CN104997018B - A kind of Chinese yew ferment health products and its preparation method and application - Google Patents
A kind of Chinese yew ferment health products and its preparation method and application Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a kind of Chinese yew ferment health products and its preparation method and application, the Chinese yew ferment health products are mainly (3 8) by weight ratio:(1‑4):Chinese yew, fruit and the sugar of (3 10) are prepared for raw material.The present invention with Chinese yew, fruit and sugar for raw material, it is fermented to obtain Chinese yew enzyme stoste, the content of taxol in enzyme stoste is optionally adjusted with sterile water, be then made needed for formulation obtain the Chinese yew ferment health products.The Chinese yew ferment health products of the present invention can direct oral application, have no toxic side effect, it is nonirritant, it is in good taste, with anticancer, anti-cancer efficacy, and the vitamin and mineral matter of needed by human body can be supplemented, strengthen immunity of organisms, the synergistic effect of Chinese yew and fruit and ferment can be played, is a kind of health products of integration of drinking and medicinal herbs.
Description
Technical field
The invention belongs to medicinal plant exploitation and field of fermentation engineering, there is provided a kind of Chinese yew ferment health products and its system
Preparation Method and application.
Background technology
Chinese yew is the general name of taxaceae Chinese yew genus plants.The medical value of Chinese yew early in《Compendium of Materia Medica》In just
It is on the books, it is mainly used for treating cholera, typhoid fever and for toxin expelling.《Modern Chinese medicine voluminous dictionary》、《Book on Chinese herbal medicine pushes away old》In it is all on the books,
Its is bitter in taste, flat, slightly poisonous, thoughts of returning home warp, and effect dispersing swelling and dissipating binds, cure mainly tumour, nephrosis, rheumatism etc..Modern Chinese medicine is also used
In treatment diabetes, nephrosis and gynecological disease etc..400 multiple compounds are isolated from Chinese yew at present, mainly into
It is divided into two kinds of taxanes and non-taxanes.Taxanes is Taxane diterpenes class compound, non-bearing taxanes master
To be triterpene, steroidal, high terpene, flavones, Phenylpropanoid Glycosides class and phenols etc..Contain the active anticancer medicines such as taxol in branches and leaves of yew
Thing, Chinese yew complete stool or branches and leaves are fermented, extract, and retain active ingredient, improve dissolution rate, improve bioavailability, inspire medicine
Effect, Chinese yew ferment oral liquid play the synergistic effect of Chinese yew and fructus hippophae, reach anticancer, strengthen body immunity.
Fruit contains abundant vitamin and mineral element, and nutritional ingredient can be provided for body, some fruit are also in addition
With health care and medical value, there is certain anticancer, anti-cancer efficacy.For example, fructus hippophae has very high edible and medicinal valency
Value.Fructus hippophae is rich in multivitamin, there is the title of " vitamin treasure-house ".Unrighted acid in hippophae rhamnoides fruit oil, easily by people
Body absorbs, and can reduce cholesterol and triglycerides in blood, has the function that to prevent hypertension and coronary heart disease.Sea-buckthorn
Also there is fruit oil anti-width to penetrate, antifatigue effect, strengthen body energy, have very well to treatment burn and duodenal bulbar ulcer etc.
The effect of.Fructus hippophae has the function of a variety of medicine, and can invigorate blood circulation decompression, and can also disappear asthma cough-relieving, there is a constant current modulation to disease of digestive system
Effect, and have the function that to delay and prevent canceration.The antitumaous effect of fructus hippophae is drawn except through immunologic mechanism or other approach
Outside role, also directly suppress cancer cell effect and block the effect of carcinogenic factor, Hippophae Rhamnoides L. juice is preferably drunk through being diluted to
After concentration, the nitroso synthesis of N- can be blocked, in addition Hippophae Rhamnoides L. juice also has resistance to carcinogenic substance N- N-nitrosodimethylamines (NDMA)
The disconnected effect with protection, cumarin, isocoumarin, furocoumarin, guassin and more are contained in the flavones contained by fructus hippophae
Phenols, serotonin etc. have the component of combined anti-cancer effect.Strawberry contains abundant vitamin and mineral, and nutritive value is very
Height, and the absorption of carcinogenic chemical can be prevented, there is protective effect on cancer risk.
Ferment is being commonly called as " enzyme ", can produce ferment by plant or fruit fermentation, ferment is played for health
Key effect, ferment more lack, and people is just more easy to aging；Conversely, ferment storage is the more, people is just more healthy.The ferment storage of one people
Storage and energy are directly proportional.Age is incremented by, and ferment can be reduced slowly, and when reducing to the needs that can not meet metabolism, people will
It is dead.When internal ferment effect it is weak or reduce, just have various symptoms appearance.The disease of people is by internal countless ferment groups
Some loses vigor, or out of balance caused, it is now known that there are about 115 kinds of diseases, all has connection with ferment obstacle.
Therefore, the pharmaceutical activity of Chinese yew and the nutritional health function of fruit and ferment are combined together, can played
Treatment and health-care effect well.
The content of the invention
It is an object of the invention to provide a kind of Chinese yew ferment health products and its preparation method and application.
To reach the invention purpose, the present invention uses following technical scheme：
On the one hand, the present invention provides a kind of Chinese yew ferment health products, the Chinese yew ferment health products are with weight ratio
For (3-8):(1-4):Chinese yew, fruit and the sugar of (3-10) are prepared for raw material.
Chinese yew ferment health products of the present invention combine the antitumaous effect of active pharmaceutical ingredient taxol in Chinese yew
And the nutrition health-care functions of fruit, anticancer, enhancing immunity of organisms and other effects can be played, is a kind of health care of integration of drinking and medicinal herbs
Product.
The formulation of Chinese yew ferment health products of the present invention is but is not limited to oral liquid, tablet, capsule or granule
In any one, be preferably oral liquid.
In Chinese yew ferment health products of the present invention, the fruit is fructus hippophae, apple, strawberry, Kiwi berry, Portugal
In grape, lemon or orange any one or at least two combination, be preferably fructus hippophae, apple and the combination of strawberry.
Preferably, the sugar can be any one in honey, syrup, glucose or white granulated sugar or at least two group
Close, be preferably the combination of the combination of honey and syrup, more preferably lime tree nectar and syrup.
On the other hand, the present invention provides the preparation method of the Chinese yew ferment health products, the method is with red
Beans China fir, fruit and sugar are raw material, fermented to obtain Chinese yew enzyme stoste, optionally adjust Japanese yew in enzyme stoste with sterile water
The content of alcohol, is then made required formulation and obtains the Chinese yew ferment health products.
As the preferred technical solution of the present invention, the preparation method of the Chinese yew ferment health products comprises the following steps：
(1) crushed material of Chinese yew and fruit juice and sugar are added to fermentation tank, adds sterile water, fermentation obtains ferment
Plain fermentation seed；
(2) it is another to take the crushed material of the proportioning Chinese yew identical with step (1) proportioning to be added with fruit juice and sugar to another
One fermentation tank, adds sterile water, adds the ferment fermentation seed that step (1) obtains, and fermentation obtains ferment fermenation raw liquid；
(3) fermenation raw liquid for obtaining step (2) filters, the content of detection wherein taxol, when content reaches 0.01-
During 0.08mg/L, that is, complete fermentation；If content is less than 0.01mg/L, continue to ferment；If content is higher than 0.08mg/
L, then add sterile water and be diluted to 0.01-0.08mg/L, and required formulation is then made and obtains the Chinese yew ferment health products.
In the preparation method of the Chinese yew ferment health products, it is by Chinese yew that step (1) described taxus chinensis powder, which minces,
Complete stool or branches and leaves drying, crush, and crosses what 20-40 mesh (such as 20 mesh, 30 mesh or 40 mesh) sieve obtained.
Preferably, step (1) the fruit juice be fruit is cleaned dry after break into juice.
Preferably, the crushed material of step (1) and step (2) described Chinese yew and the weight ratio of fruit juice and sugar are
(3-8):(1-4):(3-10), such as 3:1:3、3:2:3、3:3:4、3:4:3、3:4:5、3:4:7、3:4:8、3:4:9、3:4:
10、4:1:3、4:2:3、4:3:3、4:4:3、4:4:5、4:4:7、5:1:3、5:2:3、5:3:3、5:3:7、5:4:3、5:4:5、5:
4:7、5:4:9、6:1:5、7:1:3、7:2:5、7:4:8、8:1:3、8:3:5、8:4:7、8:2:9 or 8:3:10.
Since the crushed material of Chinese yew in step (1) and step (2) and the weight ratio of fruit juice and sugar are (3-
8):(1-4):(3-10), and the specific raw material proportioning used in two steps is identical, therefore, prepares the Chinese yew ferment mouth
The weight ratio for taking Chinese yew, fruit and sugar in the raw material of liquid is also (3-8):(1-4):(3-10).
Preferably, the fruit is any one in fructus hippophae, apple, strawberry, Kiwi berry, grape, lemon or orange
Or at least two combination, be preferably fructus hippophae, apple and the combination of strawberry.
Preferably, the sugar can be any one in honey, syrup, glucose or white granulated sugar or at least two group
Close, be preferably the combination of the combination of honey and syrup, more preferably lime tree nectar and syrup.
Preferably, step (1) and the addition of step (2) described sterile water for taxus chinensis powder mince with fruit juice and
1-2 times of the gross weight of sugar, such as 1 times, 1.2 times, 1.5 times, 1.8 times or 2 times.
Preferably, step (1) and step (2) described fermentation temperature are 25-35 DEG C, for example, 25 DEG C, 28 DEG C, 30 DEG C, 32 DEG C,
33 DEG C, 34 DEG C or 35 DEG C.
Preferably, step (1) described fermentation time is 30-35 days, such as 30 days, 31 days, 32 days, 33 days, 34 days or 35
My god.
Preferably, step (1) fermentation carries out under shake.
Preferably, step (2) described fermentation time is 18-20 days, such as 18 days, 19 days or 20 days.
Preferably, in step (2) described fermentation process, daily stirring twice, it is 10-15 minutes each, for example, 10 minutes, 11
Minute, 12 minutes, 13 minutes, 14 minutes or 15 minutes.
Step (1) is 30-35 days by the fermentation time of raw material production fermentation seed, and fermentation time is relatively long, step (2)
The time fermented using fermentation seed is 21-25 days, is conducive to accelerate fermentation process due to adding fermentation seed, so hair
The time is relatively short used in ferment, and when carrying out industrial production, upper wholesale zymotic fluid can be used as down the fermentation seed of wholesale ferment.
Zymotic fluid is stirred daily in step (2) twice, it is 10-15 minutes each, this is because appropriate stirring is conducive to
Fermentation generation ethanol, and ethanol is conducive to the dissolution of taxol, but stirred easily lead to is become sour more.
Preferably, step (3) is described continues to be monitored until taxol contains the content of taxol in fermentation process
Amount reaches 0.01-0.08mg/L, completes fermentation, and required formulation is then made and obtains the Chinese yew ferment health products.
The purpose of step (3) is that to control the content of taxol in gained Chinese yew ferment health products be 0.01-0.08mg/L,
Such as 0.01mg/L, 0.02mg/L, 0.03mg/L, 0.04mg/L, 0.05mg/L, 0.06mg/L, 0.07mg/L or 0.08mg/L.
The detection method of step (3) described content of taxol is completed using the prior art, such as can use efficient liquid phase
The technologies such as chromatography are detected.
In the preparation method of Chinese yew ferment health products of the present invention, the formulation is oral liquid, tablet, capsule
Or any one in granule, it is preferably oral liquid.
In the formulation of the present invention such as preparation process of oral liquid, tablet, capsule or granule, it is molded for formulation
Method using the prior art well known to those skilled in the art method realize.
As optimal technical scheme, the preparation method of Chinese yew ferment oral liquid of the present invention comprises the following steps：
(1) crushed material of Chinese yew and fruit juice and sugar are added to fermentation tank, adds sterile water, fermentation obtains ferment
Plain fermentation seed；
(2) it is another to take the China fir crushed material of the proportioning red bean identical with step (1) proportioning to be added with fruit juice and sugar to another
One fermentation tank, adds sterile water, adds the ferment fermentation seed that step (1) obtains, and fermentation obtains ferment fermenation raw liquid；
(3) fermenation raw liquid is filtered, the content of detection wherein taxol is when content reaches 0.01-0.08mg/L, i.e., complete
Into fermentation；If content is less than 0.01mg/L, continue to ferment；If content is higher than 0.08mg/L, sterile water is added
0.01-0.08mg/L is diluted to, the oral liquid is then made.
In Chinese yew ferment oral liquid of the present invention, step (1) and step (2) described taxus chinensis powder minces and fruit
The weight ratio of juice and sugar is (3-8):(1-4):(3-10), is preferably 3:3:4.
Preferably, the fruit is any one in fructus hippophae, apple, strawberry, Kiwi berry, grape, lemon or orange
Or at least two combination, be preferably fructus hippophae, apple and the combination of strawberry, more preferably weight ratio be 1:1:1 sand
The combination of spine fruit, apple and strawberry.
Preferably, the sugar can be any one in honey, syrup, glucose or white granulated sugar or at least two group
Close, be preferably the combination of the combination of honey and syrup, more preferably lime tree nectar and syrup, more preferably weight ratio
For 1:The combination of 1 lime tree nectar and syrup.
Preferably, step (1) and the addition of step (2) described sterile water for taxus chinensis powder mince with fruit juice and
1-2 times of the gross weight of sugar.
Preferably, step (1) and step (2) described fermentation temperature are 25-35 DEG C.
Preferably, step (1) described fermentation time is 30-35 days.
Preferably, step (1) fermentation carries out under shake.
Preferably, step (2) described fermentation time is 18-20 days.
Preferably, in step (2) described fermentation process, stirring is twice, 10-15 minutes each daily.
Preferably, step (3) is described continues to be monitored until taxol contains the content of taxol in fermentation process
Amount reaches 0.01-0.08mg/L, completes fermentation, the Chinese yew ferment oral liquid is then made.
The purpose of step (3) is that to control the content of taxol in gained Chinese yew ferment oral liquid be 0.01-0.08mg/L,
Such as 0.01mg/L, 0.02mg/L, 0.03mg/L, 0.04mg/L, 0.05mg/L, 0.06mg/L, 0.07mg/L or 0.08mg/L.
The detection method of step (3) described content of taxol is completed using the prior art, such as can use efficient liquid phase
The technologies such as chromatography are detected.
Step (3) oral liquid that is made can be that the oral liquid is made in direct packaging, can also add before packing
Enter suitable additives, such as common flavouring, bacteriostatic agent, antioxidant, colouring agent etc., oral liquid is made in then packing.
The technical solution further preferred as the present invention, the preparation method bag of Chinese yew ferment oral liquid of the present invention
Include following steps：
(a) by Chinese yew complete stool or branches and leaves drying, crushing, 20-40 mesh sieves are crossed, it is spare；
(b) it is 1 by weight ratio:1:1 fructus hippophae, apple and strawberry cleans that to break into fruit juice after airing spare；
(c) taxus chinensis powder that step (a) obtains is minced and (weight ratio is for the fruit juice of step (b) acquisition and sugar
1:1 lime tree nectar and the combination of syrup) according to weight ratio 3:3:4 proportioning is added to fermentation tank, is incorporated as Chinese yew crushing
Thing and fruit juice and 1-2 times of sterile water of the gross weight of sugar, 25-35 DEG C is shaken lower fermentation and obtains within 30-35 days ferment hair
Ferment seed；
(d) taxus chinensis powder that step (a) obtains separately is taken to mince with the fruit juice of step (b) acquisition and sugar according to weight
Than 3:3:4 proportioning adds the 1-2 for another fermentation tank, being incorporated as the gross weight that taxus chinensis powder minces with fruit juice and sugar
Sterile water again, adds the ferment fermentation seed that step (c) obtains, and 25-35 DEG C ferments 18-20 days, stirs daily twice, often
Secondary stirring 10-15 minutes, obtains ferment fermenation raw liquid；
(e) fermenation raw liquid is filtered, the content of detection wherein taxol is when content reaches 0.01-0.08mg/L, i.e., complete
Into fermentation；If content is less than 0.01mg/L, continue to ferment；If content is higher than 0.08mg/L, sterile water is added
0.01-0.08mg/L is diluted to, the oral liquid is then made.
The present invention is fermented with Chinese yew, fruit and sugar for raw material, produces ferment during the fermentation, is further promoted
Into the progress of fermentation, sugar provides substrate for fermentative microflora, and the metabolism of flora can be continuous by the nutritional ingredient of medicinal material, food materials
Decomposition, macromolecules degradation for less nutrient molecule by human body be more easy to absorb play efficacy effect, and sugar can to fermentation
The tart flavour of the lactic acid of generation plays the role of reconciliation, obtains preferable mouthfeel；Fruit is except that can provide abundant vitamin and ore deposit
Outside the nutriments such as matter-element element, it produces alcohol during the fermentation so that contained taxol active pharmaceutical ingredient in Chinese yew
It is more soluble in zymotic fluid, improves the dissolution rate and bioavailability of medicine, inspires drug effect；Therefore the present invention provides one kind to connect
The health products of nearly China Traditional Chinese Medicine clinic integration of drinking and medicinal herbs.
On the other hand, the answering in anti-cancer and cancer-preventing health products are prepared the present invention provides the Chinese yew ferment health products
With.The Chinese yew ferment health products of the present invention can play the synergistic effect of Chinese yew and fruit and ferment, reach anticancer and
Strengthen immunity of organisms and other effects.It can be used as anticancer, anti-cancer medicine and nutrient and healthcare products.
Relative to the prior art, the invention has the advantages that：
The present invention with Chinese yew, fruit and sugar for the fermented Chinese yew ferment health products being prepared of raw material, can be direct
Oral application, has no toxic side effect, nonirritant, in good taste, has anticancer, anti-cancer efficacy, and can supplement the dimension life of needed by human body
Element and mineral matter, strengthen immunity of organisms, can play the synergistic effect of Chinese yew and fruit and ferment, are a kind of medicine foods
Homologous health care health products.
Brief description of the drawings
Fig. 1 is the process flow chart that the present invention prepares Chinese yew ferment oral liquid.
Embodiment
Technical scheme is further illustrated below by embodiment.Those skilled in the art should be bright
, the embodiment be only to aid in understand the present invention, be not construed as to the present invention concrete restriction.
Embodiment 1
In the present embodiment, Chinese yew ferment oral liquid is prepared by the following method, specifically includes following steps：
(a) by the drying of Chinese yew complete stool, crushing, 20 mesh sieves are crossed, it is spare；
(b) it is 1 by weight ratio:1:1 fructus hippophae, apple and strawberry cleans that to break into fruit juice after airing spare；
(c) taxus chinensis powder that step (a) obtains is minced and (weight ratio is for the fruit juice of step (b) acquisition and sugar
1:1 lime tree nectar and the combination of syrup) according to weight ratio 3:3:4 proportioning is added to fermentation tank, is incorporated as Chinese yew crushing
Thing and fruit juice and 1-2 times of sterile water of the gross weight of sugar, 25 DEG C are shaken lower fermentation and obtain ferment fermentation seed in 30 days；
(d) taxus chinensis powder that step (a) obtains separately is taken to mince with the fruit juice of step (b) acquisition and sugar according to weight
Than 3:3:4 proportioning, which is added, to another fermentation tank, is incorporated as 2 times that taxus chinensis powder minces with fruit juice and sugared gross weight
Sterile water, add the ferment fermentation seed that step (c) obtains, 25 DEG C ferment 18 days, and stirring daily twice, stirs 10 every time
Minute, obtain ferment fermenation raw liquid；
(e) fermenation raw liquid is filtered, the content of detection wherein taxol is 0.02mg/L, and packing, is made Chinese yew ferment
Oral liquid.
Embodiment 2
In the present embodiment, Chinese yew ferment oral liquid is prepared by the following method, specifically includes following steps：
(a) branches and leaves of yew is dried, crushed, cross 40 mesh sieves, it is spare；
(b) it is 1 by weight ratio:1:1 fructus hippophae, apple and strawberry cleans that to break into fruit juice after airing spare；
(c) taxus chinensis powder that step (a) obtains is minced and (weight ratio is for the fruit juice of step (b) acquisition and sugar
1:1 lime tree nectar and the combination of syrup) according to weight ratio 3:3:4 proportioning is added to fermentation tank, is incorporated as Chinese yew crushing
Thing and fruit juice and 1-2 times of sterile water of the gross weight of sugar, 35 DEG C are shaken lower fermentation and obtain ferment fermentation seed in 35 days；
(d) taxus chinensis powder that step (a) obtains separately is taken to mince with the fruit juice of step (b) acquisition and sugar according to weight
Than 3:3:4 proportioning, which is added, to another fermentation tank, is incorporated as 1 times that taxus chinensis powder minces with fruit juice and sugared gross weight
Sterile water, add the ferment fermentation seed that step (c) obtains, 30 DEG C ferment 20 days, and stirring daily twice, stirs 15 every time
Minute, obtain ferment fermenation raw liquid；
(e) fermenation raw liquid is filtered, the content of detection wherein taxol is 0.09mg/L, adds sterile water and is diluted to content
For 0.03mg/L, flavouring, bacteriostatic agent, antioxidant, colouring agent etc. are then added, Chinese yew ferment oral liquid is made in packing.
Embodiment 3
In the present embodiment, Chinese yew ferment oral liquid is prepared by the following method, specifically includes following steps：
(a) by the drying of Chinese yew complete stool, crushing, 30 mesh sieves are crossed, it is spare；
(b) it is 1 by weight ratio:1:1 fructus hippophae, apple and strawberry cleans that to break into fruit juice after airing spare；
(c) taxus chinensis powder that step (a) obtains is minced and (weight ratio is for the fruit juice of step (b) acquisition and sugar
1:1 lime tree nectar and the combination of syrup) according to weight ratio 3:3:4 proportioning is added to fermentation tank, is incorporated as Chinese yew crushing
Thing and fruit juice and 1-2 times of sterile water of the gross weight of sugar, 30 DEG C are shaken lower fermentation and obtain ferment fermentation seed in 32 days；
(d) taxus chinensis powder that step (a) obtains separately is taken to mince with the fruit juice of step (b) acquisition and sugar according to weight
Than 3:3:4 proportioning, which is added, to another fermentation tank, is incorporated as 2 times that taxus chinensis powder minces with fruit juice and sugared gross weight
Sterile water, add the ferment fermentation seed that step (c) obtains, 35 DEG C ferment 18 days, and stirring daily twice, stirs 10 every time
Minute, obtain ferment fermenation raw liquid；
(e) fermenation raw liquid is filtered, the content of detection wherein taxol is 0.05mg/L, and packing, is made Chinese yew ferment
Oral liquid.
Embodiment 4
In the present embodiment, Chinese yew ferment tablet is prepared by the following method, specifically includes following steps：
(a) by the drying of Chinese yew complete stool, crushing, 30 mesh sieves are crossed, it is spare；
(b) it is 1 by weight ratio:1 fructus hippophae and grape cleans that to break into fruit juice after airing spare；
(c) taxus chinensis powder that step (a) obtains is minced with the fruit juice of step (b) acquisition and white sugar according to weight
Measure ratio 3:1:3 proportioning is added to fermentation tank, is incorporated as the 2 of the gross weight that taxus chinensis powder minces with fruit juice and white sugar
Sterile water again, 30 DEG C are shaken lower fermentation and obtain ferment fermentation seed in 30 days；
(d) separately take step (a) obtain taxus chinensis powder mince with step (b) obtain fruit juice and white sugar according to
Weight ratio 3:1:3 proportioning is added to another fermentation tank, be incorporated as taxus chinensis powder mince it is total with fruit juice and white sugar
2 times of sterile water of weight, adds the ferment fermentation seed that step (c) obtains, and 35 DEG C ferment 18 days, stirs daily twice,
Stirring 15 minutes every time, obtain ferment fermenation raw liquid；
(e) fermenation raw liquid is filtered, when the content of detection wherein taxol is less than 0.01mg/L, continues to ferment, after
The content of taxol is monitored during supervention ferment, continues fermentation 2 days, the content of taxol reaches 0.015mg/L, fermentation
Liquid concentrates, and is molded to obtain according to the auxiliary material progress tablet such as content addition excipient, stabilizer, adhesive, lubricant, disintegrant red
Beans China fir ferment tablet.
Embodiment 5
In the present embodiment, Chinese yew ferment granule is prepared by the following method, specifically includes following steps：
(a) branches and leaves of yew is dried, crushed, cross 20 mesh sieves, it is spare；
(b) fructus hippophae cleaned to break into fruit juice after airing spare；
(c) taxus chinensis powder that step (a) obtains is minced with the fruit juice of step (b) acquisition and glucose according to weight
Measure ratio 8:3:10 proportioning is added to fermentation tank, is incorporated as taxus chinensis powder and is minced and the gross weight of fruit juice and glucose
1 times of sterile water, 30 DEG C are shaken lower fermentation and obtain ferment fermentation seed in 30 days；
(d) separately take step (a) obtain taxus chinensis powder mince with step (b) obtain fruit juice and glucose according to
Weight ratio 8:3:10 proportioning is added to another fermentation tank, be incorporated as taxus chinensis powder mince it is total with fruit juice and glucose
1 times of sterile water of weight, adds the ferment fermentation seed that step (c) obtains, and 35 DEG C ferment 18 days, stirs daily twice,
Stirring 10 minutes every time, obtain ferment fermenation raw liquid；
(e) fermenation raw liquid is filtered, the content of detection wherein taxol is 0.09mg/L, adds sterile water and is diluted to content
Shaping is carried out for auxiliary materials such as 0.03mg/L, zymotic fluid concentration, addition excipient, stabilizer, adhesives, and Chinese yew ferment is made
Granula.
Embodiment 6
In the present embodiment, Chinese yew ferment capsule is prepared by the following method, specifically includes following steps：
(a) branches and leaves of yew is dried, crushed, cross 40 mesh sieves, it is spare；
(b) strawberry, Kiwi berry, grape and lemon cleaned to break into fruit juice after airing spare；
(c) taxus chinensis powder that step (a) obtains is minced and (weight ratio is for the fruit juice of step (b) acquisition and sugar
1:2 lime tree nectar and the combination of syrup) according to weight ratio 4:4:5 proportioning is added to fermentation tank, is incorporated as Chinese yew crushing
Thing and fruit juice and 2 times of sterile water of the gross weight of sugar, 35 DEG C are shaken lower fermentation and obtain ferment fermentation seed in 35 days；
(d) the fruit juice and sugar (weight ratio that the taxus chinensis powder that step (a) obtains minces and step (b) obtains separately are taken
For 1:2 lime tree nectar and the combination of syrup) according to weight ratio 4:4:5 proportioning is added to another fermentation tank, is incorporated as red bean
China fir crushed material and fruit juice and 2 times of sterile water of the gross weight of sugar, add the ferment fermentation kind that step (c) obtains
Son, 35 DEG C ferment 18 days, and twice, stirring 15 minutes, obtain ferment fermenation raw liquid every time for stirring daily；
(e) fermenation raw liquid is filtered, the content of detection wherein taxol is 0.08mg/L, and zymotic fluid concentration, adds figuration
The auxiliary materials such as agent, stabilizer, lubricant carry out shaping and Chinese yew ferment capsule are made.
Applicant states that the present invention illustrates the Chinese yew ferment health medicine of the present invention and its system by above-described embodiment
Preparation Method and application, but the invention is not limited in above-described embodiment, that is, do not mean that the present invention has to rely on above-described embodiment
It could implement.Person of ordinary skill in the field is it will be clearly understood that any improvement in the present invention, to raw material selected by the present invention
Equivalence replacement and the addition of auxiliary element, the selection of concrete mode etc., all fall within protection scope of the present invention and the open scope
Within.
Claims (39)
1. a kind of Chinese yew ferment health products, it is characterised in that the Chinese yew ferment health products are (3-8) by weight ratio:(1-
4):Chinese yew, fruit and the sugar of (3-10) are prepared for raw material；
The fruit is any one or at least two in fructus hippophae, apple, strawberry, Kiwi berry, grape, lemon or orange
Combination；The sugar is the combination of any one or at least two in honey, syrup, glucose or white granulated sugar；
The Chinese yew ferment health products are prepared by following methods：
(1) crushed material of Chinese yew and fruit juice and sugar are added to fermentation tank, adds sterile water, fermentation obtains ferment hair
Ferment seed；
(2) it is another to take the crushed material of the proportioning Chinese yew identical with step (1) proportioning to be added with fruit juice and sugar to another hair
Fermentation tank, adds sterile water, adds the ferment fermentation seed that step (1) obtains, and fermentation obtains ferment fermenation raw liquid；
(3) fermenation raw liquid for obtaining step (2) filters, the content of detection wherein taxol, when content reaches 0.01-
During 0.08mg/L, that is, complete fermentation；If content is less than 0.01mg/L, continue to ferment；If content is higher than 0.08mg/
L, then add sterile water and be diluted to 0.01-0.08mg/L, and required formulation is then made and obtains the Chinese yew ferment health products；
Step (1) and step (2) described fermentation temperature are 25-35 DEG C, and step (1) described fermentation time is 30-35 days, step
(2) fermentation time is 18-20 days, and in step (2) described fermentation process, stirring is twice, 10-15 minutes each daily.
2. Chinese yew ferment health products according to claim 1, it is characterised in that the agent of the Chinese yew ferment health products
Type is any one in oral liquid, tablet, capsule or granule.
3. Chinese yew ferment health products according to claim 2, it is characterised in that the agent of the Chinese yew ferment health products
Type is oral liquid.
4. Chinese yew ferment health products according to claim 1, it is characterised in that the fruit for fructus hippophae, apple and
The combination of strawberry.
5. Chinese yew ferment health products according to claim 1, it is characterised in that the sugar is the group of honey and syrup
Close.
6. Chinese yew ferment health products according to claim 5, it is characterised in that the sugar is lime tree nectar and syrup
Combination.
7. the preparation method of the Chinese yew ferment health products according to any one of claim 1-6, it is characterised in that described
Method be with Chinese yew, fruit and sugar for raw material, it is fermented to obtain Chinese yew enzyme stoste, optionally with sterile water adjust ferment
The content of taxol in stoste, is then made required formulation and obtains the Chinese yew ferment health products；
It the described method comprises the following steps：
(1) crushed material of Chinese yew and fruit juice and sugar are added to fermentation tank, adds sterile water, fermentation obtains ferment hair
Ferment seed；
(2) it is another to take the crushed material of the proportioning Chinese yew identical with step (1) proportioning to be added with fruit juice and sugar to another hair
Fermentation tank, adds sterile water, adds the ferment fermentation seed that step (1) obtains, and fermentation obtains ferment fermenation raw liquid；
(3) fermenation raw liquid for obtaining step (2) filters, the content of detection wherein taxol, when content reaches 0.01-
During 0.08mg/L, that is, complete fermentation；If content is less than 0.01mg/L, continue to ferment；If content is higher than 0.08mg/
L, then add sterile water and be diluted to 0.01-0.08mg/L, and required formulation is then made and obtains the Chinese yew ferment health products；
Step (1) and step (2) described fermentation temperature are 25-35 DEG C, and step (1) described fermentation time is 30-35 days, step
(2) fermentation time is 18-20 days, and in step (2) described fermentation process, stirring is twice, 10-15 minutes each daily.
8. preparation method according to claim 7, it is characterised in that it is by red bean that step (1) described taxus chinensis powder, which minces,
China fir complete stool or branches and leaves drying, crush, and crosses what 20-40 mesh sieves obtained.
9. preparation method according to claim 7, it is characterised in that step (1) the fruit juice is to clean fruit
Juice is broken into after drying.
10. preparation method according to claim 7, it is characterised in that the powder of step (1) and step (2) described Chinese yew
It is (3-8) to mince with the weight ratio of fruit juice and sugar:(1-4):(3-10).
11. preparation method according to claim 7, it is characterised in that the fruit is fructus hippophae, apple, strawberry, macaque
In peach, grape, lemon or orange any one or at least two combination.
12. preparation method according to claim 11, it is characterised in that the fruit is fructus hippophae, apple and strawberry
Combination.
13. preparation method according to claim 7, it is characterised in that the sugar is honey, syrup, glucose or white sand
In sugar any one or at least two combination.
14. preparation method according to claim 13, it is characterised in that the sugar is the combination of honey and syrup.
15. preparation method according to claim 14, it is characterised in that the sugar is the combination of lime tree nectar and syrup.
16. preparation method according to claim 7, it is characterised in that step (1) and step (2) described sterile water plus
Enter 1-2 times of the gross weight that amount is minced for taxus chinensis powder with fruit juice and sugar.
17. preparation method according to claim 7, it is characterised in that step (1) fermentation carries out under shake.
18. preparation method according to claim 7, it is characterised in that in step (2) described fermentation process, stirring daily
Twice, it is 10-15 minutes each.
19. preparation method according to claim 7, it is characterised in that step (3) is described to be continued in fermentation process to Japanese yew
The content of alcohol is monitored until the content of taxol reaches 0.01-0.08mg/L, and completion fermentation, is then made required formulation i.e.
Obtain the Chinese yew ferment health products.
20. preparation method according to claim 7, it is characterised in that the formulation for oral liquid, tablet, capsule or
Any one in granule.
21. preparation method according to claim 20, it is characterised in that the formulation is oral liquid.
22. preparation method according to claim 21, it is characterised in that the preparation method of the oral liquid includes following step
Suddenly：
(1) crushed material of Chinese yew and fruit juice and sugar are added to fermentation tank, adds sterile water, fermentation obtains ferment hair
Ferment seed；
(2) it is another to take the crushed material of Chinese yew to be added with fruit juice and sugar to another fermentation tank, sterile water is added, adds step
Suddenly the ferment fermentation seed that (1) obtains, fermentation obtain ferment fermenation raw liquid；
(3) fermenation raw liquid is filtered, the content of detection wherein taxol, when content reaches 0.01-0.08mg/L, that is, completes hair
Ferment；If content is less than 0.01mg/L, continue to ferment；If content is higher than 0.08mg/L, sterile water dilution is added
To 0.01-0.08mg/L, the oral liquid is then made.
23. preparation method according to claim 22, it is characterised in that step (1) and step (2) Chinese yew crush
The weight ratio of thing and fruit juice and sugar is (3-8):(1-4):(3-10).
24. preparation method according to claim 23, it is characterised in that step (1) and step (2) Chinese yew crush
Thing is 3 with the weight ratio of fruit juice and sugar:3:4.
25. preparation method according to claim 22, it is characterised in that the fruit is fructus hippophae, apple, strawberry, Mi
In monkey peach, grape, lemon or orange any one or at least two combination.
26. preparation method according to claim 25, it is characterised in that the fruit is fructus hippophae, apple and strawberry
Combination.
27. preparation method according to claim 26, it is characterised in that the fruit is that weight ratio is 1:1:1 sea-buckthorn
The combination of fruit, apple and strawberry.
28. preparation method according to claim 22, it is characterised in that the sugar is honey, syrup, glucose or white sand
In sugar any one or at least two combination.
29. preparation method according to claim 28, it is characterised in that the sugar is the combination of honey and syrup.
30. preparation method according to claim 29, it is characterised in that the sugar is the combination of lime tree nectar and syrup.
31. preparation method according to claim 30, it is characterised in that the sugar is that weight ratio is 1:1 lime tree nectar and
The combination of syrup.
32. preparation method according to claim 22, it is characterised in that step (1) and step (2) described sterile water plus
Enter 1-2 times of the gross weight that amount is minced for taxus chinensis powder with fruit juice and sugar.
33. preparation method according to claim 22, it is characterised in that step (1) and step (2) described fermentation temperature are
25-35℃。
34. preparation method according to claim 33, it is characterised in that step (1) described fermentation time is 30-35 days.
35. preparation method according to claim 22, it is characterised in that step (1) fermentation carries out under shake.
36. preparation method according to claim 22, it is characterised in that step (2) described fermentation time is 18-20 days.
37. preparation method according to claim 22, it is characterised in that in step (2) described fermentation process, stirring daily
Twice, it is 10-15 minutes each.
38. preparation method according to claim 22, it is characterised in that step (3) is described to be continued in fermentation process to purple
The content of China fir alcohol is monitored until the content of taxol reaches 0.01-0.08mg/L, and completion fermentation, is then made the red bean
China fir ferment oral liquid.
39. the Chinese yew ferment health products according to any one of claim 1-6 are in anti-cancer and cancer-preventing health products are prepared
Using.
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| CN105707852A (en) * | 2015-12-10 | 2016-06-29 | 黔东南森林王红豆杉发展有限责任公司 | Taxus chinensis fruit enzyme preparation method |
| CN114009765B (en) * | 2021-11-09 | 2024-01-30 | 四川贝美森生物科技有限公司 | Taxus chinensis fermentation liquor product with antibacterial function and preparation method thereof |
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| CN102071230A (en) * | 2010-11-23 | 2011-05-25 | 李民生 | Method for extracting paclitaxel from taxus chinensis through microorganism fermentation |
| CN103860609A (en) * | 2012-12-12 | 2014-06-18 | 丁再发 | Manufacturing method for taxus chinensis essence |
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