CN107319171A - It is a kind of to strengthen the Chinese herb feed additive of chicken immunity - Google Patents

Abstract

The present invention provides a kind of Chinese herb feed additive of enhancing chicken immunity, is related to animal immune technical field, the technical scheme of use is：A kind of to strengthen the Chinese herb feed additive of chicken immunity, the additive raw material includes the component of following mass fraction：5~6 parts of Echinacea, 3~4 parts of the Radix Astragali, 2~3 parts of Radix Angelicae Sinensis, 1~2 part of grass-leaved sweetflag, 1~2 part of honey-fried licorice root.Beneficial effect is：（1）This compound preparation compatibility science, synergy, can significantly improve the autoimmune function of chicken, greatly strengthen body and integrate constitution, protect poultry from the infection of virus, epidemic disease etc.；（2）Without chemicals such as antibiotic and other chemical synthesis antimicrobials, drug residue free in poultry product improves human food's safety, green, environmental protection；（3）Ultrafine powder greatly improves Chinese herbal medicine utilization rate, reduces usage amount, and reduction is wasted；（4）Simple production process, cost are relatively low, good in economic efficiency, have a extensive future.

Description

It is a kind of to strengthen the Chinese herb feed additive of chicken immunity

Technical field

The invention belongs to animal immune technical field, it is related to a kind of animal immunity potentiator, and in particular to one kind enhancing chicken The Chinese herb feed additive of immunity.

Background technology

With intensive, the large-scale development of aquaculture industry, animal epidemics are directly connected to the success or failure of cultivation, control animal Epidemic situation, development healthy aquaculture turns into the important topic of aquaculture.Huge economy can be all caused due to epidemic disease every year in poultry husbandry Loss, according to measuring and calculating, bird flu in 2013 causes broiler chicken baby chick direct losses more than 3,700,000,000 yuan, live chickens and chicken meat product lost on sale More than 13,000,000,000 yuan, usually prevent the various infectious diseases of chicken in production with vaccine, but in recent years in be even more generally existing it is immune Infectious disease still outbreak of epidemic after inoculation, increase dosage do not reach preferable therapeutic effect yet, still can be infected and Cause a disease, its one of the main reasons is that immunologic function declines.Therefore, explore how to improve animal body itself resistance, it is effectively pre- Anti- disease, is when the urgent technical assignment of previous item.

Chinese herbal medicine belong to naturally, Green medicament, it is high to animal and human safety, meet international veterinary science development trend. As immunopotentiator in terms of livestock and poultry immunity of organisms, disease preventing and treating is improved, with unique effect, a large amount of scholars are received Attention.But the Chinese herbal medicine of current raising chicken immunity is usually to be simply mixed rear fried by a variety of herbal components or beat Powder, on the one hand can not give full play to its curative effect, and the compatibility not given full play between component coordinates synergy, causes curative effect to be paid no attention to Think, practical effect is unsatisfactory, even the Chinese herbal medicine that taste number is a lot, formula is complicated, except cost is higher, it is complicated to prepare Deng also add the uncertain factor in effect while effect is undesirable.Therefore, Further Research into Chinese Medical Theories, and combine Actual tests, science selection component, optimized proportion coordinate the herbal composite class additive of exquisite excellent effect, are to improve chicken The effective way of immunity, is significant to aquaculture industry prevention and control animal epidemic.

The content of the invention

The present invention is solves existing chicken immune reinforcing agent complicated component, the technical problem of effect difference strengthens chicken there is provided one kind The Chinese herb feed additive of immunity, to strengthen the body resistance to consolidate the constitution, tonifying middle-Jiao and Qi, raising immunity of organisms is the principles of formulating prescriptions, with Echinacea and The Radix Astragali is aided with Radix Angelicae Sinensis, grass-leaved sweetflag and honey-fried licorice root as main component, and coordinating the drug actions of a prescription realizes strengthening vital QI to eliminate pathogenic factors, bacteria removal, virus With enhancing Abwehrkraft des Koepers, prevent from infecting the purpose of epidemic disease.

The technical solution adopted by the present invention is：

A kind of to strengthen the Chinese herb feed additive of chicken immunity, the additive raw material includes the component of following mass fraction：It is purple Bore 5~6 parts of chrysanthemum, 3~4 parts of the Radix Astragali, 2~3 parts of Radix Angelicae Sinensis, 1~2 part of grass-leaved sweetflag, 1~2 part of honey-fried licorice root.

It is preferred that, the additive raw material includes the component of following mass fraction：5 parts of Echinacea, 3 parts of the Radix Astragali, Radix Angelicae Sinensis 3 Part, 2 parts of grass-leaved sweetflag, 1 part of honey-fried licorice root.

It is preferred that, the Chinese herb feed additive is powder or granule.

It is preferred that, the Chinese herb feed additive preparation method comprises the following steps：

(1) get the raw materials ready：Echinacea, the Radix Astragali, Radix Angelicae Sinensis, grass-leaved sweetflag, radix glycyrrhizae are distinguished into removal of impurities, cleans and dries, it is standby；

(2) honey-fried licorice root is prepared：By refined honey and water with mass ratio 1:1-1.5 is mixed into honeydew, is heated to honeydew boiling, adds dry Dry radix glycyrrhizae, stands 30-60min, then is stir-fried 3-10min with slow fire, 55-70 DEG C of drying to tack-free, obtained honey-fried licorice root；

(3) 5~6 parts of Echinacea, 3~4 parts of the Radix Astragali, 2~3 parts of Radix Angelicae Sinensis, 1~2 part of grass-leaved sweetflag and honey-fried licorice root 1 are weighed by mass parts ~2 parts add to Study on Supermicro-pulverization of Traditional Chinese Drugs machine, crush 30s-1min, obtain Chinese herb feed additive.

The present invention also provides any of the above-described containing 0.5 ~ 1.5wt.% in a kind of feed of enhancing chicken immunity, the feed Described Chinese herb feed additive.

In above-mentioned technical proposal, Echinacea is the class composite family Wild Flowers for originating in America, with enhancing cellular immunity With humoral immunity, antibacterial, antiviral effect, main active is polysaccharide, glycoprotein, caffeic acid derivative and alkylamide Class, Cichoric acid is immunized and anti-inflammatory efficacy, and can suppress hyaluronic acid as the main component of caffeic acid derivative with enhancing Enzyme；Polynary unsaturated isobutylamides contained by the root and aerial part of Echinacea, with immunoloregulation function, can prevent cause of disease Inflammation caused by body, there is stronger anti-inflammatory activity, is also acted on antibiotic sample, available for bacterium infection, research surface purple cone Chrysanthemum can stimulate body immune system to strengthen body to bacterium and the resistance of virus infection.

The Radix Astragali has effects that invigorating qi for strengthening superficies, promoting pus discharge and tissue regeneration, Li Shui, " card that can control all laboured breathing deficiency of blood ".Modern pharmacology Research shows that the Radix Astragali has immunostimulation, antiviral, anti-oxidant and antineoplastic action, to the antibody tormation function of normal body It is obviously promoted effect.The Radix Astragali is mainly containing saponins, flavonoids, polysaccharide and amino acids etc., and astragalus polyose has immune tune Section effect and the generation having no side effect, Radix Astragali soap former times can be obviously promoted B cell proliferation differentiation and the synthesis of thick liquid cell antibody.Animal Experiment shows that the Radix Astragali can promote T lymphopoiesis, strengthens the phagocytic function of monocytes/macrophages, and inducement interferon promotees Enter NK cytoactives, improve lymphocyte complement receptors activity, also significant viral infection resisting function.

Radix Angelicae Sinensis has Yang nourishing-strengthening, strengthening the body resistance to consolidate the constitution benefit, blood and blood and activates blood circulation and disperses blood clots and the effects such as moisturize laxation, to marrow hemopoiesis Progenitor cells have obvious proliferation function, can dramatically increase content of hemoglobin and red blood cell number, and red blood cell is important day Right immunocyte, Radix Angelicae Sinensis can strengthen erythrocyte immune ability, so that strengthening immunity of organisms plays its antitumor action.Research Prove that Radix Angelicae Sinensis can improve hematopoieticmicroenviron-ment, strengthen the expression of hematopoietic cell surface adhesion molecule, promote the hematopoietic regulation factor Expression, promotes the generation of cell factor, and activating complement system promotes the generation of antibody, so as to play many-sided to immune system Adjustment effect.

Grass-leaved sweetflag is aroid, and its main component is the volatile oil containing asarone and beta-Asarone, amino acid And carbohydrate, with a surname's key slit phlegm, dampness elimination appetizing effect is for oral administration to promote digestive juice secretion, prevents stomach and intestine abnormal fermentation.Stone Chang Pu has anticonvulsant action, and can calm the nerves calmness, while having cooling, antitumor action；And grass-leaved sweetflag also has certain exempt from Epidemic disease adjustment effect, can avoid evil spirits gas, anti-epidemic disease infection, the Thymus and Spleen index of immunosuppressed mice can be improved, so as to carry The immunity of high body.

Radix glycyrrhizae with coordinating the drug actions of a prescription, solution hundred poison and it is famous, containing glycyrrhizin, enoxolone, glycyrol, isoglycyrol, The plurality of active ingredients such as cumarin, alkaloid.Clinical practice point " raw to use " and " honey is processed " are not, raw to be truly had not with curative effect with processing Together.Radix glycyrrhizae life is with mild-natured, with purging intense heat and detonicating, based on expelling phlegm and arresting coughing；Honey-fried licorice root is sweet warm-natured, and with tonifying middle-Jiao and Qi, relieving spasm to stop pain is It is main.Research finds that honey-fried licorice root has the effect of anti-inflammatory and antiallergic action, can adjust the immunologic function of body, and glycyrrhizin enhancing is same The propagation of allosome T cells is planted, interferon-γ and IL-10 expression is improved, IL-4 expression is reduced, promotes 1 type complementary T cell immune responses；Glycyrrhizic acid and enoxolone have anti-inflammatory, anti-oxidant, antitumor, antimicrobial, antiviral and immune The effect such as regulation.In body under normal circumstances, enoxolone can strengthen immune response；Under inflammatory conditions, enoxolone can To suppress too drastic inflammatory reaction；Liquiritigenin can strengthen CD4⁺ T cell immune responses, raising IFN-γ and IL-2's Expression；Licorice polysaccharide can strengthen the expression of antibody level and IFN-γ that ovalbumin induction is produced, enhance body Immune response.

The present invention is to strengthen the body resistance to consolidate the constitution, tonifying middle-Jiao and Qi, and raisings immunity of organisms is the principles of formulating prescriptions, using Echinacea and the Radix Astragali as Key agents are constituted, with Radix Astragali tonifying middle-Jiao and Qi, strengthening vital QI to eliminate pathogenic factors, adjust body's immunity, strengthen the antibacterial, antiviral of Echinacea Effect, comprehensive strengthen immunity；With Radix Angelicae Sinensis activating complement system, promote the generation of antibody, Compatibility with Radix Astragali, with enhancing it is immune and Promote the double effects of hematopoiesis, the Radix Astragali, Radix Angelicae Sinensis compatibility share rear Synergistic, the common bioactivity for improving medicine, such as Radix Astragali In active component Astragaloside IV and calycosin when stomach and intestine are operated, limited by cross-film ability and efflux protein, And the volatile oil component in Radix Angelicae Sinensis has the function that enhancing absorbs, so as to ensure that the effective dose of Astragaloside IV.Experimental study is sent out Existing, IL-2, IL-6, IL-10 show special activity only under conditions of the Radix Angelicae Sinensis Radix Astragali is decocted altogether, and two medicines are when sharing, body Interleukin 2（IL-2）Secretory volume increases by 3 times, interleukin-6（IL-6）And interleukin 10（IL-10）Increase Plus 20 times, these effects can significantly improve the proliferation rate of T- lymphocytes, and final astragalus, angelica compatibility can tonifying Qi promotion hematopoiesis It can strengthen immune again.Further ingenious science selection grass-leaved sweetflag, can promote the feed intake of broiler chicken, and improvement animal appetite is depressed, drink The maximum phase of an eclipse lacks and the dull symptom of gastral cavilty, so that production performance is improved, while calmness of calming the nerves, moisturizing viscera, benefit six internal organs, grass-leaved sweetflag Pungent, temperature, is equipped with the Radix Astragali, Radix Angelicae Sinensis, radix glycyrrhizae isothermal tonic, brings out the best in each other, and itself has immunoregulatory function basis On substantially increase the absorption efficiency of each medicine, strengthen giving full play to for each drug effect, so that the fast quick-recovery of immunity of organisms and carrying Height, resultant effect is greatly improved；Honey-fried licorice root coordinating the drug actions of a prescription, it is each in anti-inflammatory, the immune enhancing simultaneously of anti-oxidant, antiviral and regulation Curative effect of medication, all medicines share, strengthening vital QI to eliminate pathogenic factors, so as to reach bacteria removal, virus, strengthens Abwehrkraft des Koepers, prevents from infecting epidemic disease Purpose.

The beneficial effects of the invention are as follows：（1）The Chinese herbal compound preparation compatibility science that the present invention is provided, synergy, energy The autoimmune function of chicken is significantly improved, body is greatly strengthen and integrates constitution, protect poultry from the sense of virus, epidemic disease etc. Dye；（2）This Chinese herbal compound preparation is without chemicals such as antibiotic and other chemical synthesis antimicrobials, without medicine in poultry product Thing is remained, and substantially increases human food's safety, food-safe significant, green, environmental protection；（3）Further improve Technical scheme in, ultrafine powder greatly improves Chinese herbal medicine utilization rate, reduces usage amount, reduces side effect, and reduction is wasted； （4）This Chinese herbal compound preparation dispensing and simple production process, cost are relatively low, good in economic efficiency, it is adaptable to industrialized production and It is a wide range of to promote, have a extensive future.

Embodiment

The present invention is using the Chinese herbal medicine resource of China's abundant, and theoretical according to modern traditional Chinese medicine, scientific composition compatibility is developed The Chinese herb feed additive of the enhancing chicken immunity of compound, illustrates this Chinese herb feed additive below by way of specific embodiment and experiment Influence after composition and its various dose addition feeding chickling to immune organs of chicken treated and antibody level, is added with testing the Chinese herbal medicine Plus agent is applied to the effect of enhancing chicken immunity, to be better understood from the present invention, wherein involved raw material, such as nothing are especially said It is bright, commercially obtain, involved experimental method, operating method, are conventional meanses unless otherwise instructed.

The composition compatibility example ginseng of Chinese herb feed additive for strengthening chicken immunity is shown in Table 1.

The Chinese herb feed additive composition compatibility example of the enhancing chicken immunity of table 1（Ratio of weight and number）

Component	Compatibility 1	Compatibility 2	Compatibility 3	Compatibility 4
					Echinacea	5	5	6	6
The Radix Astragali	3	4	3	4
					Radix Angelicae Sinensis	2	2	3	3
Grass-leaved sweetflag	1	2	2	2
					Honey-fried licorice root	1	2	2	1

Above-mentioned to be used to strengthen the Chinese herb feed additive of chicken immunity, preparation method is as follows：

(1) get the raw materials ready：Echinacea, the Radix Astragali, Radix Angelicae Sinensis, grass-leaved sweetflag, radix glycyrrhizae are picked up clearly except the unqualified individual such as the chopped cooked entrails of sheep, Ran Houqing respectively Wash 1-2 times, dry naturally or 40-60 DEG C of drying, it is standby；

(2) honey-fried licorice root is prepared：By refined honey and water with mass ratio 1:1-1.5 is mixed into honeydew, is heated to honeydew boiling, adds dry Dry radix glycyrrhizae, wherein radix glycyrrhizae are 1 with refined honey mass ratio:0.8-1.2, stands 30-60min so that honeydew fully soaks radix glycyrrhizae, then Stir-fried 3-10min with slow fire, honeydew, 55-70 DEG C of drying to tack-free, obtained honey-fried licorice root are uniformly hung to all radix glycyrrhizaes；

(3) Echinacea, the Radix Astragali, Radix Angelicae Sinensis, grass-leaved sweetflag and honey-fried licorice root are weighed by mass parts, added in the lump to Study on Supermicro-pulverization of Traditional Chinese Drugs machine, 30s-1min is crushed, Chinese herb feed additive is obtained.

Powder is made for ultrafine powder, particle diameter is preferably smaller than 100 μm, even up to 40 μm, 10 μm, less than 1 μm, ultra micro Pulvis specific surface area increases, and can improve the utilization rate of Chinese medicine, strengthens curative effect of medication；Further, in ultrafine powder Chinese medicine is generally broken wall medicine, further improves the utilization rate of Chinese medicine, strengthens curative effect of medication.

Test influence of 1 Chinese herb feed additive of the present invention to bursa of fabricius vaccine immune effect

The white plumage broiler chicks of 1 age in days are normally raised to 6 ages in days, select body weight, development and close 300 of health status, random decile For A, B, C, D, E and F totally 6 big group, every group 50, A, B, C, D, E are medication group, and F is control group.6 age in days broiler chicks are opened Begin to feed the feed for adding Chinese herb feed additive of the present invention, each group feeding medicining condition is as shown in table 2 below, continuous feeding 7 days, phase Between free water, be not considered as agitation chicken group, conventinal breeding management.13 ages in days carry out the inoculation of bursa of farbricius Attenuate vaccine to each group chicken and exempted from Epidemic disease, two multiple dose collunarium eye droppings.Immune Indexes are determined in different days, 1.1,1.2 and 1.3 parts are seen.

The experiment of table 2 packet and each group feeding medicining condition

The measure of 1.1 Immune Organs Indexes

In 21,28,35,42 ages in days, experiment each group randomly selects 10 chickens, weighs, further take the bursa of farbricius, spleen, and With scales/electronic balance weighing, index and spleen index, bursal index are calculated, 3, table 4 is the results are shown in Table.

Calculation formula：Index and spleen index=spleen weight（mg）/ body weight（g）, bursal index=bursa of farbricius weight（mg）/ body weight（g）

The different days each group index and spleen index of table 3 compares

Different days, each medication group index and spleen index is all remarkably higher than control group, illustrates that Chinese herb feed additive of the present invention can promote spleen Dirty growth and development.In table 1 each medication group respectively with control group comparison in difference, it is extremely significantly high in 21 ages in days, 28 ages in days, 42 ages in days In control group（P<0.01）, in 35 age in days, difference is not notable（P>0.05）, it is visible to compare A, B and C group, in basal feed point A, B group of additive shown in 1 wt.%, 1.5wt.% compatibility 2 are not added, and in the test of 21 and 42 ages in days, its index and spleen index is significantly Higher than C groups, the index and spleen index tested in 28,35 ages in days, A, B and C group difference is not notable, the visible control that compares of Integrated comparative Group, raising of the B groups to index and spleen index is the most notable, be respectively higher than in 21 ages in days, 28 ages in days, 42 age in days control group 16.7%, 20.4% and 38.1%.

The different days each group bursal index of table 4 compares

Table 4 shows that the bursal index of each medication group is all remarkably higher than control group, illustrates that Chinese herb feed additive of the present invention can promote The growth and development of the bursa of farbricius.In 21 ages in days, 28 ages in days, 35 ages in days, 42 ages in days, each medication group bursal index pole is significantly higher than Control group（P<0.01）.Added in basal feed in A, B and C group of additive shown in compatibility 2, B groups are carried relative to control group High effect is the most obvious, is respectively increased 40.8%, 32.2%, 40.7% and 27.4%.

1.2 ELISA determine IBDV antibody in peripheral blood

In 20,27,34 ages in days, each group takes 10 broiler chicken at random, and wing venous blood sampling, 3000r/m centrifuges 15 min, draws serum Detect IBDV antibody.Operated according to kit specification, after kit reaction terminating, determine and inhale at ELIASA 450nm wavelength Luminosity（Optical density, OD) value, standard curve is drawn using the standard sample OD values of concentration known, accordingly standard Curve calculates each cytokine content.

The different days each group IBDV antibody titers of table 5（log10）Compare

As can be seen from Table 5, because infections chicken cloacal bursa Attenuate vaccine is immunized in 13 ages in days, what is existed in Broiler Chicken is still Maternal antibody, so compared with control group, the antibody level between various dose group, the different compatibility additive experimental groups of addition does not have It is variant.The antibody of five experimental groups generation of medicine is fed when 20 ages in days, 27 ages in days and 34 age in days obviously higher than control Group（P<0.01）.Added in basal feed in A, B and C group of additive shown in compatibility 2, B, C group antibody of middle and high dosage It is significantly higher than the A groups of low dosage（P<0.01）.There is no difference between B, C group of middle and high dosage, middle dosage B groups are in 34 age in days Improved relative to control group up to 21.9%.

CD4 in 1.3 flow cytomery peripheral bloods⁺/CD8⁺ The content of T lymphocytes

CD4, CD8 content in 20 ages in days, 27 ages in days, 34 ages in days detection peripheral blood.

The different days each group CD4 of table 6⁺, CD8⁺Comparision contents

During 20 age in days, after immune IBDV vaccines one week, medication group can raise the CD4 in peripheral blood⁺T lymphocytes are sub- The content of group, wherein B groups, C groups and E groups is significantly higher than control group（P＜ 0.01）, content is approximately as many as 3 times of control group, low The A groups and D groups CD4 of dosage⁺The content of T lymphocyte subgroups is as many as 2 times of control group；Each dosage group is to CD8 simultaneously⁺ T lymphocyte subgroups also have facilitation.A groups, B groups and control group compare only slight raising, C groups then apparently higher than Control group, higher than control group 50%, difference is extremely notable（P＜ 0.01）.It can be seen that, the Chinese herb feed additive of edible the application is exempted to chicken Improve fairly obvious on epidemic disease systemic immunity cell quantity.

The CD4 of each group during 27 age in days⁺、CD8⁺Content than 20 age in days Integrated comparatives be to have declined.But each medication group Remain above control group, B, C group and control group significant difference（P＜ 0.05）.

Each medication group CD4 during 34 age in days⁺、CD8⁺Content have decline, it may be possible to due to it is pharmaceutically-active disappear, wherein C groups CD4⁺Content is notable with control group comparing difference（P＜ 0.05）, B groups CD8⁺Content is notable with control group comparing difference（P ＜ 0.05）.

Immunoenhancement result of the checking of experiment 2 Chinese herb feed additive of the present invention to newcastle disease vaccine

It will be raised through preparation to the white plumage broiler chicks 120 of 7 ages in days, be randomly divided into A, B, C, D totally 4 groups, every group 30, raise Feed the Chinese herb feed additive shown in compatibility 2.A groups are low dose group（Additive containing 1wt.% 1% in basal feed）, B groups are middle dose Amount group（Additive containing 1.5wt.% in basal feed）, C groups are high dose group（Contain 3.0% additive in basal feed）, D groups are Control group（Basal feed）.Medication group is administered since 7 ages in days, successive administration 15d, and control group is without any medicine, each group Identical conventinal breeding management condition is taken, experiment uses chick in 7,21 age in days ewcastle disease LaSoat vaccine routine immunizations, and 15 blood samplings are chosen respectively at each machine of 14,21,28,35 ages in days, remaining 15, respectively at the blood sampling of 42,49,56,63 ages in days, are divided From serum, hemagglutination-inhibition test is carried out with 96 hole " V " shape blood-coagulation-boards according to a conventional method（HI）, the blood clotting suppression of NDV serum antibodies Potency is represented with log2.

The different days various dose each group chicken HI antibody titers of table 7（log2）

Group

14 ages in days

21 ages in days

28 ages in days

35 ages in days

42 ages in days

49 ages in days

56 ages in days

63 ages in days

A

6.0±1.18

4.7±1.17

5.8±0.56

7.6±0.84

7.5±1.21

7.7±0.77

7.6±0.44

7.5±0.67

B

5.7±0.32

5.4±1.49

6.7±0.78

8.0±0.57

8.6±0.43

9.0±0.34

8.5±0.58

8.2±1.78

C

5.2±0.45

4.3±0.48

6.3±1.72

7.2±0.99

7.6±0.38

7.4±1.06

8.0±0.41

7.6±0.23

D

5.3±1.16

4.2±0.55

6.1±0.47

7.0±0.34

7.3±1.09

7.1±0.94

7.3±1.23

7.2±0.87

As can be seen from the above two tables, A, B, C group for feeding Chinese herb feed additive of the present invention improve to ND antibody levels Effect, wherein with the wt.% addition best results of B groups 1.5.Antibody level and control group comparing difference are notable since 21 ages in days （P＜ 0.05）, 49 age in days antibody levels reach the log2 of highest 9.0,1.9 titres are higher by than control group, to immunoenhancement result About 27% is improved, the enhancing effect to chicken immunity is very notable.And the time that medication group antibody is maintained is longer, to 63 ages in days During off-test, the antibody level of B groups is still maintained at 8.2 log2,1.0 titres is higher by than control group, to immunoenhancement result Improve about 14%.

Test influence of 3 Chinese herb feed additives of the present invention to meat chicken production performance

It will raise to the white plumage broiler chicks 120 of 7 ages in days, be randomly divided into A, B, C, D totally 4 groups, every group 30, feed compatibility 2 Shown Chinese herb feed additive.A groups are low dose group（Additive containing 1wt.% 1% in basal feed）, B groups are middle dose group（Base Additive containing 1.5wt.% in plinth feed）, C groups are high dose group（Contain 3.0% additive in basal feed）, D groups are control group （Basal feed）.Medication group is administered since 7 ages in days, and successive administration to experiment terminates, and control group fed is without any medicine Basal feed, each group takes identical conventinal breeding management condition, records the scale of feeding of daily each group, enters per dosage group weekly Row is weighed, and calculates rate of body weight gain, feedstuff-meat ratio, feedstuff-meat ratio=feed weight/body weight.In an experiment, respectively at 13,20,27,34,41 ages in days Carry out 5 times to weigh, weight gain rate and feedstuff-meat ratio measurement result are shown in Table 8 and table 9 respectively.

The weightening of the different days various dose each group chicken of table 8 is compared（g）

Group	13 ages in days	20 ages in days	27 ages in days	34 ages in days	41 ages in days
						A	288.1±22.4	590.4±16.6	993.1±30.3	1307.9±18.5	1753.1±44.8
B	340.7±21.9	641.1±29.8	1046.6±22.7	1348.5±10.1	1911.8±33.9
						C	321.5±32.6	620.3±28.3	1009.5±33.3	1307.2±44.0	1835.3±29.8
D	270.3±12.9	577.4±19.7	979.6±20.5	1207.2±28.1	1500.3±50.2

The different days various dose each group chicken feedstuff-meat ratio of table 9 compares

Group	13 ages in days	20 ages in days	27 ages in days	34 ages in days	41 ages in days
						A	1.39±0.89	1.40±0.56	1.63±1.23	1.79±1.17	2.40±1.33
B	1.37±0.89	1.44±0.56	1.61±1.23	1.83±1.17	2.34±1.33
						C	1.38±0.89	1.58±0.56	1.76±1.23	1.86±1.17	2.48±1.33
D	1.53±0.89	1.74±0.56	1.83±1.23	2.15±1.17	2.52±1.33

The data of table 9 are visible, and the weightening of each medication group chicken is above control group, B groups middle dose group apparently higher than other two medication groups, It is extremely notable with control group and A, C group difference（P＜ 0.01）, illustrate that Chinese herb feed additive of the present invention can promote the weightening of broiler chicken, But it is not incremented by gradient with dosage, it may be possible to because dosage have impact on greatly very much the feed intake of chicken.The visible each age in days of the data of table 10 is not Feedstuff-meat ratio with dosage medication group is substantially less than control group（P＜ 0.05）, illustrate that Chinese herb feed additive of the present invention can improve meat Chicken feed conversion ratio, difference is not notable between A groups, B groups（P>0.05）.

Summary experiment is found, adds the Chinese herb feed additive of the 1wt. %-1.5wt. % present invention, to embodying chicken immune Every index of correlation of power is significantly increased, and the production performance to chicken substantially increases, and also substantially increases feed conversion rate, and Chinese herb feed additive component of the present invention is simple, compatibility more optimizes that science, preparation method be simple, cost is low, can greatly improve cultivation The economic benefit at family, while product quality is ensure that, it is significant to human health.

Claims (5)

1. a kind of strengthen the Chinese herb feed additive of chicken immunity, it is characterised in that the additive raw material includes following quality The component of number：5~6 parts of Echinacea, 3~4 parts of the Radix Astragali, 2~3 parts of Radix Angelicae Sinensis, 1~2 part of grass-leaved sweetflag, 1~2 part of honey-fried licorice root.

2. Chinese herb feed additive according to claim 1, it is characterised in that the additive raw material includes following quality The component of number：5 parts of Echinacea, 3 parts of the Radix Astragali, 3 parts of Radix Angelicae Sinensis, 2 parts of grass-leaved sweetflag, 1 part of honey-fried licorice root.

3. the Chinese herb feed additive described in claim 1 or 2, it is characterised in that the Chinese herb feed additive is powder or particle Agent.

4. the Chinese herb feed additive described in claim 1, it is characterised in that the Chinese herb feed additive preparation method includes following Step：

(1) get the raw materials ready：Echinacea, the Radix Astragali, Radix Angelicae Sinensis, grass-leaved sweetflag, radix glycyrrhizae are distinguished into removal of impurities, cleans and dries, it is standby；

(2) honey-fried licorice root is prepared：By refined honey and water with mass ratio 1:1-1.5 is mixed into honeydew, is heated to honeydew boiling, adds dry Dry radix glycyrrhizae, stands 30-60min, then is stir-fried 3-10min with slow fire, 55-70 DEG C of drying to tack-free, obtained honey-fried licorice root；

(3) 5~6 parts of Echinacea, 3~4 parts of the Radix Astragali, 2~3 parts of Radix Angelicae Sinensis, 1~2 part of grass-leaved sweetflag and honey-fried licorice root 1 are weighed by mass parts ~2 parts add to Study on Supermicro-pulverization of Traditional Chinese Drugs machine, crush 30s-1min, obtain Chinese herb feed additive.

5. a kind of strengthen the feed of chicken immunity, it is characterised in that contains 0.5 ~ 1.5wt.% claims 1-4 in the feed Any described Chinese herb feed additive.