weight portion of haematococcus pluvialis 13.
The preparation method of above-mentioned ganoderma lucidum spore oil plant, comprises the following steps：
S1, ganoderma lucidum spore oil and antioxidant accurately are weighed, stirring makes it fully mix after mixing, is prepared into stable homogeneous
Content, it is standby；
S2, hydrophilic gel, adhesive, flocculation aid, plasticizer, antioxidant and water are accurately weighed, stirred after mixing
Mix, heat the mixture to 80~90 DEG C, be completely dissolved colloid, be then made soft capsule；
S3, the above thing and soft capsule through pelleting, shape, wash ball, dry, be made ganoderma lucidum spore oil vegetalitas flexible glue
Capsule.
Embodiment 2
A kind of soft capsule softgel shell, following components of its raw material comprising following weight parts：The weight of hydrophilic gel 30
Part, the weight portion of adhesive 25, the weight portion of flocculation aid 8, the weight portion of plasticizer 2.0, the weight portion of the first antioxidant 0.03, the weight of water 35
Amount part.
The hydrophilic gel is the weight portion of carragheen 15, yellow glue 15 weight portions of original；Described adhesive is maltose 20
Weight portion, the weight portion of Hydroxypropyl methylcellulose 5；The flocculation aid is potassium chloride；The plasticizer is glycerine；Described first is anti-oxidant
Agent is L-AA.
A kind of ganoderma lucidum spore oil soft capsule is made up of content and above-mentioned softgel shell.The content includes following contents
Following components：The weight portion of ganoderma lucidum spore oil 90, the weight portion of the second antioxidant 10；Second antioxidant is natural dimension life
Plain E1.5 weight portions, the weight portion of haematococcus pluvialis 8.5.
The preparation method of above-mentioned ganoderma lucidum spore oil plant is identical with the preparation method of embodiment 1.
Embodiment 3
A kind of soft capsule softgel shell, following components of its raw material comprising following weight parts：The weight of hydrophilic gel 60
Part, the weight portion of adhesive 12, the weight portion of flocculation aid 7, the weight portion of plasticizer 10, the weight portion of the first antioxidant 0.1, the weight of water 55
Part.
The hydrophilic gel is the weight portion of Arabic gum 50, the weight portion of sodium alginate 10；Described adhesive is modified
The weight portion of starch 4, the weight portion of resistant dextrin 8；The flocculation aid is potassium citrate；The plasticizer is the weight of calcium gluconae 1
Part, the weight portion of glycerine 6, the weight portion of D-sorbite 3；First antioxidant is soybean lecithin.
A kind of ganoderma lucidum spore oil soft capsule is made up of content and above-mentioned softgel shell.The content includes following contents
Following components：The weight portion of ganoderma lucidum spore oil 95, the weight portion of the second antioxidant 5；Second antioxidant is that rain gives birth to red ball
Algae.
The preparation method of above-mentioned ganoderma lucidum spore oil plant is same as Example 1.
Embodiment 4
A kind of soft capsule softgel shell, following components of its raw material comprising following weight parts：The weight of hydrophilic gel 80
Part, the weight portion of adhesive 50, the weight portion of flocculation aid 20, the weight portion of plasticizer 15, the weight portion of the first antioxidant 0.1, the weight of water 70
Amount part.
The hydrophilic gel is the weight portion of carragheen 30, the weight portion of sweet dew glue 30, the weight portion of algin 20；It is described viscous
Mixture is the weight portion of resistant dextrin 35, the weight portion of sodium carboxymethylcellulose 15；The flocculation aid is calcium chloride；The plasticizer is
The weight portion of glycerine 10, the weight portion of D-sorbite 5；First antioxidant is propylgallate.
A kind of ganoderma lucidum spore oil soft capsule is made up of content and above-mentioned softgel shell.The content includes following contents
Following components：The weight portion of ganoderma lucidum spore oil 99, the weight portion of the second antioxidant 1；Second antioxidant is natural dimension life
Plain E1 weight portions.
The preparation method of above-mentioned ganoderma lucidum spore oil plant is same as Example 1.
Effect example 1, disintegration time is determined
To embodiment 1-4 all samples and commercially available G. lucidum spores Softgel (gelatin) foundation《Chinese Pharmacopoeia》(2015
Version) in the method for record carry out disintegration time measure, disintegration time assay method is that, using simulated gastric fluid inspection, experimental result is shown in
Table 1.
Table 1, disintegration time
As can be seen from Table 1, G. lucidum spores Softgel disintegration time is both less than 30min, but embodiment in embodiment 1-4
G. lucidum spores Softgel disintegration time is 9.63min in 3, better than G. lucidum spores Softgel in other embodiment.With it is commercially available
Spore fat capsule (gelatin) disintegration time is compared, and has slight difference, but difference is less, illustrates plant type flexible glue in the present invention
Capsule capsule skin meets the requirement of soft capsule disintegration time.
Effect example 2, stability test
According to disintegration time measurement result, the miospore fat capsule sample of embodiment 3 and 4 and commercially available spore oil flexible glue are chosen
Capsule (gelatin) carries out stablizing experiment, and experiment condition is 40 DEG C, and relative humidity 75% is placed 6 months, respectively at the 0th, 1,3,6
Sample within individual month, determine respectively color, shape, plumpness, softgel shell hardness, whether the project such as seepage.
Experimental result shows that the miospore fat capsule softgel shell of embodiment 4 is hardened at the 3rd month, has seepage to show at the 6th month
As.And change little compared with other times when embodiment 3 and commercially available spore fat capsule 6th month, and embodiment 3 and city
Soft capsule is sold compared to no notable difference, illustrates that the miospore fat capsule of embodiment 3 is relatively stablized, meet the requirement of relevant criterion.
Experiment above shows that not only disintegration time and stability meet relevant criterion to plant type G. lucidum spores Softgel
It is required that, while without significant difference, therefore a kind of plant type of the present invention compared with commercially available spore fat capsule (gelatin)
The characteristics of G. lucidum spores Softgel and preparation method thereof has green plants source, safety and reliability, stable chemical nature.
Embodiment described above only expresses several embodiments of the invention, and its description is more specific and detailed, but simultaneously
Therefore the limitation to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that for one of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to guarantor of the invention
Shield scope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of soft capsule softgel shell, it is characterised in that following components of its raw material comprising following weight percentage：
2. softgel shell according to claim 1, it is characterised in that following components of its raw material comprising following weight percentage：
3. softgel shell according to claim 2, it is characterised in that following components of its raw material comprising following weight percentage：
4. the softgel shell according to claim any one of 1-3, it is characterised in that the hydrophilic gel be Arabic gum,
One or more in carragheen, agar, yellow glue original, acetylation gellan gum, sweet dew glue, sodium alginate, algin.
5. the softgel shell according to claim any one of 1-3, it is characterised in that described adhesive be maltose, modified starch,
One or more in dextrin, Hydroxypropyl methylcellulose, sodium carboxymethylcellulose.
6. the softgel shell according to claim any one of 1-3, it is characterised in that the flocculation aid is potassium chloride, calcium chloride, phosphorus
One or more in sour potassium, potassium citrate；The plasticizer is in calcium gluconae, glycerine, D-sorbite, polyethylene glycol
One or more.
7. the softgel shell according to claim any one of 1-3, it is characterised in that first antioxidant is Tea Polyphenols, big
One or more in Fabaceous Lecithin, L-AA, propylgallate.
8. a kind of ganoderma lucidum spore oil soft capsule, the softgel shell described in content and claim any one of 1-7 is constituted, described
Following components of the content comprising following contents：
The weight portion of ganoderma lucidum spore oil 85~99,
The weight portion of second antioxidant 1~15,
Second antioxidant is one or more in natural VE, BQT, haematococcus pluvialis.
9. ganoderma lucidum spore oil soft capsule according to claim 8, it is characterised in that the content contains comprising following
Following components of amount：
The weight portion of ganoderma lucidum spore oil 90~95,
The weight portion of second antioxidant 5~10.
10. the preparation method of the ganoderma lucidum spore oil soft capsule described in claim 8 or 9, it is characterised in that including following step
Suddenly：
S1, ganoderma lucidum spore oil and the second antioxidant are well mixed, are prepared into the content of stable homogeneous；
S2, by hydrophilic gel, adhesive, flocculation aid, plasticizer, antioxidant and water mix, heat the mixture to 80
~90 DEG C, colloid is completely dissolved, is then made soft capsule；
S3, by the content and soft capsule of preparation through pelleting, shape, wash ball, drying be made ganoderma lucidum spore oil vegetalitas flexible glue
Capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710045534.XA CN106692105A (en) | 2017-01-20 | 2017-01-20 | Plant soft capsule shell and ganoderma lucidum spores oil plant soft capsule and preparation methods thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710045534.XA CN106692105A (en) | 2017-01-20 | 2017-01-20 | Plant soft capsule shell and ganoderma lucidum spores oil plant soft capsule and preparation methods thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107549859A (en) * | 2017-09-19 | 2018-01-09 | 太仓市林港农场专业合作社 | A kind of immune soft capsule of galic essential oil compound enhancing and preparation method thereof |
| CN109999007A (en) * | 2019-03-18 | 2019-07-12 | 广州普正生物科技有限公司 | A kind of high leakproofness chewing soft capsule and preparation method thereof |
| CN110403198A (en) * | 2019-07-25 | 2019-11-05 | 邓跃进 | A kind of probiotics soft capsule and preparation method thereof |
| CN114146102A (en) * | 2021-07-22 | 2022-03-08 | 康道生物（南通）有限公司 | Ganoderma lucidum spore oil capsule and preparation method thereof |
| CN115104727A (en) * | 2021-08-02 | 2022-09-27 | 上海禾向健康科技发展有限公司 | Ganoderma lucidum haematococcus pluvialis extract capsule and application thereof |
| CN117567796A (en) * | 2024-01-17 | 2024-02-20 | 广东臻品健康科技有限公司 | Plant capsule material and preparation method thereof |
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| CN1489992A (en) * | 2002-10-18 | 2004-04-21 | 上海众伟生化有限公司 | Autonomic soft capsules and producing process thereof |
| CN102885860A (en) * | 2012-10-16 | 2013-01-23 | 九三粮油工业集团有限公司 | Ganoderma lucidum spore oil soft capsule for strengthening immunity and preparation method of soft capsule |
| CN106072085A (en) * | 2016-06-14 | 2016-11-09 | 王斐芬 | The preparation method of Haematocoocus Pluvialls wall cell disruption powder |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1489992A (en) * | 2002-10-18 | 2004-04-21 | 上海众伟生化有限公司 | Autonomic soft capsules and producing process thereof |
| CN102885860A (en) * | 2012-10-16 | 2013-01-23 | 九三粮油工业集团有限公司 | Ganoderma lucidum spore oil soft capsule for strengthening immunity and preparation method of soft capsule |
| CN106072085A (en) * | 2016-06-14 | 2016-11-09 | 王斐芬 | The preparation method of Haematocoocus Pluvialls wall cell disruption powder |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107549859A (en) * | 2017-09-19 | 2018-01-09 | 太仓市林港农场专业合作社 | A kind of immune soft capsule of galic essential oil compound enhancing and preparation method thereof |
| CN107549859B (en) * | 2017-09-19 | 2019-11-01 | 太仓市林港农场专业合作社 | A kind of galic essential oil compound enhances immune soft capsule and preparation method thereof |
| CN109999007A (en) * | 2019-03-18 | 2019-07-12 | 广州普正生物科技有限公司 | A kind of high leakproofness chewing soft capsule and preparation method thereof |
| CN110403198A (en) * | 2019-07-25 | 2019-11-05 | 邓跃进 | A kind of probiotics soft capsule and preparation method thereof |
| CN110403198B (en) * | 2019-07-25 | 2022-12-16 | 邓跃进 | Probiotic soft capsule and preparation method thereof |
| CN114146102A (en) * | 2021-07-22 | 2022-03-08 | 康道生物（南通）有限公司 | Ganoderma lucidum spore oil capsule and preparation method thereof |
| CN115104727A (en) * | 2021-08-02 | 2022-09-27 | 上海禾向健康科技发展有限公司 | Ganoderma lucidum haematococcus pluvialis extract capsule and application thereof |
| CN117567796A (en) * | 2024-01-17 | 2024-02-20 | 广东臻品健康科技有限公司 | Plant capsule material and preparation method thereof |
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