CN101028070A - Mangosteen extract, its production and use - Google Patents
Mangosteen extract, its production and use Download PDFInfo
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- CN101028070A CN101028070A CNA2007100902072A CN200710090207A CN101028070A CN 101028070 A CN101028070 A CN 101028070A CN A2007100902072 A CNA2007100902072 A CN A2007100902072A CN 200710090207 A CN200710090207 A CN 200710090207A CN 101028070 A CN101028070 A CN 101028070A
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Abstract
A mangosteen extract in the form of red-brown paste or pink powder used for health-care food or beverage is prepared from mangosteen fruit through extracting in water or low-carbon alcohol chosen from methanol, ethanol, propanol, isopropanol and butanol, filtering, concentrating, chromatography to obtain pasty product, and drying to obtain powder product.
Description
Technical field
The present invention relates to a kind of mangosteen extract and preparation method thereof, the invention still further relates to mangosteen extract at health food, field of food, particularly at fruit juice, bake and bank up with earth Application in Food.
Background technology
Mangosteen (Mangosteen Carcinia Mangostana L), the original name mangosteen originates in Southeast Asia, Thailand is the country that abounds with mangosteen, generally plants just to begin the result in 10 years, and is very strict to environmental requirement, and the fruit tree life-span reached on 70 years, and planting cost is not high again, but needed plantation just can gather in the crops in 7 or eight years, therefore be genuine green fruit, very famous and precious, its delicate fragrance gas is refreshing, lubricious and oiliness stagnating, equally celebrated for their achievements with durian, be known as " queen in the fruit ".Mangosteen is a kind of advantageous fruit, and fruit is rounded, not of uniform size, and big ratio tennis is smaller, and shell is thick hard, is difficult for infringement pulp.Ripe mangosteen epidermis is an aubergine, generally all is being with one section carpopodium and yellowish green base of fruit.Mangosteen peel is not only thick but also hard, contains purple juice, and taste is very pained.At the umbilical region of pericarp, the pattern of picture flower sample is arranged, in pattern can be judged, a few lobe pulp are arranged, pattern has several petals, and the pulp of the inside just has several lobes.Cut pericarp open, just can expose snow-white pulp, pulp is as the tight central authorities that are arranged in of garlic clove.Mangosteen pulp is not only white but also tender, and taste is sour-sweet, and tasty and refreshing succulence is highly palatable, is the fruit that men and women, old and young like.The pulp lobe varies, the nuclear that brown is arranged that has in the big lobe, and valvula then is pulp entirely.Mangosteen contains abundant folic acid and mineral matters such as calcium, phosphorus, also contains vitamin B1, B2 and vitamin C etc., has certain medical value.
The attribute of mangosteen and durian is just opposite, and one belongs to Great Cold, and one belongs to big heat.Mangosteen contains a kind of particular matter, has to fall dry, refrigerant analgesic effect, can restrain the scorching of durian, eats mangosteen more and helps quench to press heat, and is refrigerant good to eat.In Thailand, people look the durian mangosteen " man and wife fruit ".If eaten on the too much durian fire, be able to eat several mangosteens and just can alleviate.Mangosteen contains rich in protein and lipid, and body is had the effect of well taking a tonic or nourishing food to build up one's health, to weak, malnutritive, all have and well take good care of effect after being ill.
The mangosteen common people are edible, and people weak, after being ill is more suitable for.Mangosteen is rich in cellulose, but its meeting imbibition in stomach, too much eating can cause constipation on the contrary; It is higher to contain sugar, so the overweight people should eat less, and the glycosuria patient more answers diet; It also contains higher potassium matter, so ephrosis and heart patient should eat less.
Be treatment dysentery at the south east asia mangosteen, sprain, typhoid fever, ulcer, skin infection, the folk tradition medication of anti-inflammatory and sterilization.Discover: α-, β-and γ one mangostin (α-, β-and γ-mangostin) is an isolated main bioactive compound from mangosteen.α-mangostin is called mangostin again, and (α-mangostin=mangostin), their chemical constitution is seen accompanying drawing 2.
● α-mangostin:R1=H, R2=Me (1,3,6-trihydroxy-7-methoxyl group-2, two (3-methyl-2-butene the base)-9H-xanthene-9-ketone of 8-);
● β-mangostin:R1=R2=Me (1,3,6-trihydroxy-7-methoxyl group-2, two (3-methyl-2-butene the base)-9H-xanthene-9-ketone of 8-);
● γ-mangostin:R1=R2=H (1,3,6,7-tetrahydroxy-2, two (3-methyl-2-butene the base)-9H-xanthene-9-ketone of 8-).
α-and γ-mangostin anti-inflammatory, sterilization, anti-amoebic dysentery in various degree arranged and controls the activity of ulcer, be animal cyclic adenosine monophosphate-protein kinase (cAMP-PKA) catalytic subunit (cAK) and plant Ca
2+-dependent protein matter kinases (CDPK) effective inhibitors is to sarcoplasmic reticulum Ca
2+-adenosine triphosphatase (Ca
2+-ATPase) strong inhibitory action and relative weak inhibition cAMP phosphodiesterase effect are arranged, also be tryptamines and the strong antagonist of histamine receptor simultaneously.In addition, the two can also suppress HIV-1 proteinase activity etc.β-mangostin has the antimalarial effect to anti-plasmodium falciparum.
Through patent retrieval, find patent " application number 200610016501.4 mangosteen peel extracts and extracting method and medicinal usage thereof ", this disclosure of the Invention a kind of mangosteen peel extracts and extracting method and medical usage, relate to a kind of extract and extracting method and medicinal usage thereof of new Chinese medicine.Mangosteen peel is pulverized back 30%-95% alcohol extract, reclaim the bulk drug that ethanol can obtain being used for study of tcm new drug.The present invention extracts the mangosteen peel extracts of purifying, has the effect of diseases such as treating hyperlipemia, coronary heart disease, angina pectoris, resist myocardial ischemia.Just by promptly obtaining a kind of mangosteen extract behind simple alcohol extract, the recovery ethanol, with low content of technology, active material is not clear in this invention.
Summary of the invention
One of purpose of the present invention provides a kind of mangosteen extract.
Two of purpose of the present invention provides a kind of mangosteen that utilizes and extracts the method for preparing mangosteen extract.
Three of purpose of the present invention has provided mangosteen extract at health food, field of food, particularly at fruit juice, bake and bank up with earth Application in Food.
Mangosteen extract of the present invention is a paste or Powdered, and the mangosteen extract of paste is a bronzing, has the distinctive fragrance of mangosteen, about 15～25 mother-in-law U.S. degree; Pulverous mangosteen extract is a pale red, has the distinctive fragrance of mangosteen, and wherein the mangosteen extract weight content is more than 80%, and mangostin content is more than 50%.
For obtaining mangosteen extract, the present invention adopts following technical scheme:
The present invention extracts the method for mangosteen extract from mangosteen, a kind of is to be raw material with the mangosteen, through extracting solvent extraction, concentrated, column chromatography, concentrated, obtains the method for paste mangosteen extract; Perhaps, the paste mangosteen that obtains obtains the method for Powdered mangosteen extract again through super-dry.
The described raw material of the inventive method is full fruit of mangosteen or pericarp, needs earlier mangosteen is cleaned before extraction, fragmentation.
The described extracting method of the inventive method is extracted for heating.
Extracting solvent described in the inventive method is water or low-carbon alcohols.Described low-carbon alcohols is methyl alcohol, ethanol, propyl alcohol, isopropyl alcohol or butanols, and the weight concentration of described low-carbon alcohols is 40%～95%; Optimize and select, the weight concentration of described low-carbon alcohols is 50%～90%.
Heating in the described extracting method of the inventive method is extracted, extraction time is a key that influences yield and content, and general extraction time is 1～3 time, according to test, take all factors into consideration the utilization rate of extraction equipment usage space and the working substance content of finished product, extraction time is preferably 2 times; The solvent consumption is 8～10 times of raw material weight, and temperature is 40～90 ℃, and extraction time is solvent boiling back 1～3 hour.
Of the present invention temperature is controlled at below 60 ℃ with needing to reclaim the low-carbon alcohols processing behind the low-carbon alcohols extraction mangosteen, and vacuum degree control is more than 0.06Mpa, and the soup and the raw material weight ratio that reclaim low-carbon alcohols should be controlled between 1: 2～5.
Column chromatography of the present invention comprises the steps:
1), concentrates with extracting liquid filtering;
2) filtrate after will concentrating by column chromatography, is adsorbed with resin;
3) being colourless with washed with de-ionized water resin to trickle, is the ethanolic solution wash-out of 50-60% again with concentration, collects eluent;
4) eluent is concentrated, obtain the mangosteen extract of paste, obtain pulverous mangosteen extract by drying again.
Eluent described in the inventive method column chromatography process concentrates and is meant, the mangosteen eluent, after filtration, it is concentrated then that (vacuum concentrates, temperature is controlled at below 60 degrees centigrade, vacuum 0.06-0.1MPa), be concentrated into about 15～25 mother-in-law U.S. degree, promptly be concentrated into the 1/5-1/3 of original extracting liquid volume, obtain the mangosteen extract of paste.
Column chromatography resin of the present invention is selected from the macroporous absorbent resin that model is D101 type, DA201 type, SIP series, X-5 type, AB-8 type, GDX104 type, LD605 type, LD601 type, CAD-40 type, DM-130 type, R-A type, CHA-111 type, WLD type (mixed type), H107 type, NKA-9 type, the synthetic polymeric adsorbent of small grain size that model is HP20SS or SP20SS.
The mangosteen extract of paste of the present invention is meant by spray-drying (160～200 ℃ of intake air temperatures, 80～110 ℃ of air outlet temperature) or freeze drying again through super-dry, obtains Powdered mangosteen extract.
The Powdered mangosteen extract content height that the inventive method is produced, its weight content is more than 80%, mangostin content is more than 50%, has avoided the loss of active component.
Another object of the present invention is to provide the paste that obtains by the bright preparation method of we or pulverous mangosteen extract at health food, field of food, particularly at fruit juice, bake and bank up with earth Application in Food.
The mangosteen extract that the inventive method is produced has following advantage:
● the content height, avoided the loss of active component;
● when keeping mangosteen abundant nutrition composition, removed sugar that content is high in the mangosteen and potassium matter;
● production technology is simple, with short production cycle.
Description of drawings
The HPLC collection of illustrative plates of accompanying drawing 1 mangosteen extract.
Accompanying drawing 2 mangostins (α-, the chemical constitution of β-and γ-mangostin)
The specific embodiment
Embodiment 1
1) pre-treatment: with the full fruit cleaning of mangosteen, fragmentation;
2) extract: place 8 times of amount deionized waters to extract 2 times the full fruit of the mangosteen after the fragmentation in 80 ℃, stir frequently in the leaching process, be heated to the boiling back and kept temperature 2 hours, collect and extract feed liquid for the first time, extract the deionized water that adds 10 times of amounts more for the second time, ebuillition of heated insulation 2 hours is collected and is extracted feed liquid for the second time;
3) filter: extract is passed through centrifuge centrifugal filtration;
4) filtrate is concentrated after, by column chromatography, be that D101 type resin adsorbs with model;
5) being colourless with washed with de-ionized water resin to trickle, is 50% ethanolic solution wash-out again with concentration, collects eluent;
6) concentrate: it is concentrated to reduce pressure in the eluent importing inspissator after will filtering, and temperature is controlled at below 60 degrees centigrade, and vacuum degree control is concentrated into about 15 mother-in-law U.S. degree more than 0.06MPa, obtains the mangosteen extract of paste;
7) spray-drying: the mangosteen extract of paste passes through spray-drying again, 160～200 ℃ of intake air temperatures, and 80～110 ℃ of air outlet temperature get Powdered mangosteen extract.
Embodiment 2
1) pre-treatment: with the full fruit cleaning of mangosteen, fragmentation;
2) extract: place 8 times of amount 40% methyl alcohol to extract 2 times the full fruit of the mangosteen after the fragmentation in 40 ℃, stir frequently in the leaching process, be heated to the boiling back and kept temperature 2 hours, collect and extract feed liquid for the first time, extract 40% methyl alcohol that adds 10 times of amounts more for the second time, ebuillition of heated insulation 2 hours is collected and is extracted feed liquid for the second time;
3) filter: extract is passed through centrifuge centrifugal filtration;
4) filtrate is concentrated after, by column chromatography, adsorb for the DA201 resin with model;
5) being colourless with washed with de-ionized water resin to trickle, is 60% ethanolic solution wash-out again with concentration, collects eluent;
6) concentrate: it is concentrated to reduce pressure in the eluent importing inspissator after will filtering, and temperature is controlled at below 60 degrees centigrade, and vacuum degree control is concentrated into about 20 mother-in-law U.S. degree more than 0.06MPa, obtains the mangosteen extract of paste;
7) spray-drying: the mangosteen extract of paste passes through spray-drying again, 160～200 ℃ of intake air temperatures, and 80～110 ℃ of air outlet temperature get Powdered mangosteen extract.
Embodiment 3
1) pre-treatment: with the full fruit cleaning of mangosteen, fragmentation;
2) extract: place 8 times of amount 60% ethanol to extract 2 times the full fruit of the mangosteen after the fragmentation in 60 ℃, stir frequently in the leaching process, be heated to the boiling back and kept temperature 2 hours, collect and extract feed liquid for the first time, extract 60% ethanol that adds 10 times of amounts more for the second time, ebuillition of heated insulation 2 hours is collected and is extracted feed liquid for the second time;
3) filter: extract is passed through centrifuge centrifugal filtration;
4) filtrate is concentrated after, by column chromatography, adsorb for the D101 resin with model;
5) being colourless with washed with de-ionized water resin to trickle, is 60% ethanolic solution wash-out again with concentration, collects eluent;
6) concentrate: it is concentrated to reduce pressure in the eluent importing inspissator after will filtering, and temperature is controlled at below 60 degrees centigrade, and vacuum degree control is concentrated into about 25 mother-in-law U.S. degree more than 0.06MPa, obtains the mangosteen extract of paste;
7) freeze drying: the mangosteen extract of paste passes through freeze drying again, gets Powdered mangosteen extract.
Embodiment 4
1) pre-treatment: with the full fruit cleaning of mangosteen, fragmentation;
2) extract: place 8 times of amount 50% ethanol to extract 2 times the mangosteen peel after the fragmentation in 60 ℃, stir frequently in the leaching process, be heated to the boiling back and kept temperature 2 hours, collect and extract feed liquid for the first time, extract 50% ethanol that adds 10 times of amounts more for the second time, ebuillition of heated insulation 2 hours is collected and is extracted feed liquid for the second time;
3) filter: extract is passed through centrifuge centrifugal filtration;
4) filtrate is concentrated after, by column chromatography, be that the small grain size synthetic resin of HP20SS adsorbs with model;
5) being colourless with washed with de-ionized water resin to trickle, is 60% ethanolic solution wash-out again with concentration, collects eluent;
6) concentrate: it is concentrated to reduce pressure in the eluent importing inspissator after will filtering, and temperature is controlled at below 60 degrees centigrade, and vacuum degree control is concentrated into about 25 mother-in-law U.S. degree more than 0.06MPa, obtains the mangosteen extract of paste;
7) spray-drying: the mangosteen extract of paste passes through spray-drying again, 160～200 ℃ of intake air temperatures, and 80～110 ℃ of air outlet temperature get Powdered mangosteen extract.
1) pre-treatment: with the full fruit cleaning of mangosteen, fragmentation;
2) extract: place 8 times of amount 95% propyl alcohol to extract 2 times the mangosteen peel after the fragmentation in 90 ℃, stir frequently in the leaching process, be heated to the boiling back and kept temperature 2 hours, collect and extract feed liquid for the first time, extract 95% propyl alcohol that adds 10 times of amounts more for the second time, ebuillition of heated insulation 2 hours is collected and is extracted feed liquid for the second time;
3) filter: extract is passed through centrifuge centrifugal filtration;
4) filtrate is concentrated after, by column chromatography, be that CAD-40 type resin adsorbs with model;
5) being colourless with washed with de-ionized water resin to trickle, is 55% ethanolic solution wash-out again with concentration, collects eluent;
6) concentrate: it is concentrated to reduce pressure in the eluent importing inspissator after will filtering, and temperature is controlled at below 60 degrees centigrade, and vacuum degree control is concentrated into about 25 mother-in-law U.S. degree more than 0.06MPa, obtains the mangosteen extract of paste;
7) spray-drying: the mangosteen extract of paste passes through spray-drying again, 160～200 ℃ of intake air temperatures, and 80～110 ℃ of air outlet temperature get Powdered mangosteen extract.
Embodiment 7
Health-care food for assisting blood fat lowering:
Get mangosteen extract (Powdered) 500g, add medical starch 2500g, the two fully mixes, and makes 10000 capsules, and every heavy 0.3g contains mangosteen extract 50mg.
Prove that through zoopery this prescription has significant effect for reducing blood fat.
Embodiment 8
The blended fruit juice prescription of mangosteen flavor:
Mangosteen extract (paste) 1580kg
Mangosteen extract (Powdered) 728kg
Lichee pulp 208kg
Longan pulp 208kg
Sodium Benzoate 5kg
Embodiment 9
Mangosteen flavor Si Fulei egg roll
Title material weight/gram title material weight
/ gram
Big master's Tata powder 600 weak strength flours 240
Sweet milk 600 brandy 30
Granulated sugar 300 protein 14s are individual
14 in cream 240 yolk
Mangosteen extract (Powdered) 100
Procedure of processing:
1, the cream heating is dissolved, and adds weak strength flour and mixes thoroughly;
Gradation added yolk when 2, the sweet milk gradation added the about 50-C in back, mixed back adding brandy thoroughly;
3, egg white icing is stirred to the neutrality foaming in addition, mix thoroughly with above-mentioned material;
4, get angry that fiery 180-C needs the water proof heated baking under the temperature 200-C;
5, middle applying butter frost or Mu Si filling.
Claims (11)
1, a kind of method of extracting mangosteen extract from mangosteen is characterized in that: be raw material with the mangosteen, through extracting solvent extraction, concentrated, column chromatography, concentrated, obtain the paste mangosteen extract; Perhaps, the paste mangosteen that obtains obtains Powdered mangosteen extract again through super-dry.
2, extract the method for mangosteen extract according to claim 1 from mangosteen, it is characterized in that: described extraction raw material is full fruit of mangosteen or pericarp.
3, extract the method for mangosteen extract according to claim 1 from mangosteen, it is characterized in that: described extraction solvent is water or low-carbon alcohols, as methyl alcohol, ethanol, propyl alcohol, isopropyl alcohol or butanols.
4, as extract the method for mangosteen extract as described in the claim 3 from mangosteen, it is characterized in that: the weight concentration of described low-carbon alcohols is 40%～95%.
5, as extract the method for mangosteen extract as described in the claim 4 from mangosteen, it is characterized in that: the weight concentration optimization of described low-carbon alcohols selects 50%～90%.
6, extract the method for mangosteen extract according to claim 1 from mangosteen, it is characterized in that: described column chromatography comprises the steps:
1), concentrates with extracting liquid filtering;
2) filtrate after will concentrating by column chromatography, is adsorbed with resin;
3) being colourless with washed with de-ionized water resin to trickle, is the ethanolic solution wash-out of 50-60% again with concentration, collects eluent;
4) eluent is concentrated, obtain the mangosteen extract of paste; Obtain pulverous mangosteen extract by drying again.
7, extract the method for mangosteen extract according to claim 1 from mangosteen, it is characterized in that: described column chromatography resin is selected from the macroporous absorbent resin that model is D101 type, DA201 type, SIP series, X-5 type, AB-8 type, GDX104 type, LD605 type, LD601 type, CAD-40 type, DM-130 type, R-A type, CHA-111 type, WLD type (mixed type), H107 type, NKA-9 type, the synthetic polymeric adsorbent of small grain size that model is HP20SS or SP20SS.
8, extract the method for mangosteen extract according to claim 1 from mangosteen, it is characterized in that: described drying is meant spray-drying or freeze drying.
9, a kind of mangosteen extract is characterized in that: obtained by the described extracting method of claim 1, extract is a paste or Powdered, and the mangosteen extract of paste is a bronzing, has the distinctive fragrance of mangosteen, about 15～25 mother-in-law U.S. degree; Pulverous mangosteen extract is a pale red, has the distinctive fragrance of mangosteen, and wherein the mangosteen extract weight content is more than 80%, and mangostin content is more than 50%.
10, the application of mangosteen extract in health food, field of food.
11, as the application of mangosteen extract in health food, field of food as described in the claim 10, it is characterized in that: mangosteen extract at fruit juice, bake and bank up with earth Application in Food.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2007100902072A CN101028070A (en) | 2007-04-13 | 2007-04-13 | Mangosteen extract, its production and use |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100902072A CN101028070A (en) | 2007-04-13 | 2007-04-13 | Mangosteen extract, its production and use |
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| CN101028070A true CN101028070A (en) | 2007-09-05 |
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| CNA2007100902072A Pending CN101028070A (en) | 2007-04-13 | 2007-04-13 | Mangosteen extract, its production and use |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101982539A (en) * | 2010-11-15 | 2011-03-02 | 广州百花香料股份有限公司 | Bamboo juice essence |
| CN101396101B (en) * | 2008-09-17 | 2011-10-26 | 丁予章 | Production technique of mangosteen extract |
| CN101525328B (en) * | 2008-03-06 | 2012-08-22 | 陕西嘉禾植物化工有限责任公司 | Method for extracting alpha-mangostin from mangosteen fruit peel |
| WO2013036210A1 (en) * | 2011-09-06 | 2013-03-14 | Supaphol Pitt | Medical face mask coated with mangosteen shell extracts |
| CN104892561A (en) * | 2015-06-08 | 2015-09-09 | 桂林莱茵生物科技股份有限公司 | Method for extracting high-content alpha-mangostin from mangosteen skin |
| CN107162092A (en) * | 2017-07-01 | 2017-09-15 | 荥经力宏技术推广服务有限公司 | A kind of minimizing technology of industrial wastewater Pesticides |
| CN113717144A (en) * | 2021-09-24 | 2021-11-30 | 浏阳朗林生物科技有限公司 | Method for extracting alpha-mangostin and gamma-mangostin from mangosteen |
-
2007
- 2007-04-13 CN CNA2007100902072A patent/CN101028070A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101525328B (en) * | 2008-03-06 | 2012-08-22 | 陕西嘉禾植物化工有限责任公司 | Method for extracting alpha-mangostin from mangosteen fruit peel |
| CN101396101B (en) * | 2008-09-17 | 2011-10-26 | 丁予章 | Production technique of mangosteen extract |
| CN101982539A (en) * | 2010-11-15 | 2011-03-02 | 广州百花香料股份有限公司 | Bamboo juice essence |
| CN101982539B (en) * | 2010-11-15 | 2012-05-23 | 广州百花香料股份有限公司 | Bamboo juice essence |
| WO2013036210A1 (en) * | 2011-09-06 | 2013-03-14 | Supaphol Pitt | Medical face mask coated with mangosteen shell extracts |
| CN104892561A (en) * | 2015-06-08 | 2015-09-09 | 桂林莱茵生物科技股份有限公司 | Method for extracting high-content alpha-mangostin from mangosteen skin |
| CN104892561B (en) * | 2015-06-08 | 2017-06-16 | 桂林莱茵生物科技股份有限公司 | A kind of method that high content of alpha mangostin is extracted from mangosteen skin |
| CN107162092A (en) * | 2017-07-01 | 2017-09-15 | 荥经力宏技术推广服务有限公司 | A kind of minimizing technology of industrial wastewater Pesticides |
| CN113717144A (en) * | 2021-09-24 | 2021-11-30 | 浏阳朗林生物科技有限公司 | Method for extracting alpha-mangostin and gamma-mangostin from mangosteen |
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