CN107438594B - 一种用于合成环酰胺的有效的工艺 - Google Patents

一种用于合成环酰胺的有效的工艺 Download PDF

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Publication number
CN107438594B
CN107438594B CN201580078598.9A CN201580078598A CN107438594B CN 107438594 B CN107438594 B CN 107438594B CN 201580078598 A CN201580078598 A CN 201580078598A CN 107438594 B CN107438594 B CN 107438594B
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CN
China
Prior art keywords
formula
solvent
amphoteric
compound
rearrangement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201580078598.9A
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English (en)
Chinese (zh)
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CN107438594A (zh
Inventor
马努基·库马尔·莫哈帕特拉
罗摩莫汉拉奥·本德普迪
保罗·文森特·马修莱
文森特·保罗
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Anthea Aromatics Pvt Ltd
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Anthea Aromatics Pvt Ltd
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Publication of CN107438594A publication Critical patent/CN107438594A/zh
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Publication of CN107438594B publication Critical patent/CN107438594B/zh
Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B21/00—Nitrogen; Compounds thereof
    • C01B21/082—Compounds containing nitrogen and non-metals and optionally metals
    • C01B21/14—Hydroxylamine; Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G9/00—Compounds of zinc
    • C01G9/02—Oxides; Hydroxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D201/00—Preparation, separation, purification or stabilisation of unsubstituted lactams
    • C07D201/02—Preparation of lactams
    • C07D201/04—Preparation of lactams from or via oximes by Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D201/00—Preparation, separation, purification or stabilisation of unsubstituted lactams
    • C07D201/02—Preparation of lactams
    • C07D201/04—Preparation of lactams from or via oximes by Beckmann rearrangement
    • C07D201/06—Preparation of lactams from or via oximes by Beckmann rearrangement from ketones by simultaneous oxime formation and rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D201/00—Preparation, separation, purification or stabilisation of unsubstituted lactams
    • C07D201/16—Separation or purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D227/00—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00
    • C07D227/02—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D227/06—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D227/08—Oxygen atoms
    • C07D227/087—One doubly-bound oxygen atom in position 2, e.g. lactams
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/34—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
    • B01D3/36—Azeotropic distillation

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201580078598.9A 2015-04-02 2015-06-04 一种用于合成环酰胺的有效的工艺 Expired - Fee Related CN107438594B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1410/MUM/2015 2015-04-02
PCT/IB2015/054222 WO2016156932A1 (en) 2015-04-02 2015-06-04 An efficient process for the synthesis of cyclic amides
IN1410MU2015 IN2015MU01410A (enExample) 2015-04-02 2015-06-04

Publications (2)

Publication Number Publication Date
CN107438594A CN107438594A (zh) 2017-12-05
CN107438594B true CN107438594B (zh) 2020-11-06

Family

ID=53490015

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580078598.9A Expired - Fee Related CN107438594B (zh) 2015-04-02 2015-06-04 一种用于合成环酰胺的有效的工艺

Country Status (7)

Country Link
US (1) US10093622B2 (enExample)
EP (1) EP3277664B1 (enExample)
JP (1) JP6513823B2 (enExample)
CN (1) CN107438594B (enExample)
ES (1) ES2757073T3 (enExample)
IN (1) IN2015MU01410A (enExample)
WO (1) WO2016156932A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109481958B (zh) * 2018-11-29 2021-04-20 万华化学集团股份有限公司 一种降低环十二酮肟在硫酸萃取过程中的水解率的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2275407A1 (en) * 2008-05-02 2011-01-19 Ube Industries, Ltd. Process for production of amide or lactam

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2988546A (en) 1961-06-13 Lactam
JPS5144941B1 (enExample) * 1970-03-27 1976-12-01
DE2130036B2 (de) 1971-06-18 1977-02-10 Davy Powergas GmbH, 5000 Köln Verfahren zur herstellung von lactamen
DE19805815C1 (de) 1998-02-13 1999-11-11 Ansgar W Lohse Diagnostikum zum Erkennen der autoimmunen Hepatitis
JP2001019670A (ja) 1999-07-05 2001-01-23 Mitsubishi Chemicals Corp 転位反応による有機化合物の製造方法
US8309714B2 (en) * 2007-11-29 2012-11-13 Ube Industries, Ltd. Process for producing laurolactam
FR2931478B1 (fr) 2008-05-26 2012-08-03 Arkema France Prodece de preparation de lactames comprenant une etape de photonitrosation suivie d'une etape de transposition de beckmann
JP5369653B2 (ja) * 2008-12-03 2013-12-18 宇部興産株式会社 アミド又はラクタムの製造方法
CN104086487B (zh) * 2014-07-18 2016-07-06 河北工业大学 一种以环己酮为原料直接合成己内酰胺的方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2275407A1 (en) * 2008-05-02 2011-01-19 Ube Industries, Ltd. Process for production of amide or lactam

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
p-Toluenesulfonic acid mediated zinc chloride: highly effective catalyst for the Beckmann rearrangement;Lin-fei Xiao，等;《Tetrahedron Letters》;20070731(第48期);7218–7221 *
Solvent-Free and One-Step Beckmann Rearrangement of Ketones and Aldehydes by Zinc Oxide;Hashem Sharghi，等;《Synthesis》;20020604(第8期);1057-1060 *

Also Published As

Publication number Publication date
ES2757073T3 (es) 2020-04-28
EP3277664A1 (en) 2018-02-07
JP2018512419A (ja) 2018-05-17
EP3277664B1 (en) 2019-08-07
WO2016156932A1 (en) 2016-10-06
CN107438594A (zh) 2017-12-05
US10093622B2 (en) 2018-10-09
US20180093949A1 (en) 2018-04-05
JP6513823B2 (ja) 2019-05-15
IN2015MU01410A (enExample) 2015-05-15

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